ATE493412T1 - Spirohydantoin-aryl-cgrp-rezeptorantagonisten - Google Patents

Spirohydantoin-aryl-cgrp-rezeptorantagonisten

Info

Publication number
ATE493412T1
ATE493412T1 AT06844350T AT06844350T ATE493412T1 AT E493412 T1 ATE493412 T1 AT E493412T1 AT 06844350 T AT06844350 T AT 06844350T AT 06844350 T AT06844350 T AT 06844350T AT E493412 T1 ATE493412 T1 AT E493412T1
Authority
AT
Austria
Prior art keywords
spirohydantoin
aryl
receptor antagonists
cgrp receptor
cgrp
Prior art date
Application number
AT06844350T
Other languages
English (en)
Inventor
Ian Bell
Craig Stump
Cory Theberge
Michael Wood
C Blair Zartman
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of ATE493412T1 publication Critical patent/ATE493412T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT06844350T 2005-11-18 2006-11-14 Spirohydantoin-aryl-cgrp-rezeptorantagonisten ATE493412T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73824105P 2005-11-18 2005-11-18
PCT/US2006/044086 WO2007061676A2 (en) 2005-11-18 2006-11-14 Spirohydantoin aryl cgrp receptor antagonists

Publications (1)

Publication Number Publication Date
ATE493412T1 true ATE493412T1 (de) 2011-01-15

Family

ID=38067723

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06844350T ATE493412T1 (de) 2005-11-18 2006-11-14 Spirohydantoin-aryl-cgrp-rezeptorantagonisten

Country Status (8)

Country Link
US (1) US8071770B2 (de)
EP (1) EP1951251B1 (de)
JP (1) JP2009515971A (de)
AT (1) ATE493412T1 (de)
AU (1) AU2006316626A1 (de)
CA (1) CA2629406A1 (de)
DE (1) DE602006019304D1 (de)
WO (1) WO2007061676A2 (de)

Families Citing this family (25)

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RS57194B1 (sr) 2005-11-14 2018-07-31 Teva Pharmaceuticals Int Gmbh Antagonistička antitela specifična za peptid koji je u vezi sa genom za kalcitonin za lečenje klaster glavobolje
EP1954268B1 (de) 2005-11-18 2012-09-26 Merck Sharp & Dohme Corp. Spirolactam-bicyclische cgrp-rezeptor-antagonisten
EP1951051B1 (de) 2005-11-18 2012-10-03 Merck Sharp & Dohme Corp. Spirohydantoin tricyclische cgrp-rezeptor-antagonisten
JP2009515973A (ja) 2005-11-18 2009-04-16 メルク エンド カムパニー インコーポレーテッド スピロラクタム三環式ｃｇｒｐ受容体アンタゴニスト
US7851464B2 (en) 2005-11-18 2010-12-14 Merck Sharp & Dohme Corp. Spirolactam aryl CGRP receptor antagonists
CA2629454A1 (en) 2005-11-18 2007-05-31 Merck & Co., Inc. Bicyclic spirohydantoin cgrp receptor antagonists
EP2265288B1 (de) 2008-03-04 2016-05-11 Labrys Biologics Inc. Verfahren zur behandlung von entzündlichen schmerzen
MX2010009722A (es) * 2008-03-04 2010-09-30 Pfizer Ltd Procedimiento de tratamiento del dolor cronico.
US8318762B2 (en) 2008-05-28 2012-11-27 Pfizer Inc. Pyrazolospiroketone acetyl-CoA carboxylase inhibitors
US8377955B2 (en) * 2008-06-12 2013-02-19 Merck, Sharp & Dohme, Corp. Branched 3- and 6-substituted quinolines as CGRP receptors antagonists
AR072297A1 (es) 2008-06-27 2010-08-18 Novartis Ag Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona.
WO2010021919A1 (en) 2008-08-18 2010-02-25 Merck Sharp & Dohme Corp. 3- and 6-quinolines with n-attached heterocyclic cgrp receptor antagonists
EP3165236B1 (de) 2009-08-28 2022-03-16 Teva Pharmaceuticals International GmbH Verfahren zur behandlung von eingeweideschmerz mittels verabreichung von antagonistischen antikörpern gegen calcitoningen-assoziiertes peptid
MX2012005429A (es) 2009-11-10 2012-06-19 Pfizer Inhibidores de n1-pirazoloespirocetona acetil-coa carboxilasa.
DK2621493T3 (en) 2010-09-30 2016-10-24 Pfizer N1 PYRAZOLOSPIROKETON-ACETYL-CoA carboxylase INHIBITORS
AU2011322117B2 (en) 2010-10-29 2015-01-22 Pfizer Inc. N1/N2-lactam acetyl-CoA carboxylase inhibitors
CU24164B1 (es) 2011-04-22 2016-03-31 Pfizer Inhibidores sustituidos de acetil-coa carboxilasa
NZ732875A (en) 2011-05-20 2022-08-26 H Lundbeck As Use of anti-cgrp or anti-cgrp-r antibodies or antibody fragments to treat or prevent chronic and acute forms of diarrhea
KR101965461B1 (ko) 2011-05-20 2019-04-04 앨더바이오 홀딩스 엘엘씨 필요한 대상체, 특히 편두통 환자의 광선공포증 또는 광선 혐오증을 예방 또는 억제하기 위한 항-cgrp 항체 및 항체 단편의 용도
LT3495392T (lt) 2011-05-20 2021-09-27 H. Lundbeck A/S Anti-cgrp kompozicijos ir jų panaudojimas
US10556945B2 (en) 2014-03-21 2020-02-11 Teva Pharmaceuticals International Gmbh Antagonist antibodies directed against calcitonin gene-related peptide and methods using same
JP6568099B2 (ja) 2014-03-21 2019-08-28 テバ・ファーマシューティカルズ・インターナショナル・ゲーエムベーハーＴｅｖａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｔｅｒｎａｔｉｏｎａｌ ＧｍｂＨ カルシトニン遺伝子関連ペプチドに対するアンタゴニスト抗体及びその使用方法
BR112019005823A2 (pt) 2016-09-23 2019-06-25 Teva Pharmaceuticals Int Gmbh tratamento para enxaqueca refratária
GB201707938D0 (en) 2017-05-17 2017-06-28 Univ Sheffield Compounds
WO2020146527A1 (en) 2019-01-08 2020-07-16 Alder Biopharmaceuticals, Inc. Acute treatment and rapid treatment of headache using anti-cgrp antibodies

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3561198D1 (en) 1984-03-23 1988-01-28 Pfizer Spiro-indenes and spiro-1,2-dihydro-naphthalenes for treatment of diabetic complications
US4722632A (en) 1984-05-21 1988-02-02 Oerlikron-Buehrle Ag Tensilely stressed window usable with infrared detector
FR2709306B1 (fr) 1993-07-20 1995-10-20 Adir Nouveaux dérivés de benzospiroalcène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
US7288559B2 (en) 2003-03-14 2007-10-30 Merck + Co, Inc. Carboxamide spirohydantoin CGRP receptor antagonists
WO2004087649A2 (en) 2003-03-14 2004-10-14 Merck & Co., Inc. Benodiazepine spirohydantoin cgrp receptor antagonists
EP1605936B1 (de) 2003-03-14 2011-07-20 Merck Sharp & Dohme Corp. Aryl-spirohydantoin-cgrp-rezeptor-antagonisten
WO2004082605A2 (en) 2003-03-14 2004-09-30 Merck & Co. Inc. Bicyclic anilide spirohydantoin cgrp receptor antagonists
JP4673295B2 (ja) 2003-03-14 2011-04-20 メルク・シャープ・エンド・ドーム・コーポレイション 単環式アニリドスピロヒダントインｃｇｒｐ受容体拮抗物質
WO2006029153A2 (en) 2004-09-08 2006-03-16 Merck & Co., Inc. Monocyclic anilide spirolactam cgrp receptor antagonists
CA2580020A1 (en) 2004-09-09 2006-03-23 Ian M. Bell Aryl spirolactam cgrp receptor antagonists
EP1793827B1 (de) * 2004-09-09 2010-04-07 Merck Sharp & Dohme Corp. Tricyclische anilid-spirohydantoin-cgrp-rezeptorantagonisten
US7390798B2 (en) 2004-09-13 2008-06-24 Merck & Co., Inc. Carboxamide spirolactam CGRP receptor antagonists
JP2008512489A (ja) 2004-09-13 2008-04-24 メルク エンド カムパニー インコーポレーテッド 三環式アニリドスピロヒダントインｃｇｒｐ受容体拮抗薬
US8003792B2 (en) 2004-09-13 2011-08-23 Merck Sharp & Dohme Corp. Bicyclic anilide spirolactam CGRP receptor antagonists
US7384931B2 (en) 2004-11-03 2008-06-10 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
US7384930B2 (en) 2004-11-03 2008-06-10 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
CA2629454A1 (en) 2005-11-18 2007-05-31 Merck & Co., Inc. Bicyclic spirohydantoin cgrp receptor antagonists
JP2009515973A (ja) 2005-11-18 2009-04-16 メルク エンド カムパニー インコーポレーテッド スピロラクタム三環式ｃｇｒｐ受容体アンタゴニスト
US7851464B2 (en) 2005-11-18 2010-12-14 Merck Sharp & Dohme Corp. Spirolactam aryl CGRP receptor antagonists
EP1951051B1 (de) 2005-11-18 2012-10-03 Merck Sharp & Dohme Corp. Spirohydantoin tricyclische cgrp-rezeptor-antagonisten
EP1954268B1 (de) 2005-11-18 2012-09-26 Merck Sharp & Dohme Corp. Spirolactam-bicyclische cgrp-rezeptor-antagonisten

Also Published As

Publication number Publication date
US20090239870A1 (en) 2009-09-24
US8071770B2 (en) 2011-12-06
CA2629406A1 (en) 2007-05-31
EP1951251A4 (de) 2009-05-27
WO2007061676A2 (en) 2007-05-31
AU2006316626A1 (en) 2007-05-31
WO2007061676A3 (en) 2007-12-21
EP1951251B1 (de) 2010-12-29
DE602006019304D1 (de) 2011-02-10
EP1951251A2 (de) 2008-08-06
JP2009515971A (ja) 2009-04-16

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