ATE463245T1 - Tricyclische anilid-spirohydantoin-cgrp- rezeptorantagonisten - Google Patents
Tricyclische anilid-spirohydantoin-cgrp- rezeptorantagonistenInfo
- Publication number
- ATE463245T1 ATE463245T1 AT05796847T AT05796847T ATE463245T1 AT E463245 T1 ATE463245 T1 AT E463245T1 AT 05796847 T AT05796847 T AT 05796847T AT 05796847 T AT05796847 T AT 05796847T AT E463245 T1 ATE463245 T1 AT E463245T1
- Authority
- AT
- Austria
- Prior art keywords
- receptor antagonists
- cgrp receptor
- anilide
- tricyclic
- spirohydantoin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60829404P | 2004-09-09 | 2004-09-09 | |
| PCT/US2005/031617 WO2006031491A2 (en) | 2004-09-09 | 2005-09-06 | Tricyclic anilide spirolactam cgrp receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE463245T1 true ATE463245T1 (de) | 2010-04-15 |
Family
ID=36060520
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05796847T ATE463245T1 (de) | 2004-09-09 | 2005-09-06 | Tricyclische anilid-spirohydantoin-cgrp- rezeptorantagonisten |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7696192B2 (de) |
| EP (1) | EP1793827B1 (de) |
| JP (1) | JP2008512456A (de) |
| CN (1) | CN101014345A (de) |
| AT (1) | ATE463245T1 (de) |
| AU (1) | AU2005285270B2 (de) |
| CA (1) | CA2579717A1 (de) |
| DE (1) | DE602005020472D1 (de) |
| WO (1) | WO2006031491A2 (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006031513A2 (en) * | 2004-09-09 | 2006-03-23 | Merck & Co., Inc. | Aryl spirolactam cgrp receptor antagonists |
| US7696192B2 (en) * | 2004-09-09 | 2010-04-13 | Merck Sharp & Dohme Corp. | Tricyclic anilide spirolactam CGRP receptor antagonists |
| ATE518852T1 (de) * | 2004-09-13 | 2011-08-15 | Merck Sharp & Dohme | Tricyclische anilid-spirohydantoin-cgrp- rezeptorantagonisten |
| EP1797073B1 (de) * | 2004-09-13 | 2010-04-14 | Merck Sharp & Dohme Corp. | Bicyclische anilidspirolactame als antagonisten des cgrp-rezeptors |
| US8071770B2 (en) | 2005-11-18 | 2011-12-06 | Merck Sharp & Dohme Corp. | Spirohydantoin aryl CGRP receptor antagonists |
| AU2006316644B2 (en) | 2005-11-18 | 2011-11-10 | Merck Sharp & Dohme Corp. | Spirohydantoin tricyclic CGRP receptor antagonists |
| CA2629415A1 (en) * | 2005-11-18 | 2007-05-31 | Merck & Co., Inc. | Spirolactam tricyclic cgrp receptor antagonists |
| CA2629409A1 (en) | 2005-11-18 | 2007-05-31 | Merck & Co., Inc. | Spirolactam aryl cgrp receptor antagonists |
| TW200732302A (en) * | 2005-12-13 | 2007-09-01 | Daicel Chem | Indoline derivative |
| KR20090018107A (ko) * | 2006-05-09 | 2009-02-19 | 머크 앤드 캄파니 인코포레이티드 | 치환된 스피로사이클릭 ｃｇｒｐ 수용체 길항제 |
| US7951795B2 (en) * | 2006-12-08 | 2011-05-31 | Merck Sharp & Dohme Corp. | Constrained spirocyclic compounds as CGRP receptor antagonists |
| EP2146715A4 (de) * | 2007-04-11 | 2011-08-31 | Merck Sharp & Dohme | Cgr-rezeptorantagonisten mit tertiären amid-, sulfonamid-, carbamat- und harnstoffendgruppen |
| CA2683757A1 (en) * | 2007-04-16 | 2008-10-30 | Merck & Co., Inc. | Aryl heterocyclic cgrp receptor antagonists |
| US8173655B2 (en) * | 2007-04-16 | 2012-05-08 | Merck, Sharp & Dohme Corp. | Bicyclic anilide heterocyclic CGRP receptor antagonists |
| US8993588B2 (en) * | 2007-06-05 | 2015-03-31 | Merck Sharp & Dohme Corp. | Carboxamide heterocyclic CGRP receptor antagonists |
| CA2689444A1 (en) * | 2007-06-07 | 2008-12-18 | Merck Sharp & Dohme Corp. | Tricyclic anilide heterocyclic cgrp receptor antagonists |
| EP2299813B1 (de) * | 2008-06-12 | 2015-12-16 | Merck Sharp & Dohme Corp. | Verzweigte 3- und 6-substituierte chinoline als cgrp-rezeptorantagonisten |
| CA2735821A1 (en) * | 2008-09-08 | 2010-03-11 | Merck Sharp & Dohme Corp. | Monocyclic amide cgrp receptor antagonists |
| EP2378877A4 (de) * | 2008-12-17 | 2012-05-23 | Merck Sharp & Dohme | Imidazolinonderivate als cgrp-rezeptorantagonisten |
| EP2471776A1 (de) | 2010-12-28 | 2012-07-04 | Bayer CropScience AG | Pyridin-2-ylpropandinitrile und deren Verwendung als Herbizide |
