ATE550336T1 - Ä1,2,3ü-triazolyl-substituierte chinoline und coumarine als leukotrien-biosynthese-hemmer - Google Patents
Ä1,2,3ü-triazolyl-substituierte chinoline und coumarine als leukotrien-biosynthese-hemmerInfo
- Publication number
- ATE550336T1 ATE550336T1 AT08714553T AT08714553T ATE550336T1 AT E550336 T1 ATE550336 T1 AT E550336T1 AT 08714553 T AT08714553 T AT 08714553T AT 08714553 T AT08714553 T AT 08714553T AT E550336 T1 ATE550336 T1 AT E550336T1
- Authority
- AT
- Austria
- Prior art keywords
- leucotrien
- coumarines
- triazolyl
- biosynthesis inhibitors
- substituted quinolines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89947107P | 2007-02-05 | 2007-02-05 | |
| US90035307P | 2007-02-08 | 2007-02-08 | |
| PCT/CA2008/000230 WO2008095292A1 (en) | 2007-02-05 | 2008-02-05 | [1,2,3] triazolyl substituted quinolines and coumarins as inhibitors of leukotriene biosynthesis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE550336T1 true ATE550336T1 (de) | 2012-04-15 |
Family
ID=39676707
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08714553T ATE550336T1 (de) | 2007-02-05 | 2008-02-05 | Ä1,2,3ü-triazolyl-substituierte chinoline und coumarine als leukotrien-biosynthese-hemmer |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7960409B2 (de) |
| EP (1) | EP2118093B1 (de) |
| JP (1) | JP5514554B2 (de) |
| CN (1) | CN101657443B (de) |
| AR (1) | AR065093A1 (de) |
| AT (1) | ATE550336T1 (de) |
| AU (1) | AU2008213767B2 (de) |
| CA (1) | CA2676498A1 (de) |
| CL (1) | CL2008000307A1 (de) |
| PE (1) | PE20090041A1 (de) |
| TW (1) | TW200838511A (de) |
| WO (2) | WO2008095293A1 (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100120578A1 (en) * | 2008-11-07 | 2010-05-13 | Hichem Bouguerra | Drive and steering control system for an endless track vehicle |
| CN102050809B (zh) * | 2009-11-03 | 2014-12-17 | 中国医学科学院药物研究所 | 拮抗cklf1/ccr4相互作用的3-哌嗪基香豆素衍生物 |
| SG11201401818RA (en) | 2011-10-26 | 2014-05-29 | Allergan Inc | Amide derivatives of n-urea substituted amino acids as formyl peptide receptor like-1 (fprl-1) receptor modulators |
| CN104010504B (zh) | 2011-11-03 | 2016-04-06 | 默沙东公司 | 作为mGluR2负变构调节剂的喹啉甲酰胺和喹啉甲腈的衍生物、组合物、及其用途 |
| US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| KR20150070348A (ko) | 2012-10-16 | 2015-06-24 | 얀센 파마슈티카 엔.브이. | RoRγt의 헤테로아릴 결합 퀴놀리닐 조절제 |
| PE20150778A1 (es) | 2012-10-16 | 2015-05-23 | Janssen Pharmaceutica Nv | Moduladores de quinolinilo unidos a metileno de ror-gamma-t |
| WO2014062667A1 (en) | 2012-10-16 | 2014-04-24 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of ror-gamma-t |
| JP6064062B2 (ja) | 2013-03-15 | 2017-01-18 | ファイザー・インク | Ａｍｐｋを活性化させるインダゾール化合物 |
| US9403816B2 (en) | 2013-10-15 | 2016-08-02 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of RORγt |
| AU2014334619A1 (en) | 2013-10-15 | 2016-04-21 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORyt |
| ES2739621T3 (es) | 2013-10-15 | 2020-02-03 | Janssen Pharmaceutica Nv | Moduladores de alcohol secundario de ROR Gamma T de tipo quinolinilo |
| US10555941B2 (en) | 2013-10-15 | 2020-02-11 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORγt |
| US9328095B2 (en) | 2013-10-15 | 2016-05-03 | Janssen Pharmaceutica Nv | Heteroaryl linked quinolinyl modulators of RORgammat |
| US9284308B2 (en) | 2013-10-15 | 2016-03-15 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of RORγt |
| ES2742843T3 (es) | 2013-10-15 | 2020-02-17 | Janssen Pharmaceutica Nv | Moduladores de quinolinilo de ROR(gamma)t |
| US9221804B2 (en) | 2013-10-15 | 2015-12-29 | Janssen Pharmaceutica Nv | Secondary alcohol quinolinyl modulators of RORγt |
| US10544134B2 (en) | 2015-09-24 | 2020-01-28 | Guizhou Bailing Group Pharmaceutical Co., Ltd. | 4-substituted coumarin derivatives and preparation methods and uses thereof |
