DK0863887T3 - Mellemprodukter til hemisyntese af taxaner og fremgangsmåder til deres fremstilling - Google Patents
Mellemprodukter til hemisyntese af taxaner og fremgangsmåder til deres fremstillingInfo
- Publication number
- DK0863887T3 DK0863887T3 DK96934977T DK96934977T DK0863887T3 DK 0863887 T3 DK0863887 T3 DK 0863887T3 DK 96934977 T DK96934977 T DK 96934977T DK 96934977 T DK96934977 T DK 96934977T DK 0863887 T3 DK0863887 T3 DK 0863887T3
- Authority
- DK
- Denmark
- Prior art keywords
- hemisynthesis
- taxanes
- intermediates
- processes
- preparation
- Prior art date
Links
- 229940123237 Taxane Drugs 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title 1
- 229930190007 Baccatin Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0834—Compounds having one or more O-Si linkage
- C07F7/0838—Compounds with one or more Si-O-Si sequences
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9512739A FR2740451B1 (fr) | 1995-10-27 | 1995-10-27 | Nouveaux intermediaires pour l'hemisynthese de taxanes, leurs procedes de preparation et leur utilisation dans la synthese generale des taxanes |
| PCT/FR1996/001676 WO1997015562A1 (fr) | 1995-10-27 | 1996-10-25 | Intermediaires pour l'hemisynthese de taxanes et leurs procedes de preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0863887T3 true DK0863887T3 (da) | 2002-04-22 |
Family
ID=9484016
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK96934977T DK0863887T3 (da) | 1995-10-27 | 1996-10-25 | Mellemprodukter til hemisyntese af taxaner og fremgangsmåder til deres fremstilling |
Country Status (25)
| Country | Link |
|---|---|
| US (5) | US6265587B1 (da) |
| EP (1) | EP0863887B1 (da) |
| JP (1) | JP2000500437A (da) |
| KR (1) | KR100489865B1 (da) |
| CN (1) | CN100374428C (da) |
| AT (1) | ATE212342T1 (da) |
| AU (1) | AU710314B2 (da) |
| BR (1) | BR9610908A (da) |
| CZ (1) | CZ125598A3 (da) |
| DE (1) | DE69618812T2 (da) |
| DK (1) | DK0863887T3 (da) |
| EE (1) | EE03610B1 (da) |
| ES (1) | ES2170876T3 (da) |
| FR (1) | FR2740451B1 (da) |
| GE (1) | GEP20001938B (da) |
| HU (1) | HU225507B1 (da) |
| IL (1) | IL155876A (da) |
| NO (1) | NO981823L (da) |
| NZ (1) | NZ320356A (da) |
| PL (1) | PL327458A1 (da) |
| PT (1) | PT863887E (da) |
| RU (1) | RU2159237C2 (da) |
| SK (1) | SK52398A3 (da) |
| TR (1) | TR199800713T2 (da) |
| WO (1) | WO1997015562A1 (da) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2740451B1 (fr) * | 1995-10-27 | 1998-01-16 | Seripharm | Nouveaux intermediaires pour l'hemisynthese de taxanes, leurs procedes de preparation et leur utilisation dans la synthese generale des taxanes |
| KR100225535B1 (ko) * | 1996-08-27 | 1999-10-15 | 정지석 | 파클리탁셀의 제조방법 |
| US6150537A (en) * | 1997-12-12 | 2000-11-21 | Emory University | Methods for the esterification of alcohols and compounds useful therefor as potential anticancer agents |
| KR100267596B1 (ko) * | 1998-04-17 | 2000-10-16 | 강재헌 | 베타-아미노-알파-하이드록시산과 균등한 옥사졸린 유도체의 입체선택적 합성방법 |
| WO2001030770A1 (en) * | 1999-10-26 | 2001-05-03 | Dong Kook Pharmaceutical Co., Ltd. | Stereoselective synthesis of oxazoline derivative |
| ES2178539B1 (es) * | 2000-03-14 | 2004-08-01 | Dong Kook Pharmaceutical Co., Ltd. | Procedimiento para la preparacion de un compuesto de oxazolina. |
