ATE423121T1 - Diphenylimidazopyrimidin- und -imidazolamine als b-sekretase-inhibitoren - Google Patents
Diphenylimidazopyrimidin- und -imidazolamine als b-sekretase-inhibitorenInfo
- Publication number
- ATE423121T1 ATE423121T1 AT05758187T AT05758187T ATE423121T1 AT E423121 T1 ATE423121 T1 AT E423121T1 AT 05758187 T AT05758187 T AT 05758187T AT 05758187 T AT05758187 T AT 05758187T AT E423121 T1 ATE423121 T1 AT E423121T1
- Authority
- AT
- Austria
- Prior art keywords
- diphenylimidazopyrimidine
- imidazolamine
- secretase inhibitors
- secretase
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58018704P | 2004-06-16 | 2004-06-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE423121T1 true ATE423121T1 (de) | 2009-03-15 |
Family
ID=34982285
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05758187T ATE423121T1 (de) | 2004-06-16 | 2005-06-14 | Diphenylimidazopyrimidin- und -imidazolamine als b-sekretase-inhibitoren |
Country Status (24)
Country | Link |
---|---|
US (2) | US7456186B2 (de) |
EP (1) | EP1758907B1 (de) |
JP (1) | JP2008503460A (de) |
KR (1) | KR20070026811A (de) |
CN (1) | CN1997646A (de) |
AR (1) | AR049399A1 (de) |
AT (1) | ATE423121T1 (de) |
AU (1) | AU2005264917A1 (de) |
BR (1) | BRPI0512220A (de) |
CA (1) | CA2578600A1 (de) |
DE (1) | DE602005012825D1 (de) |
EC (1) | ECSP067080A (de) |
ES (1) | ES2321853T3 (de) |
GT (1) | GT200500157A (de) |
IL (1) | IL180018A0 (de) |
MX (1) | MXPA06014792A (de) |
NO (1) | NO20065847L (de) |
PA (1) | PA8637201A1 (de) |
PE (1) | PE20060299A1 (de) |
RU (1) | RU2006144075A (de) |
SV (1) | SV2007002146A (de) |
TW (1) | TW200602048A (de) |
WO (1) | WO2006009655A1 (de) |
ZA (1) | ZA200610593B (de) |
Families Citing this family (77)
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US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
US7700603B2 (en) | 2003-12-15 | 2010-04-20 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
US7592348B2 (en) | 2003-12-15 | 2009-09-22 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
EP1756087B1 (de) * | 2004-06-16 | 2009-10-07 | Wyeth | Amino-5,5-diphenylimidazolon-derivate zur beta-sekretase-hemmung |
WO2006014944A1 (en) * | 2004-07-28 | 2006-02-09 | Schering Corporation | Macrocyclic beta-secretase inhibitors |
EP2264036A1 (de) * | 2005-01-14 | 2010-12-22 | Wyeth LLC (Formerly Known As Wyeth) | Amino-Imidazolone als Beta-Sekretase-Hemmer |
JP2008528622A (ja) * | 2005-02-01 | 2008-07-31 | ワイス | β−セクレターゼのインヒビターとしてのアミノピリジン |
MX2007009864A (es) | 2005-02-14 | 2007-09-04 | Wyeth Corp | Azolilacilguanidinas como inhibidores de (-secretasa. |
TW200800959A (en) * | 2005-06-10 | 2008-01-01 | Wyeth Corp | Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor |
AU2006259572A1 (en) | 2005-06-14 | 2006-12-28 | Schering Corporation | Aspartyl protease inhibitors |
US7759353B2 (en) * | 2005-06-14 | 2010-07-20 | Schering Corporation | Substituted spiro iminopyrimidinones as aspartyl protease inhibitors, compositions, and methods of treatment |
WO2006138192A1 (en) * | 2005-06-14 | 2006-12-28 | Schering Corporation | Aspartyl protease inhibitors |
WO2006138230A2 (en) * | 2005-06-14 | 2006-12-28 | Schering Corporation | The preparation and use of protease inhibitors |
ES2436795T3 (es) | 2005-06-14 | 2014-01-07 | Merck Sharp & Dohme Corp. | Inhibidores heterocíclicos de aspartil proteasa, preparación y uso de los mismos |
JP4859922B2 (ja) | 2005-06-14 | 2012-01-25 | シェーリング コーポレイション | アスパルチルプロテアーゼ阻害剤としての化合物の調製および使用 |
