ATE423121T1 - Diphenylimidazopyrimidin- und -imidazolamine als b-sekretase-inhibitoren - Google Patents

Diphenylimidazopyrimidin- und -imidazolamine als b-sekretase-inhibitoren

Info

Publication number
ATE423121T1
ATE423121T1 AT05758187T AT05758187T ATE423121T1 AT E423121 T1 ATE423121 T1 AT E423121T1 AT 05758187 T AT05758187 T AT 05758187T AT 05758187 T AT05758187 T AT 05758187T AT E423121 T1 ATE423121 T1 AT E423121T1
Authority
AT
Austria
Prior art keywords
diphenylimidazopyrimidine
imidazolamine
secretase inhibitors
secretase
inhibitors
Prior art date
Application number
AT05758187T
Other languages
English (en)
Inventor
Michael Sotirios Malamas
James Joseph Erdei
Iwan Suwandi Gunawan
Keith Douglas Barnes
Matthew Robert Johnson
Yu Hui
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Application granted granted Critical
Publication of ATE423121T1 publication Critical patent/ATE423121T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT05758187T 2004-06-16 2005-06-14 Diphenylimidazopyrimidin- und -imidazolamine als b-sekretase-inhibitoren ATE423121T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US58018704P 2004-06-16 2004-06-16

Publications (1)

Publication Number Publication Date
ATE423121T1 true ATE423121T1 (de) 2009-03-15

Family

ID=34982285

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05758187T ATE423121T1 (de) 2004-06-16 2005-06-14 Diphenylimidazopyrimidin- und -imidazolamine als b-sekretase-inhibitoren

Country Status (24)

Country Link
US (2) US7456186B2 (de)
EP (1) EP1758907B1 (de)
JP (1) JP2008503460A (de)
KR (1) KR20070026811A (de)
CN (1) CN1997646A (de)
AR (1) AR049399A1 (de)
AT (1) ATE423121T1 (de)
AU (1) AU2005264917A1 (de)
BR (1) BRPI0512220A (de)
CA (1) CA2578600A1 (de)
DE (1) DE602005012825D1 (de)
EC (1) ECSP067080A (de)
ES (1) ES2321853T3 (de)
GT (1) GT200500157A (de)
IL (1) IL180018A0 (de)
MX (1) MXPA06014792A (de)
NO (1) NO20065847L (de)
PA (1) PA8637201A1 (de)
PE (1) PE20060299A1 (de)
RU (1) RU2006144075A (de)
SV (1) SV2007002146A (de)
TW (1) TW200602048A (de)
WO (1) WO2006009655A1 (de)
ZA (1) ZA200610593B (de)

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TW200808796A (en) * 2006-06-14 2008-02-16 Astrazeneca Ab New compounds III
TW200815443A (en) * 2006-06-14 2008-04-01 Astrazeneca Ab Novel compounds I
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US7700606B2 (en) * 2006-08-17 2010-04-20 Wyeth Llc Imidazole amines as inhibitors of β-secretase
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Also Published As

Publication number Publication date
ZA200610593B (en) 2009-09-30
ECSP067080A (es) 2007-05-30
WO2006009655A1 (en) 2006-01-26
AU2005264917A1 (en) 2006-01-26
CN1997646A (zh) 2007-07-11
JP2008503460A (ja) 2008-02-07
SV2007002146A (es) 2007-03-20
EP1758907A1 (de) 2007-03-07
BRPI0512220A (pt) 2008-02-19
DE602005012825D1 (de) 2009-04-02
PA8637201A1 (es) 2006-06-02
CA2578600A1 (en) 2006-01-26
IL180018A0 (en) 2007-05-15
US20090042912A1 (en) 2009-02-12
TW200602048A (en) 2006-01-16
NO20065847L (no) 2006-12-18
MXPA06014792A (es) 2007-02-16
ES2321853T3 (es) 2009-06-12
KR20070026811A (ko) 2007-03-08
PE20060299A1 (es) 2006-05-18
US20050282826A1 (en) 2005-12-22
GT200500157A (es) 2006-11-07
RU2006144075A (ru) 2008-07-27
US7456186B2 (en) 2008-11-25
EP1758907B1 (de) 2009-02-18
AR049399A1 (es) 2006-07-26

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