ATE463245T1 - Tricyclische anilid-spirohydantoin-cgrp- rezeptorantagonisten - Google Patents

Tricyclische anilid-spirohydantoin-cgrp- rezeptorantagonisten

Info

Publication number
ATE463245T1
ATE463245T1 AT05796847T AT05796847T ATE463245T1 AT E463245 T1 ATE463245 T1 AT E463245T1 AT 05796847 T AT05796847 T AT 05796847T AT 05796847 T AT05796847 T AT 05796847T AT E463245 T1 ATE463245 T1 AT E463245T1
Authority
AT
Austria
Prior art keywords
receptor antagonists
cgrp receptor
anilide
tricyclic
spirohydantoin
Prior art date
Application number
AT05796847T
Other languages
English (en)
Inventor
Ian Bell
Steven Gallicchio
Craig Stump
Cory Theberge
Joseph VACCA
Blair C Zartman
Xufang Zhang
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of ATE463245T1 publication Critical patent/ATE463245T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT05796847T 2004-09-09 2005-09-06 Tricyclische anilid-spirohydantoin-cgrp- rezeptorantagonisten ATE463245T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60829404P 2004-09-09 2004-09-09
PCT/US2005/031617 WO2006031491A2 (en) 2004-09-09 2005-09-06 Tricyclic anilide spirolactam cgrp receptor antagonists

Publications (1)

Publication Number Publication Date
ATE463245T1 true ATE463245T1 (de) 2010-04-15

Family

ID=36060520

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05796847T ATE463245T1 (de) 2004-09-09 2005-09-06 Tricyclische anilid-spirohydantoin-cgrp- rezeptorantagonisten

Country Status (9)

Country Link
US (2) US7696192B2 (de)
EP (1) EP1793827B1 (de)
JP (1) JP2008512456A (de)
CN (1) CN101014345A (de)
AT (1) ATE463245T1 (de)
AU (1) AU2005285270B2 (de)
CA (1) CA2579717A1 (de)
DE (1) DE602005020472D1 (de)
WO (1) WO2006031491A2 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
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JP2008512456A (ja) * 2004-09-09 2008-04-24 メルク エンド カムパニー インコーポレーテッド 三環式アニリドスピロラクタムｃｇｒｐ受容体拮抗薬
ATE537153T1 (de) * 2004-09-09 2011-12-15 Merck Sharp & Dohme Arylspirolactamverbindungen als antagonisten des cgrp-rezeptors
ATE464305T1 (de) * 2004-09-13 2010-04-15 Merck Sharp & Dohme Bicyclische anilidspirolactame als antagonisten des cgrp-rezeptors
ATE518852T1 (de) 2004-09-13 2011-08-15 Merck Sharp & Dohme Tricyclische anilid-spirohydantoin-cgrp- rezeptorantagonisten
WO2007061677A2 (en) 2005-11-18 2007-05-31 Merck & Co., Inc. Spirolactam aryl cgrp receptor antagonists
US8071770B2 (en) 2005-11-18 2011-12-06 Merck Sharp & Dohme Corp. Spirohydantoin aryl CGRP receptor antagonists
EP1951042B1 (de) * 2005-11-18 2012-10-10 Merck Sharp & Dohme Corp. Spirolactam tricyclische cgrp-rezeptor-antagonisten
WO2007061694A2 (en) * 2005-11-18 2007-05-31 Merck & Co., Inc. Spirohydantoin tricyclic cgrp receptor antagonists
TW200732302A (en) * 2005-12-13 2007-09-01 Daicel Chem Indoline derivative
BRPI0711352A2 (pt) * 2006-05-09 2011-09-27 Merck & Co Inc composto, composição farmacêutica, e, métodos para o antagonismo de atividade receptora de cgrp em um mamìfero, e para, tratar, controlar, melhorar ou reduzir o risco de dor de cabeça, enxaqueca , ou cefaléia vascular
EP2091533B1 (de) * 2006-12-08 2012-11-28 Merck Sharp & Dohme Corp. Eingeschränkte spirocyclische verbindungen als cgrp-rezeptor-antagonisten
AU2008239754A1 (en) * 2007-04-11 2008-10-23 Merck Sharp & Dohme Corp. CGRP receptor antagonists with tertiary amide, sulfonamide, carbamate and urea end groups
JP2010524931A (ja) * 2007-04-16 2010-07-22 メルク・シャープ・エンド・ドーム・コーポレイション 二環式アニリドヘテロ環式ｃｇｒｐ受容体アンタゴニスト
WO2008130524A1 (en) * 2007-04-16 2008-10-30 Merck & Co., Inc. Aryl heterocyclic cgrp receptor antagonists
EP2161996B1 (de) * 2007-06-05 2014-07-16 Merck Sharp & Dohme Corp. Heterocyclische carboxamid-cgrp-rezeptorantagonisten
JP2010529120A (ja) * 2007-06-07 2010-08-26 メルク・シャープ・エンド・ドーム・コーポレイション 三環式アニリド複素環ｃｇｒｐ受容体アンタゴニスト
EP2299813B1 (de) * 2008-06-12 2015-12-16 Merck Sharp & Dohme Corp. Verzweigte 3- und 6-substituierte chinoline als cgrp-rezeptorantagonisten
WO2010027927A1 (en) * 2008-09-08 2010-03-11 Merck Sharp & Dohme Corp. Monocyclic amide cgrp receptor antagonists
US20110306626A1 (en) * 2008-12-17 2011-12-15 Selnick Harold G Imidazolinone derivatives as cgrp receptor antagonists
EP2471776A1 (de) 2010-12-28 2012-07-04 Bayer CropScience AG Pyridin-2-ylpropandinitrile und deren Verwendung als Herbizide
US9174989B2 (en) 2012-05-09 2015-11-03 Merck Sharp & Dohme Corp. Process for making CGRP receptor antagonists
US8652527B1 (en) 2013-03-13 2014-02-18 Upsher-Smith Laboratories, Inc Extended-release topiramate capsules
US9101545B2 (en) 2013-03-15 2015-08-11 Upsher-Smith Laboratories, Inc. Extended-release topiramate capsules
KR102445288B1 (ko) 2016-07-01 2022-09-19 쥐원 쎄라퓨틱스, 인크. N-(헤테로아릴)-피롤로[3,2-d]피리미딘-2-아민의 합성
CN106008528A (zh) * 2016-07-28 2016-10-12 安徽赛迪生物科技有限公司 一种合成4-氯-5,7-二氢-6h-吡咯并[2,3-d]嘧啶-6-酮的方法
CA3067873A1 (en) 2017-06-29 2019-01-03 G1 Therapeutics, Inc. Morphic forms of g1t38 and methods of manufacture thereof
WO2021005493A1 (en) * 2019-07-05 2021-01-14 Allergan Pharmaceuticals International Limited Cgrp antagonists and botulinum toxins for the treatment of inflammatory and neurologic disorders
US20210121541A1 (en) * 2019-07-05 2021-04-29 Allergan Pharmaceuticals International Limited CGRP Antagonists and Clostridial Derivatives for the Treatment of Neuropsychiatric and Neurological Disorders

