ATE520680T1 - Hiv-hemmende 5-heterocyclylpyrimidine - Google Patents
Hiv-hemmende 5-heterocyclylpyrimidineInfo
- Publication number
- ATE520680T1 ATE520680T1 AT05794656T AT05794656T ATE520680T1 AT E520680 T1 ATE520680 T1 AT E520680T1 AT 05794656 T AT05794656 T AT 05794656T AT 05794656 T AT05794656 T AT 05794656T AT E520680 T1 ATE520680 T1 AT E520680T1
- Authority
- AT
- Austria
- Prior art keywords
- heterocyclylpyrimidines
- hiv
- inhibiting
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04104812 | 2004-09-30 | ||
| PCT/EP2005/054930 WO2006035067A2 (en) | 2004-09-30 | 2005-09-29 | Hiv inhibiting 5-heterocyclyl pyrimidines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE520680T1 true ATE520680T1 (de) | 2011-09-15 |
Family
ID=34929638
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05794656T ATE520680T1 (de) | 2004-09-30 | 2005-09-29 | Hiv-hemmende 5-heterocyclylpyrimidine |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8575342B2 (de) |
| EP (1) | EP1797069B1 (de) |
| JP (1) | JP5008567B2 (de) |
| KR (1) | KR20070057899A (de) |
| CN (1) | CN101031558B (de) |
| AR (1) | AR050969A1 (de) |
| AT (1) | ATE520680T1 (de) |
| AU (1) | AU2005288864B2 (de) |
| BR (1) | BRPI0516746A (de) |
| CA (1) | CA2577467C (de) |
| ES (1) | ES2371923T3 (de) |
| IL (1) | IL180959A (de) |
| MX (1) | MX2007003797A (de) |
| RU (1) | RU2405778C2 (de) |
| TW (1) | TW200626574A (de) |
| WO (1) | WO2006035067A2 (de) |
| ZA (1) | ZA200702653B (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005288866B2 (en) | 2004-09-30 | 2012-07-26 | Janssen Sciences Ireland Uc | HIV inhibiting 5-substituted pyrimidines |
| MX2007003797A (es) | 2004-09-30 | 2007-04-23 | Tibotec Pharm Ltd | 5-heterociclil pirimidinas inhibidoras del virus de inmunodeficiencia humana. |
| EP1853567B1 (de) * | 2005-02-18 | 2014-12-31 | Janssen R&D Ireland | Hiv-hemmende 2-(4-cyanophenylamino) pyrimidinoxidderivate |
| CA2645958C (en) * | 2006-03-30 | 2014-11-04 | Tibotec Pharmaceuticals Ltd. | Hiv inhibiting 5-amido substituted pyrimidines |
| KR101475091B1 (ko) | 2006-12-13 | 2014-12-22 | 에프. 호프만-라 로슈 아게 | 비뉴클레오시드 역전사 효소 억제제로서 2-(피페리딘-4-일)-4-페녹시- 또는 페닐아미노-피리미딘 유도체 |
| ES2618057T3 (es) | 2006-12-29 | 2017-06-20 | Janssen Sciences Ireland Uc | Pirimidinas 5,6-sustituidas inhibidoras del VIH |
| CN101573343B (zh) * | 2006-12-29 | 2016-02-24 | 爱尔兰詹森科学公司 | 抑制人免疫缺陷病毒的6-取代的嘧啶 |
| US20100137313A1 (en) * | 2008-10-03 | 2010-06-03 | Astrazeneca Ab | Heterocyclic derivatives and methods of use thereof |
| WO2011146313A1 (en) | 2010-05-19 | 2011-11-24 | The University Of North Carolina At Chapel Hill | Pyrazolopyrimidine compounds for the treatment of cancer |
| FI3392252T3 (fi) | 2011-08-23 | 2024-01-08 | Libertas Bio Inc | Pyrimidopyridazinoniyhdisteet ja niiden käyttö |
| JP2014532060A (ja) | 2011-10-03 | 2014-12-04 | ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル | 癌を治療するためのピロロピリミジン化合物 |
| CA2873878A1 (en) * | 2012-05-22 | 2013-11-28 | The University Of North Carolina At Chapel Hill | Pyrimidine compounds for the treatment of cancer |
| WO2014062774A1 (en) | 2012-10-17 | 2014-04-24 | The University Of North Carolina At Chapel Hill | Pyrazolopyrimidine compounds for the treatment of cancer |
| US9771330B2 (en) | 2012-11-27 | 2017-09-26 | The University Of North Carolina At Chapel Hill | Pyrimidine compounds for the treatment of cancer |
| RU2547844C1 (ru) * | 2013-10-29 | 2015-04-10 | Федеральное государственное бюджетное учреждение науки Институт органического синтеза им. И.Я. Постовского Уральского отделения Российской академии наук | Способ получения 5-(гет)арил-4-(2-тиенил)-2-(тио)морфолилпиримидина |
| WO2015157115A1 (en) | 2014-04-11 | 2015-10-15 | The University Of North Carolina At Chapel Hill | Mertk-specific pyrimidine compounds |
| US9957253B2 (en) * | 2014-04-28 | 2018-05-01 | Mmv Medicines For Malaria Venture | Triaminopyrimidine compounds useful for preventing or treating malaria |
| TWI803187B (zh) * | 2014-08-08 | 2023-05-21 | 日商中外製藥股份有限公司 | 包含４環性化合物的非晶質體之固體分散體及製劑 |
| US10709708B2 (en) | 2016-03-17 | 2020-07-14 | The University Of North Carolina At Chapel Hill | Method of treating cancer with a combination of MER tyrosine kinase inhibitor and an epidermal growth factor receptor (EGFR) inhibitor |
| WO2019222538A1 (en) * | 2018-05-16 | 2019-11-21 | The University Of North Carolina At Chapel Hill | Aminopyrimidines and aminopyridines as mertk inhibitors and their application in cancer treatment |
| CA3158698A1 (en) | 2020-02-19 | 2021-08-26 | Alexander Vitalievich Kurkin | Pyrimidine-based bicycles as antiviral agents for the treatment and prevention of hiv infection |
| CN111875548A (zh) * | 2020-07-16 | 2020-11-03 | 山东大学 | 一种5位芳环取代的二芳基嘧啶类衍生物及其制备方法与应用 |
| US11351149B2 (en) | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
| WO2022059996A1 (ko) * | 2020-09-15 | 2022-03-24 | 서울대학교 기술지주 주식회사 | 혈액 순환 미세체외소체 매개 암 치료용 조성물 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3459731A (en) | 1966-12-16 | 1969-08-05 | Corn Products Co | Cyclodextrin polyethers and their production |
| EP0862463A1 (de) | 1995-11-23 | 1998-09-09 | Janssen Pharmaceutica N.V. | Feste mischungen von cyclodextrinen, hergestellt durch schmelzextrusionsverfahren |
| NO311614B1 (no) | 1996-10-01 | 2001-12-17 | Janssen Pharmaceutica Nv | Substituerte diamino-1,3,5-triazinderivater |
| SK287996B6 (sk) | 1998-03-27 | 2012-09-03 | Janssen Pharmaceutica N. V. | Pyrimide compound, pharmaceutical composition the compound is comprised, method for preparation thereof, combination and product containing the composition and use of the pyrimide compound |
| EP0945447A1 (de) | 1998-03-27 | 1999-09-29 | Janssen Pharmaceutica N.V. | Trisubstituierte 1,3,5-Triazinderivate zur Behandlung von HIV Infektionen |
| AP1683A (en) | 1998-11-10 | 2006-11-29 | Janssen Pharmaceutica Nv | HIV replication inhibiting pyrimidines. |
| GB9828511D0 (en) * | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
| WO2001058700A1 (de) | 2000-02-14 | 2001-08-16 | Claus Rayhle | Klammer |
| CA2406562C (en) * | 2000-05-08 | 2009-09-15 | Janssen Pharmaceutica N.V. | Hiv replication inhibiting pyrimidines and triazines |
| ES2272567T3 (es) | 2000-12-21 | 2007-05-01 | Vertex Pharmaceuticals Incorporated | Compuestos de pirazol utiles como inhibidores de proteina quinasas. |
| JO3429B1 (ar) | 2001-08-13 | 2019-10-20 | Janssen Pharmaceutica Nv | مشتقات برميدينات مثبطة فيروس الايدز |
| TWI329105B (en) * | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| CN100457754C (zh) | 2002-11-15 | 2009-02-04 | 泰博特克药品有限公司 | 作为抗感染化合物的取代的吲哚吡啶 |
| US7504396B2 (en) | 2003-06-24 | 2009-03-17 | Amgen Inc. | Substituted heterocyclic compounds and methods of use |
| MX2007003797A (es) | 2004-09-30 | 2007-04-23 | Tibotec Pharm Ltd | 5-heterociclil pirimidinas inhibidoras del virus de inmunodeficiencia humana. |
| AU2005288865B2 (en) | 2004-09-30 | 2012-07-19 | Janssen Sciences Ireland Uc | HIV inhibiting 5-carbo- or heterocyclic substituted pyrimidines |
| AU2005288866B2 (en) | 2004-09-30 | 2012-07-26 | Janssen Sciences Ireland Uc | HIV inhibiting 5-substituted pyrimidines |
| CA2645958C (en) | 2006-03-30 | 2014-11-04 | Tibotec Pharmaceuticals Ltd. | Hiv inhibiting 5-amido substituted pyrimidines |
| ES2618057T3 (es) | 2006-12-29 | 2017-06-20 | Janssen Sciences Ireland Uc | Pirimidinas 5,6-sustituidas inhibidoras del VIH |
| CN101573343B (zh) | 2006-12-29 | 2016-02-24 | 爱尔兰詹森科学公司 | 抑制人免疫缺陷病毒的6-取代的嘧啶 |
-
2005
- 2005-09-29 MX MX2007003797A patent/MX2007003797A/es active IP Right Grant
- 2005-09-29 RU RU2007116152/04A patent/RU2405778C2/ru active
- 2005-09-29 KR KR1020077007388A patent/KR20070057899A/ko not_active Application Discontinuation
- 2005-09-29 TW TW094134107A patent/TW200626574A/zh unknown
- 2005-09-29 BR BRPI0516746-9A patent/BRPI0516746A/pt active Search and Examination
- 2005-09-29 AU AU2005288864A patent/AU2005288864B2/en not_active Ceased
- 2005-09-29 CA CA2577467A patent/CA2577467C/en not_active Expired - Fee Related
- 2005-09-29 ES ES05794656T patent/ES2371923T3/es active Active
- 2005-09-29 EP EP05794656A patent/EP1797069B1/de active Active
- 2005-09-29 CN CN2005800331107A patent/CN101031558B/zh not_active Expired - Fee Related
- 2005-09-29 US US11/575,818 patent/US8575342B2/en not_active Expired - Fee Related
- 2005-09-29 AT AT05794656T patent/ATE520680T1/de not_active IP Right Cessation
- 2005-09-29 JP JP2007534026A patent/JP5008567B2/ja not_active Expired - Fee Related
- 2005-09-29 WO PCT/EP2005/054930 patent/WO2006035067A2/en active Application Filing
- 2005-09-30 AR ARP050104153A patent/AR050969A1/es not_active Application Discontinuation
-
2007
- 2007-01-25 IL IL180959A patent/IL180959A/en active IP Right Grant
- 2007-03-29 ZA ZA200702653A patent/ZA200702653B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101031558A (zh) | 2007-09-05 |
| EP1797069B1 (de) | 2011-08-17 |
| ES2371923T3 (es) | 2012-01-11 |
| AU2005288864A1 (en) | 2006-04-06 |
| MX2007003797A (es) | 2007-04-23 |
| CA2577467C (en) | 2013-05-28 |
| CA2577467A1 (en) | 2006-04-06 |
| IL180959A (en) | 2012-08-30 |
| WO2006035067A2 (en) | 2006-04-06 |
| AR050969A1 (es) | 2006-12-06 |
| WO2006035067A3 (en) | 2006-08-24 |
| BRPI0516746A (pt) | 2008-09-23 |
| US8575342B2 (en) | 2013-11-05 |
| JP2008514679A (ja) | 2008-05-08 |
| AU2005288864B2 (en) | 2012-08-23 |
| RU2405778C2 (ru) | 2010-12-10 |
| KR20070057899A (ko) | 2007-06-07 |
| ZA200702653B (en) | 2008-08-27 |
| CN101031558B (zh) | 2011-10-05 |
| US20090181993A1 (en) | 2009-07-16 |
| RU2007116152A (ru) | 2008-11-10 |
| JP5008567B2 (ja) | 2012-08-22 |
| TW200626574A (en) | 2006-08-01 |
| EP1797069A2 (de) | 2007-06-20 |
| IL180959A0 (en) | 2007-07-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |