DK0708768T3 - Trisubstituerede imidazoler, der har multiple terapeutiske egenskaber - Google Patents

Trisubstituerede imidazoler, der har multiple terapeutiske egenskaber

Info

Publication number
DK0708768T3
DK0708768T3 DK94923503T DK94923503T DK0708768T3 DK 0708768 T3 DK0708768 T3 DK 0708768T3 DK 94923503 T DK94923503 T DK 94923503T DK 94923503 T DK94923503 T DK 94923503T DK 0708768 T3 DK0708768 T3 DK 0708768T3
Authority
DK
Denmark
Prior art keywords
therapeutic properties
multiple therapeutic
trisubstituted imidazoles
trisubstituted
imidazoles
Prior art date
Application number
DK94923503T
Other languages
English (en)
Inventor
Jerry Leroy Adams
Peter William Sheldrake
Timothy Francis Gallagher
Ravi Shanker Garigipati
Paul Elliot Bender
Jeffrey Charles Boehm
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Application granted granted Critical
Publication of DK0708768T3 publication Critical patent/DK0708768T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
DK94923503T 1993-07-16 1994-07-15 Trisubstituerede imidazoler, der har multiple terapeutiske egenskaber DK0708768T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9273393A 1993-07-16 1993-07-16
PCT/US1994/007969 WO1995002591A1 (en) 1993-07-16 1994-07-15 Tri-substituted imidazoles having multiple therapeutic properties

Publications (1)

Publication Number Publication Date
DK0708768T3 true DK0708768T3 (da) 2003-08-04

Family

ID=22234840

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94923503T DK0708768T3 (da) 1993-07-16 1994-07-15 Trisubstituerede imidazoler, der har multiple terapeutiske egenskaber

Country Status (31)

Country Link
EP (5) EP0708768B1 (da)
JP (4) JPH09500137A (da)
CN (2) CN1050126C (da)
AP (1) AP484A (da)
AT (2) ATE236896T1 (da)
AU (1) AU694130C (da)
BR (2) BR9407079A (da)
CA (1) CA2167311A1 (da)
CZ (1) CZ11996A3 (da)
DE (2) DE69434316T2 (da)
DK (1) DK0708768T3 (da)
DZ (1) DZ1798A1 (da)
ES (2) ES2197167T3 (da)
FI (1) FI960177A0 (da)
HK (4) HK1049657A1 (da)
HU (1) HUT75313A (da)
IL (2) IL110296A (da)
MA (1) MA23270A1 (da)
MY (1) MY116478A (da)
NO (4) NO316881B1 (da)
NZ (2) NZ329994A (da)
PL (4) PL181705B1 (da)
PT (1) PT708768E (da)
RU (1) RU2140918C1 (da)
SG (1) SG52368A1 (da)
SI (1) SI0708768T1 (da)
SK (1) SK282342B6 (da)
TW (1) TW330934B (da)
UA (1) UA63875C2 (da)
WO (1) WO1995002591A1 (da)
ZA (1) ZA945193B (da)

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NO20010839D0 (no) 2001-02-19
PT708768E (pt) 2003-08-29
EP0708768A1 (en) 1996-05-01
TW330934B (en) 1998-05-01
ZA945193B (en) 1995-04-20
PL181721B1 (en) 2001-09-28
NO10838A (no) 1996-01-15
MA23270A1 (fr) 1995-04-01
HK1049658A1 (zh) 2003-05-23
EP1227091A3 (en) 2002-08-07
HU9503855D0 (en) 1996-02-28
CN1050126C (zh) 2000-03-08
NZ329994A (en) 1999-07-29
EP1227091A2 (en) 2002-07-31
RU2140918C1 (ru) 1999-11-10
PL181723B1 (pl) 2001-09-28
JPH09500137A (ja) 1997-01-07
ATE236896T1 (de) 2003-04-15
IL124318A0 (en) 1998-12-06
JP2004149541A (ja) 2004-05-27
SK4796A3 (en) 1997-01-08
CA2167311A1 (en) 1995-01-26
NO20010837D0 (no) 2001-02-19
SK282342B6 (sk) 2002-01-07
EP0708768A4 (en) 1996-08-21
WO1995002591A1 (en) 1995-01-26
HK1049659A1 (zh) 2003-05-23
NO960173D0 (no) 1996-01-15
EP1291346A1 (en) 2003-03-12
EP0708768B1 (en) 2003-04-09
EP1227092A2 (en) 2002-07-31
MY116478A (en) 2004-02-28
DE69434316T2 (de) 2006-03-09
UA63875C2 (en) 2004-02-16
HUT75313A (en) 1997-05-28
CN1218801A (zh) 1999-06-09
HK1049657A1 (zh) 2003-05-23
CZ11996A3 (en) 1996-10-16
ES2237650T3 (es) 2005-08-01
DE69434316D1 (de) 2005-04-28
AU694130C (en) 2002-12-05
CN1129447A (zh) 1996-08-21
SG52368A1 (en) 1998-09-28
NO960173L (no) 1996-01-15
NZ269457A (en) 1998-08-26
AU694130B2 (en) 1998-07-16
NO20010838D0 (no) 2001-02-19
SI0708768T1 (en) 2003-10-31
FI960177A (fi) 1996-01-15
IL110296A (en) 1999-12-31
BR1100546A (pt) 2004-08-31
AU7335494A (en) 1995-02-13
EP1291346B1 (en) 2005-03-23
AP484A (en) 1996-04-23
NO316881B1 (no) 2004-06-14
IL110296A0 (en) 1994-10-21
EP1227092A3 (en) 2002-08-07
NO10837A (no) 1996-01-15
JP2004099622A (ja) 2004-04-02
DZ1798A1 (fr) 2002-02-17
EP1229035A1 (en) 2002-08-07
DE69432463T2 (de) 2004-02-12
ATE291576T1 (de) 2005-04-15
AP9400654A0 (en) 1994-07-31
DE69432463D1 (de) 2003-05-15
BR9407079A (pt) 1996-08-27
AU705568B2 (en) 1999-05-27
PL181705B1 (pl) 2001-09-28
JP2004083600A (ja) 2004-03-18
PL181694B1 (pl) 2001-09-28
AU7185098A (en) 1998-08-27
HK1012392A1 (en) 1999-07-30
PL312614A1 (en) 1996-04-29
FI960177A0 (fi) 1996-01-15
NO10839A (no) 1996-01-15
ES2197167T3 (es) 2004-01-01

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