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MC1999A1 (fr) * 1987-12-18 1990-01-26 Hoffmann La Roche Composes tricycliques
WO1989008654A1 (en) * 1988-03-11 1989-09-21 Pfizer Inc. Pyrroloquinoline and pyrrolophenothiazine carboxamides and related compounds
US4906655A (en) * 1989-01-24 1990-03-06 Warner-Lambert Company Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents
AUPN449295A0 (en) * 1995-07-28 1995-08-24 Inner And Eastern Health Care Network, The Radioprotectors
EP0851759A4 (de) * 1995-09-05 2000-12-06 Smithkline Beecham Corp Verbindungen und verfahren dazu
DE19963868A1 (de) * 1999-12-30 2001-07-12 Boehringer Ingelheim Pharma Neue substituierte Piperidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
AU5227001A (en) * 2000-05-03 2001-11-12 Hoffmann La Roche Hydantoin-containing glucokinase activators
US20040204341A1 (en) * 2001-06-12 2004-10-14 Christopher Allen Nr2b receptor antagonists for the treatment or prevention of migraines
DK1539766T3 (en) * 2002-06-05 2017-04-03 Bristol Myers Squibb Co CALCITONIN GEN-RELATED PEPTIDE RECEPTOR ANTAGONISTS
US7192954B2 (en) 2003-03-14 2007-03-20 Merck & Co., Inc. Monocyclic anilide spirohydantoin CGRP receptor antagonists
US7659300B2 (en) * 2004-09-08 2010-02-09 Merck Sharp & Dohme Corp. Monocyclic anilide spirolactam CGRP receptor antagonists
JP2008512456A (ja) * 2004-09-09 2008-04-24 メルク エンド カムパニー インコーポレーテッド 三環式アニリドスピロラクタムｃｇｒｐ受容体拮抗薬

Also Published As

Publication number Publication date
US20080214511A1 (en) 2008-09-04
CN101014345A (zh) 2007-08-08
AU2005285270B2 (en) 2011-04-21
US20100160334A1 (en) 2010-06-24
US8133891B2 (en) 2012-03-13
EP1793827B1 (de) 2010-04-07
DE602005020472D1 (de) 2010-05-20
AU2005285270A1 (en) 2006-03-23
WO2006031491A2 (en) 2006-03-23
US7696192B2 (en) 2010-04-13
CA2579717A1 (en) 2006-03-23
WO2006031491A3 (en) 2006-11-09
EP1793827A4 (de) 2009-07-29
EP1793827A2 (de) 2007-06-13
JP2008512456A (ja) 2008-04-24

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