ATE518852T1 - Tricyclische anilid-spirohydantoin-cgrp- rezeptorantagonisten - Google Patents

Tricyclische anilid-spirohydantoin-cgrp- rezeptorantagonisten

Info

Publication number
ATE518852T1
ATE518852T1 AT05796599T AT05796599T ATE518852T1 AT E518852 T1 ATE518852 T1 AT E518852T1 AT 05796599 T AT05796599 T AT 05796599T AT 05796599 T AT05796599 T AT 05796599T AT E518852 T1 ATE518852 T1 AT E518852T1
Authority
AT
Austria
Prior art keywords
receptor antagonists
cgrp receptor
anilide
tricyclic
spirohydantoin
Prior art date
Application number
AT05796599T
Other languages
English (en)
Inventor
Ian Bell
Steven Gallicchio
C Blair Zartman
Cory Theberge
Xufang Zhang
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of ATE518852T1 publication Critical patent/ATE518852T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT05796599T 2004-09-13 2005-09-09 Tricyclische anilid-spirohydantoin-cgrp- rezeptorantagonisten ATE518852T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60929404P 2004-09-13 2004-09-13
PCT/US2005/032288 WO2006031676A2 (en) 2004-09-13 2005-09-09 Tricyclic anilide spirohydantoin cgrp receptor antagonists

Publications (1)

Publication Number Publication Date
ATE518852T1 true ATE518852T1 (de) 2011-08-15

Family

ID=36060577

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05796599T ATE518852T1 (de) 2004-09-13 2005-09-09 Tricyclische anilid-spirohydantoin-cgrp- rezeptorantagonisten

Country Status (8)

Country Link
US (1) US7750010B2 (de)
EP (1) EP1794146B1 (de)
JP (1) JP2008512489A (de)
CN (1) CN101076527B (de)
AT (1) ATE518852T1 (de)
AU (1) AU2005285083B2 (de)
CA (1) CA2579850A1 (de)
WO (1) WO2006031676A2 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007061694A2 (en) * 2005-11-18 2007-05-31 Merck & Co., Inc. Spirohydantoin tricyclic cgrp receptor antagonists
DE602006019304D1 (de) 2005-11-18 2011-02-10 Merck Sharp & Dohme Spirohydantoin-aryl-cgrp-rezeptorantagonisten
EP1951042B1 (de) 2005-11-18 2012-10-10 Merck Sharp & Dohme Corp. Spirolactam tricyclische cgrp-rezeptor-antagonisten
AU2006316627A1 (en) 2005-11-18 2007-05-31 Merck Sharp & Dohme Corp. Spirolactam aryl CGRP receptor antagonists
WO2007133491A1 (en) 2006-05-09 2007-11-22 Merck & Co., Inc. Substituted spirocyclic cgrp receptor antagonists
CN101516875A (zh) * 2006-07-21 2009-08-26 沃泰克斯药物股份有限公司 Cgrp受体拮抗剂
US7951795B2 (en) 2006-12-08 2011-05-31 Merck Sharp & Dohme Corp. Constrained spirocyclic compounds as CGRP receptor antagonists
JP2010523663A (ja) 2007-04-11 2010-07-15 メルク・シャープ・エンド・ドーム・コーポレイション 第３級アミド、スルホンアミド、カルバミン酸及び尿素末端基をもつｃｇｒｐ受容体アンタゴニスト
CA2683745A1 (en) 2007-04-16 2008-10-30 Merck & Co., Inc. Bicyclic anilide heterocyclic cgrp receptor antagonists
US8143266B2 (en) 2007-04-16 2012-03-27 Merck, Sharp & Dohme Corp Aryl heterocyclic CGRP receptor antagonists
WO2008153849A1 (en) * 2007-06-05 2008-12-18 Merck & Co., Inc. Carboxamide heterocyclic cgrp receptor antagonists
EP2166842A4 (de) * 2007-06-07 2012-01-25 Merck Sharp & Dohme Tricyclische anilidheterocyclen als cgrp-rezeptor-antagonisten
TW201026672A (en) * 2008-10-07 2010-07-16 Schering Corp Spiroaminooxazoline analogues as alpha2C adrenergic receptor modulators
ME02847B (de) 2009-07-27 2018-01-20 Gilead Sciences Inc Kondensierte heterocyclische verbindungen als ionenkanalmodulatoren
US20110200669A1 (en) * 2010-02-15 2011-08-18 Winston Laboratories, Inc. Method and compositions of civamide to treat disease of the intestines
BR112012033402A2 (pt) 2010-07-02 2017-01-24 Gilead Sciences Inc moduladores de canais de íons conforme os compostos heterocíclicos fundidos
ES2648820T3 (es) 2011-05-10 2018-01-08 Gilead Sciences, Inc. Compuestos heterocíclicos condensados como moduladores de los canales de sodio
TWI478908B (zh) 2011-07-01 2015-04-01 Gilead Sciences Inc 作為離子通道調節劑之稠合雜環化合物
NO3175985T3 (de) 2011-07-01 2018-04-28
US8652527B1 (en) 2013-03-13 2014-02-18 Upsher-Smith Laboratories, Inc Extended-release topiramate capsules
US9101545B2 (en) 2013-03-15 2015-08-11 Upsher-Smith Laboratories, Inc. Extended-release topiramate capsules
WO2025143096A1 (ja) * 2023-12-29 2025-07-03 キッセイ薬品工業株式会社 含窒素縮環化合物

