DK1251127T3 - Nye sidekædede-bærende taxaner og mellemprodukter deraf - Google Patents

Nye sidekædede-bærende taxaner og mellemprodukter deraf

Info

Publication number
DK1251127T3
DK1251127T3 DK02014813T DK02014813T DK1251127T3 DK 1251127 T3 DK1251127 T3 DK 1251127T3 DK 02014813 T DK02014813 T DK 02014813T DK 02014813 T DK02014813 T DK 02014813T DK 1251127 T3 DK1251127 T3 DK 1251127T3
Authority
DK
Denmark
Prior art keywords
oxazoline
intermediates
chain
bearing
new side
Prior art date
Application number
DK02014813T
Other languages
English (en)
Inventor
David J Kucera
Shu-Hui Chen
Ivan D Trifunovich
Jianmei Wei
Michael A Poss
Jerome L Moniot
John K Thottathil
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of DK1251127T3 publication Critical patent/DK1251127T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK02014813T 1992-12-23 1993-12-15 Nye sidekædede-bærende taxaner og mellemprodukter deraf DK1251127T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99544392A 1992-12-23 1992-12-23
EP94906439A EP0626953A4 (en) 1992-12-23 1993-12-15 NEW SIDE CHAINS WEARING TAXANS AND THEIR INTERMEDIATE PRODUCTS.

Publications (1)

Publication Number Publication Date
DK1251127T3 true DK1251127T3 (da) 2006-03-06

Family

ID=25541806

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02014813T DK1251127T3 (da) 1992-12-23 1993-12-15 Nye sidekædede-bærende taxaner og mellemprodukter deraf

Country Status (22)

Country Link
EP (2) EP1251127B1 (da)
JP (2) JP3492690B2 (da)
KR (3) KR100378612B1 (da)
CN (4) CN1089761C (da)
AT (1) ATE309229T1 (da)
AU (3) AU679206B2 (da)
CA (1) CA2119261C (da)
CZ (1) CZ292993B6 (da)
DE (1) DE69333905T2 (da)
DK (1) DK1251127T3 (da)
ES (1) ES2252362T3 (da)
FI (2) FI115056B (da)
HK (1) HK1048310B (da)
HU (3) HU0203995D0 (da)
IL (13) IL121539A (da)
NO (7) NO304521B1 (da)
NZ (1) NZ261070A (da)
PL (1) PL186176B1 (da)
RU (1) RU2125042C1 (da)
TW (1) TW247908B (da)
WO (1) WO1994014787A1 (da)
ZA (1) ZA939672B (da)