TW200738683A (en) * | 2005-06-30 | 2007-10-16 | Wyeth Corp | Amino-5-(5-membered)heteroarylimidazolone compounds and the use thereof for β-secretase modulation |
WO2007005404A1 (en) * | 2005-06-30 | 2007-01-11 | Wyeth | AMINO-5-(6-MEMBERED)HETEROARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR ß-SECRETASE MODULATION |
TW200730523A (en) * | 2005-07-29 | 2007-08-16 | Wyeth Corp | Cycloalkyl amino-hydantoin compounds and use thereof for β-secretase modulation |
TW200800213A (en) * | 2005-09-02 | 2008-01-01 | Abbott Lab | Novel imidazo based heterocycles |
RU2008106936A (ru) * | 2005-09-26 | 2009-11-10 | Вайет (Us) | Соединения амино-5-[4-(дифторметокси)фенил]-5-фенилимидазолона для ингибирования бета-секретазы |
BRPI0617852A2 (pt) | 2005-10-25 | 2011-08-09 | Shionogi & Co | compostos derivados de aminodi-hidrotiazina assim como composições contendo os mesmos |
JP2009520027A (ja) * | 2005-12-19 | 2009-05-21 | ワイス | 2−アミノ−5−ピペリジニルイミダゾロン化合物およびβ−セクレターゼ調節におけるその使用 |
WO2007100536A1 (en) * | 2006-02-24 | 2007-09-07 | Wyeth | DIHYDROSPIRO[DIBENZO[A,D][7]ANNULENE-5,4'-IMIDAZOL] COMPOUNDS FOR THE INHIBITION OF β-SECRETASE |
TW200808741A (en) * | 2006-06-09 | 2008-02-16 | Wyeth Corp | 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline hydrochloric acid salts |
TW200808796A (en) * | 2006-06-14 | 2008-02-16 | Astrazeneca Ab | New compounds III |
TW200815443A (en) * | 2006-06-14 | 2008-04-01 | Astrazeneca Ab | Novel compounds I |
TW200815447A (en) * | 2006-06-14 | 2008-04-01 | Astrazeneca Ab | Novel compounds IV |
TW200815449A (en) * | 2006-06-14 | 2008-04-01 | Astrazeneca Ab | Novel compounds II |
TW200815349A (en) * | 2006-06-22 | 2008-04-01 | Astrazeneca Ab | New compounds |
TW200817406A (en) * | 2006-08-17 | 2008-04-16 | Wyeth Corp | Imidazole amines as inhibitors of β-secretase |
US7700606B2 (en) * | 2006-08-17 | 2010-04-20 | Wyeth Llc | Imidazole amines as inhibitors of β-secretase |
WO2008036196A2 (en) * | 2006-09-21 | 2008-03-27 | Wyeth | Indolylalkylpyridin-2-amines for the inhibition of beta-secretase |
WO2008063114A1 (en) * | 2006-11-20 | 2008-05-29 | Astrazeneca Ab | Amino- imidazolones and their use as medicament for treating cognitive impairment alzheimer disease, neurodegeneration and dementia |
CL2007003410A1 (es) * | 2006-11-28 | 2008-04-11 | Wyeth Corp | Compuestos derivados de 5-fluoro-8-{4-[4-(6-metoxiquinolin-8-il)piperazin-1-il]piperidin-1-il}quinolina; procedimiento de preparacion; compuestos intermediarios; procedimiento de preparacion; composicion farmaceutica; y uso en el tratamiento de trast |
WO2008073370A1 (en) * | 2006-12-12 | 2008-06-19 | Schering Corporation | Aspartyl protease inhibitors containing a tricyclic ring system |
CN101668751A (zh) | 2006-12-12 | 2010-03-10 | 先灵公司 | 天冬氨酰蛋白酶抑制剂 |
TW200901974A (en) | 2007-01-16 | 2009-01-16 | Wyeth Corp | Compounds, compositions, and methods of making and using them |
CL2008000784A1 (es) * | 2007-03-20 | 2008-05-30 | Wyeth Corp | Compuestos amino-5-[-4-(diflourometoxi) fenil sustituido]-5-fenilmidazolona, inhibidores de b-secretasa; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar alzheimer, deterioro cognitivo, sindrome de down, disminucion co |
PE20090617A1 (es) * | 2007-03-23 | 2009-05-08 | Wyeth Corp | Compuestos amino-5-[-4-(difluorometoxi)fenil]-5-fenilimidazolona para la inhibicion de -secretasa |
