ATE463245T1 - Tricyclische anilid-spirohydantoin-cgrp- rezeptorantagonisten - Google Patents

Tricyclische anilid-spirohydantoin-cgrp- rezeptorantagonisten

Info

Publication number
ATE463245T1
ATE463245T1 AT05796847T AT05796847T ATE463245T1 AT E463245 T1 ATE463245 T1 AT E463245T1 AT 05796847 T AT05796847 T AT 05796847T AT 05796847 T AT05796847 T AT 05796847T AT E463245 T1 ATE463245 T1 AT E463245T1
Authority
AT
Austria
Prior art keywords
receptor antagonists
cgrp receptor
anilide
tricyclic
spirohydantoin
Prior art date
Application number
AT05796847T
Other languages
English (en)
Inventor
Ian Bell
Steven Gallicchio
Craig Stump
Cory Theberge
Joseph VACCA
Blair C Zartman
Xufang Zhang
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of ATE463245T1 publication Critical patent/ATE463245T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT05796847T 2004-09-09 2005-09-06 Tricyclische anilid-spirohydantoin-cgrp- rezeptorantagonisten ATE463245T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60829404P 2004-09-09 2004-09-09
PCT/US2005/031617 WO2006031491A2 (en) 2004-09-09 2005-09-06 Tricyclic anilide spirolactam cgrp receptor antagonists

Publications (1)

Publication Number Publication Date
ATE463245T1 true ATE463245T1 (de) 2010-04-15

Family

ID=36060520

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05796847T ATE463245T1 (de) 2004-09-09 2005-09-06 Tricyclische anilid-spirohydantoin-cgrp- rezeptorantagonisten

Country Status (9)

Country Link
US (2) US7696192B2 (de)
EP (1) EP1793827B1 (de)
JP (1) JP2008512456A (de)
CN (1) CN101014345A (de)
AT (1) ATE463245T1 (de)
AU (1) AU2005285270B2 (de)
CA (1) CA2579717A1 (de)
DE (1) DE602005020472D1 (de)
WO (1) WO2006031491A2 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006031491A2 (en) * 2004-09-09 2006-03-23 Merck & Co., Inc. Tricyclic anilide spirolactam cgrp receptor antagonists
WO2006031513A2 (en) * 2004-09-09 2006-03-23 Merck & Co., Inc. Aryl spirolactam cgrp receptor antagonists
ATE464305T1 (de) * 2004-09-13 2010-04-15 Merck Sharp & Dohme Bicyclische anilidspirolactame als antagonisten des cgrp-rezeptors
CA2579850A1 (en) 2004-09-13 2006-03-23 Merck & Co., Inc. Tricyclic anilide spirohydantoin cgrp receptor antagonists
DE602006019304D1 (de) 2005-11-18 2011-02-10 Merck Sharp & Dohme Spirohydantoin-aryl-cgrp-rezeptorantagonisten
EP1951042B1 (de) * 2005-11-18 2012-10-10 Merck Sharp & Dohme Corp. Spirolactam tricyclische cgrp-rezeptor-antagonisten
AU2006316627A1 (en) 2005-11-18 2007-05-31 Merck Sharp & Dohme Corp. Spirolactam aryl CGRP receptor antagonists
WO2007061694A2 (en) * 2005-11-18 2007-05-31 Merck & Co., Inc. Spirohydantoin tricyclic cgrp receptor antagonists
TW200732302A (en) * 2005-12-13 2007-09-01 Daicel Chem Indoline derivative
WO2007133491A1 (en) * 2006-05-09 2007-11-22 Merck & Co., Inc. Substituted spirocyclic cgrp receptor antagonists
US7951795B2 (en) * 2006-12-08 2011-05-31 Merck Sharp & Dohme Corp. Constrained spirocyclic compounds as CGRP receptor antagonists
JP2010523663A (ja) * 2007-04-11 2010-07-15 メルク・シャープ・エンド・ドーム・コーポレイション 第３級アミド、スルホンアミド、カルバミン酸及び尿素末端基をもつｃｇｒｐ受容体アンタゴニスト
US8143266B2 (en) * 2007-04-16 2012-03-27 Merck, Sharp & Dohme Corp Aryl heterocyclic CGRP receptor antagonists
CA2683745A1 (en) * 2007-04-16 2008-10-30 Merck & Co., Inc. Bicyclic anilide heterocyclic cgrp receptor antagonists
WO2008153849A1 (en) * 2007-06-05 2008-12-18 Merck & Co., Inc. Carboxamide heterocyclic cgrp receptor antagonists
EP2166842A4 (de) * 2007-06-07 2012-01-25 Merck Sharp & Dohme Tricyclische anilidheterocyclen als cgrp-rezeptor-antagonisten
WO2009152010A1 (en) * 2008-06-12 2009-12-17 Merck & Co., Inc. Branched 3- and 6-substituted quinolines as cgrp receptor antagonists
CA2735821A1 (en) * 2008-09-08 2010-03-11 Merck Sharp & Dohme Corp. Monocyclic amide cgrp receptor antagonists
JP2012512248A (ja) * 2008-12-17 2012-05-31 メルク・シャープ・エンド・ドーム・コーポレイション Ｃｇｒｐ受容体アンタゴニストとしてのイミダゾリノン誘導体
EP2471776A1 (de) 2010-12-28 2012-07-04 Bayer CropScience AG Pyridin-2-ylpropandinitrile und deren Verwendung als Herbizide
US9174989B2 (en) * 2012-05-09 2015-11-03 Merck Sharp & Dohme Corp. Process for making CGRP receptor antagonists
US8652527B1 (en) 2013-03-13 2014-02-18 Upsher-Smith Laboratories, Inc Extended-release topiramate capsules
US9101545B2 (en) 2013-03-15 2015-08-11 Upsher-Smith Laboratories, Inc. Extended-release topiramate capsules
CN109789142B (zh) 2016-07-01 2022-08-23 G1治疗公司 N-(杂芳基)-吡咯并[3,2-d]嘧啶-2-胺的合成
CN106008528A (zh) * 2016-07-28 2016-10-12 安徽赛迪生物科技有限公司 一种合成4-氯-5,7-二氢-6h-吡咯并[2,3-d]嘧啶-6-酮的方法
EP4455146A3 (de) 2017-06-29 2025-01-01 G1 Therapeutics, Inc. Morphische formen von git38 und verfahren zur herstellung davon
WO2021005494A1 (en) * 2019-07-05 2021-01-14 Allergan Pharmaceuticals International Limited Cgrp antagonists and clostridial derivatives for the treatment of neuropsychiatric and neurological disorders
US20210130445A1 (en) * 2019-07-05 2021-05-06 Allergan Pharmaceuticals International Limited CGRP Antagonists and Botulinum Toxins for the Treatment of Inflammatory and Neurologic Disorders