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US5710287A (en) 1991-09-23 1998-01-20 Florida State University Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
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US5677470A (en) * 1994-06-28 1997-10-14 Tanabe Seiyaku Co., Ltd. Baccatin derivatives and processes for preparing the same
CA2162759A1 (en) * 1994-11-17 1996-05-18 Kenji Tsujihara Baccatin derivatives and processes for preparing the same
US5840929A (en) * 1995-04-14 1998-11-24 Bristol-Myers Squibb Company C4 methoxy ether derivatives of paclitaxel
ATE309235T1 (de) * 1995-09-12 2005-11-15 Zeneus Pharma Ltd Hydrolyse-einleitende hydrophobe taxane derivate
FR2740451B1 (fr) * 1995-10-27 1998-01-16 Seripharm Nouveaux intermediaires pour l'hemisynthese de taxanes, leurs procedes de preparation et leur utilisation dans la synthese generale des taxanes
US5773629A (en) * 1996-06-14 1998-06-30 Industrial Technology Research Institute Synthesis of (4S, 5R) -2, 4-diphenyl-5-carboxy-oxazoline derivative as taxol side-chain precursor
US5635531A (en) * 1996-07-08 1997-06-03 Bristol-Myers Squibb Company 3'-aminocarbonyloxy paclitaxels
US5773464A (en) * 1996-09-30 1998-06-30 Bristol-Myers Squibb Company C-10 epoxy taxanes
US5977386A (en) * 1996-12-24 1999-11-02 Bristol-Myers Squibb Company 6-thio-substituted paclitaxels
US5902822A (en) * 1997-02-28 1999-05-11 Bristol-Myers Squibb Company 7-methylthiooxomethyl and 7-methylthiodioxomethyl paclitaxels
US6017935A (en) * 1997-04-24 2000-01-25 Bristol-Myers Squibb Company 7-sulfur substituted paclitaxels
AU759030B2 (en) 1997-12-31 2003-04-03 Bristol-Myers Squibb Company 2-aroyl-4-acyl paclitaxel (taxol) analogs
CA2381401A1 (en) 1999-08-11 2001-02-15 Bristol-Myers Squibb Company Process for the preparation of a paclitaxel c-4 methyl carbonate analog
EP1391459A1 (en) * 1999-08-11 2004-02-25 Bristol-Myers Squibb Company Process for the preparation of a paclitaxel C-4 methyl carbonate analog and intermediates
CO5280224A1 (es) 2000-02-02 2003-05-30 Univ Florida State Res Found Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen
US6750246B1 (en) 2000-02-03 2004-06-15 Bristol-Myers Squibb Company C-4 carbonate taxanes
US6916942B2 (en) 2000-02-03 2005-07-12 Bristol-Myers Squibb Company Process for the preparation of C-4 carbonate taxanes
EP1318794A2 (en) 2000-09-22 2003-06-18 Bristol-Myers Squibb Company Method for reducing toxicity of combined chemotherapies
AU2001290636A1 (en) * 2000-09-22 2002-04-02 Bristol-Myers Squibb Company Method for reducing toxicity of combined chemotherapies
US7063977B2 (en) 2001-08-21 2006-06-20 Bristol-Myers Squibb Company Enzymatic resolution of t-butyl taxane derivatives
AU2003256861C1 (en) 2002-08-04 2008-08-28 Phyton Holdings, Llc Methods and compositions for converting taxane amides to paclitaxel or other taxanes
US8703982B2 (en) 2003-03-17 2014-04-22 Phyton Holdings Llc Purification of taxanes
JP4499383B2 (ja) * 2003-07-11 2010-07-07 良明 木曽 水溶性プロドラッグ
US7371759B2 (en) 2003-09-25 2008-05-13 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
US7420059B2 (en) 2003-11-20 2008-09-02 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
CN1960721A (zh) 2004-03-05 2007-05-09 佛罗里达州立大学研究基金有限公司 C7乳酰氧基取代的紫杉烷类
PL1871753T3 (pl) 2005-03-31 2012-12-31 Accord Healthcare Inc Wytwarzanie taksanów z 9-dihydro-13-acetylobakatyny iii
PL217731B1 (pl) 2006-06-01 2014-08-29 Tomasz Byrski Sposób wykrywania genetycznie uwarunkowanej obniżonej odpowiedzi na chemioterapię cytostatykiem taksanowym, zastosowanie mutacji założycielskiej oraz zestawu do wykrywania takiej odpowiedzi
WO2008122039A2 (en) 2007-04-02 2008-10-09 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Selenocysteine mediated hybrid antibody molecules
US20110118473A1 (en) * 2007-08-22 2011-05-19 6570763 Canada Inc. Process for converting 9-dihydro-13acetylbaccatin iii paclitaxel and docetaxel
CA3152081A1 (en) 2012-04-04 2013-10-10 Halozyme, Inc. Combination therapy with an anti-hyaluronan agent and a tumor-targeted taxane
US9353150B2 (en) 2012-12-04 2016-05-31 Massachusetts Institute Of Technology Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment
EP2972394A4 (en) 2013-03-15 2016-11-02 Sloan Kettering Inst Cancer HSP90 TARGETING CARDIAC IMAGING AND TREATMENT THEREOF
US10918627B2 (en) 2016-05-11 2021-02-16 Massachusetts Institute Of Technology Convergent and enantioselective total synthesis of Communesin analogs
US11932650B2 (en) 2017-05-11 2024-03-19 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
WO2019222435A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20
WO2020247054A1 (en) 2019-06-05 2020-12-10 Massachusetts Institute Of Technology Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof

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US4616005A (en) * 1982-06-23 1986-10-07 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
WO1985004876A1 (en) * 1984-04-24 1985-11-07 Takeda Chemical Industries, Ltd. 2-azetidinone derivatives and process for their preparation
JP2503994B2 (ja) * 1986-09-02 1996-06-05 味の素株式会社 オキサゾリンカルボン酸誘導体及びその製造法
DE3825242A1 (de) * 1987-07-27 1989-02-09 Ciba Geigy Ag Durch schwefelhaltige gruppen substituierte histidinylamino-verbindungen
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
JP2847584B2 (ja) * 1991-06-21 1999-01-20 高砂香料工業株式会社 シクロヘキシル酪酸誘導体及びその製造法
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NO310238B1 (no) * 1992-12-24 2001-06-11 Bristol Myers Squibb Co Kjemiske forbindelser og farmasöytisk preparat samt anvendelse av slike preparater

Also Published As

Publication number Publication date
FI943852A (fi) 1994-08-22
IL121541A0 (en) 1998-02-08
CN1235973A (zh) 1999-11-24
HU0203995D0 (en) 2003-04-28
NO982744L (no) 1994-08-16
CN1094725A (zh) 1994-11-09
CN1230542A (zh) 1999-10-06
ATE309229T1 (de) 2005-11-15
IL121539A (en) 2004-07-25
HK1048310B (zh) 2006-02-17
IL121540A (en) 2005-05-17
IL121541A (en) 2000-11-21
NO973256D0 (no) 1997-07-14
HU9401449D0 (en) 1994-09-28
EP0626953A4 (en) 1995-05-03
FI943852A0 (fi) 1994-08-22
NO311217B1 (no) 2001-10-29
CZ292993B6 (cs) 2004-01-14
NO20033865L (no) 1994-08-16
PL186176B1 (pl) 2003-11-28
NO973253D0 (no) 1997-07-14
CA2119261C (en) 2006-01-31
WO1994014787A1 (en) 1994-07-07
HU222175B1 (hu) 2003-04-28
RU2125042C1 (ru) 1999-01-20
IL122209A0 (en) 1998-04-05
NO943021D0 (no) 1994-08-16
KR950700269A (ko) 1995-01-16
EP1251127A1 (en) 2002-10-23
HU225294B1 (en) 2006-09-28
IL145280A (en) 2007-05-15
DE69333905D1 (de) 2005-12-15
NO973254D0 (no) 1997-07-14
CZ146594A3 (en) 1995-06-14
EP0626953A1 (en) 1994-12-07
HK1048310A1 (en) 2003-03-28
JP2003113166A (ja) 2003-04-18
NO313802B1 (no) 2002-12-02
AU679206B2 (en) 1997-06-26
IL121542A (en) 2001-03-19
CN1109026C (zh) 2003-05-21
NO973255L (no) 1994-08-16
IL108161A (en) 1999-03-12
IL145280A0 (en) 2002-06-30
NO973254L (no) 1994-08-16
FI20031464A (fi) 2003-10-07
DE69333905T2 (de) 2006-08-03
KR100327625B1 (ko) 2002-11-07
CN1150178C (zh) 2004-05-19
IL121542A0 (en) 1998-02-08
KR100378612B1 (ko) 2003-04-03
JP3492690B2 (ja) 2004-02-03
AU715633B2 (en) 2000-02-10
AU697836B2 (en) 1998-10-15
ES2252362T3 (es) 2006-05-16
NO314355B1 (no) 2003-03-10
CN1590386A (zh) 2005-03-09
NZ261070A (en) 1997-10-24
TW247908B (da) 1995-05-21
NO973253L (no) 1994-08-16
NO973256L (no) 1994-08-16
CN1089761C (zh) 2002-08-28
NO943021L (no) 1994-08-16
NO982744D0 (no) 1998-06-15
IL122208A0 (en) 1998-04-05
IL121539A0 (en) 1998-02-08
ZA939672B (en) 1995-06-23
IL121540A0 (en) 1998-02-08
IL108161A0 (en) 1994-04-12
AU3246397A (en) 1997-10-30
NO304521B1 (no) 1999-01-04
NO309426B1 (no) 2001-01-29
KR100356448B1 (ko) 2002-10-19
AU6014694A (en) 1994-07-19
NO316071B1 (no) 2003-12-08
FI115056B (fi) 2005-02-28
HUT75195A (en) 1997-04-28
EP1251127B1 (en) 2005-11-09
NO20033865D0 (no) 2003-09-01
NO973255D0 (no) 1997-07-14
CA2119261A1 (en) 1994-06-24
JPH07504444A (ja) 1995-05-18
AU3246497A (en) 1997-10-09

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