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0159143B1 (de) * 1984-03-23 1987-12-16 Pfizer Inc. Spiro-Indene und Spiro-1,2-Dihydro-Naphthalene für die Behandlung von diabetischen Komplikationen
MC1999A1 (fr) * 1987-12-18 1990-01-26 Hoffmann La Roche Composes tricycliques
WO1989008654A1 (en) * 1988-03-11 1989-09-21 Pfizer Inc. Pyrroloquinoline and pyrrolophenothiazine carboxamides and related compounds
US4906655A (en) * 1989-01-24 1990-03-06 Warner-Lambert Company Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents
WO1997009046A1 (en) * 1995-09-05 1997-03-13 Smithkline Beecham Corporation Compounds and methods
DE19963868A1 (de) * 1999-12-30 2001-07-12 Boehringer Ingelheim Pharma Neue substituierte Piperidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
JP2004537526A (ja) * 2001-06-12 2004-12-16 メルク　エンド　カムパニー　インコーポレーテッド 片頭痛の治療又は予防用ｎｒ２ｂ受容体拮抗薬
MXPA04011960A (es) * 2002-06-05 2005-03-31 Squibb Bristol Myers Co Antagonistas de receptores de peptidos relacionados con el gen de calcitonina.
WO2004082605A2 (en) * 2003-03-14 2004-09-30 Merck & Co. Inc. Bicyclic anilide spirohydantoin cgrp receptor antagonists
ATE516803T1 (de) 2003-03-14 2011-08-15 Merck Sharp & Dohme Aryl-spirohydantoin-cgrp-rezeptor-antagonisten
EP1606286B1 (de) 2003-03-14 2011-05-11 Merck Sharp & Dohme Corp. Benzodiazepinspirohydantoine als cgrp-rezeptorantagonisten
CA2518852A1 (en) 2003-03-14 2004-09-30 Merck & Co., Inc. Monocyclic anilide spirohydantoin cgrp receptor antagonists
CN101014602B (zh) 2004-09-08 2011-08-10 默沙东公司 单环酰苯胺螺环内酰胺cgrp受体拮抗剂
WO2006031513A2 (en) 2004-09-09 2006-03-23 Merck & Co., Inc. Aryl spirolactam cgrp receptor antagonists
WO2006031491A2 (en) 2004-09-09 2006-03-23 Merck & Co., Inc. Tricyclic anilide spirolactam cgrp receptor antagonists
US7390798B2 (en) 2004-09-13 2008-06-24 Merck & Co., Inc. Carboxamide spirolactam CGRP receptor antagonists
ATE464305T1 (de) 2004-09-13 2010-04-15 Merck Sharp & Dohme Bicyclische anilidspirolactame als antagonisten des cgrp-rezeptors

Also Published As

Publication number Publication date
US7750010B2 (en) 2010-07-06
CA2579850A1 (en) 2006-03-23
WO2006031676A3 (en) 2007-04-26
EP1794146A2 (de) 2007-06-13
CN101076527B (zh) 2011-11-30
AU2005285083A1 (en) 2006-03-23
CN101076527A (zh) 2007-11-21
WO2006031676A2 (en) 2006-03-23
JP2008512489A (ja) 2008-04-24
EP1794146A4 (de) 2010-06-30
EP1794146B1 (de) 2011-08-03
US20090221535A1 (en) 2009-09-03
AU2005285083B2 (en) 2011-03-10

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