| WO2002066448A1 (en) * | 2001-02-20 | 2002-08-29 | Dabur India Limited | Method of preparation of paclitaxel (taxol) using 3-(alk-2-ynyloxy) carbonyl-5-oxazolidine carboxylic acid |
| FR2846327B1 (fr) * | 2002-10-25 | 2006-03-24 | Merck Sante Sas | Derives de n-benzodioxolyl, n-benzodioxanyl et n-benzodioxepinyl arylcarboxamides utilisables dans le traitement de dyslipidemies et compositions pharmaceutiques les contenant. |
| EP1919926A2 (en) | 2005-06-10 | 2008-05-14 | Florida State University Research Foundation, Inc. | Processes for the production of polycyclic fused ring compounds |
| JP5113745B2 (ja) | 2005-06-10 | 2013-01-09 | フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド | ドセタキセルの製造法 |
| GB0701523D0 (en) * | 2007-01-26 | 2007-03-07 | Chatham Biotec Ltd | Semi-synthetic process for the preparation of taxane derivatives |
| CN101468974B (zh) * | 2007-12-28 | 2011-02-09 | 上海百灵医药科技有限公司 | 多烯紫杉醇的半合成方法 |
| EP2519332B1 (en) | 2009-12-30 | 2014-03-05 | BASF Pharma (Callanish) Limited | Simulated moving bed chromatographic separation process for the purification of polyunsaturated fatty acids |
| GB201111591D0 (en) | 2011-07-06 | 2011-08-24 | Equateq Ltd | Further new process |
| GB201111589D0 (en) | 2011-07-06 | 2011-08-24 | Equateq Ltd | New modified process |
| GB201111595D0 (en) | 2011-07-06 | 2011-08-24 | Equateq Ltd | Improved process |
| GB201111594D0 (en) | 2011-07-06 | 2011-08-24 | Equateq Ltd | New improved process |
| GB201111601D0 (en) | 2011-07-06 | 2011-08-24 | Equateq Ltd | New process |
| CN103508918B (zh) * | 2012-06-18 | 2015-09-09 | 上海医药工业研究院 | 带有环丁基的α-羟基β-氨基酯类化合物及其制备方法 |
| GB201300354D0 (en) | 2013-01-09 | 2013-02-20 | Basf Pharma Callanish Ltd | Multi-step separation process |
| US8802880B1 (en) | 2013-05-07 | 2014-08-12 | Group Novasep | Chromatographic process for the production of highly purified polyunsaturated fatty acids |
| US9428711B2 (en) | 2013-05-07 | 2016-08-30 | Groupe Novasep | Chromatographic process for the production of highly purified polyunsaturated fatty acids |
| EP2883860B1 (fr) | 2013-12-11 | 2016-08-24 | Novasep Process | Procédé chromatographique de production d'acides gras polyinsaturés |
| WO2015104464A1 (fr) | 2014-01-07 | 2015-07-16 | Novasep Process | Procédé de purification d'acides aminés aromatiques |
| JP6205530B2 (ja) * | 2015-07-07 | 2017-09-27 | 忠勝 萬代 | パクリタキセル及びドセタキセルの側鎖前駆体の製造方法 |
| CN112876503B (zh) * | 2021-03-18 | 2022-04-29 | 中国科学院兰州化学物理研究所 | 用于癌症硼中子俘获治疗药物的硼酸盐化合物及其制备 |
| CN114195820B (zh) * | 2021-12-17 | 2023-11-10 | 中山大学 | 异丝氨酸衍生物及其制备与在紫杉醇合成中的应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4876399A (en) * | 1987-11-02 | 1989-10-24 | Research Corporation Technologies, Inc. | Taxols, their preparation and intermediates thereof |
| US5008411A (en) * | 1988-05-24 | 1991-04-16 | Hoffmann-La Roche Inc. | Glycidic acid ester and process of preparation |
| US5274300A (en) * | 1988-10-26 | 1993-12-28 | Sepracor, Inc. | Enzymatic hydrolysis of glycidate esters in the presence of bisulfite anion |
| US5304670A (en) | 1989-08-23 | 1994-04-19 | Centre National De La Recherche Scientifique | Process for the enantioselective preparation of phenylisoserine derivatives |
| IL95436A (en) * | 1989-08-23 | 1996-07-23 | Centre Nat Rech Scient | Process for preparing the history of phenylisosarine |
| JPH088879B2 (ja) * | 1989-09-13 | 1996-01-31 | 田辺製薬株式会社 | 光学活性３―フェニルグリシッド酸エステル類化合物の製法 |
| FR2658513B1 (fr) * | 1990-02-21 | 1994-02-04 | Rhone Poulenc Sante | Procede de preparation de l'acide cis-beta-phenylglycidique-(2r,3r). |
| FR2678930B1 (fr) | 1991-07-10 | 1995-01-13 | Rhone Poulenc Rorer Sa | Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii. |
| WO1993010076A1 (en) * | 1991-11-22 | 1993-05-27 | The University Of Mississippi | Synthesis and optical resolution of the taxol side chain and related compounds |
| CZ292993B6 (cs) * | 1992-12-23 | 2004-01-14 | Bristol-Myers Squibb Company | Způsob přípravy taxanu nesoucího oxazolinový postranní řetězec a taxan tímto způsobem připravený |
| FR2740451B1 (fr) * | 1995-10-27 | 1998-01-16 | Seripharm | Nouveaux intermediaires pour l'hemisynthese de taxanes, leurs procedes de preparation et leur utilisation dans la synthese generale des taxanes |
| US6228955B1 (en) * | 1996-04-19 | 2001-05-08 | Chirotech Technology, Ltd. | Asymmetric epoxides, their synthesis and use |
-
1995
- 1995-10-27 FR FR9512739A patent/FR2740451B1/fr not_active Expired - Fee Related
-
1996
- 1996-10-25 JP JP9516372A patent/JP2000500437A/ja not_active Ceased
- 1996-10-25 DK DK96934977T patent/DK0863887T3/da active
- 1996-10-25 CN CNB961978538A patent/CN100374428C/zh not_active Expired - Fee Related
- 1996-10-25 RU RU98110071/04A patent/RU2159237C2/ru not_active IP Right Cessation
- 1996-10-25 KR KR1019980703067A patent/KR100489865B1/ko not_active IP Right Cessation
- 1996-10-25 CZ CZ981255A patent/CZ125598A3/cs unknown
- 1996-10-25 EP EP96934977A patent/EP0863887B1/fr not_active Expired - Lifetime
- 1996-10-25 PT PT96934977T patent/PT863887E/pt unknown
- 1996-10-25 WO PCT/FR1996/001676 patent/WO1997015562A1/fr active IP Right Grant
- 1996-10-25 ES ES96934977T patent/ES2170876T3/es not_active Expired - Lifetime
- 1996-10-25 AT AT96934977T patent/ATE212342T1/de not_active IP Right Cessation
- 1996-10-25 NZ NZ320356A patent/NZ320356A/xx unknown
- 1996-10-25 BR BR9610908A patent/BR9610908A/pt unknown
- 1996-10-25 DE DE69618812T patent/DE69618812T2/de not_active Expired - Lifetime
- 1996-10-25 AU AU73086/96A patent/AU710314B2/en not_active Ceased
- 1996-10-25 EE EE9800149A patent/EE03610B1/xx not_active IP Right Cessation
- 1996-10-25 GE GEAP19964253A patent/GEP20001938B/en unknown
- 1996-10-25 TR TR1998/00713T patent/TR199800713T2/xx unknown
- 1996-10-25 SK SK523-98A patent/SK52398A3/sk unknown
- 1996-10-25 HU HU9802487A patent/HU225507B1/hu not_active IP Right Cessation
- 1996-10-25 PL PL96327458A patent/PL327458A1/xx unknown
- 1996-10-25 US US09/065,041 patent/US6265587B1/en not_active Expired - Fee Related
-
1998
- 1998-04-23 NO NO981823A patent/NO981823L/no not_active Application Discontinuation
-
2001
- 2001-04-18 US US09/836,326 patent/US6825365B2/en not_active Expired - Fee Related
-
2003
- 2003-05-12 IL IL155876A patent/IL155876A/en not_active IP Right Cessation
-
2004
- 2004-06-04 US US10/859,953 patent/US7279586B2/en not_active Expired - Fee Related
-
2005
- 2005-03-11 US US11/076,856 patent/US7220871B2/en not_active Expired - Fee Related
-
2007
- 2007-03-07 US US11/714,817 patent/US7432383B2/en not_active Expired - Fee Related
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