BR1100546A - Compostos e composições de piridil imidazol. - Google Patents

Compostos e composições de piridil imidazol.

Info

Publication number
BR1100546A
BR1100546A BR1100546-7A BR1100546A BR1100546A BR 1100546 A BR1100546 A BR 1100546A BR 1100546 A BR1100546 A BR 1100546A BR 1100546 A BR1100546 A BR 1100546A
Authority
BR
Brazil
Prior art keywords
compositions
imidazole compounds
pyridyl imidazole
pyridyl
compounds
Prior art date
Application number
BR1100546-7A
Other languages
English (en)
Inventor
Jerry Leroy Adams
Peter William Sheldrake
Timothy F Gallagher
Ravi Shanker Garigipati
Paul Elliot Bender
Jeffrey Charles Boehm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to BR1100546-7A priority Critical patent/BR1100546A/pt
Publication of BR1100546A publication Critical patent/BR1100546A/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • AIDS & HIV (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
BR1100546-7A 1993-07-16 1997-05-13 Compostos e composições de piridil imidazol. BR1100546A (pt)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR1100546-7A BR1100546A (pt) 1993-07-16 1997-05-13 Compostos e composições de piridil imidazol.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9273393A 1993-07-16 1993-07-16
BR1100546-7A BR1100546A (pt) 1993-07-16 1997-05-13 Compostos e composições de piridil imidazol.

Publications (1)

Publication Number Publication Date
BR1100546A true BR1100546A (pt) 2004-08-31

Family

ID=22234840

Family Applications (2)

Application Number Title Priority Date Filing Date
BR9407079A BR9407079A (pt) 1993-07-16 1994-07-15 Imidazois tri-substituídos possuindo múltiplas propriedades terapêuticas
BR1100546-7A BR1100546A (pt) 1993-07-16 1997-05-13 Compostos e composições de piridil imidazol.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR9407079A BR9407079A (pt) 1993-07-16 1994-07-15 Imidazois tri-substituídos possuindo múltiplas propriedades terapêuticas

Country Status (31)

Country Link
EP (5) EP1227091A3 (pt)
JP (4) JPH09500137A (pt)
CN (2) CN1050126C (pt)
AP (1) AP484A (pt)
AT (2) ATE236896T1 (pt)
AU (1) AU694130C (pt)
BR (2) BR9407079A (pt)
CA (1) CA2167311A1 (pt)
CZ (1) CZ11996A3 (pt)
DE (2) DE69434316T2 (pt)
DK (1) DK0708768T3 (pt)
DZ (1) DZ1798A1 (pt)
ES (2) ES2197167T3 (pt)
FI (1) FI960177A0 (pt)
HK (4) HK1049657A1 (pt)
HU (1) HUT75313A (pt)
IL (2) IL110296A (pt)
MA (1) MA23270A1 (pt)
MY (1) MY116478A (pt)
NO (4) NO316881B1 (pt)
NZ (2) NZ269457A (pt)
PL (4) PL181721B1 (pt)
PT (1) PT708768E (pt)
RU (1) RU2140918C1 (pt)
SG (1) SG52368A1 (pt)
SI (1) SI0708768T1 (pt)
SK (1) SK282342B6 (pt)
TW (1) TW330934B (pt)
UA (1) UA63875C2 (pt)
WO (1) WO1995002591A1 (pt)
ZA (1) ZA945193B (pt)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3857751A (en) * 1971-11-15 1974-12-31 Tufdura Ltd Composite sheet capable of withstanding impingement by particulate materials
US5916891A (en) 1992-01-13 1999-06-29 Smithkline Beecham Corporation Pyrimidinyl imidazoles
US5840746A (en) * 1993-06-24 1998-11-24 Merck Frosst Canada, Inc. Use of inhibitors of cyclooxygenase in the treatment of neurodegenerative diseases
US5593992A (en) * 1993-07-16 1997-01-14 Smithkline Beecham Corporation Compounds
US5670527A (en) * 1993-07-16 1997-09-23 Smithkline Beecham Corporation Pyridyl imidazole compounds and compositions
US5616601A (en) * 1994-07-28 1997-04-01 Gd Searle & Co 1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation
US6613789B2 (en) 1994-07-28 2003-09-02 G. D. Searle & Co. Heterocyclo-substituted imidazoles for the treatment of inflammation
KR19980701374A (ko) * 1995-01-12 1998-05-15 스티븐 베네티아너 신규 화합물(Novel Compounds)
GB9500580D0 (en) * 1995-01-12 1995-03-01 Merck Sharp & Dohme Therapeutic agents
JPH11503110A (ja) * 1995-02-17 1999-03-23 スミスクライン・ビーチャム・コーポレイション Il−8受容体拮抗剤
US5739143A (en) * 1995-06-07 1998-04-14 Smithkline Beecham Corporation Imidazole compounds and compositions
US5658903A (en) 1995-06-07 1997-08-19 Smithkline Beecham Corporation Imidazole compounds, compositions and use
US6369068B1 (en) 1995-06-07 2002-04-09 Smithkline Beecham Corporation Amino substituted pyrimidine containing compounds
US6083949A (en) * 1995-10-06 2000-07-04 Merck & Co., Inc. Substituted imidazoles having anti-cancer and cytokine inhibitory activity
US5717100A (en) * 1995-10-06 1998-02-10 Merck & Co., Inc. Substituted imidazoles having anti-cancer and cytokine inhibitory activity
DE19540027A1 (de) * 1995-10-27 1997-04-30 Gruenenthal Gmbh Substituierte Imidazolidin-2,4-dion-Verbindungen als pharmazeutische Wirkstoffe
ZA9610687B (en) * 1995-12-22 1997-09-29 Smithkline Beecham Corp Novel synthesis.
EP0883402A4 (en) * 1996-01-11 1999-08-11 Smithkline Beecham Corp NEW CYCLOALKYL-SUBSTITUTED IMIDAZOLES
US6046208A (en) * 1996-01-11 2000-04-04 Smithkline Beecham Corporation Substituted imidazole compounds
AP9700912A0 (en) 1996-01-11 1997-01-31 Smithkline Beecham Corp Novel cycloalkyl substituted imidazoles
ZA97175B (en) * 1996-01-11 1997-11-04 Smithkline Beecham Corp Novel substituted imidazole compounds.
PL187516B1 (pl) * 1996-01-11 2004-07-30 Smithkline Beecham Corp Nowe podstawione pochodne imidazolu, sposób ich wytwarzania oraz kompozycja farmaceutyczna zawierająca te związki
JP2000507224A (ja) * 1996-03-08 2000-06-13 スミスクライン・ビーチャム・コーポレイション Csaid化合物の血管形成の抑制物質としての使用
US6096739A (en) * 1996-03-25 2000-08-01 Smithkline Beecham Corporation Treatment for CNS injuries
JP3418624B2 (ja) * 1996-06-10 2003-06-23 メルク エンド カンパニー インコーポレーテッド サイトカイン阻害活性を有する置換イミダゾール類
EP0956018A4 (en) 1996-08-21 2000-01-12 Smithkline Beecham Corp IMIDAZOLE COMPOUNDS, COMPOSITIONS CONTAINING THEM AND THEIR USE
US5945418A (en) * 1996-12-18 1999-08-31 Vertex Pharmaceuticals Incorporated Inhibitors of p38
US6608060B1 (en) 1996-12-18 2003-08-19 Vertex Pharmaceuticals Incorporated Inhibitors of p38
US6147080A (en) * 1996-12-18 2000-11-14 Vertex Pharmaceuticals Incorporated Inhibitors of p38
US5929076A (en) * 1997-01-10 1999-07-27 Smithkline Beecham Corporation Cycloalkyl substituted imidazoles
US6187799B1 (en) 1997-05-23 2001-02-13 Onyx Pharmaceuticals Inhibition of raf kinase activity using aryl ureas
WO1998056377A1 (en) 1997-06-13 1998-12-17 Smithkline Beecham Corporation Novel pyrazole and pyrazoline substituted compounds
EP0994870A4 (en) 1997-06-19 2002-10-23 Smithkline Beecham NEW IMIDAZOLE COMPOUNDS SUBSTITUTED BY AN ARYLOXYREST
US6489325B1 (en) 1998-07-01 2002-12-03 Smithkline Beecham Corporation Substituted imidazole compounds
US6562832B1 (en) 1997-07-02 2003-05-13 Smithkline Beecham Corporation Substituted imidazole compounds
WO1999001452A1 (en) 1997-07-02 1999-01-14 Smithkline Beecham Corporation Novel cycloalkyl substituted imidazoles
TW517055B (en) * 1997-07-02 2003-01-11 Smithkline Beecham Corp Novel substituted imidazole compounds
US7301021B2 (en) 1997-07-02 2007-11-27 Smithkline Beecham Corporation Substituted imidazole compounds
US6362193B1 (en) 1997-10-08 2002-03-26 Smithkline Beecham Corporation Cycloalkenyl substituted compounds
CA2316296A1 (en) * 1997-10-10 1999-04-22 Imperial College Of Science, Technology And Medicine Use of csaidtm compounds for the management of uterine contractions
JP3337992B2 (ja) * 1997-11-04 2002-10-28 ファイザー製薬株式会社 5−置換ピコリン酸化合物及びその製造方法
AR017219A1 (es) 1997-12-19 2001-08-22 Smithkline Beecham Corp Derivados de imidazol 1,4,5 sustituidos, composiciones que los comprenden, procedimiento para la preparacion de dichos derivados, uso de los derivados parala manufactura de un medicamento
GB9809869D0 (en) * 1998-05-09 1998-07-08 Medical Res Council Inhibition of protein kinases
EP1080087A4 (en) 1998-05-22 2001-11-21 Smithkline Beecham Corp NEW 2-ALKYL-SUBSTITUTED IMIDAZOLES
US6858617B2 (en) 1998-05-26 2005-02-22 Smithkline Beecham Corporation Substituted imidazole compounds
WO1999067283A2 (en) 1998-06-24 1999-12-29 University Of Dundee Two-kinase domain mitogen- and stress-activated protein kinases and uses thereof
AU4395399A (en) * 1998-07-02 2000-01-24 Sankyo Company Limited Five-membered heteroaryl compounds
US6207687B1 (en) * 1998-07-31 2001-03-27 Merck & Co., Inc. Substituted imidazoles having cytokine inhibitory activity
ES2221426T3 (es) * 1998-08-20 2004-12-16 Smithkline Beecham Corporation Nuevos compuestos de triazol sustituidos.
ATE258055T1 (de) 1998-11-04 2004-02-15 Smithkline Beecham Corp Pyridin-4-yl oder pyrimidin-4-yl substituierte pyrazine
US6239279B1 (en) 1998-12-16 2001-05-29 Smithkline Beecham Corporation Synthesis for 4-aryl-5-pyrimidine imidazole substituted derivatives
US20020065296A1 (en) 1999-01-13 2002-05-30 Bayer Corporation Heteroaryl ureas containing nitrogen hetero-atoms as p38 kinase inhibitors
ATE556713T1 (de) 1999-01-13 2012-05-15 Bayer Healthcare Llc Omega-carboxyarylsubstituierte-diphenyl- harnstoffe als p38-kinasehemmer
