NO981823L - Mellomprodukter for hemisyntese av taxaner og fremstilling derav - Google Patents
Mellomprodukter for hemisyntese av taxaner og fremstilling deravInfo
- Publication number
- NO981823L NO981823L NO981823A NO981823A NO981823L NO 981823 L NO981823 L NO 981823L NO 981823 A NO981823 A NO 981823A NO 981823 A NO981823 A NO 981823A NO 981823 L NO981823 L NO 981823L
- Authority
- NO
- Norway
- Prior art keywords
- hemisynthesis
- taxanes
- intermediates
- preparation
- taxane
- Prior art date
Links
- 229940123237 Taxane Drugs 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title 1
- 229930190007 Baccatin Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0834—Compounds having one or more O-Si linkage
- C07F7/0838—Compounds with one or more Si-O-Si sequences
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9512739A FR2740451B1 (fr) | 1995-10-27 | 1995-10-27 | Nouveaux intermediaires pour l'hemisynthese de taxanes, leurs procedes de preparation et leur utilisation dans la synthese generale des taxanes |
| PCT/FR1996/001676 WO1997015562A1 (fr) | 1995-10-27 | 1996-10-25 | Intermediaires pour l'hemisynthese de taxanes et leurs procedes de preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO981823L true NO981823L (no) | 1998-04-23 |
| NO981823D0 NO981823D0 (no) | 1998-04-23 |
Family
ID=9484016
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO981823A NO981823D0 (no) | 1995-10-27 | 1998-04-23 | Mellomprodukter for hemisyntese av taxaner og fremstilling derav |
Country Status (25)
| Country | Link |
|---|---|
| US (5) | US6265587B1 (no) |
| EP (1) | EP0863887B1 (no) |
| JP (1) | JP2000500437A (no) |
| KR (1) | KR100489865B1 (no) |
| CN (1) | CN100374428C (no) |
| AT (1) | ATE212342T1 (no) |
| AU (1) | AU710314B2 (no) |
| BR (1) | BR9610908A (no) |
| CZ (1) | CZ125598A3 (no) |
| DE (1) | DE69618812T2 (no) |
| DK (1) | DK0863887T3 (no) |
| EE (1) | EE03610B1 (no) |
| ES (1) | ES2170876T3 (no) |
| FR (1) | FR2740451B1 (no) |
| GE (1) | GEP20001938B (no) |
| HU (1) | HU225507B1 (no) |
| IL (1) | IL155876A (no) |
| NO (1) | NO981823D0 (no) |
| NZ (1) | NZ320356A (no) |
| PL (1) | PL327458A1 (no) |
| PT (1) | PT863887E (no) |
| RU (1) | RU2159237C2 (no) |
| SK (1) | SK52398A3 (no) |
| TR (1) | TR199800713T2 (no) |
| WO (1) | WO1997015562A1 (no) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2740451B1 (fr) * | 1995-10-27 | 1998-01-16 | Seripharm | Nouveaux intermediaires pour l'hemisynthese de taxanes, leurs procedes de preparation et leur utilisation dans la synthese generale des taxanes |
| KR100225535B1 (ko) * | 1996-08-27 | 1999-10-15 | 정지석 | 파클리탁셀의 제조방법 |
| US6150537A (en) * | 1997-12-12 | 2000-11-21 | Emory University | Methods for the esterification of alcohols and compounds useful therefor as potential anticancer agents |
| KR100267596B1 (ko) * | 1998-04-17 | 2000-10-16 | 강재헌 | 베타-아미노-알파-하이드록시산과 균등한 옥사졸린 유도체의 입체선택적 합성방법 |
| US6143900A (en) * | 1999-10-26 | 2000-11-07 | Dong Kook Pharmaceutical Co., Ltd. | Stereoselective synthesis of oxazoline derivative |
| ES2178539B1 (es) * | 2000-03-14 | 2004-08-01 | Dong Kook Pharmaceutical Co., Ltd. | Procedimiento para la preparacion de un compuesto de oxazolina. |
| WO2002066448A1 (en) * | 2001-02-20 | 2002-08-29 | Dabur India Limited | Method of preparation of paclitaxel (taxol) using 3-(alk-2-ynyloxy) carbonyl-5-oxazolidine carboxylic acid |
| FR2846327B1 (fr) * | 2002-10-25 | 2006-03-24 | Merck Sante Sas | Derives de n-benzodioxolyl, n-benzodioxanyl et n-benzodioxepinyl arylcarboxamides utilisables dans le traitement de dyslipidemies et compositions pharmaceutiques les contenant. |