US20080249305A1 (en) * | 2007-03-27 | 2008-10-09 | Calderwood David J | Novel imidazole based heterocycles |
JP5383483B2 (ja) | 2007-04-24 | 2014-01-08 | 塩野義製薬株式会社 | アルツハイマー症治療用医薬組成物 |
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CL2009000953A1 (es) * | 2008-04-22 | 2010-12-31 | Schering Corp | Compuestos derivados de 2-imino-3-metil-pirrolo pirimidinona, composicion farmaceutica, util para inhibir la beta-secretasa, destinado al tratamiento de la enfermedad de alzheimer, sindrome de down, parkinson, perdida de la memoria, demencia, accidente cerebrovascular, microgliosis e inflamacion cerebral, glaucoma amiloidosis, diabetes tipo ii, entre otras. |
KR101324426B1 (ko) | 2008-06-13 | 2013-10-31 | 시오노기세야쿠 가부시키가이샤 | β 세크레타제 저해 작용을 갖는 황 함유 복소환 유도체 |
EP2324032B1 (de) * | 2008-08-19 | 2014-10-01 | Vitae Pharmaceuticals, Inc. | Beta-sekretase inhibitoren |
JP5417860B2 (ja) * | 2008-08-26 | 2014-02-19 | 住友化学株式会社 | α−ヒドロキシエステル類の製造方法 |
JPWO2010047372A1 (ja) | 2008-10-22 | 2012-03-22 | 塩野義製薬株式会社 | Bace1阻害活性を有する2−アミノピリミジン−4−オンおよび2−アミノピリジン誘導体 |
US20100125081A1 (en) * | 2008-11-14 | 2010-05-20 | Astrazeneca Ab | New compounds 574 |
TW201020244A (en) | 2008-11-14 | 2010-06-01 | Astrazeneca Ab | New compounds |
US20100125087A1 (en) * | 2008-11-14 | 2010-05-20 | Astrazeneca Ab | New compounds 575 |
AU2010223937B2 (en) | 2009-03-13 | 2015-01-22 | Vitae Pharmaceuticals, Inc. | Inhibitors of beta-secretase |
EP2281824A1 (de) | 2009-08-07 | 2011-02-09 | Noscira, S.A. | Furan-Imidazolon-Derivate zur Behandlung von kognitiven, neurodegenerativen oder neuronalen Erkrankungen oder Funktionsstörungen |
EP2485591B1 (de) | 2009-10-08 | 2016-03-23 | Merck Sharp & Dohme Corp. | Iminothiadiazindioxinverbindungen als bace-hemmer, zusammensetzungen und ihre verwendung |
UA108363C2 (uk) | 2009-10-08 | 2015-04-27 | Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування | |
EP2485920B1 (de) | 2009-10-08 | 2016-04-27 | Merck Sharp & Dohme Corp. | Heterozyklische pentafluorsulfur-imin-verbindungen als bace-1-hemmer sowie zusammensetzungen damit und ihre verwendung |
MX2012006491A (es) | 2009-12-11 | 2012-07-03 | Shionogi & Co | Derivados de oxazina. |
US8889703B2 (en) | 2010-02-24 | 2014-11-18 | Vitae Pharmaceuticals, Inc. | Inhibitors of beta-secretase |
EP2634188A4 (de) | 2010-10-29 | 2014-05-07 | Shionogi & Co | Kondensiertes aminodihydropyrimidinderivat |
WO2012057248A1 (ja) | 2010-10-29 | 2012-05-03 | 塩野義製薬株式会社 | ナフチリジン誘導体 |
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AU2013235422B2 (en) | 2012-03-19 | 2016-12-15 | Buck Institute For Research On Aging | APP specific BACE inhibitors (ASBIs) and uses thereof |
TW201422592A (zh) | 2012-08-27 | 2014-06-16 | Boehringer Ingelheim Int | β-分泌酶抑制劑 |
WO2014052398A1 (en) | 2012-09-28 | 2014-04-03 | Vitae Pharmaceuticals, Inc. | Inhibitor of beta-secretase |
EP2908825B1 (de) | 2012-10-17 | 2018-04-18 | Merck Sharp & Dohme Corp. | Tricyclische substituierte thiadiazindioxidverbindungen als bace-hemmer, zusammensetzungen und deren verwendung |
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JP2016501827A (ja) | 2012-10-24 | 2016-01-21 | 塩野義製薬株式会社 | Bace1阻害作用を有するジヒドロオキサジンまたはオキサゼピン誘導体 |
WO2014127042A1 (en) | 2013-02-12 | 2014-08-21 | Buck Institute For Research On Aging | Hydantoins that modulate bace-mediated app processing |
KR101668857B1 (ko) | 2015-01-08 | 2016-10-24 | 한양대학교 에리카산학협력단 | 이미다졸-1-일 피리미딘 유도체, 또는 이의 약학적으로 허용가능한 염 및 이를 유효성분으로 포함하는 약학적 조성물 |
MA54133B1 (fr) | 2018-03-08 | 2022-01-31 | Incyte Corp | Composés d'aminopyrazine diol utilisés comme inhibiteurs de pi3k-y |
US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
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EP1756087B1 (de) | 2004-06-16 | 2009-10-07 | Wyeth | Amino-5,5-diphenylimidazolon-derivate zur beta-sekretase-hemmung |
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WO2007100536A1 (en) | 2006-02-24 | 2007-09-07 | Wyeth | DIHYDROSPIRO[DIBENZO[A,D][7]ANNULENE-5,4'-IMIDAZOL] COMPOUNDS FOR THE INHIBITION OF β-SECRETASE |
US7700606B2 (en) | 2006-08-17 | 2010-04-20 | Wyeth Llc | Imidazole amines as inhibitors of β-secretase |
-
2005
- 2005-06-14 WO PCT/US2005/020736 patent/WO2006009655A1/en active Application Filing
- 2005-06-14 JP JP2007516603A patent/JP2008503460A/ja active Pending
- 2005-06-14 AT AT05758187T patent/ATE423121T1/de not_active IP Right Cessation
- 2005-06-14 AU AU2005264917A patent/AU2005264917A1/en not_active Abandoned
- 2005-06-14 MX MXPA06014792A patent/MXPA06014792A/es active IP Right Grant
- 2005-06-14 ES ES05758187T patent/ES2321853T3/es active Active
- 2005-06-14 BR BRPI0512220-1A patent/BRPI0512220A/pt not_active IP Right Cessation
- 2005-06-14 EP EP05758187A patent/EP1758907B1/de active Active
- 2005-06-14 KR KR1020077000970A patent/KR20070026811A/ko not_active Application Discontinuation
- 2005-06-14 RU RU2006144075/04A patent/RU2006144075A/ru not_active Application Discontinuation
- 2005-06-14 CA CA002578600A patent/CA2578600A1/en not_active Abandoned
- 2005-06-14 CN CNA2005800194504A patent/CN1997646A/zh active Pending
- 2005-06-14 TW TW094119581A patent/TW200602048A/zh unknown
- 2005-06-14 DE DE602005012825T patent/DE602005012825D1/de active Active
- 2005-06-14 PE PE2005000678A patent/PE20060299A1/es not_active Application Discontinuation
- 2005-06-15 US US11/152,925 patent/US7456186B2/en not_active Expired - Fee Related
- 2005-06-15 AR ARP050102450A patent/AR049399A1/es unknown
- 2005-06-15 PA PA20058637201A patent/PA8637201A1/es unknown
- 2005-06-16 GT GT200500157A patent/GT200500157A/es unknown
- 2005-06-16 SV SV2005002146A patent/SV2007002146A/es unknown
-
2006
- 2006-12-12 IL IL180018A patent/IL180018A0/en unknown
- 2006-12-13 EC EC2006007080A patent/ECSP067080A/es unknown
- 2006-12-15 ZA ZA200610593A patent/ZA200610593B/xx unknown
- 2006-12-18 NO NO20065847A patent/NO20065847L/no not_active Application Discontinuation
-
2008
- 2008-10-07 US US12/246,790 patent/US20090042912A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ES2321853T3 (es) | 2009-06-12 |
JP2008503460A (ja) | 2008-02-07 |
CN1997646A (zh) | 2007-07-11 |
MXPA06014792A (es) | 2007-02-16 |
AU2005264917A1 (en) | 2006-01-26 |
RU2006144075A (ru) | 2008-07-27 |
AR049399A1 (es) | 2006-07-26 |
GT200500157A (es) | 2006-11-07 |
PA8637201A1 (es) | 2006-06-02 |
IL180018A0 (en) | 2007-05-15 |
TW200602048A (en) | 2006-01-16 |
BRPI0512220A (pt) | 2008-02-19 |
ECSP067080A (es) | 2007-05-30 |
KR20070026811A (ko) | 2007-03-08 |
CA2578600A1 (en) | 2006-01-26 |
US7456186B2 (en) | 2008-11-25 |
ZA200610593B (en) | 2009-09-30 |
PE20060299A1 (es) | 2006-05-18 |
US20050282826A1 (en) | 2005-12-22 |
DE602005012825D1 (de) | 2009-04-02 |
SV2007002146A (es) | 2007-03-20 |
US20090042912A1 (en) | 2009-02-12 |
EP1758907A1 (de) | 2007-03-07 |
EP1758907B1 (de) | 2009-02-18 |
NO20065847L (no) | 2006-12-18 |
WO2006009655A1 (en) | 2006-01-26 |
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