BR112013030698A2 - derivados de benzamida substituídas - Google Patents

derivados de benzamida substituídas

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Publication number
BR112013030698A2
BR112013030698A2 BR112013030698A BR112013030698A BR112013030698A2 BR 112013030698 A2 BR112013030698 A2 BR 112013030698A2 BR 112013030698 A BR112013030698 A BR 112013030698A BR 112013030698 A BR112013030698 A BR 112013030698A BR 112013030698 A2 BR112013030698 A2 BR 112013030698A2
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BR
Brazil
Prior art keywords
disorders
halogen
trifluoromethyl
lower alkyl
pyridin
Prior art date
Application number
BR112013030698A
Other languages
English (en)
Other versions
BR112013030698B1 (pt
Inventor
Guido Galley
Philippe Pflieger
RENé TRUSSARDI
Roger Norcross
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR112013030698A2 publication Critical patent/BR112013030698A2/pt
Publication of BR112013030698B1 publication Critical patent/BR112013030698B1/pt

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/281,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/301,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

resumo patente de invenção: "derivados de benzamida substituídas". a presente invenção refere-se aos compostos de fórmula i em que r1 é hidrogênio, halogênio, ciano, alquila inferior, alquila inferior substituída por halogênio, alcóxi inferior, alcóxi inferior substituído por halogênio ou c(o)nh2, ou é fenila opcionalmente substituída por halogênio, ciano ou alcóxi inferior substituído por halogênio, ou é 2,2-difluorobenzo[d][1,3]dioxol-5-ila, ou é 6-(trifluorometil)pirazin-2-ila ou 5-(trifluorometil)pirazin-2-ila ou é 6-(trifluorometil)pirimidin-4-ila, ou é 6-(trifluorometil)piridin-3-ila, ou é 5-cianopirazin-2-ila ou é 2-(trifluorometil)pirimidin-4-ila; n é 1 ou 2 r2 é halogênio, alquila inferior ou ciano e r3 é hidrogênio, ou r2 é hidrogênio e r3 é halogênio, alquila inferior ou ciano; x é uma ligação, -nr'-, -ch2nh- ou -chr'-; r' é hidrogênio ou alquila inferior; z é uma ligação, -ch2- ou -o-; ar é fenila ou é heteroarila, selecionada a partir do grupo consistindo em 1h-indazol-3ila, piridina-2-ila, piridina-3-ila, piridina-4-ila, pirimidina-5-ila, 1h-pirazol-3-ila, 1h-pirazol-4-ila ou 1h-pirazol-5-ila; ou a um sal de adição de ácido farmaceuticamente adequado dos mesmos, que podem ser usados no tratamento da depressão, distúrbios de ansiedade, desordem bipolar, desordem da hiperatividade por déficit de atenção (adhd), desordens relacionadas com o estresse, desordens de psicoses, esquizofrenia, doenças neurológicas, doença de parkinson, distúrbios neurodegenerativas, doença de alzheimer, epilepsia, enxaqueca, hipertensão, abuso de drogas, desordens metabólicas, distúrbios alimentares, diabetes, complicações diabéticas, obesidade, dislipidemia, desordens do consumo de energia e assimilação, doenças e mau funcionamento da homeostase da temperatura corporal, perturbações do sono e do ritmo circadiano, e distúrbios cardiovasculares.
BR112013030698-0A 2011-06-10 2012-06-06 Derivados de benzamida substituídas e composição farmacêutica que os compreende BR112013030698B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11169441 2011-06-10
EP11169441.0 2011-06-10
PCT/EP2012/060637 WO2012168265A1 (en) 2011-06-10 2012-06-06 Substituted benzamide derivatives

Publications (2)

Publication Number Publication Date
BR112013030698A2 true BR112013030698A2 (pt) 2016-12-06
BR112013030698B1 BR112013030698B1 (pt) 2022-05-31

Family

ID=46298391

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013030698-0A BR112013030698B1 (pt) 2011-06-10 2012-06-06 Derivados de benzamida substituídas e composição farmacêutica que os compreende

Country Status (32)

Country Link
US (1) US9029370B2 (pt)
EP (1) EP2718271B1 (pt)
JP (1) JP5788087B2 (pt)
KR (1) KR101574906B1 (pt)
CN (1) CN103596937B (pt)
AR (1) AR086880A1 (pt)
AU (1) AU2012266462B2 (pt)
BR (1) BR112013030698B1 (pt)
CA (1) CA2834675C (pt)
CL (1) CL2013003485A1 (pt)
CO (1) CO6811866A2 (pt)
CY (1) CY1116769T1 (pt)
DK (1) DK2718271T3 (pt)
EA (1) EA022376B1 (pt)
EC (1) ECSP13013073A (pt)
ES (1) ES2546529T3 (pt)
HK (1) HK1192562A1 (pt)
HR (1) HRP20151201T1 (pt)
IL (1) IL229335A (pt)
MA (1) MA35194B1 (pt)
MX (1) MX354410B (pt)
MY (1) MY162461A (pt)
PE (1) PE20140968A1 (pt)
PL (1) PL2718271T3 (pt)
PT (1) PT2718271E (pt)
RS (1) RS54415B1 (pt)
SG (1) SG194840A1 (pt)
SI (1) SI2718271T1 (pt)
TW (1) TWI445701B (pt)
UA (1) UA110388C2 (pt)
WO (1) WO2012168265A1 (pt)
ZA (1) ZA201308401B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9073911B2 (en) 2011-06-09 2015-07-07 Hoffmann-La Roche Inc. Pyrazole derivatives
ES2554843T3 (es) * 2012-01-12 2015-12-23 F. Hoffmann-La Roche Ag Derivados heterocíclicos como receptores asociados de trazas de amina (TAARs)
JP2015531782A (ja) * 2012-09-14 2015-11-05 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft うつ病、糖尿病及びパーキンソン病のような幾つかの障害の処置において使用するためのtaar調節薬としてのピラゾールカルボキサミド誘導体
JP6027244B2 (ja) * 2012-09-17 2016-11-16 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft トリアゾールカルボキサミド誘導体
BR112015009990A2 (pt) * 2012-11-07 2017-07-11 Hoffmann La Roche derivados de pirazina
WO2015165085A1 (en) * 2014-04-30 2015-11-05 F.Hoffmann-La Roche Ag Morpholin-pyridine derivatives
PL3149002T3 (pl) * 2014-05-28 2018-08-31 F.Hoffmann-La Roche Ag Pochodne 5-oksa-2-azabicyklo[2.2.2]oktan-4-ylu i 5-oksa-2-azabicyklo [2.2.1]heptan-4-ylu jako modulatory TAAR1
CN104478798B (zh) * 2014-12-18 2017-01-18 武汉华纳联合药业有限公司 N‑氨基烷基磺酰基‑3‑吡啶甲酰胺衍生物及其在制备治疗心脑血管病药物中的应用
EP3757102A1 (en) * 2016-03-17 2020-12-30 F. Hoffmann-La Roche AG 5-ethyl-4-methyl-pyrazole-3-carboxamide derivative having activity as agonist of taar
IL295975A (en) * 2020-02-28 2022-10-01 Univ Texas Inhibitors of receptor interaction with protein kinase i for the treatment of disease

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Also Published As

Publication number Publication date
CA2834675C (en) 2019-09-03
CA2834675A1 (en) 2012-12-13
DK2718271T3 (en) 2015-08-24
HK1192562A1 (zh) 2014-08-22
UA110388C2 (en) 2015-12-25
AU2012266462A1 (en) 2013-10-31
NZ616820A (en) 2015-11-27
CY1116769T1 (el) 2017-03-15
TWI445701B (zh) 2014-07-21
BR112013030698B1 (pt) 2022-05-31
KR20140028102A (ko) 2014-03-07
PL2718271T3 (pl) 2016-01-29
MY162461A (en) 2017-06-15
HRP20151201T1 (hr) 2015-12-04
MX2013014371A (es) 2014-01-31
ES2546529T3 (es) 2015-09-24
US20120316165A1 (en) 2012-12-13
SI2718271T1 (sl) 2015-11-30
RS54415B1 (en) 2016-04-28
EP2718271A1 (en) 2014-04-16
MA35194B1 (fr) 2014-06-02
CL2013003485A1 (es) 2014-09-12
AU2012266462B2 (en) 2016-09-22
PE20140968A1 (es) 2014-08-06
TW201307308A (zh) 2013-02-16
US9029370B2 (en) 2015-05-12
MX354410B (es) 2018-03-05
AR086880A1 (es) 2014-01-29
PT2718271E (pt) 2015-10-29
IL229335A0 (en) 2014-01-30
WO2012168265A1 (en) 2012-12-13
CN103596937B (zh) 2016-06-29
SG194840A1 (en) 2013-12-30
EP2718271B1 (en) 2015-08-12
ZA201308401B (en) 2014-08-27
JP5788087B2 (ja) 2015-09-30
CO6811866A2 (es) 2013-12-16
EA022376B1 (ru) 2015-12-30
EA201391815A1 (ru) 2014-04-30
ECSP13013073A (es) 2014-01-31
KR101574906B1 (ko) 2015-12-04
IL229335A (en) 2016-11-30
JP2014516067A (ja) 2014-07-07
CN103596937A (zh) 2014-02-19

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

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