MX2007003094A - 4-(metilo ciclico condensado)-imidazol-2-tionas como agonistas alfa2 adrenergicos. - Google Patents

4-(metilo ciclico condensado)-imidazol-2-tionas como agonistas alfa2 adrenergicos.

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Publication number
MX2007003094A
MX2007003094A MX2007003094A MX2007003094A MX2007003094A MX 2007003094 A MX2007003094 A MX 2007003094A MX 2007003094 A MX2007003094 A MX 2007003094A MX 2007003094 A MX2007003094 A MX 2007003094A MX 2007003094 A MX2007003094 A MX 2007003094A
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MX
Mexico
Prior art keywords
compounds
formula
receptors
cyclicmethyl
imidazole
Prior art date
Application number
MX2007003094A
Other languages
English (en)
Inventor
Larry A Wheeler
Ken Chow
Daniel W Gil
Michael E Garst
Phong X Nguyen
John E Donello
Todd M Heidelbaugh
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of MX2007003094A publication Critical patent/MX2007003094A/es

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Abstract

Se describen compuestos de la formula (I) en donde las variables tienen el significado definido en la descripcion, los cuales son agonistas de receptores adrenergicos alfa2. varios compuestos de la descripcion son especificos o selectivos para receptores adrenergicos alfa2B y/o alfa2c en preferencia sobre los receptores adrenergicos alfa2A. Ademas, algunos de los compuestos reclamados no tienen o solo tienen una actividad cardiovascular y/o sedante minima. Los compuestos de la formula I son utiles como medicamentos en mamiferos, incluyendo humanos, para el tratamiento de enfermedades y/o alivio de condiciones que respondan a tratamiento por agonistas de receptores adrenergicos alfa2. los compuestos de la formula que no tienen una actividad cardiovascular y/o sedante son utiles para tratar dolor y otras condiciones con minimos efectos secundarios.
MX2007003094A 2004-09-24 2005-09-07 4-(metilo ciclico condensado)-imidazol-2-tionas como agonistas alfa2 adrenergicos. MX2007003094A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61293904P 2004-09-24 2004-09-24
PCT/US2005/032023 WO2006036497A2 (en) 2004-09-24 2005-09-07 4-(condensed cyclicmethyl)-imidazole-2-thiones acting as alpha2 adrenergic agonists

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MX2007003094A true MX2007003094A (es) 2007-06-07

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MX2007003094A MX2007003094A (es) 2004-09-24 2005-09-07 4-(metilo ciclico condensado)-imidazol-2-tionas como agonistas alfa2 adrenergicos.

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US (2) US7396849B2 (es)
EP (1) EP1791833A2 (es)
JP (1) JP2008514602A (es)
KR (1) KR20070063016A (es)
CN (1) CN101052638B (es)
AR (1) AR051106A1 (es)
AU (1) AU2005289998A1 (es)
BR (1) BRPI0516950A (es)
CA (1) CA2581823A1 (es)
MX (1) MX2007003094A (es)
NZ (1) NZ553290A (es)
TW (1) TW200626146A (es)
WO (1) WO2006036497A2 (es)

Families Citing this family (13)

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Publication number Priority date Publication date Assignee Title
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JP2008514602A (ja) * 2004-09-24 2008-05-08 アラーガン、インコーポレイテッド α２アドレナリン作動剤としての４−（縮合環メチル）−イミダゾール−２−チオン
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