ES2340179T3 - Antagonistas de urea del receptor p2y1 utiles en el tratamiento de afecciones tromboticas. - Google Patents

Antagonistas de urea del receptor p2y1 utiles en el tratamiento de afecciones tromboticas. Download PDF

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ES2340179T3
ES2340179T3 ES05747470T ES05747470T ES2340179T3 ES 2340179 T3 ES2340179 T3 ES 2340179T3 ES 05747470 T ES05747470 T ES 05747470T ES 05747470 T ES05747470 T ES 05747470T ES 2340179 T3 ES2340179 T3 ES 2340179T3
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affections
thrombotic
receiver
useful
treatment
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Hannguang J. Chao
Huji Tuerdi
Timothy Herpin
Jacques Yves Roberge
Yalei Liu
R. Michael Lawrence
Robert P. Rehfuss
Charles G. Clark
Jennifer X. Qiao
Timur Gungor
Patrick Y.S. Lam
Tammy C. Wang
Rejean Ruel
Alexandre L. L'heureux
Carl Thibeault
Gilles Bouthillier
Dora M. Schnur
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Abstract

Un compuesto de fórmula (I): **(Ver fórmula)** o un estereoisómero o sal farmacéuticamente aceptable o solvato del mismo, en la que: el anillo A es arilo C6-10 sustituido con 0-5 R1 o un heterociclo de 5 a 10 miembros que comprende: átomos de carbono y 1-4 heteroátomos seleccionados de N, NR11, O y S(O)p, en el que dicho heterociclo está sustituido con 0-5 R1; el anillo B está sustituido con 0-3 R7 y se selecciona de: **(Ver fórmula)** W es O o S; X2 es -(CR16R17)s- o -(CR16R17)tC(O)(CR16R17)r-; Y es O, S, NH, -OCR18R19-, -CH=CH- o -CONCH-; R1 es, independientemente en cada aparición, =O, F, Cl, Br, I, CF3, -CF2CF3, OCF3, -OCF2CF2H, -OCF2CF3, SiMe3, -(CRfRf)r-ORc, SRc, CN, NO2, -(CRfRf)r-NR12R13, -(CRfRf)rC(O)Rc, -(CRfRf)r-CO2Rc, -(CRfRf)r-C(O)NR12R13, -C(O)NR14(CRfRf)tN12R13, -(CRfRf)r-OC(O)NR12R13, -(CRfRf)r-NR14C(O)NR12R13, -(CRfRf)r-NR14C(O)Rd, -(CRfRf)r-NR14C(O)ORh, -NR14(CRfRf)nC(O)Rd, -NR14CO(CRfRf)nORc, -(CH2)r-CR13(=NORc), -S(O)pNR12R13, -(CRfRf)r-NR14S(O)pNR12R13, -NR14SO2CF3, -NR14S(O)pRd, -S(O)2CF3, -S(O)Rd, -S(O)2Rd, -OP(O)(OEt)2, -O(CH2)2 OP(O)(OEt)2, 4,4,5,5-tetrametil-1,3,2-dioxaborolanilo, alquilo C1-8 sustituido con 0-2 Ra, alquenilo C2-8 sustituido con 0-2 Ra, alquinilo C2-8 sustituido con 0-2 Ra, -(CRfRf)r-carbociclo C3-13 sustituido con 0-5 Rb o -(CRfRf)r-heterociclo de 5 a 10 miembros que comprende: átomos de carbono y 1-4 heteroátomos seleccionados de N, NR11, O y S(O)p, en el que dicho heterociclo está sustituido con 0-5 Rb; alternativamente, dos R1 en dos átomos de carbono adyacentes se combinan con los átomos de carbono a los que están unidos para formar un carbociclo o heterociclo de 5 a 7 miembros que comprende: átomos de carbono y 0-3 heteroátomos adicionales seleccionados de N, NR11, O y S(O)p y 0-2 grupos carbonilo, en el que dicho carbociclo o heterociclo está sustituido con 0-4 Rb; R6 es -(CRfRf)n-fenilo sustituido con 0-3 R6a o -(CRfRf)n-piridilo sustituido con 0-3 R6a; R6a es, independientemente en cada