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MC1999A1 (fr) * 1987-12-18 1990-01-26 Hoffmann La Roche Composes tricycliques
WO1989008654A1 (en) * 1988-03-11 1989-09-21 Pfizer Inc. Pyrroloquinoline and pyrrolophenothiazine carboxamides and related compounds
US4906655A (en) * 1989-01-24 1990-03-06 Warner-Lambert Company Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents
AUPN449295A0 (en) * 1995-07-28 1995-08-24 Inner And Eastern Health Care Network, The Radioprotectors
WO1997009046A1 (en) * 1995-09-05 1997-03-13 Smithkline Beecham Corporation Compounds and methods
DE19963868A1 (de) * 1999-12-30 2001-07-12 Boehringer Ingelheim Pharma Neue substituierte Piperidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
CN1209361C (zh) * 2000-05-03 2005-07-06 霍夫曼-拉罗奇有限公司 含乙内酰脲的葡糖激酶激活剂
JP2004537526A (ja) * 2001-06-12 2004-12-16 メルク　エンド　カムパニー　インコーポレーテッド 片頭痛の治療又は予防用ｎｒ２ｂ受容体拮抗薬
MXPA04011960A (es) * 2002-06-05 2005-03-31 Squibb Bristol Myers Co Antagonistas de receptores de peptidos relacionados con el gen de calcitonina.
CA2518852A1 (en) 2003-03-14 2004-09-30 Merck & Co., Inc. Monocyclic anilide spirohydantoin cgrp receptor antagonists
CN101014602B (zh) 2004-09-08 2011-08-10 默沙东公司 单环酰苯胺螺环内酰胺cgrp受体拮抗剂
WO2006031491A2 (en) * 2004-09-09 2006-03-23 Merck & Co., Inc. Tricyclic anilide spirolactam cgrp receptor antagonists

Also Published As

Publication number Publication date
US20080214511A1 (en) 2008-09-04
EP1793827A4 (de) 2009-07-29
AU2005285270A1 (en) 2006-03-23
US20100160334A1 (en) 2010-06-24
CA2579717A1 (en) 2006-03-23
WO2006031491A2 (en) 2006-03-23
AU2005285270B2 (en) 2011-04-21
EP1793827B1 (de) 2010-04-07
EP1793827A2 (de) 2007-06-13
CN101014345A (zh) 2007-08-08
WO2006031491A3 (en) 2006-11-09
DE602005020472D1 (de) 2010-05-20
US7696192B2 (en) 2010-04-13
JP2008512456A (ja) 2008-04-24
US8133891B2 (en) 2012-03-13

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