PE20091069A1 - Derivados de pirazol como inhibidores de 5-lo - Google Patents
Derivados de pirazol como inhibidores de 5-loInfo
- Publication number
- PE20091069A1 PE20091069A1 PE2008001974A PE2008001974A PE20091069A1 PE 20091069 A1 PE20091069 A1 PE 20091069A1 PE 2008001974 A PE2008001974 A PE 2008001974A PE 2008001974 A PE2008001974 A PE 2008001974A PE 20091069 A1 PE20091069 A1 PE 20091069A1
- Authority
- PE
- Peru
- Prior art keywords
- halo
- methyl
- och3
- derivatives
- pyran
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 102000001381 Arachidonate 5-Lipoxygenase Human genes 0.000 abstract 3
- 108010093579 Arachidonate 5-lipoxygenase Proteins 0.000 abstract 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 3
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- SCVJRXQHFJXZFZ-KVQBGUIXSA-N 2-amino-9-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3h-purine-6-thione Chemical compound C1=2NC(N)=NC(=S)C=2N=CN1[C@H]1C[C@H](O)[C@@H](CO)O1 SCVJRXQHFJXZFZ-KVQBGUIXSA-N 0.000 abstract 1
- 101000790711 Chlamydomonas reinhardtii Uncharacterized membrane protein ycf78 Proteins 0.000 abstract 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical class C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical class C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- DGOYLVBDCVINQZ-UHFFFAOYSA-N oxane-4-carboxamide Chemical compound NC(=O)C1CCOCC1 DGOYLVBDCVINQZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Tropical Medicine & Parasitology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
Abstract
SE REFIERE A DERIVADOS DE PIRAZOL DE FORMULA (I), DONDE Q ES -S- O -S(O)-; X E Y SON CADA UNO C, N; L ES ENLACE, -(CH2)-, -O-, ENTRE OTROS; R1 Y R2 SON CADA UNO H, METILO, ETILO; R3 ES -CN, -C(O)NH2, -C(O)NH2, -C(O)NH(CH3); R4 ES H, HALO; R5 ES H, HALO -CN, -OCH3; R6 ES H, HALO, -CN; R7 ES HALO, -CN, METILO, -OCH3; R8 ES H, HALO, -OCH3, ENTRE OTROS; R9 ES -CN, METILO, CF3, ENTRE OTROS; R10 ES H, -CN, HALO; R11 ES H, ALQUILO C1-C7; R12 ES H, HALO. SON COMPUESTOS PREFERIDOS: 4-[3-({5-CLORO-6-[(1-METIL-1H-PIRAZOL-5-IL)OXI]PIRIDIN-3-IL}TIO)FENIL]TETRAHIDRO-2H-PIRAN-4-CARBOXAMIDA; (2S,4R)-4-[3-({5-CLORO-6-[(1-METIL-1H-PIRAZOL-5-IL)OXI]PIRIDIN-3-IL)TIO}-2-FLUOROFENIL]-2-METILTETRAHIDRO-2H-PIRAN-4-CARBOXAMIDA; ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCESO PARA SU PREPARACION Y UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO TIENE ACTIVIDAD INHIBITORIA DE 5-LIPOXIGENASA (5-LP), SIENDO UTIL PARA EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIA MEDIADAS POR 5-LP TAL COMO EL ASMA
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US426107P | 2007-11-26 | 2007-11-26 | |
| US423607P | 2007-11-26 | 2007-11-26 | |
| US5549708P | 2008-05-23 | 2008-05-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20091069A1 true PE20091069A1 (es) | 2009-07-19 |
Family
ID=40568336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008001974A PE20091069A1 (es) | 2007-11-26 | 2008-11-25 | Derivados de pirazol como inhibidores de 5-lo |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US8097733B2 (es) |
| EP (1) | EP2225229A1 (es) |
| JP (1) | JP4718650B2 (es) |
| KR (1) | KR20100072090A (es) |
| CN (1) | CN101918392A (es) |
| AP (1) | AP2010005269A0 (es) |
| AR (1) | AR069743A1 (es) |
| AU (1) | AU2008331199A1 (es) |
| BR (1) | BRPI0819661A2 (es) |
| CA (1) | CA2705729C (es) |
| CL (1) | CL2008003495A1 (es) |
| CO (1) | CO6280402A2 (es) |
| CR (1) | CR11392A (es) |
| DO (1) | DOP2010000155A (es) |
| EA (1) | EA201000703A1 (es) |
| EC (1) | ECSP10010200A (es) |
| IL (1) | IL205602A0 (es) |
| MA (1) | MA31863B1 (es) |
| MX (1) | MX2010004604A (es) |
| NI (1) | NI201000089A (es) |
| PA (1) | PA8805301A1 (es) |
| PE (1) | PE20091069A1 (es) |
| SV (1) | SV2010003579A (es) |
| TN (1) | TN2010000231A1 (es) |
| TW (1) | TW200927098A (es) |
| UY (1) | UY31487A1 (es) |
| WO (1) | WO2009069044A1 (es) |
| ZA (1) | ZA201002758B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY155535A (en) | 2008-05-23 | 2015-10-30 | Novartis Ag | Derivatives of quinolines and quinoxalines as protien tyrosine kinase inhibitors |
| US20110269807A1 (en) * | 2010-04-30 | 2011-11-03 | Allergan, Inc. | Novel treatment for age related macular degeneration and ocular ischemic disease associated with complement activation by targeting 5-lipoxygenase |
| WO2011161615A1 (en) | 2010-06-24 | 2011-12-29 | Ranbaxy Laboratories Limited | 5-lipoxygenase inhibitors |
| AU2014298959B2 (en) | 2013-07-29 | 2018-04-05 | Merck Patent Gmbh | 1,3-disubstituted cyclopentane derivatives |
| GB201403605D0 (en) * | 2014-02-28 | 2014-04-16 | Mologic Ltd | Monitoring inflammation status |
| UA124524C2 (uk) | 2015-05-18 | 2021-10-05 | Шеньян Сайнокем Аґрокемікалз Р&Д Ко., Лтд. | Сполукa заміщеного піразолу, якa містить піримідиніл, її одержання і застосування |
| CN111825678A (zh) * | 2020-06-05 | 2020-10-27 | 连庆泉 | 一种卡马替尼的制备方法 |
| WO2021252951A1 (en) | 2020-06-12 | 2021-12-16 | Vanderbilt University | Methods of treatment for gastrointestinal motility disorders |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5254581A (en) | 1990-06-21 | 1993-10-19 | Imperial Chemical Industries Plc | Pyran derivatives and their use as inhibitors of 5-lipoxygenase |
| IE913866A1 (en) | 1990-11-28 | 1992-06-03 | Ici Plc | Aryl derivatives |
| US5272173A (en) | 1990-11-28 | 1993-12-21 | Imperial Chemical Industries Plc | 5-lipoxygenase inhibitors |
| GB9300894D0 (en) | 1992-02-07 | 1993-03-10 | Zeneca Ltd | Oxime derivatives |
| US5883106A (en) | 1994-10-18 | 1999-03-16 | Pfizer Inc. | 5-lipoxygenase inhibitors |
| JP3400392B2 (ja) * | 1994-10-18 | 2003-04-28 | ファイザー製薬株式会社 | ５−リポキシゲナーゼ阻害剤及び新規医薬組成物 |
| US6063928A (en) | 1994-10-18 | 2000-05-16 | Pfizer Inc | 5-lipoxygenase inhibitors |
| SK281577B6 (sk) * | 1994-10-18 | 2001-05-10 | Pfizer Inc. | Heterocyklické zlúčeniny a farmaceutický prostriedok na ich báze |
| US6239285B1 (en) | 1998-02-06 | 2001-05-29 | Pfizer Inc | Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems |
| MX2008009475A (es) | 2006-01-23 | 2008-10-20 | Amira Pharmaceuticals Inc | Inhibidores triciclicos de 5-lipoxigenasa. |
| US7674811B2 (en) | 2006-03-14 | 2010-03-09 | Ranbaxy Laboratories Limited | 5-lipoxygenase inhibitors |
| AP2009004849A0 (en) * | 2006-11-27 | 2009-06-30 | Pfizer Prod Inc | Pyrazole analogs |
-
2008
- 2008-11-20 EA EA201000703A patent/EA201000703A1/ru unknown
- 2008-11-20 KR KR1020107011376A patent/KR20100072090A/ko not_active Ceased
- 2008-11-20 BR BRPI0819661A patent/BRPI0819661A2/pt not_active IP Right Cessation
- 2008-11-20 CN CN2008801178682A patent/CN101918392A/zh active Pending
- 2008-11-20 CA CA2705729A patent/CA2705729C/en not_active Expired - Fee Related
- 2008-11-20 JP JP2010535484A patent/JP4718650B2/ja not_active Expired - Fee Related
- 2008-11-20 MX MX2010004604A patent/MX2010004604A/es not_active Application Discontinuation
- 2008-11-20 AP AP2010005269A patent/AP2010005269A0/en unknown
- 2008-11-20 EP EP08853504A patent/EP2225229A1/en not_active Withdrawn
- 2008-11-20 AU AU2008331199A patent/AU2008331199A1/en not_active Abandoned
- 2008-11-20 WO PCT/IB2008/054873 patent/WO2009069044A1/en not_active Ceased
- 2008-11-24 US US12/276,779 patent/US8097733B2/en not_active Expired - Fee Related
- 2008-11-24 CL CL2008003495A patent/CL2008003495A1/es unknown
- 2008-11-25 PE PE2008001974A patent/PE20091069A1/es not_active Application Discontinuation
- 2008-11-25 UY UY31487A patent/UY31487A1/es not_active Application Discontinuation
- 2008-11-25 TW TW097145472A patent/TW200927098A/zh unknown
- 2008-11-26 PA PA20088805301A patent/PA8805301A1/es unknown
- 2008-11-26 AR ARP080105131A patent/AR069743A1/es not_active Application Discontinuation
-
2010
- 2010-04-20 ZA ZA2010/02758A patent/ZA201002758B/en unknown
- 2010-04-26 CR CR11392A patent/CR11392A/es not_active Application Discontinuation
- 2010-05-06 IL IL205602A patent/IL205602A0/en unknown
- 2010-05-21 TN TN2010000231A patent/TN2010000231A1/fr unknown
- 2010-05-24 DO DO2010000155A patent/DOP2010000155A/es unknown
- 2010-05-25 NI NI201000089A patent/NI201000089A/es unknown
- 2010-05-26 CO CO10063358A patent/CO6280402A2/es not_active Application Discontinuation
- 2010-05-26 SV SV2010003579A patent/SV2010003579A/es not_active Application Discontinuation
- 2010-05-26 EC EC2010010200A patent/ECSP10010200A/es unknown
- 2010-05-26 MA MA32869A patent/MA31863B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2008331199A1 (en) | 2009-06-04 |
| IL205602A0 (en) | 2010-11-30 |
| AR069743A1 (es) | 2010-02-17 |
| ECSP10010200A (es) | 2010-06-29 |
| CA2705729C (en) | 2012-09-18 |
| SV2010003579A (es) | 2011-03-23 |
| CO6280402A2 (es) | 2011-05-20 |
| PA8805301A1 (es) | 2009-06-23 |
| CN101918392A (zh) | 2010-12-15 |
| KR20100072090A (ko) | 2010-06-29 |
| US8097733B2 (en) | 2012-01-17 |
| US20090227634A1 (en) | 2009-09-10 |
| BRPI0819661A2 (pt) | 2019-09-24 |
| EP2225229A1 (en) | 2010-09-08 |
| CL2008003495A1 (es) | 2010-03-12 |
| JP4718650B2 (ja) | 2011-07-06 |
| JP2011504514A (ja) | 2011-02-10 |
| MX2010004604A (es) | 2010-08-04 |
| TW200927098A (en) | 2009-07-01 |
| DOP2010000155A (es) | 2010-07-15 |
| UY31487A1 (es) | 2009-07-17 |
| WO2009069044A1 (en) | 2009-06-04 |
| AP2010005269A0 (en) | 2010-06-30 |
| MA31863B1 (fr) | 2010-11-01 |
| ZA201002758B (en) | 2011-06-29 |
| TN2010000231A1 (fr) | 2011-11-11 |
| CR11392A (es) | 2010-05-28 |
| NI201000089A (es) | 2010-10-05 |
| CA2705729A1 (en) | 2009-06-04 |
| EA201000703A1 (ru) | 2010-12-30 |
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