| JOP20190058B1 (ar) | 2016-09-27 | 2023-09-17 | Merck Sharp And Dohme Llc | مشتقات كرومان، أيزوكرومان وداي هيدرو أيزو بنزوفوران كمُعدلات تفارغية سالبة mGluR2، تركيبات، واستخدامها |
| BR112020000523A2 (pt) * | 2017-07-14 | 2020-07-14 | Innate Tumor Immunity, Inc. | moduladores de nlrp3 |
| CN108299369B (zh) * | 2018-01-15 | 2021-07-30 | 安徽师范大学 | 香豆素-4-磺酸酯衍生物及其制备方法 |
| BR112021008741A2 (pt) * | 2018-11-09 | 2021-08-10 | Vivace Therapeutics, Inc. | compostos bicíclicos |
| KR20220016456A (ko) | 2019-04-16 | 2022-02-09 | 비바체 테라퓨틱스, 인크. | 바이사이클릭 화합물 |
| CN110038012B (zh) * | 2019-05-30 | 2021-06-11 | 济南大学 | 具有1,2,3-三氮唑结构片段的生物碱化合物在制备促血管生成药物中的应用 |
| WO2023034340A1 (en) * | 2021-08-30 | 2023-03-09 | Pretzel Therapeutics, Inc. | Hydroxy and alkoxy coumarins as modulators of polrmt |
| WO2023034346A1 (en) * | 2021-08-30 | 2023-03-09 | Pretzel Therapeutics, Inc. | Chromen-2-one modulators of polrmt |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5424320A (en) | 1993-06-23 | 1995-06-13 | Merck Frosst Canada, Inc. | Heteroaryl coumarins as inhibitors of leukotriene biosynthesis |
| US5410054A (en) * | 1993-07-20 | 1995-04-25 | Merck Frosst Canada, Inc. | Heteroaryl quinolines as inhibitors of leukotriene biosynthesis |
| US5552437A (en) | 1994-10-27 | 1996-09-03 | Merck Frosst Canada, Inc. | Bisarylcarbinol derivatives as inhibitors of leukotriene biosynthesis |
| US7439260B2 (en) | 2003-06-11 | 2008-10-21 | Merck Forsst Canada & Co. | 7-(1,3-thiazol-2-YL)thio-coumarin derivatives and their use as leukotriene biosynthesis inhibitors |
| AR055041A1 (es) | 2005-03-23 | 2007-08-01 | Merck Frosst Canada Ltd | Tiadiazoles y oxadiazoles como inhibidores de la sintesis de leucotrienos. composiciones farmaceuticas. |
| EP1915369A4 (de) | 2005-08-11 | 2010-09-08 | Merck Frosst Canada Ltd | Neue substituierte 1,2,3-triazolylmethylbenzothiophene oder endole und ihre verwendung als inhibitoren der leukotrienbiosynthese |
-
2008
- 2008-01-30 AR ARP080100376A patent/AR065093A1/es unknown
- 2008-01-31 CL CL200800307A patent/CL2008000307A1/es unknown
- 2008-02-01 TW TW097104101A patent/TW200838511A/zh unknown
- 2008-02-01 US US12/012,246 patent/US7960409B2/en not_active Expired - Fee Related
- 2008-02-04 PE PE2008000245A patent/PE20090041A1/es not_active Application Discontinuation
- 2008-02-05 JP JP2009547507A patent/JP5514554B2/ja not_active Expired - Fee Related
- 2008-02-05 WO PCT/CA2008/000231 patent/WO2008095293A1/en active Application Filing
- 2008-02-05 EP EP08714553A patent/EP2118093B1/de not_active Not-in-force
- 2008-02-05 WO PCT/CA2008/000230 patent/WO2008095292A1/en active Application Filing
- 2008-02-05 AT AT08714553T patent/ATE550336T1/de active
- 2008-02-05 CN CN2008800112245A patent/CN101657443B/zh not_active Expired - Fee Related
- 2008-02-05 AU AU2008213767A patent/AU2008213767B2/en not_active Ceased
- 2008-02-05 CA CA002676498A patent/CA2676498A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2118093A4 (de) | 2010-03-17 |
| AU2008213767A1 (en) | 2008-08-14 |
| CN101657443A (zh) | 2010-02-24 |
| WO2008095293A1 (en) | 2008-08-14 |
| CA2676498A1 (en) | 2008-08-14 |
| EP2118093B1 (de) | 2012-03-21 |
| CL2008000307A1 (es) | 2008-05-30 |
| CN101657443B (zh) | 2013-10-23 |
| JP5514554B2 (ja) | 2014-06-04 |
| EP2118093A1 (de) | 2009-11-18 |
| US7960409B2 (en) | 2011-06-14 |
| AR065093A1 (es) | 2009-05-13 |
| WO2008095292A1 (en) | 2008-08-14 |
| US20080188521A1 (en) | 2008-08-07 |
| JP2010517947A (ja) | 2010-05-27 |
| AU2008213767B2 (en) | 2013-06-06 |
| PE20090041A1 (es) | 2009-02-07 |
| TW200838511A (en) | 2008-10-01 |
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