ATE464305T1 - Bicyclische anilidspirolactame als antagonisten des cgrp-rezeptors - Google Patents
Bicyclische anilidspirolactame als antagonisten des cgrp-rezeptorsInfo
- Publication number
- ATE464305T1 ATE464305T1 AT05795448T AT05795448T ATE464305T1 AT E464305 T1 ATE464305 T1 AT E464305T1 AT 05795448 T AT05795448 T AT 05795448T AT 05795448 T AT05795448 T AT 05795448T AT E464305 T1 ATE464305 T1 AT E464305T1
- Authority
- AT
- Austria
- Prior art keywords
- antagonists
- spirolactames
- cgrp receptor
- cgrp
- anilide
- Prior art date
Links
- 108010078311 Calcitonin Gene-Related Peptide Receptors Proteins 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title abstract 2
- 150000003931 anilides Chemical class 0.000 title 1
- 102000008323 calcitonin gene-related peptide receptor activity proteins Human genes 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 108090000932 Calcitonin Gene-Related Peptide Proteins 0.000 abstract 2
- 102100025588 Calcitonin gene-related peptide 1 Human genes 0.000 abstract 2
- 102000014468 Calcitonin Gene-Related Peptide Receptors Human genes 0.000 abstract 1
- 208000006561 Cluster Headache Diseases 0.000 abstract 1
- 206010019233 Headaches Diseases 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 208000018912 cluster headache syndrome Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 231100000869 headache Toxicity 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60929204P | 2004-09-13 | 2004-09-13 | |
| PCT/US2005/032041 WO2006031610A2 (en) | 2004-09-13 | 2005-09-09 | Bicyclic anilide spirolactam cgrp receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE464305T1 true ATE464305T1 (de) | 2010-04-15 |
Family
ID=36060555
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05795448T ATE464305T1 (de) | 2004-09-13 | 2005-09-09 | Bicyclische anilidspirolactame als antagonisten des cgrp-rezeptors |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8003792B2 (de) |
| EP (1) | EP1797073B1 (de) |
| JP (1) | JP2008512481A (de) |
| CN (1) | CN101018781A (de) |
| AT (1) | ATE464305T1 (de) |
| AU (1) | AU2005285109B2 (de) |
| CA (1) | CA2579847A1 (de) |
| DE (1) | DE602005020656D1 (de) |
| WO (1) | WO2006031610A2 (de) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006031513A2 (en) * | 2004-09-09 | 2006-03-23 | Merck & Co., Inc. | Aryl spirolactam cgrp receptor antagonists |
| US7390798B2 (en) * | 2004-09-13 | 2008-06-24 | Merck & Co., Inc. | Carboxamide spirolactam CGRP receptor antagonists |
| CA2579850A1 (en) | 2004-09-13 | 2006-03-23 | Merck & Co., Inc. | Tricyclic anilide spirohydantoin cgrp receptor antagonists |
| US7875627B2 (en) * | 2004-12-07 | 2011-01-25 | Abbott Laboratories | Thienopyridyl compounds that inhibit vanilloid receptor subtype 1 (VR1) and uses thereof |
| US20080306087A1 (en) * | 2005-08-08 | 2008-12-11 | Astrazeneca Ab | Therapeutic Agents |
| WO2007061694A2 (en) | 2005-11-18 | 2007-05-31 | Merck & Co., Inc. | Spirohydantoin tricyclic cgrp receptor antagonists |
| DE602006019304D1 (de) | 2005-11-18 | 2011-02-10 | Merck Sharp & Dohme | Spirohydantoin-aryl-cgrp-rezeptorantagonisten |
| EP1951042B1 (de) * | 2005-11-18 | 2012-10-10 | Merck Sharp & Dohme Corp. | Spirolactam tricyclische cgrp-rezeptor-antagonisten |