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US7122666B2 (en) 1999-07-21 2006-10-17 Sankyo Company, Limited Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses
AU1783201A (en) 1999-11-23 2001-06-04 Smithkline Beecham Corporation 3,4-dihydro-(1h)quinazolin-2-one compounds as csbp/p38 kinase inhibitors
US6759410B1 (en) 1999-11-23 2004-07-06 Smithline Beecham Corporation 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors
JP2003528043A (ja) 1999-11-23 2003-09-24 スミスクライン・ビーチャム・コーポレイション CSBP/p38キナーゼ阻害剤としての3,4‐ジヒドロ−(1H)キナゾリン−2−オン化合物
JP2003514899A (ja) 1999-11-23 2003-04-22 スミスクライン・ビーチャム・コーポレイション CSBP/p38キナーゼ阻害剤としての3,4‐ジヒドロ−(1H)−キナゾリン−2−オン化合物
US7235551B2 (en) 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
US6627647B1 (en) 2000-03-23 2003-09-30 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted 1-(4-aminophenyl)imidazoles and their use as anti-inflammatory agents
FR2823747B1 (fr) * 2001-04-24 2003-05-23 Oreal Nouveaux composes de la famille des 3-alkyl-(4,5 diphenyl- imidazol-1-yl) et leur utilisation comme anti-inflammatoires
FR2823751B1 (fr) * 2001-04-24 2003-05-23 Oreal Nouveaux composes de la famille des 3-alkyl-(4,5 diphenyl- imidazol-1-yl) et leur utilisation comme anti-inflammatoires
WO2002094267A1 (fr) * 2001-05-24 2002-11-28 Sankyo Company, Limited Preparation pharmaceutique pour prevenir ou traiter l'arthrite
US7838541B2 (en) 2002-02-11 2010-11-23 Bayer Healthcare, Llc Aryl ureas with angiogenesis inhibiting activity
CN1318404C (zh) 2002-02-11 2007-05-30 拜耳制药公司 作为激酶抑制剂的芳基脲类化合物
RU2217196C2 (ru) * 2002-02-28 2003-11-27 Небольсин Владимир Евгеньевич Способ индукции дифференцировки клеток
CA2476594C (en) 2002-03-05 2012-10-09 Transtech Pharma, Inc. Mono-and bicyclic azole derivatives that inhibit the interaction of ligands with rage
DE60334016D1 (de) 2002-11-05 2010-10-14 Glaxo Group Ltd Antibakterielle mittel
PT1626714E (pt) 2003-05-20 2007-08-24 Bayer Pharmaceuticals Corp Diarilureias para doenças mediadas por pdgfr
BR122016015715B8 (pt) 2003-07-23 2021-05-25 Bayer Healthcare Llc composições farmacêuticas de metilamida de ácido 4[4-[3-(4-cloro-3-trifluorometilfenil)-ureido]-3-fluorofenóxi)-piridina-2-carboxílico
TWI381841B (zh) * 2005-03-11 2013-01-11 Zenyaku Kogyo Kk An immunosuppressive agent and an antitumor agent containing a heterocyclic compound as an active ingredient
US8580833B2 (en) 2009-09-30 2013-11-12 Transtech Pharma, Inc. Substituted imidazole derivatives and methods of use thereof
KR101421852B1 (ko) * 2009-10-28 2014-07-22 화이자 인코포레이티드 카세인 키나제 억제제로서의 이미다졸 유도체
CN104387301B (zh) * 2014-11-11 2016-05-04 常州大学 一种2-氟-4-甲基苯磺酰甲基异腈的合成方法
CN113350353A (zh) 2015-03-23 2021-09-07 墨尔本大学 呼吸性疾病的治疗
AU2018262108A1 (en) * 2017-05-03 2019-11-21 The University Of Melbourne Compounds for the treatment of respiratory diseases
CN110531023B (zh) * 2019-10-08 2024-06-14 安徽理工大学 一种薄层色谱分析仪
CN114112812B (zh) * 2021-10-29 2024-05-24 华北电力大学 相变颗粒测试装置、固-液相变机理可视化实验台及方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3707475A (en) * 1970-11-16 1972-12-26 Pfizer Antiinflammatory imidazoles
US3929807A (en) * 1971-05-10 1975-12-30 Ciba Geigy Corp 2-Substituted-4(5)-(aryl)-5(4)-(2,3 or -4-pyridyl)-imidazoles
EP0565582A4 (en) * 1990-12-13 1995-01-11 Smithkline Beecham Corp NOVEL CYTOKINE SUPPRESSIVE ANTI-INFLAMMATORY DRUGS.
EP0563286A4 (en) * 1990-12-13 1995-01-11 Smithkline Beecham Corp Novel csaids
IL104369A0 (en) * 1992-01-13 1993-05-13 Smithkline Beecham Corp Novel compounds and compositions

Also Published As

Publication number Publication date
CN1218801A (zh) 1999-06-09
DE69432463T2 (de) 2004-02-12
HK1049659A1 (zh) 2003-05-23
DE69432463D1 (de) 2003-05-15
NO960173L (no) 1996-01-15
SK4796A3 (en) 1997-01-08
AU7185098A (en) 1998-08-27
JP2004099622A (ja) 2004-04-02
PL181721B1 (en) 2001-09-28
JPH09500137A (ja) 1997-01-07
PL181723B1 (pl) 2001-09-28
CA2167311A1 (en) 1995-01-26
IL124318A0 (en) 1998-12-06
NO20010837D0 (no) 2001-02-19
BR9407079A (pt) 1996-08-27
HK1049657A1 (zh) 2003-05-23
AU694130B2 (en) 1998-07-16
SK282342B6 (sk) 2002-01-07
NZ329994A (en) 1999-07-29
EP1227091A3 (en) 2002-08-07
AU705568B2 (en) 1999-05-27
EP1291346B1 (en) 2005-03-23
AP484A (en) 1996-04-23
EP0708768B1 (en) 2003-04-09
EP0708768A1 (en) 1996-05-01
TW330934B (en) 1998-05-01
CN1129447A (zh) 1996-08-21
HK1049658A1 (zh) 2003-05-23
SG52368A1 (en) 1998-09-28
PL181705B1 (pl) 2001-09-28
NO20010838D0 (no) 2001-02-19
JP2004083600A (ja) 2004-03-18
AP9400654A0 (en) 1994-07-31
ES2197167T3 (es) 2004-01-01
NO10838A (no) 1996-01-15
NO960173D0 (no) 1996-01-15
NZ269457A (en) 1998-08-26
HU9503855D0 (en) 1996-02-28
ES2237650T3 (es) 2005-08-01
FI960177A (fi) 1996-01-15
AU7335494A (en) 1995-02-13
DE69434316D1 (de) 2005-04-28
EP1227091A2 (en) 2002-07-31
UA63875C2 (en) 2004-02-16
EP1227092A2 (en) 2002-07-31
PL181694B1 (pl) 2001-09-28
NO316881B1 (no) 2004-06-14
WO1995002591A1 (en) 1995-01-26
PT708768E (pt) 2003-08-29
EP1291346A1 (en) 2003-03-12
JP2004149541A (ja) 2004-05-27
IL110296A0 (en) 1994-10-21
EP1227092A3 (en) 2002-08-07
DZ1798A1 (fr) 2002-02-17
AU694130C (en) 2002-12-05
FI960177A0 (fi) 1996-01-15
SI0708768T1 (en) 2003-10-31
MY116478A (en) 2004-02-28
HUT75313A (en) 1997-05-28
EP0708768A4 (en) 1996-08-21
IL110296A (en) 1999-12-31
NO10839A (no) 1996-01-15
NO20010839D0 (no) 2001-02-19
ATE236896T1 (de) 2003-04-15
ATE291576T1 (de) 2005-04-15
PL312614A1 (en) 1996-04-29
NO10837A (no) 1996-01-15
HK1012392A1 (en) 1999-07-30
CZ11996A3 (en) 1996-10-16
EP1229035A1 (en) 2002-08-07
CN1050126C (zh) 2000-03-08
ZA945193B (en) 1995-04-20
RU2140918C1 (ru) 1999-11-10
MA23270A1 (fr) 1995-04-01
DE69434316T2 (de) 2006-03-09
DK0708768T3 (da) 2003-08-04

Similar Documents

Publication Publication Date Title
BR1100546A (pt) Compostos e composições de piridil imidazol.
DE69322254D1 (de) Pyridyl-substituierte imidazole
TR199501561A2 (tr) Imidazol türevleri.
BR9612465A (pt) Compostos heterocíclicos
DE69423670D1 (de) Siloxy-aluminoxan-Zusammensetzungen
BR1101108A (pt) Composto
DE69410628D1 (de) Wasserlösliche organosiloxanverbindungen
FR2690440B1 (fr) Arylpyrazoles fongicides.
DE59608612D1 (de) Mikrobizide benzotriazole
BR9507510A (pt) Heterociclos de n-cianoaril nitrogênio
NO933467D0 (no) Ioderte aroyloksykarboksamider
BR9607925A (pt) Composição fungicida
FI945204A0 (fi) Puolijohdekomponentti
ITMI920347A0 (it) Composizioni poliolefiniche termosaldabili
DE69206081D1 (de) Stabilisierte Polyolefinzusammensetzung.
FI920887A0 (fi) Säilöntäaineseokset
FR2677821B1 (fr) Composant de protection bidirectionnel.
GB9302107D0 (en) Benzimidazole compositions
IT1272208B (it) Composizioni pesticide.
FI944825A (fi) Fenyylibentsoamidipohjaiset fungsidiyhdisteet
DE59409946D1 (de) Antidröhnmassen.
DE59404774D1 (de) N-Cyanoaryl-Stickstoffheterocyclen
DE69418657D1 (de) Bauelement
FR2710245B3 (fr) Composition amaigrissante.
FI920129A0 (fi) Anordning foer syresaettning av brunnsvatten.

Legal Events

Date Code Title Description
B23I Processing applications acc. art. 230 and 231 (pipeline patent) patent issued