ATE521607T1 - Piperidinderivate als renin-inhibitoren - Google Patents

Piperidinderivate als renin-inhibitoren

Info

Publication number
ATE521607T1
ATE521607T1 AT05761185T AT05761185T ATE521607T1 AT E521607 T1 ATE521607 T1 AT E521607T1 AT 05761185 T AT05761185 T AT 05761185T AT 05761185 T AT05761185 T AT 05761185T AT E521607 T1 ATE521607 T1 AT E521607T1
Authority
AT
Austria
Prior art keywords
renin inhibitors
piperidine derivatives
piperidine
derivatives
renin
Prior art date
Application number
AT05761185T
Other languages
English (en)
Inventor
Peter Herold
Robert Mah
Stefan Stutz
Aleksandar Stojanovic
Vincenzo Tschinke
Nathalie Jotterand
Dirk Behnke
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of ATE521607T1 publication Critical patent/ATE521607T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
AT05761185T 2004-07-09 2005-07-11 Piperidinderivate als renin-inhibitoren ATE521607T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH11582004 2004-07-09
PCT/EP2005/053306 WO2006005741A2 (en) 2004-07-09 2005-07-11 Piperdine derivatives as renin inhibitors

Publications (1)

Publication Number Publication Date
ATE521607T1 true ATE521607T1 (de) 2011-09-15

Family

ID=35448323

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05761185T ATE521607T1 (de) 2004-07-09 2005-07-11 Piperidinderivate als renin-inhibitoren

Country Status (14)

Country Link
US (1) US20080076766A1 (de)
EP (1) EP1776359B1 (de)
JP (1) JP4842262B2 (de)
CN (1) CN101014594A (de)
AR (1) AR053406A1 (de)
AT (1) ATE521607T1 (de)
BR (1) BRPI0513199A (de)
CA (1) CA2570920A1 (de)
ES (1) ES2372502T3 (de)
IL (1) IL180242A0 (de)
PL (1) PL1776359T3 (de)
PT (1) PT1776359E (de)
TW (1) TW200613274A (de)
WO (1) WO2006005741A2 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008510755A (ja) 2004-08-25 2008-04-10 アクテリオン ファーマシューティカルズ リミテッド ビシクロノネン誘導体
GB0428526D0 (en) 2004-12-30 2005-02-09 Novartis Ag Organic compounds
AR053836A1 (es) * 2005-03-31 2007-05-23 Speedel Experimenta Ag Piperdinas 3,4,5-sustituidas
TW200722424A (en) 2005-03-31 2007-06-16 Speedel Experimenta Ag Substituted piperidines
EP1707202A1 (de) * 2005-03-31 2006-10-04 Speedel Experimenta AG Organische Verbindungen
GB0508992D0 (en) * 2005-05-03 2005-06-08 Novartis Ag Organic compounds
GB0510810D0 (en) * 2005-05-26 2005-06-29 Novartis Ag Organic compounds
AU2006253805A1 (en) 2005-05-27 2006-12-07 Actelion Pharmaceuticals Ltd. Novel piperidine carboxylic acid amide derivatives
GB0514203D0 (en) * 2005-07-11 2005-08-17 Novartis Ag Organic compounds
JP5306821B2 (ja) 2005-12-30 2013-10-02 ノバルティス アーゲー レニン阻害剤としての３，５−置換ピペリジン化合物
EP1816122A3 (de) * 2006-01-19 2007-09-19 Speedel Experimenta AG 3,4,5-substituierte Piperidine als therapeutische Zusammensetzungen
TW200804359A (en) * 2006-01-19 2008-01-16 Speedel Experimenta Ag Substituted 4-phenylpiperidines
TW200821303A (en) * 2006-08-08 2008-05-16 Speedel Experimenta Ag Organic compounds
EP1908761A1 (de) * 2006-10-04 2008-04-09 Speedel Experimenta AG Organische Verbindungen
EP1911758A1 (de) * 2006-10-04 2008-04-16 Speedel Experimenta AG Phenylpiperidinderivative zur Verwendung als Renin Inhibitoren
WO2008074450A2 (en) * 2006-12-20 2008-06-26 Nicox S.A. Non-peptidic renin inhibitors nitroderivatives
TWI452044B (zh) 2007-06-15 2014-09-11 Mitsubishi Tanabe Pharma Corp 嗎啉衍生物
EP2527338B1 (de) 2007-06-25 2015-05-06 Novartis AG N5-(2-ethoxyethyl)-n3-(2-pyridinyl) -3,5-piperidinedicarboxamide derivate als renin inhibitoren
TW200922596A (en) * 2007-10-25 2009-06-01 Speedel Experimenta Ag 4,4-disubstituted piperidines
TW200932241A (en) 2007-12-05 2009-08-01 Speedel Experimenta Ag Organic compounds
CN101939318A (zh) 2008-02-08 2011-01-05 诺瓦提斯公司 作为肾素抑制剂的取代的哌啶化合物
JP2011511038A (ja) * 2008-02-08 2011-04-07 ノバルティス アーゲー レニン阻害剤としての置換ピペリジン
WO2009106599A2 (en) * 2008-02-29 2009-09-03 Novartis Ag Substituted piperidines as therapeutic compounds
WO2009127251A1 (en) * 2008-04-16 2009-10-22 Novartis Ag Combinations comprising a renin inhibitor
JP4790871B2 (ja) * 2008-05-05 2011-10-12 メルク フロスト カナダ リミテツド レニン阻害剤としての３，４−置換ピペリジン誘導体
PE20140858A1 (es) 2008-06-19 2014-08-04 Takeda Pharmaceutical Derivados de piperidina como inhibidores de renina
EP2163245A1 (de) 2008-09-10 2010-03-17 Novartis Ag Renin-Inhibitoren zur Behandlung von Psoriasis
USRE49686E1 (en) 2008-09-19 2023-10-10 Takeda Pharmaceutical Company Limited Nitrogen-containing heterocyclic compound and use of same
CA2756780A1 (en) * 2009-04-03 2010-10-07 Merck Sharp & Dohme Corp. Renin inhibitors
EP2384745A3 (de) 2010-05-05 2012-01-18 Sanovel Ilac Sanayi ve Ticaret A.S. Pharmazeutische Zusammensetzungen mit modifizierter Freisetzung aus Dexlansoprazol
US8563035B2 (en) 2010-05-05 2013-10-22 Sanovel Ilac Sanayi Ve Ticaret Anomin Sirketi Oral tablet compositions of dexlansoprazole
EP2384746A3 (de) 2010-05-05 2012-03-07 Sanovel Ilac Sanayi ve Ticaret A.S. Orale Tablettenzusammensetzungen aus Dexlansoprazol mit dualer Freisetzung
US20250263413A1 (en) * 2020-12-02 2025-08-21 Qurient Co., Ltd. Compounds having cyclin-dependent kinase(cdk)-inhibitory function
AU2023235233A1 (en) 2022-03-14 2024-09-12 Slap Pharmaceuticals Llc Multicyclic compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL123293A (en) * 1995-09-07 2003-06-24 Hoffmann La Roche Piperidine derivatives, their preparation and pharmaceutical compositions containing them
US6197959B1 (en) * 1999-04-27 2001-03-06 Hoffmann-La Roche Inc. Piperidine derivatives
US6376672B1 (en) * 1999-04-27 2002-04-23 Hoffmann-La Roche Inc. Naphthalenylmethoxypiperidines as renin inhibitors
AU2002256418A1 (en) * 2001-04-27 2002-11-11 Vertex Pharmaceuticals Incorporated Inhibitors of bace
US20040204455A1 (en) * 2003-04-10 2004-10-14 Cody Wayne Livingston Piperidine derivative rennin inhibitors

Also Published As

Publication number Publication date
JP2008505871A (ja) 2008-02-28
JP4842262B2 (ja) 2011-12-21
CA2570920A1 (en) 2006-01-19
WO2006005741A2 (en) 2006-01-19
US20080076766A1 (en) 2008-03-27
EP1776359A2 (de) 2007-04-25
TW200613274A (en) 2006-05-01
BRPI0513199A (pt) 2008-04-29
ES2372502T3 (es) 2012-01-20
IL180242A0 (en) 2007-07-04
AR053406A1 (es) 2007-05-09
PT1776359E (pt) 2011-12-15
WO2006005741A3 (en) 2006-07-06
CN101014594A (zh) 2007-08-08
HK1104037A1 (en) 2008-01-04
PL1776359T3 (pl) 2012-01-31
EP1776359B1 (de) 2011-08-24

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