ATE516803T1 - Aryl-spirohydantoin-cgrp-rezeptor-antagonisten - Google Patents
Aryl-spirohydantoin-cgrp-rezeptor-antagonistenInfo
- Publication number
- ATE516803T1 ATE516803T1 AT04719322T AT04719322T ATE516803T1 AT E516803 T1 ATE516803 T1 AT E516803T1 AT 04719322 T AT04719322 T AT 04719322T AT 04719322 T AT04719322 T AT 04719322T AT E516803 T1 ATE516803 T1 AT E516803T1
- Authority
- AT
- Austria
- Prior art keywords
- aryl
- receptor antagonists
- cgrp receptor
- spirohydantoin
- compounds
- Prior art date
Links
- 108010078311 Calcitonin Gene-Related Peptide Receptors Proteins 0.000 title abstract 2
- QAHZIGHCEBUNGT-QMGFNSACSA-N (5r,6s,7s,8r,9r)-6,7,8-trihydroxy-9-(hydroxymethyl)-1,3-diazaspiro[4.5]decane-2,4-dione Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)C[C@]11C(=O)NC(=O)N1 QAHZIGHCEBUNGT-QMGFNSACSA-N 0.000 title 1
- 102000008323 calcitonin gene-related peptide receptor activity proteins Human genes 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 108090000932 Calcitonin Gene-Related Peptide Proteins 0.000 abstract 2
- 102100025588 Calcitonin gene-related peptide 1 Human genes 0.000 abstract 2
- 102000014468 Calcitonin Gene-Related Peptide Receptors Human genes 0.000 abstract 1
- 208000006561 Cluster Headache Diseases 0.000 abstract 1
- 206010019233 Headaches Diseases 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 208000018912 cluster headache syndrome Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 231100000869 headache Toxicity 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45491703P | 2003-03-14 | 2003-03-14 | |
| PCT/US2004/007686 WO2004082678A1 (en) | 2003-03-14 | 2004-03-10 | Aryl spirohydantoin cgrp receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE516803T1 true ATE516803T1 (de) | 2011-08-15 |
Family
ID=33029928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04719322T ATE516803T1 (de) | 2003-03-14 | 2004-03-10 | Aryl-spirohydantoin-cgrp-rezeptor-antagonisten |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7189722B2 (de) |
| EP (1) | EP1605936B1 (de) |
| JP (1) | JP4673296B2 (de) |
| AT (1) | ATE516803T1 (de) |
| AU (1) | AU2004222328B2 (de) |
| CA (1) | CA2518843A1 (de) |
| WO (1) | WO2004082678A1 (de) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7220862B2 (en) | 2002-06-05 | 2007-05-22 | Bristol-Myers Squibb Company | Calcitonin gene related peptide receptor antagonists |
| US7842808B2 (en) | 2002-06-05 | 2010-11-30 | Bristol-Myers Squibb Company | Anti-migraine spirocycles |
| CA2519515A1 (en) * | 2003-03-14 | 2004-10-14 | Merck & Co., Inc. | Benodiazepine spirohydantoin cgrp receptor antagonists |
| US7569578B2 (en) | 2003-12-05 | 2009-08-04 | Bristol-Meyers Squibb Company | Heterocyclic anti-migraine agents |
| TW200533398A (en) | 2004-03-29 | 2005-10-16 | Bristol Myers Squibb Co | Novel therapeutic agents for the treatment of migraine |
| CA2579221A1 (en) * | 2004-09-08 | 2006-03-16 | Merck & Co., Inc. | Monocyclic anilide spirolactam cgrp receptor antagonists |
| CA2580020A1 (en) * | 2004-09-09 | 2006-03-23 | Ian M. Bell | Aryl spirolactam cgrp receptor antagonists |