aparición, F, Cl, Br, I, -(CRiRi)r-ORc, SRc, CN, NO2, CF3, OCF3, -CF2CF3, -OCF2CF2H, -OCF2CF3, -NR12R13, -C(O)Rc, -C(O)ORc, -C(O)NR12R13, -NR14C(O)Rd, -S(O)pNR12R13, -S(O)Rd, -S(O)2Rd, Si(Me)3, Si(alquilo C1-4)3, haloalquilo C1-4, haloalquiloxi C1-4-, alquiloxi C1-4-, alquiltio C1-4-, alquil C1-C4-C(O)-, alquil C1-4-O-C(O)-, alquil C1-4-C(O)NH-, alquilo C1-8 sustituido con 0-2 Ra, alquenilo C2-8 sustituido con 0-2 Ra, alquinilo C2-8 sustituido con 0-2 Ra, -(CRfRf)r-carbociclo C3-10 sustituido con 0-2 Re o -(CRfRf)r-heterociclo de 5 a 10 miembros que comprende: átomos de carbono y 1-4 heteroátomos seleccionados de N, NR11, O y S(O)p, en el que dicho heterociclo está sustituido con 0-2 Re; alternativamente, cuando dos grupos R6a están unidos a átomos adyacentes, junto con los átomos a los que están unidos forman un anillo carbocíclico o heterocíclico de 5 a 7 miembros que comprende: átomos de carbono y 0-2 heteroátomos seleccionados de N, NR11, O y S(O)p, 0-1 carbonilo y 0-3 dobles enlaces de anillo, en el que dicho anillo carbocíclico o heterocíclico está sustituido con 0-2 Rb; R7 es, independientemente en cada aparición, F, Cl, Br, I, OCF3, CF3, ORc, SRc, CN, NO2, -NR12R13, -C(O)Rc, -C(O)ORc, -C(O)NR12R13, -NR14C(O)Rd, -S(O)pNR12R13, -S(O)Rd, -S(O)2Rd, alquilo C1-8 sustituido con 0-2 Ra, alquenilo C2-8 sustituido con 0-2 Ra, alquinilo C2-8 sustituido con 0-2 Ra, -(CRfRf)r-carbociclo C3-10 sustituido con 0-3 Rb o -(CRfRf)r-heterociclo de 5 a 10 miembros que comprende: átomos de carbono y 1-4 heteroátomos seleccionados de N, NR7b, O y S(O)p, en el que dicho heterociclo está sustituido con 0-3 Rb; alternativamente, dos R7 en dos átomos de carbono adyacentes forman un anillo carbocíclico o heterocíclico de 5 a 7 miembros que comprende: átomos de carbono y 0-3 heteroátomos de anillo seleccionados de O, N, NR7b y S(O)p, en el que dicho anillo carbocíclico o heterocíclico está sustituido con 0-2 R7c; R7b es H, alquilo C1-4, -C(O)(alquilo C1-4), -C(O)fenilo, -C(O)bencilo o bencilo; R7c es, independientemente en cada aparición, H, F, Cl, Br, I, OCF3, CF3, ORc, SRc, CN, NO2, -NR12R13, -C(O)Rc, -C(O)ORc, -C(O)NR12R13, -NR14C(O)Rd, -S(O)pNR12R13, -S(O)Rd, -S(O)2Rd, alquilo C1-4, fenilo sustituido con 0-3 Rb o bencilo sustituido con 0-3 Rb; R11 es, independientemente en cada aparición, H, alcoxi C1-4, alquilo C1-8 sustituido con 0-2 Ra, alquenilo C2-4 sustituido con 0-1 Ra, alquinilo C2-4 sustituido con 0-1 Ra, -C(O)(alquilo C1-6), -C(O)(CH2)n(cicloalquilo C3-6), -C(O)(CH2)n(arilo C6-10), -C(O)(CH2)n(heteroarilo de 5 a 10 miembros), -C(O)O(alquilo C1-8), -C(O)O(CH2)n(cicloalquilo C3-6), -C(O)O(CH2)n(arilo C6-10), -C(O)O(CH2)n(heteroarilo de 5 a 10 miembros), -C(O)O(CH2)2-4(alquilo C1-4), -C(O)NH(alquilo C1-8), -C(O)NH(CH2)n(cicloalquilo C3-6), -C(O)NH(CH2)n(arilo C6-10), -C(O)NH(CH2)n(heteroarilo de 5 a 10 miembros), -S(O)2(alquilo C1-8), -S(O)2(CH2)n(cicloalquilo C3-6), -S(O)2(CH2)n(arilo C6-10), -S(O)2 (CH2)n(heteroarilo