| KR20080030013A (ko) * | 2005-06-10 | 2008-04-03 | 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 | 폴리시클릭 융합 고리 화합물의 제조 방법 |
| EP1893594A2 (en) * | 2005-06-10 | 2008-03-05 | Florida State University Research Foundation, Inc. | Processes for the preparation of paclitaxel |
| GB0701523D0 (en) * | 2007-01-26 | 2007-03-07 | Chatham Biotec Ltd | Semi-synthetic process for the preparation of taxane derivatives |
| CN101468974B (zh) * | 2007-12-28 | 2011-02-09 | 上海百灵医药科技有限公司 | 多烯紫杉醇的半合成方法 |
| PE20130491A1 (es) | 2009-12-30 | 2013-05-02 | Basf Pharma Callanish Ltd | Proceso simulado de separacion cromatografica de lecho movil para la purificacion de acidos grasos poliinsaturados |
| GB201111594D0 (en) | 2011-07-06 | 2011-08-24 | Equateq Ltd | New improved process |
| GB201111591D0 (en) | 2011-07-06 | 2011-08-24 | Equateq Ltd | Further new process |
| GB201111589D0 (en) | 2011-07-06 | 2011-08-24 | Equateq Ltd | New modified process |
| GB201111601D0 (en) | 2011-07-06 | 2011-08-24 | Equateq Ltd | New process |
| GB201111595D0 (en) | 2011-07-06 | 2011-08-24 | Equateq Ltd | Improved process |
| CN103508918B (zh) * | 2012-06-18 | 2015-09-09 | 上海医药工业研究院 | 带有环丁基的α-羟基β-氨基酯类化合物及其制备方法 |
| GB201300354D0 (en) | 2013-01-09 | 2013-02-20 | Basf Pharma Callanish Ltd | Multi-step separation process |
| US9428711B2 (en) | 2013-05-07 | 2016-08-30 | Groupe Novasep | Chromatographic process for the production of highly purified polyunsaturated fatty acids |
| US8802880B1 (en) | 2013-05-07 | 2014-08-12 | Group Novasep | Chromatographic process for the production of highly purified polyunsaturated fatty acids |
| EP2883860B1 (fr) | 2013-12-11 | 2016-08-24 | Novasep Process | Procédé chromatographique de production d'acides gras polyinsaturés |
| US10975031B2 (en) | 2014-01-07 | 2021-04-13 | Novasep Process | Method for purifying aromatic amino acids |
| WO2017006573A1 (ja) * | 2015-07-07 | 2017-01-12 | 忠勝 萬代 | パクリタキセル及びドセタキセルの側鎖前駆体の製造方法 |
| CN112876503B (zh) * | 2021-03-18 | 2022-04-29 | 中国科学院兰州化学物理研究所 | 用于癌症硼中子俘获治疗药物的硼酸盐化合物及其制备 |
| CN114195820B (zh) * | 2021-12-17 | 2023-11-10 | 中山大学 | 异丝氨酸衍生物及其制备与在紫杉醇合成中的应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4876399A (en) * | 1987-11-02 | 1989-10-24 | Research Corporation Technologies, Inc. | Taxols, their preparation and intermediates thereof |
| US5008411A (en) * | 1988-05-24 | 1991-04-16 | Hoffmann-La Roche Inc. | Glycidic acid ester and process of preparation |
| US5274300A (en) * | 1988-10-26 | 1993-12-28 | Sepracor, Inc. | Enzymatic hydrolysis of glycidate esters in the presence of bisulfite anion |
| US5304670A (en) | 1989-08-23 | 1994-04-19 | Centre National De La Recherche Scientifique | Process for the enantioselective preparation of phenylisoserine derivatives |
| CA2023645C (fr) * | 1989-08-23 | 2002-03-26 | Jean-Noel Denis | Procede pour la preparation enantioselective de derives de la phenylisoserine |
| US5244803A (en) * | 1989-09-13 | 1993-09-14 | Tanabe Seiyaku Co., Ltd. | Process for preparing optically active 3-phenylglycidic acid esters |
| FR2658513B1 (fr) * | 1990-02-21 | 1994-02-04 | Rhone Poulenc Sante | Procede de preparation de l'acide cis-beta-phenylglycidique-(2r,3r). |
| FR2678930B1 (fr) * | 1991-07-10 | 1995-01-13 | Rhone Poulenc Rorer Sa | Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii. |
| WO1993010076A1 (en) * | 1991-11-22 | 1993-05-27 | The University Of Mississippi | Synthesis and optical resolution of the taxol side chain and related compounds |
| EP0626953A4 (en) * | 1992-12-23 | 1995-05-03 | Bristol Myers Squibb Co | NEW SIDE CHAINS WEARING TAXANS AND THEIR INTERMEDIATE PRODUCTS. |
| FR2740451B1 (fr) * | 1995-10-27 | 1998-01-16 | Seripharm | Nouveaux intermediaires pour l'hemisynthese de taxanes, leurs procedes de preparation et leur utilisation dans la synthese generale des taxanes |
| US6228955B1 (en) * | 1996-04-19 | 2001-05-08 | Chirotech Technology, Ltd. | Asymmetric epoxides, their synthesis and use |
-
1995
- 1995-10-27 FR FR9512739A patent/FR2740451B1/fr not_active Expired - Fee Related
-
1996
- 1996-10-25 CN CNB961978538A patent/CN100374428C/zh not_active Expired - Fee Related
- 1996-10-25 DK DK96934977T patent/DK0863887T3/da active
- 1996-10-25 AT AT96934977T patent/ATE212342T1/de not_active IP Right Cessation
- 1996-10-25 BR BR9610908A patent/BR9610908A/pt unknown
- 1996-10-25 WO PCT/FR1996/001676 patent/WO1997015562A1/fr active IP Right Grant
- 1996-10-25 HU HU9802487A patent/HU225507B1/hu not_active IP Right Cessation
- 1996-10-25 ES ES96934977T patent/ES2170876T3/es not_active Expired - Lifetime
- 1996-10-25 PL PL96327458A patent/PL327458A1/xx unknown
- 1996-10-25 KR KR1019980703067A patent/KR100489865B1/ko not_active IP Right Cessation
- 1996-10-25 PT PT96934977T patent/PT863887E/pt unknown
- 1996-10-25 EP EP96934977A patent/EP0863887B1/fr not_active Expired - Lifetime
- 1996-10-25 AU AU73086/96A patent/AU710314B2/en not_active Ceased
- 1996-10-25 JP JP9516372A patent/JP2000500437A/ja not_active Ceased
- 1996-10-25 EE EE9800149A patent/EE03610B1/xx not_active IP Right Cessation
- 1996-10-25 SK SK523-98A patent/SK52398A3/sk unknown
- 1996-10-25 DE DE69618812T patent/DE69618812T2/de not_active Expired - Lifetime
- 1996-10-25 NZ NZ320356A patent/NZ320356A/xx unknown
- 1996-10-25 US US09/065,041 patent/US6265587B1/en not_active Expired - Fee Related
- 1996-10-25 RU RU98110071/04A patent/RU2159237C2/ru not_active IP Right Cessation
- 1996-10-25 CZ CZ981255A patent/CZ125598A3/cs unknown
- 1996-10-25 GE GEAP19964253A patent/GEP20001938B/en unknown
- 1996-10-25 TR TR1998/00713T patent/TR199800713T2/xx unknown
-
1998
- 1998-04-23 NO NO981823A patent/NO981823D0/no not_active Application Discontinuation
-
2001
- 2001-04-18 US US09/836,326 patent/US6825365B2/en not_active Expired - Fee Related
-
2003
- 2003-05-12 IL IL155876A patent/IL155876A/en not_active IP Right Cessation
-
2004
- 2004-06-04 US US10/859,953 patent/US7279586B2/en not_active Expired - Fee Related
-
2005
- 2005-03-11 US US11/076,856 patent/US7220871B2/en not_active Expired - Fee Related
-
2007
- 2007-03-07 US US11/714,817 patent/US7432383B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO981823L (no) | Mellomprodukter for hemisyntese av taxaner og fremstilling derav | |
| FI930978A (fi) | Baccatin iii derivat | |
| NO973253D0 (no) | Sidekjedeholdig taxan og fremgangsmåte til fremstilling derav | |
| HU9601857D0 (en) | New benzyl-piperidine- or -tetrahydro-pyridine derivatives and processes for producing them | |
| FI952294A (fi) | Menetelmä taksaanijohdannaisten valmistamiseksi, näin saadut uudet taksaanit ja niitä sisältävät kasvainvastaiset ja leukemiavastaiset koostumukset | |
| RU93004623A (ru) | Производные таксана iii, способы их получения | |
| HUP9903318A2 (hu) | Intermedierek taxol előállítására | |
| NO20030609L (no) | Fremgangsmåte for fremstilling av baccatin III-derivater | |
| AU1381597A (en) | Method for selective protection of baccatin derivatives and its application to taxane synthesis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |