CL2007003874A1 - Compuestos derivados de benzamida; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar enfermedades cardiovasculares, hipertension, aterosclerosis, reestenosis, ictus, insuficiencia cardiaca, lesion isquemica, hipertensio - Google Patents
Compuestos derivados de benzamida; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar enfermedades cardiovasculares, hipertension, aterosclerosis, reestenosis, ictus, insuficiencia cardiaca, lesion isquemica, hipertensioInfo
- Publication number
- CL2007003874A1 CL2007003874A1 CL200703874A CL2007003874A CL2007003874A1 CL 2007003874 A1 CL2007003874 A1 CL 2007003874A1 CL 200703874 A CL200703874 A CL 200703874A CL 2007003874 A CL2007003874 A CL 2007003874A CL 2007003874 A1 CL2007003874 A1 CL 2007003874A1
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- hypertension
- compounds
- aterosclerosis
- benzamida
- ictus
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- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Applications Claiming Priority (1)
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US87862507P | 2007-01-03 | 2007-01-03 |
Publications (1)
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CL2007003874A1 true CL2007003874A1 (es) | 2008-05-16 |
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CL200703874A CL2007003874A1 (es) | 2007-01-03 | 2007-12-28 | Compuestos derivados de benzamida; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar enfermedades cardiovasculares, hipertension, aterosclerosis, reestenosis, ictus, insuficiencia cardiaca, lesion isquemica, hipertensio |
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EP (1) | EP2114869B1 (es) |
JP (1) | JP5258790B2 (es) |
AR (1) | AR064726A1 (es) |
CA (1) | CA2674389A1 (es) |
CL (1) | CL2007003874A1 (es) |
TW (1) | TW200843770A (es) |
WO (1) | WO2008086047A1 (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0721333D0 (en) * | 2007-10-31 | 2007-12-12 | Motac Neuroscience Ltd | Medicaments |
JPWO2010024258A1 (ja) * | 2008-08-29 | 2012-01-26 | 塩野義製薬株式会社 | Pi3k阻害活性を有する縮環アゾール誘導体 |
JP5789603B2 (ja) * | 2009-07-21 | 2015-10-07 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | ヘテロアリールベンズアミド、組成物および使用の方法 |
CA2780333C (en) * | 2009-11-17 | 2016-05-24 | The Regents Of The University Of Michigan | 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties |
JP5748777B2 (ja) * | 2010-02-02 | 2015-07-15 | ノバルティス アーゲー | Crf受容体アンタゴニストとしてのシクロヘキシルアミド誘導体 |
US9079880B2 (en) * | 2010-07-07 | 2015-07-14 | Boehringer Ingelheim International Gmbh | Rho kinase inhibitors |
US8697911B2 (en) | 2010-07-07 | 2014-04-15 | Boehringer Ingelheim International Gmbh | Rho kinase inhibitors |
JP5769326B2 (ja) * | 2010-10-19 | 2015-08-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Rhoキナーゼ阻害薬 |
CN103313968A (zh) | 2010-11-15 | 2013-09-18 | Abbvie公司 | Nampt和rock抑制剂 |
US9029370B2 (en) | 2011-06-10 | 2015-05-12 | Hoffmann-La Roche Inc. | Substituted benzamide derivatives |
EP2781521A4 (en) | 2011-10-19 | 2015-03-04 | Kowa Co | NOVEL COMPOUND OF SPIROINDOLINE AND THERAPEUTIC AGENT CONTAINING THE SAME |
CN104011026B (zh) | 2011-12-20 | 2016-07-20 | 拜耳知识产权股份有限公司 | 杀虫用芳酰胺 |
CN104812382A (zh) | 2012-09-20 | 2015-07-29 | 坦普尔大学 | 取代的烷基二芳基衍生物、制备方法和用途 |
EP3252049A1 (en) | 2013-01-18 | 2017-12-06 | Bristol-Myers Squibb Company | Phthalazinones and isoquinolinones as rock inhibitors |
WO2014177699A1 (en) * | 2013-05-03 | 2014-11-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Rhoa (rock) inhibitors for the treatment of enflammatory bowel disease |
US9902702B2 (en) | 2014-07-15 | 2018-02-27 | Bristol-Myers Squibb Company | Spirocycloheptanes as inhibitors of rock |
ES2838573T3 (es) | 2014-08-21 | 2021-07-02 | Bristol Myers Squibb Co | Derivados de benzamida ligados como inhibidores potentes de ROCK |
JP6883173B2 (ja) | 2015-05-12 | 2021-06-09 | ヘモストッド エスエー | 改善された血小板産生のための薬理学的特徴およびマイクロ流体特徴の組み合わせ |
CA2986083A1 (en) | 2015-06-11 | 2016-12-15 | Basilea Pharmaceutica International AG | Efflux-pump inhibitors and therapeutic uses thereof |
CN105195114B (zh) * | 2015-10-29 | 2017-08-25 | 重庆郑博生物科技有限公司 | 脓毒症多种致病因子的吸附材料及其制备方法和用途 |
AR107354A1 (es) | 2016-01-13 | 2018-04-18 | Bristol Myers Squibb Co | Salicilamidas espiroheptanos y compuestos relacionados como inhibidores de rock |
ES2829550T3 (es) | 2016-07-07 | 2021-06-01 | Bristol Myers Squibb Co | Ureas cíclicas espiro-condensadas como inhibidores de ROCK |
CN108203433B (zh) * | 2016-12-16 | 2020-07-03 | 成都先导药物开发股份有限公司 | 一种rock抑制剂及其应用 |
ES2951212T3 (es) | 2017-07-12 | 2023-10-18 | Bristol Myers Squibb Co | Fenilacetamidas como inhibidores de ROCK |
TW201908293A (zh) | 2017-07-12 | 2019-03-01 | 美商必治妥美雅史谷比公司 | 作為rock抑制劑之5員及雙環雜環醯胺 |
JP7313331B2 (ja) | 2017-07-12 | 2023-07-24 | ブリストル-マイヤーズ スクイブ カンパニー | Rock阻害剤としてのスピロヘプタニルヒダントイン |
JP7234201B2 (ja) | 2017-07-12 | 2023-03-07 | ブリストル-マイヤーズ スクイブ カンパニー | 心不全の治療のためのrockの5員アミノヘテロ環および5,6-または6,6員二環式アミノヘテロ環の阻害剤 |
EP3843845A4 (en) | 2018-08-29 | 2022-05-11 | University Of Massachusetts | INHIBITION OF PROTEIN KINASE FOR THE TREATMENT OF FRIEDREICH'S ATAXIA |
WO2023091565A1 (en) * | 2021-11-17 | 2023-05-25 | The University Of North Carolina At Chapel Hill | Nsd2-targeted chemical degraders and compositions and methods of use thereof |
WO2024076155A1 (ko) * | 2022-10-04 | 2024-04-11 | 노보렉스 주식회사 | Yeats 도메인 억제제로서 신규한 화합물 |
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CZ296163B6 (cs) * | 1996-05-20 | 2006-01-11 | Karboxyamidy chinolinu jako inhibitory TNF a inhibitory PDE-IV | |
JPH11139969A (ja) * | 1997-08-07 | 1999-05-25 | Tanabe Seiyaku Co Ltd | 医薬組成物 |
JPH11130751A (ja) | 1997-10-30 | 1999-05-18 | Yoshitomi Pharmaceut Ind Ltd | アミド化合物およびそれらの酸付加塩の標識化合物 |
US7217722B2 (en) * | 2000-02-01 | 2007-05-15 | Kirin Beer Kabushiki Kaisha | Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same |
EP1403255A4 (en) | 2001-06-12 | 2005-04-06 | Sumitomo Pharma | INHIBITORS OF RHO KINASE |
DE10357510A1 (de) * | 2003-12-09 | 2005-07-07 | Bayer Healthcare Ag | Heteroarylsubstituierte Benzole |
EP1713775A4 (en) * | 2004-01-30 | 2009-08-12 | Smithkline Beecham Corp | CHEMICAL COMPOUNDS |
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EP2114869B1 (en) | 2014-07-23 |
CA2674389A1 (en) | 2008-07-17 |
JP2010514842A (ja) | 2010-05-06 |
WO2008086047A1 (en) | 2008-07-17 |
US20100041645A1 (en) | 2010-02-18 |
JP5258790B2 (ja) | 2013-08-07 |
AR064726A1 (es) | 2009-04-22 |
EP2114869A1 (en) | 2009-11-11 |
US8093266B2 (en) | 2012-01-10 |
TW200843770A (en) | 2008-11-16 |
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