CL2008000307A1 - Compuestos derivados de cromen-2-ona sustituido; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como ateroesclerosis, asma, rinitis alergica y epoc. - Google Patents
Compuestos derivados de cromen-2-ona sustituido; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como ateroesclerosis, asma, rinitis alergica y epoc.Info
- Publication number
- CL2008000307A1 CL2008000307A1 CL200800307A CL2008000307A CL2008000307A1 CL 2008000307 A1 CL2008000307 A1 CL 2008000307A1 CL 200800307 A CL200800307 A CL 200800307A CL 2008000307 A CL2008000307 A CL 2008000307A CL 2008000307 A1 CL2008000307 A1 CL 2008000307A1
- Authority
- CL
- Chile
- Prior art keywords
- aterosclerosis
- chromen
- ona
- copd
- asthma
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89947107P | 2007-02-05 | 2007-02-05 | |
| US90035307P | 2007-02-08 | 2007-02-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2008000307A1 true CL2008000307A1 (es) | 2008-05-30 |
Family
ID=39676707
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL200800307A CL2008000307A1 (es) | 2007-02-05 | 2008-01-31 | Compuestos derivados de cromen-2-ona sustituido; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como ateroesclerosis, asma, rinitis alergica y epoc. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7960409B2 (es) |
| EP (1) | EP2118093B1 (es) |
| JP (1) | JP5514554B2 (es) |
| CN (1) | CN101657443B (es) |
| AR (1) | AR065093A1 (es) |
| AT (1) | ATE550336T1 (es) |
| AU (1) | AU2008213767B2 (es) |
| CA (1) | CA2676498A1 (es) |
| CL (1) | CL2008000307A1 (es) |
| PE (1) | PE20090041A1 (es) |
| TW (1) | TW200838511A (es) |
| WO (2) | WO2008095292A1 (es) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100120578A1 (en) * | 2008-11-07 | 2010-05-13 | Hichem Bouguerra | Drive and steering control system for an endless track vehicle |
| CN102050809B (zh) * | 2009-11-03 | 2014-12-17 | 中国医学科学院药物研究所 | 拮抗cklf1/ccr4相互作用的3-哌嗪基香豆素衍生物 |
| AU2012329098B2 (en) | 2011-10-26 | 2017-08-03 | Allergan, Inc. | Amide derivatives of N-urea substituted amino acids as formyl peptide receptor like-1 (FPRL-1) receptor modulators |
| JP5857136B2 (ja) * | 2011-11-03 | 2016-02-10 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | ｍＧｌｕＲ２−陰性アロステリック調節因子としてのキノリンカルボキサミドおよびキノリンカルボニトリル誘導体、組成物、およびその使用 |
| US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| AU2013331505A1 (en) | 2012-10-16 | 2015-04-30 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of ROR-gamma-t |
| WO2014062655A1 (en) | 2012-10-16 | 2014-04-24 | Janssen Pharmaceutica Nv | HETEROARYL LINKED QUINOLINYL MODULATORS OF RORyt |
| CA2888210C (en) | 2012-10-16 | 2021-02-09 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of ror-gamma-t |
| US9394285B2 (en) | 2013-03-15 | 2016-07-19 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| US9284308B2 (en) | 2013-10-15 | 2016-03-15 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of RORγt |
| EP3057422B1 (en) | 2013-10-15 | 2019-05-15 | Janssen Pharmaceutica NV | Quinolinyl modulators of ror(gamma)t |
| JP6423423B2 (ja) | 2013-10-15 | 2018-11-14 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｒｏｒγｔのアルキル結合キノリニルモジュレーター |
| US10555941B2 (en) | 2013-10-15 | 2020-02-11 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORγt |
| US9221804B2 (en) | 2013-10-15 | 2015-12-29 | Janssen Pharmaceutica Nv | Secondary alcohol quinolinyl modulators of RORγt |
| US9403816B2 (en) | 2013-10-15 | 2016-08-02 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of RORγt |
| US9328095B2 (en) | 2013-10-15 | 2016-05-03 | Janssen Pharmaceutica Nv | Heteroaryl linked quinolinyl modulators of RORgammat |
| CN105636952A (zh) | 2013-10-15 | 2016-06-01 | 詹森药业有限公司 | Rorγt的仲醇喹啉基调节剂 |
| AU2016327715B2 (en) * | 2015-09-24 | 2019-05-16 | Chengdu Zenitar Biomedical Technology Co., Ltd. | 4-substituted coumarin derivatives and preparation methods and uses thereof |
| MY196807A (en) | 2016-09-27 | 2023-05-03 | Merck Sharp & Dohme Llc | Chromane, isochromane and dihydroisobenzofuran derivatives as mglur2-negative allosteric modulators, compositions, and their use |
| AU2018301681B2 (en) | 2017-07-14 | 2022-07-14 | Innate Tumor Immunity, Inc. | NLRP3 modulators |
| CN108299369B (zh) * | 2018-01-15 | 2021-07-30 | 安徽师范大学 | 香豆素-4-磺酸酯衍生物及其制备方法 |
| US11866431B2 (en) | 2018-11-09 | 2024-01-09 | Vivace Therapeutics, Inc. | Bicyclic compounds |
| TWI849107B (zh) | 2019-04-16 | 2024-07-21 | 美商維瓦斯治療公司 | 雙環化合物 |
| CN110038012B (zh) * | 2019-05-30 | 2021-06-11 | 济南大学 | 具有1,2,3-三氮唑结构片段的生物碱化合物在制备促血管生成药物中的应用 |
| WO2023034339A1 (en) * | 2021-08-30 | 2023-03-09 | Pretzel Therapeutics, Inc. | Hydroxy and alkoxy coumarins as modulators of polrmt |
| WO2023034346A1 (en) * | 2021-08-30 | 2023-03-09 | Pretzel Therapeutics, Inc. | Chromen-2-one modulators of polrmt |
| CN114307937B (zh) * | 2022-02-24 | 2024-05-24 | 辽宁博仕科技股份有限公司 | 基于射流反应器的过一硫酸氢钾复合盐生产装置及方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5424320A (en) | 1993-06-23 | 1995-06-13 | Merck Frosst Canada, Inc. | Heteroaryl coumarins as inhibitors of leukotriene biosynthesis |
| US5410054A (en) | 1993-07-20 | 1995-04-25 | Merck Frosst Canada, Inc. | Heteroaryl quinolines as inhibitors of leukotriene biosynthesis |
| US5552437A (en) * | 1994-10-27 | 1996-09-03 | Merck Frosst Canada, Inc. | Bisarylcarbinol derivatives as inhibitors of leukotriene biosynthesis |
| AU2004245146B2 (en) * | 2003-06-11 | 2010-01-21 | Merck Frosst Canada Ltd | 7-(1,3-thiazol-2-yl)thio-coumarin derivatives and their use as leukotriene biosynthesis inhibitors |
| AR055041A1 (es) * | 2005-03-23 | 2007-08-01 | Merck Frosst Canada Ltd | Tiadiazoles y oxadiazoles como inhibidores de la sintesis de leucotrienos. composiciones farmaceuticas. |
| EP1915369A4 (en) | 2005-08-11 | 2010-09-08 | Merck Frosst Canada Ltd | NEW SUBSTITUTED 1,2,3-TRIAZOLYLMETHYLBENZOTHIOPHENE OR ENDOLE AND THEIR USE AS INHIBITORS OF LEUKOTRIENBIOSYNTHESIS |
-
2008
- 2008-01-30 AR ARP080100376A patent/AR065093A1/es unknown
- 2008-01-31 CL CL200800307A patent/CL2008000307A1/es unknown
- 2008-02-01 US US12/012,246 patent/US7960409B2/en not_active Expired - Fee Related
- 2008-02-01 TW TW097104101A patent/TW200838511A/zh unknown
- 2008-02-04 PE PE2008000245A patent/PE20090041A1/es not_active Application Discontinuation
- 2008-02-05 CA CA002676498A patent/CA2676498A1/en not_active Abandoned
- 2008-02-05 AT AT08714553T patent/ATE550336T1/de active
- 2008-02-05 AU AU2008213767A patent/AU2008213767B2/en not_active Ceased
- 2008-02-05 WO PCT/CA2008/000230 patent/WO2008095292A1/en active Application Filing
- 2008-02-05 WO PCT/CA2008/000231 patent/WO2008095293A1/en active Application Filing
- 2008-02-05 CN CN2008800112245A patent/CN101657443B/zh not_active Expired - Fee Related
- 2008-02-05 EP EP08714553A patent/EP2118093B1/en not_active Not-in-force
- 2008-02-05 JP JP2009547507A patent/JP5514554B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20080188521A1 (en) | 2008-08-07 |
| CN101657443B (zh) | 2013-10-23 |
| TW200838511A (en) | 2008-10-01 |
| PE20090041A1 (es) | 2009-02-07 |
| AR065093A1 (es) | 2009-05-13 |
| EP2118093B1 (en) | 2012-03-21 |
| EP2118093A4 (en) | 2010-03-17 |
| CN101657443A (zh) | 2010-02-24 |
| WO2008095292A1 (en) | 2008-08-14 |
| JP2010517947A (ja) | 2010-05-27 |
| EP2118093A1 (en) | 2009-11-18 |
| ATE550336T1 (de) | 2012-04-15 |
| CA2676498A1 (en) | 2008-08-14 |
| AU2008213767A1 (en) | 2008-08-14 |
| US7960409B2 (en) | 2011-06-14 |
| WO2008095293A1 (en) | 2008-08-14 |
| AU2008213767B2 (en) | 2013-06-06 |
| JP5514554B2 (ja) | 2014-06-04 |
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