NO973253L - Sidekjedeholdig taxan og fremgangsmåte til fremstilling derav - Google Patents

Sidekjedeholdig taxan og fremgangsmåte til fremstilling derav

Info

Publication number
NO973253L
NO973253L NO973253A NO973253A NO973253L NO 973253 L NO973253 L NO 973253L NO 973253 A NO973253 A NO 973253A NO 973253 A NO973253 A NO 973253A NO 973253 L NO973253 L NO 973253L
Authority
NO
Norway
Prior art keywords
preparation
oxazoline
taxane
sidechain
chain
Prior art date
Application number
NO973253A
Other languages
English (en)
Other versions
NO973253D0 (no
NO314355B1 (no
Inventor
Michael A Poss
David J Kucera
Jerome L Moniot
John K Thottathil
Ivan D Trifunovich
Shu-Hui Chen
Jianmei Wei
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of NO973253L publication Critical patent/NO973253L/no
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO973253D0 publication Critical patent/NO973253D0/no
Publication of NO314355B1 publication Critical patent/NO314355B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO19973253A 1992-12-23 1997-07-14 Sidekjedeholdig taxan og fremgangsmåte til fremstilling derav NO314355B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99544392A 1992-12-23 1992-12-23
PCT/US1993/012173 WO1994014787A1 (en) 1992-12-23 1993-12-15 Novel sidechain-bearing taxanes and intermediates thereof

Publications (3)

Publication Number Publication Date
NO973253L true NO973253L (no) 1994-08-16
NO973253D0 NO973253D0 (no) 1997-07-14
NO314355B1 NO314355B1 (no) 2003-03-10

Family

ID=25541806

Family Applications (7)

Application Number Title Priority Date Filing Date
NO943021A NO304521B1 (no) 1992-12-23 1994-08-16 FremgangsmÕte til fremstilling av sidekjedeholdige taxaner og mellomprodukter derav
NO19973256A NO316071B1 (no) 1992-12-23 1997-07-14 Sidekjedeholdige taxaner og mellomprodukter derav
NO19973254A NO313802B1 (no) 1992-12-23 1997-07-14 Sidekjedeholdig taxanmellomprodukt og fremgangsmÕte til fremstilling derav
NO973255A NO309426B1 (no) 1992-12-23 1997-07-14 Oksazolinforbindelse og fremgangsmåte til fremstilling derav
NO19973253A NO314355B1 (no) 1992-12-23 1997-07-14 Sidekjedeholdig taxan og fremgangsmåte til fremstilling derav
NO19982744A NO311217B1 (no) 1992-12-23 1998-06-15 Oksazolinforbindelser
NO20033865A NO20033865D0 (no) 1992-12-23 2003-09-01 Fremgangsmåte til fremstilling av en oxazolinforbindelse eller et salt derav

Family Applications Before (4)

Application Number Title Priority Date Filing Date
NO943021A NO304521B1 (no) 1992-12-23 1994-08-16 FremgangsmÕte til fremstilling av sidekjedeholdige taxaner og mellomprodukter derav
NO19973256A NO316071B1 (no) 1992-12-23 1997-07-14 Sidekjedeholdige taxaner og mellomprodukter derav
NO19973254A NO313802B1 (no) 1992-12-23 1997-07-14 Sidekjedeholdig taxanmellomprodukt og fremgangsmÕte til fremstilling derav
NO973255A NO309426B1 (no) 1992-12-23 1997-07-14 Oksazolinforbindelse og fremgangsmåte til fremstilling derav

Family Applications After (2)

Application Number Title Priority Date Filing Date
NO19982744A NO311217B1 (no) 1992-12-23 1998-06-15 Oksazolinforbindelser
NO20033865A NO20033865D0 (no) 1992-12-23 2003-09-01 Fremgangsmåte til fremstilling av en oxazolinforbindelse eller et salt derav

Country Status (22)

Country Link
EP (2) EP1251127B1 (no)
JP (2) JP3492690B2 (no)
KR (3) KR100327625B1 (no)
CN (4) CN1590386A (no)
AT (1) ATE309229T1 (no)
AU (3) AU679206B2 (no)
CA (1) CA2119261C (no)
CZ (1) CZ292993B6 (no)
DE (1) DE69333905T2 (no)
DK (1) DK1251127T3 (no)
ES (1) ES2252362T3 (no)
FI (2) FI115056B (no)
HK (1) HK1048310B (no)
HU (3) HU0203995D0 (no)
IL (13) IL121539A (no)
NO (7) NO304521B1 (no)
NZ (1) NZ261070A (no)
PL (1) PL186176B1 (no)
RU (1) RU2125042C1 (no)
TW (1) TW247908B (no)
WO (1) WO1994014787A1 (no)
ZA (1) ZA939672B (no)

