ATE452635T1 - Heteroaryl-substituierte piperidin-derivate als l-cpt1-hemmer - Google Patents
Heteroaryl-substituierte piperidin-derivate als l-cpt1-hemmerInfo
- Publication number
- ATE452635T1 ATE452635T1 AT06819660T AT06819660T ATE452635T1 AT E452635 T1 ATE452635 T1 AT E452635T1 AT 06819660 T AT06819660 T AT 06819660T AT 06819660 T AT06819660 T AT 06819660T AT E452635 T1 ATE452635 T1 AT E452635T1
- Authority
- AT
- Austria
- Prior art keywords
- heteroaryl
- substituted piperidine
- piperidine derivatives
- cpt1 inhibitors
- cpt1
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05111560 | 2005-12-01 | ||
PCT/EP2006/068745 WO2007063012A1 (en) | 2005-12-01 | 2006-11-22 | Heteroaryl substituted piperidine derivatives as l-cpt1 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE452635T1 true ATE452635T1 (de) | 2010-01-15 |
Family
ID=37719360
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT06819660T ATE452635T1 (de) | 2005-12-01 | 2006-11-22 | Heteroaryl-substituierte piperidin-derivate als l-cpt1-hemmer |
Country Status (20)
Country | Link |
---|---|
US (1) | US7645776B2 (de) |
EP (1) | EP1959951B1 (de) |
JP (1) | JP4855478B2 (de) |
KR (1) | KR101135310B1 (de) |
CN (1) | CN101321525B (de) |
AR (1) | AR056821A1 (de) |
AT (1) | ATE452635T1 (de) |
AU (1) | AU2006319247B2 (de) |
BR (1) | BRPI0619086A2 (de) |
CA (1) | CA2630460C (de) |
DE (1) | DE602006011363D1 (de) |
DK (1) | DK1959951T3 (de) |
ES (1) | ES2335698T3 (de) |
NO (1) | NO20082388L (de) |
PL (1) | PL1959951T3 (de) |
PT (1) | PT1959951E (de) |
RU (1) | RU2396269C2 (de) |
TW (1) | TWI358409B (de) |
WO (1) | WO2007063012A1 (de) |
ZA (1) | ZA200804393B (de) |
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KR100847448B1 (ko) * | 2007-03-22 | 2008-07-21 | 한국화학연구원 | 3-아릴-5-알킬-1,2,4-옥사다이아졸 유도체, 그 제조방법 및이를 포함하는 비만 예방 또는 치료용 조성물 |
WO2008145596A1 (en) * | 2007-06-01 | 2008-12-04 | F. Hoffmann-La Roche Ag | Piperidine-amide derivatives |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
JP5637982B2 (ja) * | 2008-04-09 | 2014-12-10 | インフィニティー ファーマシューティカルズ, インコーポレイテッド | 脂肪酸アミド加水分解酵素の阻害剤 |
CN102264721B (zh) | 2008-11-10 | 2015-12-09 | 沃泰克斯药物股份有限公司 | 用作atr激酶抑制剂的化合物 |
KR101745331B1 (ko) | 2008-12-19 | 2017-06-09 | 버텍스 파마슈티칼스 인코포레이티드 | Atr 키나제의 억제제로서 유용한 피라진 유도체 |
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JP5571788B2 (ja) | 2009-07-23 | 2014-08-13 | ダウ コーニング コーポレーション | ダブルパターニング方法及び材料 |
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US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
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US5196418A (en) * | 1992-02-14 | 1993-03-23 | Board Of Supervisors, Louisiana State University Agricultural & Mechanical College | Hemicholinium lipids and use thereof |
KR980009257A (ko) * | 1996-07-02 | 1998-04-30 | 주상섭 | 2-히드록시프로피온산 유도체 및 그의 제조방법 |
US6207665B1 (en) * | 1997-06-12 | 2001-03-27 | Schering Aktiengesellschaft | Piperazine derivatives and their use as anti-inflammatory agents |
WO1999065881A1 (en) * | 1998-06-19 | 1999-12-23 | Nissan Chemical Industries, Ltd. | Heterocyclic compounds as hypoglycemic agents |
JP2001031652A (ja) * | 1998-06-19 | 2001-02-06 | Nissan Chem Ind Ltd | 六員環複素環類 |
WO2001034594A1 (en) * | 1999-11-12 | 2001-05-17 | Guilford Pharmaceuticals, Inc. | Dipeptidyl peptidase iv inhibitors and methods of making and using dipeptidyl peptidase iv inhibitors |
BR0315166A (pt) * | 2002-10-11 | 2005-08-16 | Astrazeneca Ab | Uso de um composto ou de um sal farmaceuticamente aceitável do mesmo, composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, método para produzir um efeito inibidor de 11betahsd1 em um animal de sangue quente, tal como o homem, que necessita de tratamento |
-
2006
- 2006-11-22 PL PL06819660T patent/PL1959951T3/pl unknown
- 2006-11-22 JP JP2008542722A patent/JP4855478B2/ja not_active Expired - Fee Related
- 2006-11-22 BR BRPI0619086-3A patent/BRPI0619086A2/pt not_active IP Right Cessation
- 2006-11-22 CA CA2630460A patent/CA2630460C/en not_active Expired - Fee Related
- 2006-11-22 RU RU2008126398/04A patent/RU2396269C2/ru not_active IP Right Cessation
- 2006-11-22 WO PCT/EP2006/068745 patent/WO2007063012A1/en active Application Filing
- 2006-11-22 AT AT06819660T patent/ATE452635T1/de active
- 2006-11-22 CN CN2006800453448A patent/CN101321525B/zh not_active Expired - Fee Related
- 2006-11-22 EP EP06819660A patent/EP1959951B1/de not_active Not-in-force
- 2006-11-22 KR KR1020087015998A patent/KR101135310B1/ko not_active IP Right Cessation
- 2006-11-22 ES ES06819660T patent/ES2335698T3/es active Active
- 2006-11-22 DK DK06819660.9T patent/DK1959951T3/da active
- 2006-11-22 DE DE602006011363T patent/DE602006011363D1/de active Active
- 2006-11-22 PT PT06819660T patent/PT1959951E/pt unknown
- 2006-11-22 AU AU2006319247A patent/AU2006319247B2/en not_active Ceased
- 2006-11-29 TW TW095144178A patent/TWI358409B/zh not_active IP Right Cessation
- 2006-11-29 US US11/605,904 patent/US7645776B2/en not_active Expired - Fee Related
- 2006-11-29 AR ARP060105273A patent/AR056821A1/es unknown
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2008
- 2008-05-21 ZA ZA200804393A patent/ZA200804393B/xx unknown
- 2008-05-26 NO NO20082388A patent/NO20082388L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU2006319247B2 (en) | 2010-03-11 |
CA2630460C (en) | 2013-01-08 |
CN101321525A (zh) | 2008-12-10 |
PT1959951E (pt) | 2010-03-02 |
EP1959951A1 (de) | 2008-08-27 |
BRPI0619086A2 (pt) | 2011-09-20 |
DE602006011363D1 (de) | 2010-02-04 |
EP1959951B1 (de) | 2009-12-23 |
US7645776B2 (en) | 2010-01-12 |
TW200804357A (en) | 2008-01-16 |
RU2008126398A (ru) | 2010-01-10 |
AR056821A1 (es) | 2007-10-24 |
DK1959951T3 (da) | 2010-03-01 |
RU2396269C2 (ru) | 2010-08-10 |
KR101135310B1 (ko) | 2012-04-12 |
TWI358409B (en) | 2012-02-21 |
AU2006319247A1 (en) | 2007-06-07 |
ZA200804393B (en) | 2009-04-29 |
CN101321525B (zh) | 2013-01-30 |
NO20082388L (no) | 2008-08-26 |
AU2006319247A8 (en) | 2008-07-17 |
JP2009517438A (ja) | 2009-04-30 |
US20070129544A1 (en) | 2007-06-07 |
CA2630460A1 (en) | 2007-06-07 |
KR20080072097A (ko) | 2008-08-05 |
JP4855478B2 (ja) | 2012-01-18 |
ES2335698T3 (es) | 2010-03-31 |
WO2007063012A1 (en) | 2007-06-07 |
PL1959951T3 (pl) | 2010-06-30 |
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