| AU2006316627A1 (en) * | 2005-11-18 | 2007-05-31 | Merck Sharp & Dohme Corp. | Spirolactam aryl CGRP receptor antagonists |
| JP2009515976A (ja) * | 2005-11-18 | 2009-04-16 | メルク エンド カムパニー インコーポレーテッド | スピロラクタム二環式ｃｇｒｐ受容体アンタゴニスト |
| WO2007133491A1 (en) * | 2006-05-09 | 2007-11-22 | Merck & Co., Inc. | Substituted spirocyclic cgrp receptor antagonists |
| CN101516875A (zh) * | 2006-07-21 | 2009-08-26 | 沃泰克斯药物股份有限公司 | Cgrp受体拮抗剂 |
| US7951795B2 (en) * | 2006-12-08 | 2011-05-31 | Merck Sharp & Dohme Corp. | Constrained spirocyclic compounds as CGRP receptor antagonists |
| US20080207659A1 (en) * | 2007-02-15 | 2008-08-28 | Asit Kumar Chakraborti | Inhibitors of phosphodiesterase type 4 |
| CA2680307A1 (en) | 2007-03-12 | 2008-09-18 | Merck & Co., Inc. | Monocyclic anilide spirolactam cgrp receptor antagonists |
| JP2010523663A (ja) * | 2007-04-11 | 2010-07-15 | メルク・シャープ・エンド・ドーム・コーポレイション | 第３級アミド、スルホンアミド、カルバミン酸及び尿素末端基をもつｃｇｒｐ受容体アンタゴニスト |
| US8143266B2 (en) * | 2007-04-16 | 2012-03-27 | Merck, Sharp & Dohme Corp | Aryl heterocyclic CGRP receptor antagonists |
| CA2683745A1 (en) * | 2007-04-16 | 2008-10-30 | Merck & Co., Inc. | Bicyclic anilide heterocyclic cgrp receptor antagonists |
| WO2008153849A1 (en) * | 2007-06-05 | 2008-12-18 | Merck & Co., Inc. | Carboxamide heterocyclic cgrp receptor antagonists |
| US8796260B2 (en) * | 2008-02-19 | 2014-08-05 | Merck Sharp & Dohme Corp. | Imidazobenzazepine CGRP receptor antagonists |
| CA2735821A1 (en) * | 2008-09-08 | 2010-03-11 | Merck Sharp & Dohme Corp. | Monocyclic amide cgrp receptor antagonists |
| CA2737711A1 (en) * | 2008-09-18 | 2010-03-25 | Merck Sharp & Dohme Corp. | Bicyclic dihydroimidazolone cgrp receptor antagonists |
| TWI487706B (zh) * | 2010-11-12 | 2015-06-11 | Merck Sharp & Dohme | 六氫吡啶酮甲醯胺氮雜茚滿ｃｇｒｐ受體拮抗劑 |
| MY175254A (en) | 2012-04-26 | 2020-06-17 | G1 Therapeutics Inc | Synthesis of lactams |
| PE20151436A1 (es) * | 2013-01-29 | 2015-10-10 | Naurex Inc | Moduladores de receptores nmda de espiro-lactama y sus usos |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
| US12168004B2 (en) | 2014-02-05 | 2024-12-17 | Merck Sharp & Dohme Llc | Treatment of migraine |
| HK1232218A1 (zh) | 2014-02-05 | 2018-01-05 | Merck Sharp & Dohme Llc | Cgrp-活性化合物的片剂制剂 |
| ES2686326T3 (es) | 2014-07-15 | 2018-10-17 | Grünenthal GmbH | Derivados de azaspiro(4,5)decano sustituidos |
| TW201607923A (zh) | 2014-07-15 | 2016-03-01 | 歌林達有限公司 | 被取代之氮螺環（４．５）癸烷衍生物 |
| EP3414247B1 (de) * | 2016-02-08 | 2021-04-21 | F. Hoffmann-La Roche AG | Spiroindolinone als ddr1-hemmer |
| CN109789142B (zh) | 2016-07-01 | 2022-08-23 | G1治疗公司 | N-(杂芳基)-吡咯并[3,2-d]嘧啶-2-胺的合成 |
| EP3366286A1 (de) | 2017-02-22 | 2018-08-29 | Johannes Keller | Verbindungen zur behandlung von sepsis |
| EP4455146A3 (de) | 2017-06-29 | 2025-01-01 | G1 Therapeutics, Inc. | Morphische formen von git38 und verfahren zur herstellung davon |
| US12090148B2 (en) | 2020-07-29 | 2024-09-17 | Allergan Pharmaceuticals International Limited | Treatment of migraine |
| US12383545B1 (en) | 2018-06-08 | 2025-08-12 | Allergan Pharmaceuticals International Limited | Treatment of migraine |
| CN120817904A (zh) | 2018-08-24 | 2025-10-21 | 法码科思莫斯有限公司 | 1,4-二氮杂螺[5.5]十一烷-3-酮改进的合成 |
| WO2022140537A1 (en) | 2020-12-22 | 2022-06-30 | Allergan Pharmaceuticals International Limited | Treatment of migraine |
| AU2022353124A1 (en) | 2021-09-27 | 2024-04-11 | Allergan Pharmaceuticals International Limited | Combination comprising atogepant for treating migraine |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1209361C (zh) | 2000-05-03 | 2005-07-06 | 霍夫曼-拉罗奇有限公司 | 含乙内酰脲的葡糖激酶激活剂 |
| WO2004082605A2 (en) | 2003-03-14 | 2004-09-30 | Merck & Co. Inc. | Bicyclic anilide spirohydantoin cgrp receptor antagonists |
| ATE516803T1 (de) | 2003-03-14 | 2011-08-15 | Merck Sharp & Dohme | Aryl-spirohydantoin-cgrp-rezeptor-antagonisten |
| EP1606286B1 (de) | 2003-03-14 | 2011-05-11 | Merck Sharp & Dohme Corp. | Benzodiazepinspirohydantoine als cgrp-rezeptorantagonisten |
| CA2518852A1 (en) | 2003-03-14 | 2004-09-30 | Merck & Co., Inc. | Monocyclic anilide spirohydantoin cgrp receptor antagonists |
| CN101014602B (zh) * | 2004-09-08 | 2011-08-10 | 默沙东公司 | 单环酰苯胺螺环内酰胺cgrp受体拮抗剂 |
| WO2006031491A2 (en) * | 2004-09-09 | 2006-03-23 | Merck & Co., Inc. | Tricyclic anilide spirolactam cgrp receptor antagonists |
| US7390798B2 (en) | 2004-09-13 | 2008-06-24 | Merck & Co., Inc. | Carboxamide spirolactam CGRP receptor antagonists |
| WO2007133491A1 (en) * | 2006-05-09 | 2007-11-22 | Merck & Co., Inc. | Substituted spirocyclic cgrp receptor antagonists |
-
2005
- 2005-09-09 AT AT05795448T patent/ATE464305T1/de not_active IP Right Cessation
- 2005-09-09 CA CA002579847A patent/CA2579847A1/en not_active Abandoned
- 2005-09-09 CN CNA2005800306054A patent/CN101018781A/zh active Pending
- 2005-09-09 WO PCT/US2005/032041 patent/WO2006031610A2/en not_active Ceased
- 2005-09-09 US US11/662,703 patent/US8003792B2/en active Active
- 2005-09-09 AU AU2005285109A patent/AU2005285109B2/en not_active Ceased
- 2005-09-09 DE DE602005020656T patent/DE602005020656D1/de not_active Expired - Lifetime
- 2005-09-09 JP JP2007531342A patent/JP2008512481A/ja active Pending
- 2005-09-09 EP EP05795448A patent/EP1797073B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005285109B2 (en) | 2011-03-03 |
| AU2005285109A1 (en) | 2006-03-23 |
| EP1797073B1 (de) | 2010-04-14 |
| US20080096878A1 (en) | 2008-04-24 |
| CN101018781A (zh) | 2007-08-15 |
| US8003792B2 (en) | 2011-08-23 |
| DE602005020656D1 (de) | 2010-05-27 |
| EP1797073A4 (de) | 2009-09-02 |
| JP2008512481A (ja) | 2008-04-24 |
| CA2579847A1 (en) | 2006-03-23 |
| WO2006031610A3 (en) | 2006-08-31 |
| WO2006031610A2 (en) | 2006-03-23 |
| EP1797073A2 (de) | 2007-06-20 |
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| ATE464305T1 (de) | Bicyclische anilidspirolactame als antagonisten des cgrp-rezeptors | |
| ATE537153T1 (de) | Arylspirolactamverbindungen als antagonisten des cgrp-rezeptors | |
| ATE394400T1 (de) | Bicyclische anilidspirohydantoine als cgrp- rezeptorantagonisten | |
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| ATE463245T1 (de) | Tricyclische anilid-spirohydantoin-cgrp- rezeptorantagonisten | |
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| ATE509019T1 (de) | Benzodiazepinspirohydantoine als cgrp- rezeptorantagonisten | |
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| WO2008112159A3 (en) | Monocyclic anilide spirolactam cgrp receptor antagonists | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |