ATE466853T1 - Cgrp-rezeptorantagonisten - Google Patents

Cgrp-rezeptorantagonisten

Info

Publication number
ATE466853T1
ATE466853T1 AT06718339T AT06718339T ATE466853T1 AT E466853 T1 ATE466853 T1 AT E466853T1 AT 06718339 T AT06718339 T AT 06718339T AT 06718339 T AT06718339 T AT 06718339T AT E466853 T1 ATE466853 T1 AT E466853T1
Authority
AT
Austria
Prior art keywords
receptor antagonists
cgrp receptor
cgrp
compounds
diseases
Prior art date
Application number
AT06718339T
Other languages
English (en)
Inventor
Christopher Burgey
Theresa WILLIAMS
Zhengwu Deng
Craig Stump
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of ATE466853T1 publication Critical patent/ATE466853T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT06718339T 2005-01-18 2006-01-13 Cgrp-rezeptorantagonisten ATE466853T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64465005P 2005-01-18 2005-01-18
PCT/US2006/001252 WO2006078554A2 (en) 2005-01-18 2006-01-13 Cgrp receptor antagonists

Publications (1)

Publication Number Publication Date
ATE466853T1 true ATE466853T1 (de) 2010-05-15

Family

ID=36692743

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06718339T ATE466853T1 (de) 2005-01-18 2006-01-13 Cgrp-rezeptorantagonisten

Country Status (9)

Country Link
US (1) US7632832B2 (de)
EP (1) EP1856100B1 (de)
JP (1) JP2008526984A (de)
CN (1) CN101103020B (de)
AT (1) ATE466853T1 (de)
AU (1) AU2006206718B2 (de)
CA (1) CA2594940A1 (de)
DE (1) DE602006014097D1 (de)
WO (1) WO2006078554A2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008515895A (ja) * 2004-10-07 2008-05-15 メルク エンド カムパニー インコーポレーテッド Cgrp受容体拮抗薬
ES2368456T3 (es) 2006-05-02 2011-11-17 Bristol-Myers Squibb Company Compuestos restringidos como antagonistas del receptor de cgrp.
US7470680B2 (en) 2006-05-03 2008-12-30 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
CN101443323A (zh) * 2006-05-09 2009-05-27 默克公司 取代的螺环cgrp受体拮抗剂
SI2081921T1 (sl) 2006-07-10 2011-01-31 Paion Uk Ltd Soli benzodiazepina s kratkotrajnim učinkom ter njihove polimorfne oblike
EP2305647A1 (de) 2009-09-18 2011-04-06 PAION UK Limited Verfahren zur Herstellung von 3-[(4S)-8-brom-1-methyl-6-(2-pyridinyl)-4 H-imidazo[1,2-a][1,4]benzodiazepin-4-yl]propionsäuremethylester oder das Benzensulfonatsalz davon und in diesem Prozess nützliche Verbindungen
EP2450039A1 (de) 2010-11-08 2012-05-09 PAION UK Ltd. Dosierschema zur Sedierung mit CNS 7056 (Remimazolam)
ES2654787T3 (es) * 2012-04-18 2018-02-15 Contera Pharma Aps Formulación farmacéutica disponible por vía oral adecuada para la gestión mejorada de trastornos del movimiento
AR094963A1 (es) 2013-03-04 2015-09-09 Ono Pharmaceutical Co Reacción de oxidación excelente en el índice de conversión
JP7227896B2 (ja) 2016-07-11 2023-02-22 コンテラ ファーマ エー/エス 朝の無動状態を治療するための拍動性薬物送達系
EP3366286A1 (de) 2017-02-22 2018-08-29 Johannes Keller Verbindungen zur behandlung von sepsis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002525371A (ja) 1998-09-30 2002-08-13 メルク シャープ エンド ドーム リミテッド Cgrpリガンドとしてのベンゾイミダゾリニルピペリジン
ATE466860T1 (de) 2003-04-15 2010-05-15 Merck Sharp & Dohme Cgrp-rezeptorantagonisten
JP4705911B2 (ja) * 2003-06-26 2011-06-22 メルク・シャープ・エンド・ドーム・コーポレイション ベンゾジアゼピンcgrp受容体拮抗物質

Also Published As

Publication number Publication date
EP1856100A4 (de) 2009-04-15
JP2008526984A (ja) 2008-07-24
AU2006206718A1 (en) 2006-07-27
CN101103020A (zh) 2008-01-09
EP1856100A2 (de) 2007-11-21
US7632832B2 (en) 2009-12-15
CN101103020B (zh) 2011-04-27
WO2006078554A2 (en) 2006-07-27
DE602006014097D1 (de) 2010-06-17
US20080125413A1 (en) 2008-05-29
AU2006206718B2 (en) 2011-06-02
WO2006078554A3 (en) 2007-04-05
CA2594940A1 (en) 2006-07-27
EP1856100B1 (de) 2010-05-05

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties