CL2008003495A1 - Compuestos derivados de pirazol; composicion farmaceutica, metodo de preparacion y; su uso para tratar una enfermedad mediada por 5-lo tal como asma, broncocontriccion, enfisema, enfermedades obstructivas o inflamatorias de las vias respiratorias, bronquitis, lesion pulmonar aguda, bronquiectasia, rinitis alergica, entre otras. - Google Patents

Compuestos derivados de pirazol; composicion farmaceutica, metodo de preparacion y; su uso para tratar una enfermedad mediada por 5-lo tal como asma, broncocontriccion, enfisema, enfermedades obstructivas o inflamatorias de las vias respiratorias, bronquitis, lesion pulmonar aguda, bronquiectasia, rinitis alergica, entre otras.

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Publication number
CL2008003495A1
CL2008003495A1 CL2008003495A CL2008003495A CL2008003495A1 CL 2008003495 A1 CL2008003495 A1 CL 2008003495A1 CL 2008003495 A CL2008003495 A CL 2008003495A CL 2008003495 A CL2008003495 A CL 2008003495A CL 2008003495 A1 CL2008003495 A1 CL 2008003495A1
Authority
CL
Chile
Prior art keywords
bronchocontriction
bronchiectasis
emphysema
airways
bronchitis
Prior art date
Application number
CL2008003495A
Other languages
English (en)
Inventor
Edgardo Alvira
Matthew J Graneto
Margaret Lanahan Grapperahus
Kaliappan Iyanar
Todd Michael Madduk
M Mahoney
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CL2008003495A1 publication Critical patent/CL2008003495A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Virology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • AIDS & HIV (AREA)

Abstract

Compuestos derivados de pirazol, composición farmacéutica y su uso para tratar una enfermedad mediada por 5-lo tal como asma, broncocontricción, enfisema, enfermedades obstructivas o inflamatorias de las vías respiratorias, bronquitis, lesión pulmonar aguda, bronquiectasia, rinitis alérgica, entre otras.
CL2008003495A 2007-11-26 2008-11-24 Compuestos derivados de pirazol; composicion farmaceutica, metodo de preparacion y; su uso para tratar una enfermedad mediada por 5-lo tal como asma, broncocontriccion, enfisema, enfermedades obstructivas o inflamatorias de las vias respiratorias, bronquitis, lesion pulmonar aguda, bronquiectasia, rinitis alergica, entre otras. CL2008003495A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US423607P 2007-11-26 2007-11-26
US426107P 2007-11-26 2007-11-26
US5549708P 2008-05-23 2008-05-23

Publications (1)

Publication Number Publication Date
CL2008003495A1 true CL2008003495A1 (es) 2010-03-12

Family

ID=40568336

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2008003495A CL2008003495A1 (es) 2007-11-26 2008-11-24 Compuestos derivados de pirazol; composicion farmaceutica, metodo de preparacion y; su uso para tratar una enfermedad mediada por 5-lo tal como asma, broncocontriccion, enfisema, enfermedades obstructivas o inflamatorias de las vias respiratorias, bronquitis, lesion pulmonar aguda, bronquiectasia, rinitis alergica, entre otras.

Country Status (28)

Country Link
US (1) US8097733B2 (es)
EP (1) EP2225229A1 (es)
JP (1) JP4718650B2 (es)
KR (1) KR20100072090A (es)
CN (1) CN101918392A (es)
AP (1) AP2010005269A0 (es)
AR (1) AR069743A1 (es)
AU (1) AU2008331199A1 (es)
BR (1) BRPI0819661A2 (es)
CA (1) CA2705729C (es)
CL (1) CL2008003495A1 (es)
CO (1) CO6280402A2 (es)
CR (1) CR11392A (es)
DO (1) DOP2010000155A (es)
EA (1) EA201000703A1 (es)
EC (1) ECSP10010200A (es)
IL (1) IL205602A0 (es)
MA (1) MA31863B1 (es)
MX (1) MX2010004604A (es)
NI (1) NI201000089A (es)
PA (1) PA8805301A1 (es)
PE (1) PE20091069A1 (es)
SV (1) SV2010003579A (es)
TN (1) TN2010000231A1 (es)
TW (1) TW200927098A (es)
UY (1) UY31487A1 (es)
WO (1) WO2009069044A1 (es)
ZA (1) ZA201002758B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009248774B2 (en) 2008-05-23 2012-05-31 Novartis Ag Derivatives of quinolines and quinoxalines as protein tyrosine kinase inhibitors
US20110269807A1 (en) * 2010-04-30 2011-11-03 Allergan, Inc. Novel treatment for age related macular degeneration and ocular ischemic disease associated with complement activation by targeting 5-lipoxygenase
WO2011161615A1 (en) 2010-06-24 2011-12-29 Ranbaxy Laboratories Limited 5-lipoxygenase inhibitors
AU2014298959B2 (en) 2013-07-29 2018-04-05 Merck Patent Gmbh 1,3-disubstituted cyclopentane derivatives
GB201403605D0 (en) * 2014-02-28 2014-04-16 Mologic Ltd Monitoring inflammation status
US11008339B2 (en) 2015-05-18 2021-05-18 Shenyang Sinochem Agrochemicals R&D Co., Ltd. Substituted pyrazole compounds containing pyrimidine and preparation method and use thereof
CN111825678A (zh) * 2020-06-05 2020-10-27 连庆泉 一种卡马替尼的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5254581A (en) * 1990-06-21 1993-10-19 Imperial Chemical Industries Plc Pyran derivatives and their use as inhibitors of 5-lipoxygenase
IE913866A1 (en) * 1990-11-28 1992-06-03 Ici Plc Aryl derivatives
US5272173A (en) * 1990-11-28 1993-12-21 Imperial Chemical Industries Plc 5-lipoxygenase inhibitors
GB9300894D0 (en) * 1992-02-07 1993-03-10 Zeneca Ltd Oxime derivatives
US5883106A (en) * 1994-10-18 1999-03-16 Pfizer Inc. 5-lipoxygenase inhibitors
SK281577B6 (sk) * 1994-10-18 2001-05-10 Pfizer Inc. Heterocyklické zlúčeniny a farmaceutický prostriedok na ich báze
JP3400392B2 (ja) * 1994-10-18 2003-04-28 ファイザー製薬株式会社 ５−リポキシゲナーゼ阻害剤及び新規医薬組成物
US6063928A (en) * 1994-10-18 2000-05-16 Pfizer Inc 5-lipoxygenase inhibitors
US6239285B1 (en) * 1998-02-06 2001-05-29 Pfizer Inc Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems
MX2008009475A (es) * 2006-01-23 2008-10-20 Amira Pharmaceuticals Inc Inhibidores triciclicos de 5-lipoxigenasa.
EP1834953A1 (en) * 2006-03-14 2007-09-19 Ranbaxy Laboratories Limited Tetrahydropyrane derivatives as 5-lipoxygenase inhibitors
RS20090211A (en) * 2006-11-27 2010-10-31 Pfizer Products Inc. Pyrazole analogs

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TW200927098A (en) 2009-07-01
JP4718650B2 (ja) 2011-07-06
EA201000703A1 (ru) 2010-12-30
MA31863B1 (fr) 2010-11-01
NI201000089A (es) 2010-10-05
CA2705729C (en) 2012-09-18
PE20091069A1 (es) 2009-07-19
BRPI0819661A2 (pt) 2019-09-24
CA2705729A1 (en) 2009-06-04
AR069743A1 (es) 2010-02-17
DOP2010000155A (es) 2010-07-15
US8097733B2 (en) 2012-01-17
ZA201002758B (en) 2011-06-29
CR11392A (es) 2010-05-28
IL205602A0 (en) 2010-11-30
CO6280402A2 (es) 2011-05-20
ECSP10010200A (es) 2010-06-29
PA8805301A1 (es) 2009-06-23
UY31487A1 (es) 2009-07-17
KR20100072090A (ko) 2010-06-29
TN2010000231A1 (fr) 2011-11-11
MX2010004604A (es) 2010-08-04
EP2225229A1 (en) 2010-09-08
SV2010003579A (es) 2011-03-23
JP2011504514A (ja) 2011-02-10
CN101918392A (zh) 2010-12-15
WO2009069044A1 (en) 2009-06-04
US20090227634A1 (en) 2009-09-10
AU2008331199A1 (en) 2009-06-04
AP2010005269A0 (en) 2010-06-30

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