de 5 a 10 miembros), -(CRfRf)r-carbociclo C3-10 o -(CRfRf)r-heterociclo de 5 a 10 miembros; en el que dicho alquilo, cicloalquilo, fenilo, arilo y carbociclo están sustituidos con 0-2 Rb y dicho heteroarilo y heterociclo están sustituidos con 0-2 Rb y comprenden: átomos de carbono y 1-4 heteroátomos seleccionados de N, NRf, O y S(O)p; R12 es, independientemente en cada aparición, H, alquilo C1-6, -C(O)(alquilo C1-6), -C(O)(CH2)n(arilo C6-10), -C(O)(CH2)n(heteroarilo de 5 a 10 miembros), -C(O)O(alquilo C1-4), -C(O)OCH2(arilo C6-10), -(CH2)nC(O)OCH2(heteroarilo de 5 a 10 miembros), -(CH2)nOC(O)(alquilo C1-4), -(CH2)nOC(O)(arilo C6-10), -(CH2)nOC(O)(heteroarilo de 5 a 10 miembros), -(CH2)nC(O)O(alquilo C1-4), -(CH2)nC(O)O(arilo C6-10), -(CH2)nC(O)O(heteroarilo de 5 a 10 miembros), -(CH2)nC(O)NH(alquilo C1-6), -(CH2)nC(O)NH(arilo C6-10), -(CH2)nC(O)NH(heteroarilo de 5 a 10 miembros), -(CH2)tOC(O)NH(alquilo C1-6), -(CH2)tOC(O)NH(arilo C6-10), -(CH2)tOC(O)NH(heteroarilo de 5 a 10 miembros), -S(O)2(alquilo C1-6), -S(O)2(CH2)n(arilo C6-10), -S(O)2(CH2)n(heteroarilo de 5 a 10 miembros), -(CRfRf)n-(arilo C6-10) o -(CRfRf)n-heteroarilo de 5 a 10 miembros; en el que dicho alquilo y arilo están sustituidos con 0-2 Rg; y dicho heteroarilo está sustituido con 0-2 Rg y comprende: átomos de carbono y 1-4 heteroátomos seleccionados de N, NR11, O y S(O)p; R13 es, independientemente en cada aparición, H, alquilo C1-6 o -(CH2)n-fenilo; alternativamente, R12 y R13, cuando están unidos al mismo nitrógeno, se combinan para formar un anillo heterocíclico de 5 a 10 miembros que comprende: átomos de carbono y 1-2 heteroátomos adicionales seleccionados de N, NR11, O y S(O)p; R14 es, independientemente en cada aparición, H, alquilo C1-6 sustituido con 0-2 R14a, alquenilo C2-6 sustituido con 0-2 R14a, alquinilo C2-6 sustituido con 0-2 R14a, -(CH2)r-carbociclo C3-10 sustituido con 0-3 Rg o -(CH2)r-heterociclo de 5 a 10 miembros que comprende: átomos de carbono y 1-4 heteroátomos seleccionados de N, NR11, O y S(O)p, en el que dicho heterociclo está sustituido con 0-3 Rg; R14a es, independientemente en cada aparición, H, alquilo C1-4, ORf, Cl, F, Br, I, =O, CF3, CN, NO2, -C(O)Rf, -C(O)ORf, -C(O)NR12R13 o -S(O)pRf; R16 es, independientemente en cada aparición, H, F, alquilo C1-6 sustituido con 0-2 Ra, alquenilo C2-6 sustituido con 0-2 Ra, alquinilo C2-6 sustituido con 0-2 Ra o -(CH2)r-fenilo sustituido con 0-2 Rb; R17 es, independientemente en cada aparición, H, alquilo C1-6 o -(CH2)n-fenilo; alternativamente, R16 y R17 en el mismo átomo de carbono se combinan para formar un anillo carbocíclico o heterocíclico de 3 a 7 miembros que comprende: átomos de carbono y 0-2 heteroátomos seleccionados de N, NR11, O y S(O)p, 0-1 carbonilo y 0-3 dobles enlaces, en el que dicho anillo carbocíclico o heterocíclico está sustituido con 0-2 Rb; alternativamente, dos grupos R16 en átomos adyacentes se combinan para formar un anillo carbocíclico o heterocíclico de 3 a 7 miembros que comprende: átomos de carbono y 0-2 heteroátomos seleccionados de N, NR11, O y S(O)p, 0-1 carbonilo y 0-3 dobles enlaces, en el que dicho anillo carbocíclico o heterocíclico está sustituido con 0-2 Rb; R18 es, independientemente en cada aparición, H, F o alquilo C1-6; R19 es, independientemente en cada aparición, H, OH, -C(O)ORf o alquilo C1-6; Ra es, independientemente en cada aparición, F, OCF3, CF3, ORc, SRc, CN, -NR12R13, -C(O)Rc, -C(O)ORc, -C(O)NR12R13, -NR14C(O)Rd, -S(O)pNR12R13, -S(O)Rd, -S(O)2Rd, -(CH2)r-carbociclo C3-10 sustituido con 0-3 Re o -(CH2)r-heterociclo de 5 a 10 miembros que comprende: átomos de carbono y 1-4 heteroátomos seleccionados de N, NRf, O y S(O)p, en el que dicho heterociclo está sustituido con 0-3 Re; Rb es, independientemente en cada aparición, H, =O, F, Cl, Br, I, -(CH2)r-ORc, SRc, CN, NO2, CF3, OCF3, -(CH2)r-NR12R13, -C(O)Rc, -(CH2)r-C(O)ORc, -(CH2)r-C(O)NR12R13, -NR14C(O)Rd, -S(O)pNR12R13, -S(O)Rd, -S(O)2 Rd, haloalquilo C1-4, haloalquiloxi C1-4-, alquiloxi C1-4-, alquiltio C1-4-, alquil C1-4-C(O)-, alquil C1-4-O-C(O)-, alquil C1-4-C(O)-NH-, alquilo C1-8 sustituido con 0-2 Ra, alquenilo C2-8 sustituido con 0-2 Ra, alquenilo C2-8 sustituido con 0-2 Ra, -(CH2)r-carbociclo C3-10 sustituido con 0-3 Re o -(CH2)r-heterociclo de 5 a 10 miembros que comprende: átomos de carbono y 1-4 heteroátomos seleccionados de N, NRf, O y S(O)p, en el que dicho heterociclo está sustituido con 0-3 Re; Rc es, independientemente en cada aparición, H, -OP(O)(OEt)2, alquilo C1-8 sustituido con 0-2 Re, alquenilo C2-8 sustituido con 0-2 Re, alquinilo C2-8 sustituido con 0-2 Re, -(CRfRf)r-cicloalquilo C3-8 sustituido con 0-2 Re, -(CRfRf)r- arilo C6-10 sustituido con 0-2 Re o -(CRfRf)r-heterociclo de 5 a 10 miembros que comprende: átomos de carbono y 1-4 heteroátomos seleccionados de N, NRf, O y S(O)p, en el que dicho heterociclo está sustituido con 0-2 Re; Rd es, independientemente en cada aparición, CF3, OH, alcoxi C1-4, alquilo C1-6, -(CH2)r-carbociclo C3-10 sustituido con 0-2 Re o -(CH2)r-heterociclo de 5 a 10 miembros que comprende: á
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Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050026844A1 (en) 2003-04-03 2005-02-03 Regents Of The University Of California Inhibitors for the soluble epoxide hydrolase
US7470712B2 (en) * 2004-01-21 2008-12-30 Bristol-Myers Squibb Company Amino-benzazoles as P2Y1 receptor inhibitors
EP1765311A4 (en) 2004-03-16 2009-04-29 Univ California REDUCTION OF NEPHROPATHY WITH INHIBITORS OF SOLUBLE EPOXY HYDROLASE AND EPOXYEICOSANOIDS
US7550499B2 (en) * 2004-05-12 2009-06-23 Bristol-Myers Squibb Company Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
AU2005295167B2 (en) 2004-10-20 2012-05-10 The Regents Of The University Of California Improved inhibitors for the soluble epoxide hydrolase
US7645778B2 (en) * 2005-01-19 2010-01-12 Bristol-Myers Squibb Company Heteroaryl compounds as P2Y1 receptor inhibitors