| US9174989B2 (en) | 2012-05-09 | 2015-11-03 | Merck Sharp & Dohme Corp. | Process for making CGRP receptor antagonists |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
| BR112018077155A2 (pt) | 2016-07-01 | 2019-04-02 | G1 Therapeutics, Inc. | processo para preparar um composto, e, composto |
| CN106008528A (zh) * | 2016-07-28 | 2016-10-12 | 安徽赛迪生物科技有限公司 | 一种合成4-氯-5,7-二氢-6h-吡咯并[2,3-d]嘧啶-6-酮的方法 |
| NZ759691A (en) | 2017-06-29 | 2023-05-26 | G1 Therapeutics Inc | Morphic forms of git38 and methods of manufacture thereof |
| US20210130445A1 (en) * | 2019-07-05 | 2021-05-06 | Allergan Pharmaceuticals International Limited | CGRP Antagonists and Botulinum Toxins for the Treatment of Inflammatory and Neurologic Disorders |
| WO2021005494A1 (en) * | 2019-07-05 | 2021-01-14 | Allergan Pharmaceuticals International Limited | Cgrp antagonists and clostridial derivatives for the treatment of neuropsychiatric and neurological disorders |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MC1999A1 (fr) * | 1987-12-18 | 1990-01-26 | Hoffmann La Roche | Composes tricycliques |
| WO1989008654A1 (en) * | 1988-03-11 | 1989-09-21 | Pfizer Inc. | Pyrroloquinoline and pyrrolophenothiazine carboxamides and related compounds |
| US4906655A (en) * | 1989-01-24 | 1990-03-06 | Warner-Lambert Company | Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents |
| AUPN449295A0 (en) * | 1995-07-28 | 1995-08-24 | Inner And Eastern Health Care Network, The | Radioprotectors |
| EP0851759A4 (de) * | 1995-09-05 | 2000-12-06 | Smithkline Beecham Corp | Verbindungen und verfahren dazu |
| DE19963868A1 (de) * | 1999-12-30 | 2001-07-12 | Boehringer Ingelheim Pharma | Neue substituierte Piperidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| EP1280801B1 (de) * | 2000-05-03 | 2005-09-07 | F. Hoffmann-La Roche Ag | Hydantoin-enthaltende glucokinase aktivatoren |
| EP1399160A4 (de) * | 2001-06-12 | 2004-08-25 | Merck & Co Inc | Nr2b-rezeptor-antagonisten zur behandlung oder prävention von migräne |
| US20040063735A1 (en) * | 2002-06-05 | 2004-04-01 | Chaturvedula Prasad V. | Calcitonin gene related peptide receptor antagonists |
| US7192954B2 (en) * | 2003-03-14 | 2007-03-20 | Merck & Co., Inc. | Monocyclic anilide spirohydantoin CGRP receptor antagonists |
| EP1791843B1 (de) | 2004-09-08 | 2012-08-29 | Merck Sharp & Dohme Corp. | Monozyklische anilid-spirolactam-cgrp-rezeptor-antagonisten |
| US7696192B2 (en) * | 2004-09-09 | 2010-04-13 | Merck Sharp & Dohme Corp. | Tricyclic anilide spirolactam CGRP receptor antagonists |
-
2005
- 2005-09-06 US US11/662,246 patent/US7696192B2/en active Active
- 2005-09-06 JP JP2007531249A patent/JP2008512456A/ja active Pending
- 2005-09-06 WO PCT/US2005/031617 patent/WO2006031491A2/en active Application Filing
- 2005-09-06 CN CNA2005800299915A patent/CN101014345A/zh active Pending
- 2005-09-06 EP EP05796847A patent/EP1793827B1/de active Active
- 2005-09-06 DE DE602005020472T patent/DE602005020472D1/de active Active
- 2005-09-06 AT AT05796847T patent/ATE463245T1/de not_active IP Right Cessation
- 2005-09-06 CA CA002579717A patent/CA2579717A1/en not_active Abandoned
- 2005-09-06 AU AU2005285270A patent/AU2005285270B2/en not_active Ceased
-
2010
- 2010-03-05 US US12/718,386 patent/US8133891B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006031491A2 (en) | 2006-03-23 |
| CA2579717A1 (en) | 2006-03-23 |
| WO2006031491A3 (en) | 2006-11-09 |
| JP2008512456A (ja) | 2008-04-24 |
| EP1793827B1 (de) | 2010-04-07 |
| US20100160334A1 (en) | 2010-06-24 |
| DE602005020472D1 (de) | 2010-05-20 |
| CN101014345A (zh) | 2007-08-08 |
| AU2005285270B2 (en) | 2011-04-21 |
| AU2005285270A1 (en) | 2006-03-23 |
| EP1793827A4 (de) | 2009-07-29 |
| EP1793827A2 (de) | 2007-06-13 |
| US20080214511A1 (en) | 2008-09-04 |
| US7696192B2 (en) | 2010-04-13 |
| US8133891B2 (en) | 2012-03-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |