NO20091478L - Aminometyl-4-imidazoler - Google Patents
Aminometyl-4-imidazolerInfo
- Publication number
- NO20091478L NO20091478L NO20091478A NO20091478A NO20091478L NO 20091478 L NO20091478 L NO 20091478L NO 20091478 A NO20091478 A NO 20091478A NO 20091478 A NO20091478 A NO 20091478A NO 20091478 L NO20091478 L NO 20091478L
- Authority
- NO
- Norway
- Prior art keywords
- lower alkyl
- halogen
- aryl
- disorders
- optionally substituted
- Prior art date
Links
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Substances C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 16
- 229910052736 halogen Inorganic materials 0.000 abstract 11
- 150000002367 halogens Chemical group 0.000 abstract 11
- -1 2,2-dioxo-2,3-dihydro-1H-benzo [c] thiophenyl Chemical group 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 208000035475 disorder Diseases 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 208000019116 sleep disease Diseases 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 1
- 208000020925 Bipolar disease Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 208000002249 Diabetes Complications Diseases 0.000 abstract 1
- 206010012655 Diabetic complications Diseases 0.000 abstract 1
- 208000032928 Dyslipidaemia Diseases 0.000 abstract 1
- 208000030814 Eating disease Diseases 0.000 abstract 1
- 208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000017170 Lipid metabolism disease Diseases 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 230000006978 adaptation Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000036760 body temperature Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 235000014632 disordered eating Nutrition 0.000 abstract 1
- 238000005265 energy consumption Methods 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 208000022925 sleep disturbance Diseases 0.000 abstract 1
- 201000009032 substance abuse Diseases 0.000 abstract 1
- 231100000736 substance abuse Toxicity 0.000 abstract 1
- 208000011117 substance-related disease Diseases 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
Foreliggende oppfinnelse angår forbindelser med formel I I hvor R1 er hydrogen, lavere alkyl, -(CR2 )n-OH, -(CH2)n-aryl eller -(CH2)n-heteroaryl, som eventuelt er substituert med halogen, lavere alkoksy eller lavere alkyl substituert med halogen eller er -(CR2)n- cykloalkyl, eventuelt substituert med hydroksy, -(CH2)n-heterocyklyl, -(CH2)n-NH-S(O)2CH3 eller er -(CR2)nO-lavere alkyl eller lavere alkyl substituert med halogen; R er hydrogen eller lavere alkyl og når to R-grupper er til stede kan de være eller ikke være de samme; R2 er 2,2-diokso-2,3-dihydro-1H-benzo[c]tiofenyl, 6,7-dihydro-5H-cyklopentapyrimidin-2-yl, 2,2-difluor-benzo[1,3]dioksol-5-yl, 2,2,3,3-tetrafluor-2,3-dihydro-benzo[1,4]dioxin-6-yl eller er aryl eller heteroaryl, eventuelt substituert med én eller flere substituenter, valgt fra gruppen bestående av halogen, lavere alkyl, cykloalkyl, -(CH2)n-hydroksy, lavere alkyl substituert med halogen, lavere alkoksy substituert med halogen, -S(O)2-lavere alkyl, -(CH2)n-S(O)2-NH-lavere alkyl, -(CH2)n-O-lavere alkyl, nitro, amino, cyano, -NHC(O)-lavere alkyl, -C(O)NH-lavere alkyl eller O-tetrahydro-naftalenyl eller er substituert med -(CH2)n-aryl, eventuelt substituert med halogen eller med -CH=CH-aryl, eventuelt substituert med halogen eller med -(CH2)n-O-aryl, eventuelt substituert med halogen, lavere alkoksy eller lavere alkyl substituert med halogen eller med -O-(CH2)n-aryl, eventuelt substituert med halogen eller med -(CH2)n-heteroaryl eller med -(CH2)n-O-heteroaryl eller med -(CH2)n-heterocyklyl, eventuelt substituert med =O eller med -(CH2)n-O-heterocyklyl, eventuelt substituert med lavere alkyl eller med -S-aryl, -CH(OH)-aryl, -C(CH3)2-aryl, -NR-aryl eller med 2-okso-2H-pyridin-1-yl; R3 er hydrogen eller lavere alkyl; R4 er hydrogen eller lavere alkyl; n er 0, 1, 2, 3 eller 4 og deres farmasøytisk aktive salter for behandling av depresjon, angstlidelser, bipolar lidelse, oppmerksomhetssvikt hyperaktivitetslidelse (ADHD), stress-relaterte lidelser, psykotiske lidelser så som schizofreni, nevrologiske sykdommer så som Parkinsons sykdom, neurodegenerative lidelser så som Alzheimers sykdom, epilepsi, migrene, hypertensjon, stoffmisbruk og metabolske lidelser så som spiseforstyrrelser, diabetes, diabetiske komplikasjoner, fedme, dyslipidemi, lidelser knyttet til energikonsum og tilpasning, lidelser og svikt knyttet til kroppstemperatur homeostase, søvn- og døgnrytme forstyrrelser og kardiovaskulære lidelser.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06122586 | 2006-10-19 | ||
| PCT/EP2007/060666 WO2008046757A1 (en) | 2006-10-19 | 2007-10-09 | Aminomethyl-4-imidazoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20091478L true NO20091478L (no) | 2009-05-05 |
Family
ID=38876376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20091478A NO20091478L (no) | 2006-10-19 | 2009-04-17 | Aminometyl-4-imidazoler |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8586617B2 (no) |
| EP (1) | EP2076497B1 (no) |
| JP (2) | JP5335681B2 (no) |
| KR (1) | KR101176699B1 (no) |
| CN (1) | CN101528710B (no) |
| AR (1) | AR063327A1 (no) |
| AT (1) | ATE546437T1 (no) |
| AU (1) | AU2007312390B2 (no) |
| BR (1) | BRPI0717939A2 (no) |
| CA (1) | CA2666762C (no) |
| CL (1) | CL2007002971A1 (no) |
| ES (1) | ES2381589T3 (no) |
| IL (1) | IL197877A (no) |
| MX (1) | MX2009003801A (no) |
| NO (1) | NO20091478L (no) |
| PE (1) | PE20080889A1 (no) |
| RU (1) | RU2009112496A (no) |
| TW (1) | TW200833685A (no) |
| WO (1) | WO2008046757A1 (no) |
| ZA (1) | ZA200902278B (no) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007312390B2 (en) | 2006-10-19 | 2013-03-28 | F. Hoffmann-La Roche Ag | Aminomethyl-4-imidazoles |
| CA2666489C (en) * | 2006-10-19 | 2012-10-02 | F. Hoffmann-La Roche Ag | Imidazolone and imidazolidinone derivatives as 11b-hsd1 inhibitors for diabetes |
| PL2562162T3 (pl) | 2008-01-22 | 2016-01-29 | Dow Agrosciences Llc | Pochodne N-cyjano-4-amino-5-fluoropirymidyny jako fungicydy |
| US8242153B2 (en) * | 2008-07-24 | 2012-08-14 | Hoffmann-La Roche Inc. | 4,5-dihydro-oxazol-2YL derivatives |
| CN104521977A (zh) * | 2008-08-01 | 2015-04-22 | 陶氏益农公司 | 5-氟胞嘧啶作为杀真菌剂的用途 |
| US8933227B2 (en) | 2009-08-14 | 2015-01-13 | Boehringer Ingelheim International Gmbh | Selective synthesis of functionalized pyrimidines |
| WO2011018517A1 (en) | 2009-08-14 | 2011-02-17 | Boehringer Ingelheim International Gmbh | Regioselective preparation of 2-amino-5-trifluoromethylpyrimidine derivatives |
| US8354441B2 (en) * | 2009-11-11 | 2013-01-15 | Hoffmann-La Roche Inc. | Oxazoline derivatives |
| US9452980B2 (en) | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
| CN103038229B (zh) * | 2010-05-26 | 2016-05-11 | 桑诺维恩药品公司 | 杂芳基化合物及其使用方法 |
| KR101651208B1 (ko) | 2014-02-19 | 2016-08-26 | 충북대학교 산학협력단 | 클로로겐산 유도체 화합물 및 이를 유효성분으로 포함하는 항염증 및 피부미백용 조성물 |
| EP3317241A4 (en) * | 2015-07-01 | 2019-01-23 | Lifesci Pharmaceuticals, Inc. | THERAPEUTIC INHIBITOR COMPOUNDS |
| WO2017132912A1 (zh) * | 2016-02-03 | 2017-08-10 | 华东理工大学 | 苯并脂肪环取代烷基胺类化合物及其用途 |
| PE20181446A1 (es) | 2016-03-17 | 2018-09-12 | Hoffmann La Roche | Derivados de 5-etil-4-metil-pirazol-3-carboxamida con actividad como de taar |
| US10981899B2 (en) | 2016-04-28 | 2021-04-20 | Cornell University | Inhibitors of soluble adenylyl cyclase |
| US20190201410A1 (en) * | 2016-06-02 | 2019-07-04 | Purdue Pharma L.P. | Trace amine associated receptor 1 agonists and partial agonists for pain treatment |
| WO2023033681A1 (en) | 2021-09-01 | 2023-03-09 | Limited Liability Company «Excellena Research And Development» (Llc «Excellena») | Substituted 2-(5-aryl-4 h-1,2,4-triazol-3-yl)ethanamines as modulators of trace amine-associated receptor 1 (taar1) |
| WO2023033680A1 (en) | 2021-09-01 | 2023-03-09 | Limited Liability Company «Excellena Research And Development» (Llc «Excellena») | Substituted 2,3,4,5-tetrahydrobenzo[ f][1,4]oxazepines as modulators of trace amine-associated receptor 1 (taar1) |
| WO2023033679A1 (en) | 2021-09-01 | 2023-03-09 | Limited Liability Company «Excellena Research And Development» (Llc «Excellena») | (azacycloalkyl)methoxy-substituted benzamides as modulators of trace amine-associated receptor 1 (taar1) |
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Also Published As
| Publication number | Publication date |
|---|---|
| IL197877A (en) | 2015-07-30 |
| JP5567177B2 (ja) | 2014-08-06 |
| EP2076497B1 (en) | 2012-02-22 |
| ZA200902278B (en) | 2010-03-31 |
| KR20090055035A (ko) | 2009-06-01 |
| KR101176699B1 (ko) | 2012-08-23 |
| TW200833685A (en) | 2008-08-16 |
| MX2009003801A (es) | 2009-04-22 |
| ATE546437T1 (de) | 2012-03-15 |
| AU2007312390B2 (en) | 2013-03-28 |
| ES2381589T3 (es) | 2012-05-29 |
| PE20080889A1 (es) | 2008-06-27 |
| CA2666762C (en) | 2014-12-30 |
| AR063327A1 (es) | 2009-01-21 |
| CN101528710A (zh) | 2009-09-09 |
| CL2007002971A1 (es) | 2008-05-30 |
| IL197877A0 (en) | 2009-12-24 |
| EP2076497A1 (en) | 2009-07-08 |
| BRPI0717939A2 (pt) | 2013-12-03 |
| JP5335681B2 (ja) | 2013-11-06 |
| US8586617B2 (en) | 2013-11-19 |
| RU2009112496A (ru) | 2010-11-27 |
| WO2008046757A1 (en) | 2008-04-24 |
| JP2010506875A (ja) | 2010-03-04 |
| US20080119535A1 (en) | 2008-05-22 |
| AU2007312390A1 (en) | 2008-04-24 |
| JP2013173779A (ja) | 2013-09-05 |
| CA2666762A1 (en) | 2008-04-24 |
| CN101528710B (zh) | 2012-11-07 |
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