NO20083369L - Anvendelse av substituert 2-imidazol av imidazolinderivater - Google Patents

Anvendelse av substituert 2-imidazol av imidazolinderivater

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Publication number
NO20083369L
NO20083369L NO20083369A NO20083369A NO20083369L NO 20083369 L NO20083369 L NO 20083369L NO 20083369 A NO20083369 A NO 20083369A NO 20083369 A NO20083369 A NO 20083369A NO 20083369 L NO20083369 L NO 20083369L
Authority
NO
Norway
Prior art keywords
disorders
benzofuran
lower alkyl
halogen
phenyl
Prior art date
Application number
NO20083369A
Other languages
English (en)
Inventor
Guido Galley
Katrin Groebke Zbinden
Sabine Kolczewski
Roger Norcross
Henri Stalder
Marius Hoener
Original Assignee
Hoffmann La Roche
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38226290&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20083369(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20083369L publication Critical patent/NO20083369L/no

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/06—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/22—Radicals substituted by oxygen atoms
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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
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  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Foreliggende oppfinnelse angår anvendelse av forbindelser med formel I I hvor R er hydrogen, tritium, hydroksy, amino, lavere alkyl, sykloalkyl, lavere alkoksy, halogen, cyano, lavere alkyl substituert med halogen, lavere alkoksy substituert med halogen, fenyl, O-fenyl, -S-fenyl, eventuelt substituert med halogen eller er benzyl, benzyloksy, NHC(O)-lavere alkyl eller pyridin-2,3 eller 4-yl; R1 er hydrogen, hydroksy eller lavere alkyl; R2 er hydrogen eller lavere alkyl; aryl er en aromatisk gruppe, valgt fra fenyl, naftalen-1-yl eller naftalen-2-yl; hetaryl er en aromatisk gruppe, inneholdende minst ét O, N eller S ringatom, valgt fra gruppen bestående av pyridin-3-yl, pyrazolyl, benzofuran-3-yl, benzofuran-4-yl, benzofuran-5-yl, benzofuran-6-yl, benzofuran-7-yl, tiofen-2-yl, tiofen-3-yl, benzo[b]tiofen-3-yl eller indol-3-yl; n er 1, 2, 3, 4 eller 5; når n er 2, 3, 4 eller 5, kan R være lik eller ikke; den stiplede linjen kan være en binding eller ikke; og til deres farmasøytiske aktive salter for fremstilling av medikamenter for behandling av depresjon, angst lidelser, bipolar lidelse, oppmerksomhetssvikt hyperaktivitet lidelse, stressrelaterte lidelser, psykotiske lidelser så som schizofreni, nevrologiske sykdommer så som Parkinson's sykdom, neurodegenerative lidelser så som Alzheimer's sykdom, epilepsi, migrene, hypertensjon, stoffmisbruk og metabolsk lidelser så som spiseforstyrrelser, diabetes, diabetiske komplikasjoner, fedme, dyslipidemi, lidelser i energi konsum og assimilasjon, lidelser og feilfunksjon av kroppstemperatur homeostase, søvnlidelser og cirkadisk rytme og kardiovaskulære lidelser.
NO20083369A 2006-01-27 2008-08-01 Anvendelse av substituert 2-imidazol av imidazolinderivater NO20083369L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06100955 2006-01-27
PCT/EP2007/050443 WO2007085557A2 (en) 2006-01-27 2007-01-17 Use of substituted 2-imidazole of imidazoline derivatives

Publications (1)

Publication Number Publication Date
NO20083369L true NO20083369L (no) 2008-10-24

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ID=38226290

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20083369A NO20083369L (no) 2006-01-27 2008-08-01 Anvendelse av substituert 2-imidazol av imidazolinderivater

Country Status (15)

Country Link
US (1) US7875645B2 (no)
EP (1) EP1981497A2 (no)
JP (1) JP2009524617A (no)
KR (1) KR20080080410A (no)
CN (1) CN101374516A (no)
AR (1) AR059183A1 (no)
AU (1) AU2007209381A1 (no)
BR (1) BRPI0707315A2 (no)
CA (1) CA2637312A1 (no)
IL (1) IL192884A0 (no)
NO (1) NO20083369L (no)
RU (1) RU2008130455A (no)
TW (1) TW200738233A (no)
WO (1) WO2007085557A2 (no)
ZA (1) ZA200806456B (no)

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JP2019517524A (ja) * 2016-06-02 2019-06-24 パーデュー ファーマ エルピー 疼痛治療のための微量アミン関連受容体１アゴニスト及び部分アゴニスト
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CN110041261B (zh) * 2019-05-24 2022-06-24 广东先强药业有限公司 一种盐酸萘甲唑啉的制备方法
KR20220041136A (ko) * 2019-07-30 2022-03-31 셀릭스 바이오 프라이빗 리미티드 항문 및 직장 질환 치료용 조성물 및 방법
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CN110922361B (zh) * 2019-11-21 2021-01-08 武汉大安制药有限公司 一种依托咪酯氧化杂质及其制备方法
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RU2008130455A (ru) 2010-03-10
AR059183A1 (es) 2008-03-12
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CA2637312A1 (en) 2007-08-02
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JP2009524617A (ja) 2009-07-02
US7875645B2 (en) 2011-01-25
WO2007085557A2 (en) 2007-08-02
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