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US5710287A (en) 1991-09-23 1998-01-20 Florida State University Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
US5973160A (en) * 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
US5677470A (en) * 1994-06-28 1997-10-14 Tanabe Seiyaku Co., Ltd. Baccatin derivatives and processes for preparing the same
CA2162759A1 (en) * 1994-11-17 1996-05-18 Kenji Tsujihara Baccatin derivatives and processes for preparing the same
US5840929A (en) * 1995-04-14 1998-11-24 Bristol-Myers Squibb Company C4 methoxy ether derivatives of paclitaxel
NZ318300A (en) * 1995-09-12 1999-08-30 Liposome Co Inc Hydrolysis-promoting taxane hydrophobic derivatives
FR2740451B1 (fr) * 1995-10-27 1998-01-16 Seripharm Nouveaux intermediaires pour l'hemisynthese de taxanes, leurs procedes de preparation et leur utilisation dans la synthese generale des taxanes
US5773629A (en) * 1996-06-14 1998-06-30 Industrial Technology Research Institute Synthesis of (4S, 5R) -2, 4-diphenyl-5-carboxy-oxazoline derivative as taxol side-chain precursor
US5635531A (en) * 1996-07-08 1997-06-03 Bristol-Myers Squibb Company 3'-aminocarbonyloxy paclitaxels
US5773464A (en) * 1996-09-30 1998-06-30 Bristol-Myers Squibb Company C-10 epoxy taxanes
US5977386A (en) * 1996-12-24 1999-11-02 Bristol-Myers Squibb Company 6-thio-substituted paclitaxels
US5902822A (en) * 1997-02-28 1999-05-11 Bristol-Myers Squibb Company 7-methylthiooxomethyl and 7-methylthiodioxomethyl paclitaxels
US6017935A (en) * 1997-04-24 2000-01-25 Bristol-Myers Squibb Company 7-sulfur substituted paclitaxels
EP1067923A4 (en) 1997-12-31 2002-11-13 Bristol Myers Squibb Co 2-AROYL-4-ACYL PACLITAXEL (TAXEL) ANALOGS
EP1206461B8 (en) 1999-08-11 2004-07-21 Bristol-Myers Squibb Company Process for the preparation of a paclitaxel c-4 methyl carbonate analog
EP1391459A1 (en) * 1999-08-11 2004-02-25 Bristol-Myers Squibb Company Process for the preparation of a paclitaxel C-4 methyl carbonate analog and intermediates
CO5280224A1 (es) 2000-02-02 2003-05-30 Univ Florida State Res Found Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen
US6916942B2 (en) 2000-02-03 2005-07-12 Bristol-Myers Squibb Company Process for the preparation of C-4 carbonate taxanes
US6750246B1 (en) 2000-02-03 2004-06-15 Bristol-Myers Squibb Company C-4 carbonate taxanes
EP1318794A2 (en) * 2000-09-22 2003-06-18 Bristol-Myers Squibb Company Method for reducing toxicity of combined chemotherapies
WO2002024178A2 (en) * 2000-09-22 2002-03-28 Bristol-Myers Squibb Company Method for reducing toxicity of combined chemotherapies
US7063977B2 (en) 2001-08-21 2006-06-20 Bristol-Myers Squibb Company Enzymatic resolution of t-butyl taxane derivatives
CA2495476C (en) * 2002-08-04 2011-08-02 James H. Johnson Methods and compositions for converting taxane amides to paclitaxel or other taxanes
US8703982B2 (en) 2003-03-17 2014-04-22 Phyton Holdings Llc Purification of taxanes
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US7371759B2 (en) 2003-09-25 2008-05-13 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
US7420059B2 (en) 2003-11-20 2008-09-02 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
CN1960721A (zh) 2004-03-05 2007-05-09 佛罗里达州立大学研究基金有限公司 C7乳酰氧基取代的紫杉烷类
CA2599888C (en) * 2005-03-31 2010-06-15 Bioxel Pharma Inc. Preparation of taxanes from 9-dihydro-13-acetylbaccatin iii
PL217731B1 (pl) 2006-06-01 2014-08-29 Tomasz Byrski Sposób wykrywania genetycznie uwarunkowanej obniżonej odpowiedzi na chemioterapię cytostatykiem taksanowym, zastosowanie mutacji założycielskiej oraz zestawu do wykrywania takiej odpowiedzi
WO2008122039A2 (en) 2007-04-02 2008-10-09 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Selenocysteine mediated hybrid antibody molecules
EP2183234A4 (en) * 2007-08-22 2012-02-29 Canada Inc 6570763 PROCESS FOR CONVERTING 9-DIHYDRO-13-ACETYLBACCATIN III IN DOCETAXEL OR PACLITAXEL
JP6042527B2 (ja) 2012-04-04 2016-12-14 ハロザイム インコーポレイテッド 抗ヒアルロナン剤と腫瘍標的タキサンの組み合わせ治療
US9353150B2 (en) 2012-12-04 2016-05-31 Massachusetts Institute Of Technology Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment
EP2972394A4 (en) 2013-03-15 2016-11-02 Sloan Kettering Inst Cancer HSP90 TARGETING CARDIAC IMAGING AND TREATMENT THEREOF
WO2017197045A1 (en) 2016-05-11 2017-11-16 Movassaghi Mohammad Convergent and enantioselective total synthesis of communesin analogs
WO2018209239A1 (en) 2017-05-11 2018-11-15 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
WO2019222435A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20
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JP2503994B2 (ja) * 1986-09-02 1996-06-05 味の素株式会社 オキサゾリンカルボン酸誘導体及びその製造法
DE3825242A1 (de) * 1987-07-27 1989-02-09 Ciba Geigy Ag Durch schwefelhaltige gruppen substituierte histidinylamino-verbindungen
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
JP2847584B2 (ja) * 1991-06-21 1999-01-20 高砂香料工業株式会社 シクロヘキシル酪酸誘導体及びその製造法
HU226369B1 (en) * 1991-09-23 2008-09-29 Univ Florida State Process for preparing substituted isoserine-esters using metal alkoxides and beta-lactams
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CA2111527C (en) * 1992-12-24 2000-07-18 Jerzy Golik Phosphonooxymethyl ethers of taxane derivatives

Also Published As

Publication number Publication date
IL108161A0 (en) 1994-04-12
IL121541A0 (en) 1998-02-08
NO982744L (no) 1994-08-16
IL121540A (en) 2005-05-17
FI943852A (fi) 1994-08-22
EP0626953A4 (en) 1995-05-03
IL121540A0 (en) 1998-02-08
IL108161A (en) 1999-03-12
EP1251127A1 (en) 2002-10-23
DK1251127T3 (da) 2006-03-06
NO973256L (no) 1994-08-16
DE69333905T2 (de) 2006-08-03
IL121542A0 (en) 1998-02-08
CN1590386A (zh) 2005-03-09
KR950700269A (ko) 1995-01-16
ZA939672B (en) 1995-06-23
AU679206B2 (en) 1997-06-26
KR100356448B1 (ko) 2002-10-19
FI943852A0 (fi) 1994-08-22
IL121539A0 (en) 1998-02-08
IL122208A0 (en) 1998-04-05
NO309426B1 (no) 2001-01-29
NO973254L (no) 1994-08-16
HU222175B1 (hu) 2003-04-28
ES2252362T3 (es) 2006-05-16
CZ292993B6 (cs) 2004-01-14
JPH07504444A (ja) 1995-05-18
IL122209A0 (en) 1998-04-05
EP1251127B1 (en) 2005-11-09
NO943021L (no) 1994-08-16
CA2119261C (en) 2006-01-31
TW247908B (no) 1995-05-21
DE69333905D1 (de) 2005-12-15
KR100378612B1 (ko) 2003-04-03
CN1235973A (zh) 1999-11-24
NO973253D0 (no) 1997-07-14
NZ261070A (en) 1997-10-24
AU697836B2 (en) 1998-10-15
HK1048310A1 (en) 2003-03-28
IL121539A (en) 2004-07-25
FI115056B (fi) 2005-02-28
NO20033865D0 (no) 2003-09-01
AU3246397A (en) 1997-10-30
HUT75195A (en) 1997-04-28
HK1048310B (zh) 2006-02-17
NO973256D0 (no) 1997-07-14
AU715633B2 (en) 2000-02-10
JP2003113166A (ja) 2003-04-18
CN1094725A (zh) 1994-11-09
IL121541A (en) 2000-11-21
NO314355B1 (no) 2003-03-10
RU2125042C1 (ru) 1999-01-20
HU225294B1 (en) 2006-09-28
HU9401449D0 (en) 1994-09-28
IL121542A (en) 2001-03-19
IL145280A (en) 2007-05-15
NO982744D0 (no) 1998-06-15
KR100327625B1 (ko) 2002-11-07
NO304521B1 (no) 1999-01-04
CN1109026C (zh) 2003-05-21
NO20033865L (no) 1994-08-16
PL186176B1 (pl) 2003-11-28
NO313802B1 (no) 2002-12-02
EP0626953A1 (en) 1994-12-07
FI20031464A (fi) 2003-10-07
NO973254D0 (no) 1997-07-14
JP3492690B2 (ja) 2004-02-03
ATE309229T1 (de) 2005-11-15
CN1230542A (zh) 1999-10-06
NO943021D0 (no) 1994-08-16
NO316071B1 (no) 2003-12-08
CZ146594A3 (en) 1995-06-14
IL145280A0 (en) 2002-06-30
NO973255L (no) 1994-08-16
CN1150178C (zh) 2004-05-19
WO1994014787A1 (en) 1994-07-07
CN1089761C (zh) 2002-08-28
AU6014694A (en) 1994-07-19
AU3246497A (en) 1997-10-09
CA2119261A1 (en) 1994-06-24
NO973255D0 (no) 1997-07-14
NO311217B1 (no) 2001-10-29
HU0203995D0 (en) 2003-04-28

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