ATE400271T1 - Aryl-pyridinderivate als 11-beta-hsd1-hemmer - Google Patents
Aryl-pyridinderivate als 11-beta-hsd1-hemmerInfo
- Publication number
- ATE400271T1 ATE400271T1 AT05776709T AT05776709T ATE400271T1 AT E400271 T1 ATE400271 T1 AT E400271T1 AT 05776709 T AT05776709 T AT 05776709T AT 05776709 T AT05776709 T AT 05776709T AT E400271 T1 ATE400271 T1 AT E400271T1
- Authority
- AT
- Austria
- Prior art keywords
- beta
- aryl
- pyridine derivatives
- hsd1 inhibitors
- hsd1
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Child & Adolescent Psychology (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04103639 | 2004-07-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE400271T1 true ATE400271T1 (de) | 2008-07-15 |
Family
ID=35427898
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05776709T ATE400271T1 (de) | 2004-07-28 | 2005-07-20 | Aryl-pyridinderivate als 11-beta-hsd1-hemmer |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US7528159B2 (de) |
| EP (1) | EP1789041B1 (de) |
| JP (1) | JP4690402B2 (de) |
| KR (1) | KR100926842B1 (de) |
| CN (1) | CN100589803C (de) |
| AR (1) | AR049739A1 (de) |
| AT (1) | ATE400271T1 (de) |
| AU (1) | AU2005266531B2 (de) |
| BR (1) | BRPI0513864A (de) |
| CA (1) | CA2574875C (de) |
| DE (1) | DE602005008079D1 (de) |
| DK (1) | DK1789041T3 (de) |
| ES (1) | ES2309789T3 (de) |
| HR (1) | HRP20080477T3 (de) |
| IL (1) | IL180481A (de) |
| MX (1) | MX2007000789A (de) |
| MY (1) | MY138941A (de) |
| NO (1) | NO20070458L (de) |
| NZ (1) | NZ552398A (de) |
| PL (1) | PL1789041T3 (de) |
| PT (1) | PT1789041E (de) |
| RU (1) | RU2374239C2 (de) |
| SI (1) | SI1789041T1 (de) |
| TW (1) | TW200608972A (de) |
| WO (1) | WO2006010546A2 (de) |
| ZA (1) | ZA200700181B (de) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2374239C2 (ru) * | 2004-07-28 | 2009-11-27 | Ф.Хоффманн-Ля Рош Аг | Производные арилпиридина |
| WO2006106423A2 (en) * | 2005-04-07 | 2006-10-12 | Pfizer Inc. | Amino sulfonyl derivatives as inhibitors of human 11-.beta.-hydrosysteroid dehydrogenase |
| US7632838B2 (en) * | 2006-02-07 | 2009-12-15 | Wyeth | 11-beta HSD1 inhibitors |
| PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| BRPI0715160A2 (pt) | 2006-08-08 | 2013-06-11 | Sanofi Aventis | imidazolidina-2,4-dionas substituÍdas por arilamimoaril-alquil-, processo para preparÁ-las, medicamentos compeendendo estes compostos, e seu uso |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| WO2010003624A2 (en) | 2008-07-09 | 2010-01-14 | Sanofi-Aventis | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
| US20100022572A1 (en) | 2008-07-18 | 2010-01-28 | Kowa Company, Ltd. | Novel spiro compound and medicine comprising the same |
| TW201010975A (en) | 2008-08-29 | 2010-03-16 | Kowa Co | 1-adamantylazetidin-2-one derivatives and drugs containing same |
| EP2348019A4 (de) | 2008-10-29 | 2012-10-31 | Kowa Co | 1,2-diazetidin-3-on-derivat und pharmazeutischer wirkstoff damit |
| WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
| BRPI1010600A2 (pt) | 2009-05-15 | 2016-03-15 | Novartis Ag | aril piridina como inibidores de aldosterona sintase |
| DK2470552T3 (en) | 2009-08-26 | 2014-02-17 | Sanofi Sa | NOVEL, CRYSTALLINE, heteroaromatic FLUORGLYCOSIDHYDRATER, MEDICINES COVERING THESE COMPOUNDS AND THEIR USE |
| WO2011068927A2 (en) * | 2009-12-04 | 2011-06-09 | Abbott Laboratories | 11-β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11B-HSD1) INHIBITORS AND USES THEREOF |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8933024B2 (en) | 2010-06-18 | 2015-01-13 | Sanofi | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| WO2012120050A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2683704B1 (de) | 2011-03-08 | 2014-12-17 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8809325B2 (en) | 2011-03-08 | 2014-08-19 | Sanofi | Benzyl-oxathiazine derivatives substituted with adamantane and noradamantane, medicaments containing said compounds and use thereof |
| WO2012120054A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8710050B2 (en) | 2011-03-08 | 2014-04-29 | Sanofi | Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120058A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2766349B1 (de) | 2011-03-08 | 2016-06-01 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2683703B1 (de) | 2011-03-08 | 2015-05-27 | Sanofi | Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8987445B2 (en) * | 2011-03-16 | 2015-03-24 | Mitsubishi Tanabe Pharma Corporation | Sulfonamide compounds having TRPM8 antagonistic activity |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2817292B1 (de) | 2012-02-22 | 2019-12-18 | Sanford-Burnham Medical Research Institute | Sulfonamidverbindungen und verwendungen als tnap-inhibitoren |
| HK1211019A1 (en) * | 2012-12-10 | 2016-05-13 | F. Hoffmann-La Roche Ag | Benzyl sulfonamide derivatives as rorc modulators |
| CN105175323B (zh) * | 2015-09-16 | 2017-12-22 | 浙江海翔药业股份有限公司 | 一种制备2‑（4‑乙酰胺基苯磺酰基）胺基吡啶的方法 |
| CA3086668A1 (en) * | 2018-02-05 | 2019-08-08 | Universite De Strasbourg | Compounds and compositions for the treatment of pain |
| MD3762368T2 (ro) | 2018-03-08 | 2022-07-31 | Incyte Corp | Compuși diol aminopirazină ca inhibitori ai PI3K-Y |
| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
| AU2019318209B2 (en) | 2018-08-10 | 2025-09-25 | Diapin Therapeutics, Llc | Tri-peptides and treatment of metabolic, cardiovascular and inflammatory disorders |
| KR102418518B1 (ko) * | 2020-08-05 | 2022-07-07 | 성균관대학교산학협력단 | 설퍼 일라이드를 이용한 n-헤테로고리의 선택적 알킬화 방법 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5703096A (en) * | 1994-10-07 | 1997-12-30 | Sankyo Company, Limited | Oxime derivatives, their preparation and their therapeutic use |
| BR0214344A (pt) | 2001-11-22 | 2004-09-14 | Biovitrum Ab | Inibidores de 11 - beta - hidroxi esteróide desidrogenase tipo 1 |
| EP1461325B1 (de) * | 2001-11-22 | 2010-05-26 | Biovitrum Ab | Inhibitoren von 11-beta-hydroxysteroiddehydrogenase typ 1 |
| JP2005533858A (ja) * | 2002-07-27 | 2005-11-10 | アストラゼネカ アクチボラグ | 化合物 |
| RU2374239C2 (ru) * | 2004-07-28 | 2009-11-27 | Ф.Хоффманн-Ля Рош Аг | Производные арилпиридина |
-
2005
- 2005-07-20 RU RU2007107189/04A patent/RU2374239C2/ru not_active IP Right Cessation
- 2005-07-20 MX MX2007000789A patent/MX2007000789A/es active IP Right Grant
- 2005-07-20 KR KR1020077002036A patent/KR100926842B1/ko not_active Expired - Fee Related
- 2005-07-20 NZ NZ552398A patent/NZ552398A/en not_active IP Right Cessation
- 2005-07-20 ES ES05776709T patent/ES2309789T3/es not_active Expired - Lifetime
- 2005-07-20 SI SI200530343T patent/SI1789041T1/sl unknown
- 2005-07-20 CA CA2574875A patent/CA2574875C/en not_active Expired - Fee Related
- 2005-07-20 PT PT05776709T patent/PT1789041E/pt unknown
- 2005-07-20 PL PL05776709T patent/PL1789041T3/pl unknown
- 2005-07-20 BR BRPI0513864-7A patent/BRPI0513864A/pt not_active IP Right Cessation
- 2005-07-20 WO PCT/EP2005/007894 patent/WO2006010546A2/en not_active Ceased
- 2005-07-20 DE DE602005008079T patent/DE602005008079D1/de not_active Expired - Lifetime
- 2005-07-20 DK DK05776709T patent/DK1789041T3/da active
- 2005-07-20 HR HR20080477T patent/HRP20080477T3/xx unknown
- 2005-07-20 JP JP2007522984A patent/JP4690402B2/ja not_active Expired - Fee Related
- 2005-07-20 AU AU2005266531A patent/AU2005266531B2/en not_active Ceased
- 2005-07-20 AT AT05776709T patent/ATE400271T1/de active
- 2005-07-20 CN CN200580025005A patent/CN100589803C/zh not_active Expired - Fee Related
- 2005-07-20 EP EP05776709A patent/EP1789041B1/de not_active Expired - Lifetime
- 2005-07-25 TW TW094125138A patent/TW200608972A/zh unknown
- 2005-07-26 US US11/189,598 patent/US7528159B2/en not_active Expired - Fee Related
- 2005-07-26 AR ARP050103098A patent/AR049739A1/es unknown
- 2005-07-26 MY MYPI20053431A patent/MY138941A/en unknown
-
2007
- 2007-01-01 IL IL180481A patent/IL180481A/en not_active IP Right Cessation
- 2007-01-05 ZA ZA200700181A patent/ZA200700181B/xx unknown
- 2007-01-24 NO NO20070458A patent/NO20070458L/no not_active Application Discontinuation
-
2009
- 2009-02-17 US US12/372,244 patent/US8211913B2/en not_active Expired - Fee Related
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| Date | Code | Title | Description |
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| UEP | Publication of translation of european patent specification |
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