US7816382B2 (en) * 2005-06-27 2010-10-19 Bristol-Myers Squibb Company Linear urea mimics antagonists of P2Y1 receptor useful in the treatment of thrombotic condition
ATE485269T1 (de) * 2005-06-27 2010-11-15 Bristol Myers Squibb Co C-verknüpfte zyklische antagonisten des p2y1- rezeptors mit eignung bei der behandlung thrombotischer leiden
AR056867A1 (es) 2005-06-27 2007-10-31 Bristol Myers Squibb Co Antagonistas heterociclicos n- enlazados del receptor de p2y1 utiles en el tratamiento de condiciones tromboticas. composiciones farmaceuticas.
WO2007002634A1 (en) * 2005-06-27 2007-01-04 Bristol-Myers Squibb Company Carbocycle and heterocycle antagonists of p2y1 receptor useful in the treatment of thrombotic conditions
TW200808723A (en) 2006-03-13 2008-02-16 Univ California Conformationally restricted urea inhibitors of soluble epoxide hydrolase
WO2008023235A1 (en) * 2006-08-25 2008-02-28 Pfizer Products Inc. Pyrazole derivatives as anti-platelet and anti-thrombotic agents
US7960569B2 (en) * 2006-10-17 2011-06-14 Bristol-Myers Squibb Company Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
WO2008085117A1 (en) * 2007-01-12 2008-07-17 Astrazeneca Ab Pyridine compounds and their use as p2y12 antagonists.
WO2008085118A1 (en) * 2007-01-12 2008-07-17 Astrazeneca Ab Pyridine compounds and their use as p2y12 antagonists.
CL2008000093A1 (es) * 2007-01-12 2008-08-22 Astrazeneca Ab Compuestos derivados de piridina, inhibidores de p2y12; composicion farmaceutica que comprende a dichos compuestos; y su uso para el tratamiento de un desorden de agregacion plaquetaria.
KR20100049073A (ko) * 2007-07-18 2010-05-11 노파르티스 아게 비시클릭 헤테로아릴 화합물 및 키나제 억제제로서의 그의 용도
WO2009035949A2 (en) * 2007-09-13 2009-03-19 Arete Therapeutics, Inc. Soluble epoxide hydrolase inhibitors
BRPI0920707A2 (pt) 2008-10-02 2015-12-29 Respivert Ltd compostos
GB0818033D0 (en) 2008-10-02 2008-11-05 Respivert Ltd Novel compound
CA2740952C (en) * 2008-10-22 2015-12-29 Ian L. Scott Compounds for treating ophthalmic diseases and disorders
US20120059036A1 (en) * 2008-11-21 2012-03-08 Marco Valgimigli Method for reducing thrombocytopenia and thrombocytopenia-associated mortality
WO2010067130A1 (en) 2008-12-11 2010-06-17 Respivert Limited P38 map kinase inhibitors
GB0905955D0 (en) 2009-04-06 2009-05-20 Respivert Ltd Novel compounds
US8377970B2 (en) 2009-10-08 2013-02-19 Rhizen Pharmaceuticals Sa Modulators of calcium release-activated calcium channel
US9296693B2 (en) 2010-01-29 2016-03-29 The Regents Of The University Of California Acyl piperidine inhibitors of soluble epoxide hydrolase
KR20130044382A (ko) * 2010-03-01 2013-05-02 마이렉시스 인코포레이티드 화합물 및 그의 치료 용도
US8912184B1 (en) 2010-03-01 2014-12-16 Alzheimer's Institute Of America, Inc. Therapeutic and diagnostic methods
FR2965262A1 (fr) * 2010-09-24 2012-03-30 Sanofi Aventis Derives de nicotinamide, leur preparation et leur application en therapeutique
CN103929961A (zh) * 2011-06-20 2014-07-16 美国阿尔茨海默病研究所公司 化合物及其治疗应用
US9428504B2 (en) * 2012-08-01 2016-08-30 Bristol-Myers Squibb Company 7-hydroxy-spiropipiperidine indolinyl antagonists of P2Y1 receptor
US9540323B2 (en) * 2012-08-01 2017-01-10 Bristol-Myers Squibb Company 7-hydroxy-indolinyl antagonists of P2Y1 receptor
MA38483A1 (fr) * 2013-03-15 2018-02-28 Bristol Myers Squibb Co Inhibiteurs de l'ido
GB201705863D0 (en) 2017-04-11 2017-05-24 Univ London Pyridinium salts and uses thereof
FI3636446T3 (fi) * 2017-06-08 2025-05-28 Nippon Soda Co Tallennusmateriaali, tallennusarkki ja yhdisteen käyttö värikehitteenä
EP3720326A4 (en) 2017-12-07 2021-08-11 Pitco Frialator, Inc. FLUID SENSOR AND CONTROL SYSTEM
DE102018113646B4 (de) 2018-06-07 2021-06-24 Helmholtz-Zentrum Dresden - Rossendorf E.V. 2-Phenoxypyridin-3-amin-Derivate und deren Verwendung
WO2021222637A1 (en) * 2020-04-30 2021-11-04 United States Government As Represented By The Department Of Veterans Affairs Krüppel-like factor 15 (klf15) small molecule agonists in kidney disease
EP4095134A1 (en) 2021-05-25 2022-11-30 UCL Business Ltd Polycyclic compounds for the treatment of neurological indications
EP4094762A1 (en) 2021-05-25 2022-11-30 UCL Business Ltd Treatment of neurological indications

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL254871A (es) * 1959-08-14
DE3484096D1 (de) * 1983-11-30 1991-03-14 Janssen Pharmaceutica Nv Bizyklisches heterozyklyl aufveisende n-(bizyklisches heterozyklyl-4-piperidinamine.
JPS62280847A (ja) 1986-05-30 1987-12-05 Konica Corp 新規なマゼンタカプラ−を含有するハロゲン化銀写真感光材料
CA1317939C (en) * 1987-07-01 1993-05-18 Janssen Pharmaceutica Naamloze Vennootschap ¬(bicyclic heterocyclyl)methyl and -hetero| substituted hexahydro-1h-azepines and pyrrolidines
JPH0339740A (ja) 1989-07-06 1991-02-20 Konica Corp 転写型熱現像カラー感光材料
NZ238863A (en) * 1990-07-19 1993-03-26 Janssen Pharmaceutica Nv Substituted thiazolyl and pyridinyl derivatives
JP3395285B2 (ja) 1993-10-06 2003-04-07 日本製紙株式会社 感熱記録体
US5547966A (en) * 1993-10-07 1996-08-20 Bristol-Myers Squibb Company Aryl urea and related compounds
DE4443641A1 (de) 1994-12-08 1996-06-13 Bayer Ag Substituierte Carbonsäureamide
EP0809492A4 (en) * 1995-02-17 2007-01-24 Smithkline Beecham Corp IL-8 RECEPTOR ANTAGONISTS
ATE251141T1 (de) 1995-03-10 2003-10-15 Berlex Lab Benzamidin-derivate, deren herstellung und deren verwendung als anti-koagulantien
US5691364A (en) * 1995-03-10 1997-11-25 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
CA2241687A1 (en) 1996-10-30 1998-05-07 Kenneth A. Jacobson P2y receptor antagonists
US6093742A (en) * 1997-06-27 2000-07-25 Vertex Pharmaceuticals, Inc. Inhibitors of p38
EP1047418B1 (en) * 1997-12-22 2005-07-27 Bayer Pharmaceuticals Corp. Inhibition of raf kinase using substituted heterocyclic ureas
US6329395B1 (en) 1998-06-08 2001-12-11 Schering Corporation Neuropeptide Y5 receptor antagonists
DE69924132T2 (de) 1998-10-20 2006-04-06 Takeda Pharmaceutical Co. Ltd. Aromatische aminderivate, verfahren zu ihrer herstellung und mittel, die diese enthalten
JP2001089412A (ja) 1999-09-22 2001-04-03 Otsuka Pharmaceut Co Ltd ベンゼン誘導体またはその医薬的に許容される塩
WO2001023358A1 (en) * 1999-09-27 2001-04-05 Sagami Chemical Research Center Pyrazole derivatives, intermediates for the preparation thereof, processes for the preparation of both and herbicides containing the derivatives as the active ingredient
WO2001025190A1 (en) * 1999-10-01 2001-04-12 Japan Energy Corporation Novel diarylamide derivatives and use thereof as medicines
EP1252160B1 (en) * 2000-01-14 2006-08-16 The Government of the United States of America, as represented by the Secretary of the Department of Health and Human Services Methanocarba cycloalkyl nucleoside analogues
KR20020063934A (ko) 2000-01-18 2002-08-07 화이자 프로덕츠 인코포레이티드 코르티코트로핀 방출 인자 길항제
WO2002088090A2 (en) * 2001-04-27 2002-11-07 Vertex Pharmaceuticals Incorporated Pyrazole derived kinase inhibitors
AU2002317377A1 (en) * 2001-07-20 2003-03-03 Cancer Research Technology Limited Biphenyl apurinic/apyrimidinic site endonuclease inhibitors to treat cancer
CZ2004168A3 (cs) 2001-08-06 2004-05-12 Pharmaciaáitaliaás@P@A Aminoizoxazolové derivátyŹ účinné jako kinázové inhibitoryŹ způsob jejich přípravy a farmaceutické prostředkyŹ které je obsahují
US7838541B2 (en) 2002-02-11 2010-11-23 Bayer Healthcare, Llc Aryl ureas with angiogenesis inhibiting activity
US20030216396A1 (en) 2002-02-11 2003-11-20 Bayer Corporation Pyridine, quinoline, and isoquinoline N-oxides as kinase inhibitors
ATE489384T1 (de) * 2002-05-06 2010-12-15 Vertex Pharma Thiadiazole oder oxadiazole und ihre verwendung als jak proteinkinaseinhibitoren
AU2003243921B2 (en) * 2002-06-27 2009-05-07 Novo Nordisk A/S Aryl carbonyl derivatives as therapeutic agents
US7470712B2 (en) 2004-01-21 2008-12-30 Bristol-Myers Squibb Company Amino-benzazoles as P2Y1 receptor inhibitors
US7550499B2 (en) 2004-05-12 2009-06-23 Bristol-Myers Squibb Company Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
US7645778B2 (en) 2005-01-19 2010-01-12 Bristol-Myers Squibb Company Heteroaryl compounds as P2Y1 receptor inhibitors
WO2007002634A1 (en) 2005-06-27 2007-01-04 Bristol-Myers Squibb Company Carbocycle and heterocycle antagonists of p2y1 receptor useful in the treatment of thrombotic conditions
US7816382B2 (en) 2005-06-27 2010-10-19 Bristol-Myers Squibb Company Linear urea mimics antagonists of P2Y1 receptor useful in the treatment of thrombotic condition

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EP1751113B1 (en) 2010-03-10
KR20070032648A (ko) 2007-03-22
DE602005019874D1 (de) 2010-04-22
US7674828B2 (en) 2010-03-09
WO2005113511A1 (en) 2005-12-01
EP1751113A1 (en) 2007-02-14
AU2005245389A1 (en) 2005-12-01
US20050267119A1 (en) 2005-12-01
WO2005113511A9 (en) 2006-02-02
JP2008500284A (ja) 2008-01-10
NO20065534L (no) 2006-12-05
US7388021B2 (en) 2008-06-17
MXPA06013022A (es) 2007-01-23
US20080280905A1 (en) 2008-11-13
ATE460402T1 (de) 2010-03-15

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