| CA2579850A1 (en) * | 2004-09-13 | 2006-03-23 | Merck & Co., Inc. | Tricyclic anilide spirohydantoin cgrp receptor antagonists |
| CA2579847A1 (en) | 2004-09-13 | 2006-03-23 | Merck & Co., Inc. | Bicyclic anilide spirolactam cgrp receptor antagonists |
| US7384930B2 (en) | 2004-11-03 | 2008-06-10 | Bristol-Myers Squibb Company | Constrained compounds as CGRP-receptor antagonists |
| US7384931B2 (en) | 2004-11-03 | 2008-06-10 | Bristol-Myers Squibb Company | Constrained compounds as CGRP-receptor antagonists |
| US7449586B2 (en) | 2004-12-03 | 2008-11-11 | Bristol-Myers Squibb Company | Processes for the preparation of CGRP-receptor antagonists and intermediates thereof |
| US7834007B2 (en) | 2005-08-25 | 2010-11-16 | Bristol-Myers Squibb Company | CGRP antagonists |
| AP2008004467A0 (en) | 2005-11-14 | 2008-06-30 | Rinat Neurosciene Corp | Antagonist antibodies directed against calcitonin generelated peptide anf methods using same |
| EP1951251B1 (de) | 2005-11-18 | 2010-12-29 | Merck Sharp & Dohme Corp. | Spirohydantoin-aryl-cgrp-rezeptorantagonisten |
| JP2009515972A (ja) * | 2005-11-18 | 2009-04-16 | メルク エンド カムパニー インコーポレーテッド | スピロラクタムアリールｃｇｒｐ受容体アンタゴニスト |
| WO2007061692A2 (en) * | 2005-11-18 | 2007-05-31 | Merck & Co., Inc. | Spirolactam tricyclic cgrp receptor antagonists |
| WO2007061694A2 (en) | 2005-11-18 | 2007-05-31 | Merck & Co., Inc. | Spirohydantoin tricyclic cgrp receptor antagonists |
| WO2007133491A1 (en) * | 2006-05-09 | 2007-11-22 | Merck & Co., Inc. | Substituted spirocyclic cgrp receptor antagonists |
| CA2658573A1 (en) * | 2006-07-21 | 2008-01-24 | Vertex Pharmaceuticals Incorporated | Cgrp receptor antagonists |
| US7951795B2 (en) * | 2006-12-08 | 2011-05-31 | Merck Sharp & Dohme Corp. | Constrained spirocyclic compounds as CGRP receptor antagonists |
| EP2146715A4 (de) * | 2007-04-11 | 2011-08-31 | Merck Sharp & Dohme | Cgr-rezeptorantagonisten mit tertiären amid-, sulfonamid-, carbamat- und harnstoffendgruppen |
| EP2146572B1 (de) * | 2007-04-16 | 2013-11-20 | Merck Sharp & Dohme Corp. | Bicyclische heterocyclische anilid-cgrp-rezeptorantagonisten |
| EP2146712A4 (de) * | 2007-04-16 | 2010-10-13 | Merck Sharp & Dohme | Heterocyclische aryl-cgrp-rezeptorantagonisten |
| US8993588B2 (en) * | 2007-06-05 | 2015-03-31 | Merck Sharp & Dohme Corp. | Carboxamide heterocyclic CGRP receptor antagonists |
| US8163752B2 (en) * | 2007-06-07 | 2012-04-24 | Merck, Sharp & Dohme Corp. | Tricyclic anilide heterocyclic CGRP receptor antagonists |
| BRPI0907135B8 (pt) | 2008-03-04 | 2021-05-25 | Labrys Biologics Inc | uso de um anticorpo antagonista anti-cgrp para a prevenção e/ou tratamento de dor de câncer crônica |
| AU2009288206A1 (en) * | 2008-09-08 | 2010-03-11 | Merck Sharp & Dohme Corp. | Monocyclic amide CGRP receptor antagonists |
| US7815880B2 (en) * | 2008-09-30 | 2010-10-19 | Calera Corporation | Reduced-carbon footprint concrete compositions |
| AU2010288194B2 (en) | 2009-08-28 | 2013-08-29 | Teva Pharmaceuticals International Gmbh | Methods for treating visceral pain by administering antagonist antibodies directed against calcitonin gene-related peptide |
| DK2710039T3 (en) | 2011-05-20 | 2019-04-01 | Alderbio Holdings Llc | ANTI-CGRP COMPOSITIONS AND APPLICATION THEREOF |
| SG194973A1 (en) | 2011-05-20 | 2013-12-30 | Alderbio Holdings Llc | Use of anti-cgrp antibodies and antibody fragments to prevent or inhibit photophobia or light aversion in subjects in need thereof, especially migraine sufferers |
| EP2709662B1 (de) | 2011-05-20 | 2019-07-31 | AlderBio Holdings LLC | Verwendung von anti-cgrp- oder anti-cgrp-r-antikörpern oder antikörperfragmenten zur behandlung oder prävention chronischer und akuter formen von diarrhöe |
| US9227972B2 (en) | 2012-05-09 | 2016-01-05 | Merck Sharp & Dohme Corp. | Aliphatic spirolactam CGRP receptor antagonists |
| US10556945B2 (en) | 2014-03-21 | 2020-02-11 | Teva Pharmaceuticals International Gmbh | Antagonist antibodies directed against calcitonin gene-related peptide and methods using same |
| MX2016012188A (es) | 2014-03-21 | 2017-04-27 | Teva Pharmaceuticals Int Gmbh | Anticuerpos antagonistas dirigidos contra el peptido relacionado con el gen de calcitonina y metodos que usan los mismos. |
| JP6937368B2 (ja) | 2016-09-23 | 2021-09-22 | テバ・ファーマシューティカルズ・インターナショナル・ゲー・エム・ベー・ハー | 難治性片頭痛の治療方法 |
| EP3366286A1 (de) | 2017-02-22 | 2018-08-29 | Johannes Keller | Verbindungen zur behandlung von sepsis |
| CR20210373A (es) | 2019-01-08 | 2021-08-19 | H Lundbeck As | Tratamiento agudo y tratamiento rápido de la cefalea usando anticuerpos anti-cgrp |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3561198D1 (en) * | 1984-03-23 | 1988-01-28 | Pfizer | Spiro-indenes and spiro-1,2-dihydro-naphthalenes for treatment of diabetic complications |
| JP3449084B2 (ja) * | 1995-12-25 | 2003-09-22 | 富士レビオ株式会社 | ヒダントイン誘導体 |
| WO2004083187A1 (en) * | 2003-03-14 | 2004-09-30 | Merck & Co. Inc. | Monocyclic anilide spirohydantoin cgrp receptor antagonists |
| AU2004222383B2 (en) * | 2003-03-14 | 2009-10-01 | Merck Sharp & Dohme Corp. | Bicyclic anilide spirohydantoin CGRP receptor antagonists |
-
2004
- 2004-03-10 AT AT04719322T patent/ATE516803T1/de not_active IP Right Cessation
- 2004-03-10 JP JP2006507140A patent/JP4673296B2/ja not_active Expired - Fee Related
- 2004-03-10 EP EP04719322A patent/EP1605936B1/de not_active Expired - Lifetime
- 2004-03-10 WO PCT/US2004/007686 patent/WO2004082678A1/en active Application Filing
- 2004-03-10 AU AU2004222328A patent/AU2004222328B2/en not_active Ceased
- 2004-03-10 US US10/547,227 patent/US7189722B2/en active Active
- 2004-03-10 CA CA002518843A patent/CA2518843A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20060189593A1 (en) | 2006-08-24 |
| EP1605936A4 (de) | 2008-08-06 |
| AU2004222328B2 (en) | 2009-10-08 |
| JP2006520388A (ja) | 2006-09-07 |
| AU2004222328A1 (en) | 2004-09-30 |
| WO2004082678A1 (en) | 2004-09-30 |
| EP1605936B1 (de) | 2011-07-20 |
| EP1605936A1 (de) | 2005-12-21 |
| JP4673296B2 (ja) | 2011-04-20 |
| US7189722B2 (en) | 2007-03-13 |
| CA2518843A1 (en) | 2004-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |