BR112015007862A2 - derivados benzil sulfonamida como moduladores rorc - Google Patents
derivados benzil sulfonamida como moduladores rorcInfo
- Publication number
- BR112015007862A2 BR112015007862A2 BR112015007862A BR112015007862A BR112015007862A2 BR 112015007862 A2 BR112015007862 A2 BR 112015007862A2 BR 112015007862 A BR112015007862 A BR 112015007862A BR 112015007862 A BR112015007862 A BR 112015007862A BR 112015007862 A2 BR112015007862 A2 BR 112015007862A2
- Authority
- BR
- Brazil
- Prior art keywords
- sulfonamide derivatives
- benzyl sulfonamide
- rorc modulators
- rorc
- modulators
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
- C07C311/44—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/46—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/14—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Epidemiology (AREA)
Abstract
1/1 resumo "derivados benzil sulfonamida como moduladores rorc" os compostos da fórmula ia ou ib, ou sais farmaceuticamente aceitáveis dos mesmos, em que m, n, r, a, x1, x2, x3, x4, y, z, r1, r2, r3, r4, r5, r6, r7, e r8 estão de acordo com o definido no presente documento. também são descritos métodos de preparação dos compostos e emprego dos mesmos para o tratamento de doenças inflamatórias tais como artrite.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261735364P | 2012-12-10 | 2012-12-10 | |
PCT/EP2013/075876 WO2014090710A1 (en) | 2012-12-10 | 2013-12-09 | BENZYL SULFONAMIDE DERIVATIVES AS RORc MODULATORS |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112015007862A2 true BR112015007862A2 (pt) | 2017-07-04 |
Family
ID=49753168
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015007862A BR112015007862A2 (pt) | 2012-12-10 | 2013-12-09 | derivados benzil sulfonamida como moduladores rorc |
Country Status (11)
Country | Link |
---|---|
US (1) | US9302985B2 (pt) |
EP (1) | EP2928863A1 (pt) |
JP (1) | JP6367823B2 (pt) |
KR (1) | KR20150092162A (pt) |
CN (2) | CN108409613A (pt) |
BR (1) | BR112015007862A2 (pt) |
CA (1) | CA2886471A1 (pt) |
HK (2) | HK1211019A1 (pt) |
MX (1) | MX2015006844A (pt) |
RU (1) | RU2015124564A (pt) |
WO (1) | WO2014090710A1 (pt) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105899507B (zh) * | 2014-01-10 | 2019-06-07 | 豪夫迈·罗氏有限公司 | 作为RORc调节剂的芳基磺内酰胺衍生物 |
CN104892470B (zh) * | 2015-06-11 | 2017-04-12 | 嘉兴学院 | 制备n‑烷基对甲苯磺酰胺的方法 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005090297A1 (en) * | 2004-03-19 | 2005-09-29 | Biotie Therapies Corporation | Sulphonamide derivatives |
KR100926842B1 (ko) * | 2004-07-28 | 2009-11-13 | 에프. 호프만-라 로슈 아게 | 11-베타-hsd1 억제제로서의 아릴-피리딘 유도체 |
PE20080906A1 (es) * | 2006-08-17 | 2008-07-05 | Kemia Inc | Derivados heteroarilo como inhibidores de citocina |
WO2008042867A2 (en) * | 2006-09-29 | 2008-04-10 | Emiliem Inc. | Modulators of multiple kinases |
US9422235B2 (en) * | 2006-12-19 | 2016-08-23 | Pharmos Corporation | Sulfonamide derivatives with therapeutic indications |
GB0705400D0 (en) * | 2007-03-21 | 2007-05-02 | Univ Aberdeen | Therapeutic compounds andm their use |
US8039493B2 (en) * | 2007-09-27 | 2011-10-18 | Hoffmann-La Roche Inc. | Biaryl sulfonamide derivatives |
US20100311736A1 (en) * | 2007-10-22 | 2010-12-09 | Glaxosmithkline Llc | Pyridosulfonamide derivatives as p13 kinase inhibitors |
US20100197688A1 (en) * | 2008-05-29 | 2010-08-05 | Nantermet Philippe G | Epha4 rtk inhibitors for treatment of neurological and neurodegenerative disorders and cancer |
GB0817208D0 (en) * | 2008-09-19 | 2008-10-29 | Pimco 2664 Ltd | Therapeutic apsap compounds and their use |
WO2010102154A2 (en) * | 2009-03-05 | 2010-09-10 | Ligand Pharmaceuticals Incorporated | Biaryl oxyacetic acid compounds |
WO2011115892A1 (en) * | 2010-03-15 | 2011-09-22 | Griffin Patrick R | Modulators of the retinoic acid receptor-related orphan receptors |
US9586928B2 (en) * | 2011-05-16 | 2017-03-07 | The Scripps Research Institute | Modulators of the nuclear hormone receptor ROR |
GB201116641D0 (en) * | 2011-09-27 | 2011-11-09 | Glaxo Group Ltd | Novel compounds |
US20130190356A1 (en) * | 2011-12-22 | 2013-07-25 | Genentech, Inc. | Benzyl sulfonamide derivatives as rorc modulators |
CA2871534A1 (en) * | 2012-04-27 | 2013-10-31 | Glaxo Group Limited | Novel compounds |
-
2013
- 2013-12-09 JP JP2015546044A patent/JP6367823B2/ja not_active Expired - Fee Related
- 2013-12-09 MX MX2015006844A patent/MX2015006844A/es unknown
- 2013-12-09 EP EP13802615.8A patent/EP2928863A1/en not_active Withdrawn
- 2013-12-09 RU RU2015124564A patent/RU2015124564A/ru not_active Application Discontinuation
- 2013-12-09 KR KR1020157015243A patent/KR20150092162A/ko not_active Application Discontinuation
- 2013-12-09 BR BR112015007862A patent/BR112015007862A2/pt not_active Application Discontinuation
- 2013-12-09 CN CN201810251113.7A patent/CN108409613A/zh active Pending
- 2013-12-09 CN CN201380051310.XA patent/CN104684891A/zh active Pending
- 2013-12-09 CA CA 2886471 patent/CA2886471A1/en not_active Abandoned
- 2013-12-09 WO PCT/EP2013/075876 patent/WO2014090710A1/en active Application Filing
- 2013-12-10 US US14/101,561 patent/US9302985B2/en not_active Expired - Fee Related
-
2015
- 2015-12-02 HK HK15111850.9A patent/HK1211019A1/xx unknown
-
2019
- 2019-01-28 HK HK19101448.5A patent/HK1258966A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
JP2016502975A (ja) | 2016-02-01 |
MX2015006844A (es) | 2015-09-16 |
CA2886471A1 (en) | 2014-06-19 |
RU2015124564A (ru) | 2017-01-12 |
WO2014090710A1 (en) | 2014-06-19 |
HK1258966A1 (zh) | 2019-11-22 |
KR20150092162A (ko) | 2015-08-12 |
US20140163110A1 (en) | 2014-06-12 |
JP6367823B2 (ja) | 2018-08-01 |
CN104684891A (zh) | 2015-06-03 |
EP2928863A1 (en) | 2015-10-14 |
HK1211019A1 (en) | 2016-05-13 |
US9302985B2 (en) | 2016-04-05 |
CN108409613A (zh) | 2018-08-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law | ||
B07E | Notice of approval relating to section 229 industrial property law | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: suspension of the patent application procedure | ||
B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |