DE602005008079D1 - Aryl-pyridinderivate als 11-beta-hsd1-hemmer - Google Patents
Aryl-pyridinderivate als 11-beta-hsd1-hemmerInfo
- Publication number
- DE602005008079D1 DE602005008079D1 DE602005008079T DE602005008079T DE602005008079D1 DE 602005008079 D1 DE602005008079 D1 DE 602005008079D1 DE 602005008079 T DE602005008079 T DE 602005008079T DE 602005008079 T DE602005008079 T DE 602005008079T DE 602005008079 D1 DE602005008079 D1 DE 602005008079D1
- Authority
- DE
- Germany
- Prior art keywords
- beta
- pyridine derivatives
- hsd1 inhibitors
- aryl pyridine
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04103639 | 2004-07-28 | ||
| PCT/EP2005/007894 WO2006010546A2 (en) | 2004-07-28 | 2005-07-20 | Aryl-pyridine derivatives as 11-beta-hsd1 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602005008079D1 true DE602005008079D1 (de) | 2008-08-21 |
Family
ID=35427898
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602005008079T Active DE602005008079D1 (de) | 2004-07-28 | 2005-07-20 | Aryl-pyridinderivate als 11-beta-hsd1-hemmer |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US7528159B2 (de) |
| EP (1) | EP1789041B1 (de) |
| JP (1) | JP4690402B2 (de) |
| KR (1) | KR100926842B1 (de) |
| CN (1) | CN100589803C (de) |
| AR (1) | AR049739A1 (de) |
| AT (1) | ATE400271T1 (de) |
| AU (1) | AU2005266531B2 (de) |
| BR (1) | BRPI0513864A (de) |
| CA (1) | CA2574875C (de) |
| DE (1) | DE602005008079D1 (de) |
| DK (1) | DK1789041T3 (de) |
| ES (1) | ES2309789T3 (de) |
| HK (1) | HK1105592A1 (de) |
| HR (1) | HRP20080477T3 (de) |
| IL (1) | IL180481A (de) |
| MX (1) | MX2007000789A (de) |
| MY (1) | MY138941A (de) |
| NO (1) | NO20070458L (de) |
| NZ (1) | NZ552398A (de) |
| PL (1) | PL1789041T3 (de) |
| PT (1) | PT1789041E (de) |
| RU (1) | RU2374239C2 (de) |
| SI (1) | SI1789041T1 (de) |
| TW (1) | TW200608972A (de) |
| WO (1) | WO2006010546A2 (de) |
| ZA (1) | ZA200700181B (de) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ552398A (en) * | 2004-07-28 | 2010-08-27 | Hoffmann La Roche | Aryl-pyridine derivatives as 11-beta-HSD1 inhibitors for treatment of diabetes |
| WO2006106423A2 (en) * | 2005-04-07 | 2006-10-12 | Pfizer Inc. | Amino sulfonyl derivatives as inhibitors of human 11-.beta.-hydrosysteroid dehydrogenase |
| RU2008132333A (ru) * | 2006-02-07 | 2010-03-20 | Вайет (Us) | Ингибиторы 11-бета hsd1 |
| PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
| BRPI0715160A2 (pt) | 2006-08-08 | 2013-06-11 | Sanofi Aventis | imidazolidina-2,4-dionas substituÍdas por arilamimoaril-alquil-, processo para preparÁ-las, medicamentos compeendendo estes compostos, e seu uso |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| AR072707A1 (es) | 2008-07-09 | 2010-09-15 | Sanofi Aventis | Compuestos heterociclicos, procesos para su preparacion, medicamentos que comprenden estos compuestos y el uso de los mismos |
| US20100022572A1 (en) | 2008-07-18 | 2010-01-28 | Kowa Company, Ltd. | Novel spiro compound and medicine comprising the same |
| EP2322505A4 (de) | 2008-08-29 | 2011-10-19 | Kowa Co | 1-adamantylazetidin-2-on-derivat, herstellung davon und pharmazeutisches präparat damit |
| TW201022210A (en) | 2008-10-29 | 2010-06-16 | Kowa Co | 1,2-diazetidin-3-one derivatives and drugs containing same |
| WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
| PL2429995T3 (pl) | 2009-05-15 | 2014-07-31 | Novartis Ag | Arylopirydyny jako inhibitory syntazy aldosteronu |
| RU2012111354A (ru) | 2009-08-26 | 2013-10-10 | Санофи | Новые кристаллические гидраты фторгликозидов, содержащие их фармацевтические препараты и их использование |
| WO2011068927A2 (en) * | 2009-12-04 | 2011-06-09 | Abbott Laboratories | 11-β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11B-HSD1) INHIBITORS AND USES THEREOF |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8933024B2 (en) | 2010-06-18 | 2015-01-13 | Sanofi | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| WO2012120054A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120058A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683704B1 (de) | 2011-03-08 | 2014-12-17 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120055A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683698B1 (de) | 2011-03-08 | 2017-10-04 | Sanofi | Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8901114B2 (en) | 2011-03-08 | 2014-12-02 | Sanofi | Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof |
| EP2683702B1 (de) | 2011-03-08 | 2014-12-24 | Sanofi | Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683703B1 (de) | 2011-03-08 | 2015-05-27 | Sanofi | Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2012124825A1 (en) * | 2011-03-16 | 2012-09-20 | Mitsubishi Tanabe Pharma Corporation | Sulfonamide compounds having trpm8 antagonistic activity |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| BR112014020773A2 (pt) * | 2012-02-22 | 2020-10-27 | Sanford-Burnham Medical Research Institute | compostos de sulfonamida e seus usos como inibidores tnap |
| CN104684891A (zh) * | 2012-12-10 | 2015-06-03 | 弗·哈夫曼-拉罗切有限公司 | 作为RORc调节剂的苄基磺酰胺衍生物 |
| CN105175323B (zh) * | 2015-09-16 | 2017-12-22 | 浙江海翔药业股份有限公司 | 一种制备2‑（4‑乙酰胺基苯磺酰基）胺基吡啶的方法 |
| WO2019149965A1 (en) * | 2018-02-05 | 2019-08-08 | Universite De Strasbourg | Compounds and compositions for the treatment of pain |
| KR20200142508A (ko) | 2018-03-08 | 2020-12-22 | 인사이트 코포레이션 | PI3K-γ 저해제로서의 아미노피라진 다이올 화합물 |
| WO2020010003A1 (en) | 2018-07-02 | 2020-01-09 | Incyte Corporation | AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS |
| KR102418518B1 (ko) * | 2020-08-05 | 2022-07-07 | 성균관대학교산학협력단 | 설퍼 일라이드를 이용한 n-헤테로고리의 선택적 알킬화 방법 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2159938A1 (en) * | 1994-10-07 | 1996-04-08 | Hiroaki Yanagisawa | Oxime derivatives, their preparation and their therapeutic use |
| ATE469136T1 (de) * | 2001-11-22 | 2010-06-15 | Biovitrum Ab | Inhibitoren von 11-beta- hydroxysteroiddehydrogenase typ 1 |
| BR0214344A (pt) * | 2001-11-22 | 2004-09-14 | Biovitrum Ab | Inibidores de 11 - beta - hidroxi esteróide desidrogenase tipo 1 |
| EP1549600A1 (de) * | 2002-07-27 | 2005-07-06 | AstraZeneca AB | Ketone |
| NZ552398A (en) * | 2004-07-28 | 2010-08-27 | Hoffmann La Roche | Aryl-pyridine derivatives as 11-beta-HSD1 inhibitors for treatment of diabetes |
-
2005
- 2005-07-20 NZ NZ552398A patent/NZ552398A/en not_active IP Right Cessation
- 2005-07-20 SI SI200530343T patent/SI1789041T1/sl unknown
- 2005-07-20 WO PCT/EP2005/007894 patent/WO2006010546A2/en active IP Right Grant
- 2005-07-20 MX MX2007000789A patent/MX2007000789A/es active IP Right Grant
- 2005-07-20 ES ES05776709T patent/ES2309789T3/es active Active
- 2005-07-20 AU AU2005266531A patent/AU2005266531B2/en not_active Ceased
- 2005-07-20 BR BRPI0513864-7A patent/BRPI0513864A/pt not_active IP Right Cessation
- 2005-07-20 JP JP2007522984A patent/JP4690402B2/ja not_active Expired - Fee Related
- 2005-07-20 PL PL05776709T patent/PL1789041T3/pl unknown
- 2005-07-20 AT AT05776709T patent/ATE400271T1/de active
- 2005-07-20 EP EP05776709A patent/EP1789041B1/de active Active
- 2005-07-20 DE DE602005008079T patent/DE602005008079D1/de active Active
- 2005-07-20 RU RU2007107189/04A patent/RU2374239C2/ru not_active IP Right Cessation
- 2005-07-20 PT PT05776709T patent/PT1789041E/pt unknown
- 2005-07-20 CA CA2574875A patent/CA2574875C/en not_active Expired - Fee Related
- 2005-07-20 DK DK05776709T patent/DK1789041T3/da active
- 2005-07-20 KR KR1020077002036A patent/KR100926842B1/ko not_active IP Right Cessation
- 2005-07-20 CN CN200580025005A patent/CN100589803C/zh not_active Expired - Fee Related
- 2005-07-25 TW TW094125138A patent/TW200608972A/zh unknown
- 2005-07-26 US US11/189,598 patent/US7528159B2/en not_active Expired - Fee Related
- 2005-07-26 AR ARP050103098A patent/AR049739A1/es unknown
- 2005-07-26 MY MYPI20053431A patent/MY138941A/en unknown
-
2007
- 2007-01-01 IL IL180481A patent/IL180481A/en not_active IP Right Cessation
- 2007-01-05 ZA ZA200700181A patent/ZA200700181B/xx unknown
- 2007-01-24 NO NO20070458A patent/NO20070458L/no not_active Application Discontinuation
- 2007-12-20 HK HK07114003.9A patent/HK1105592A1/xx not_active IP Right Cessation
-
2008
- 2008-09-26 HR HR20080477T patent/HRP20080477T3/xx unknown
-
2009
- 2009-02-17 US US12/372,244 patent/US8211913B2/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |