ATE520680T1 - Hiv-hemmende 5-heterocyclylpyrimidine - Google Patents
Hiv-hemmende 5-heterocyclylpyrimidineInfo
- Publication number
- ATE520680T1 ATE520680T1 AT05794656T AT05794656T ATE520680T1 AT E520680 T1 ATE520680 T1 AT E520680T1 AT 05794656 T AT05794656 T AT 05794656T AT 05794656 T AT05794656 T AT 05794656T AT E520680 T1 ATE520680 T1 AT E520680T1
- Authority
- AT
- Austria
- Prior art keywords
- heterocyclylpyrimidines
- hiv
- inhibiting
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04104812 | 2004-09-30 | ||
| PCT/EP2005/054930 WO2006035067A2 (en) | 2004-09-30 | 2005-09-29 | Hiv inhibiting 5-heterocyclyl pyrimidines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE520680T1 true ATE520680T1 (de) | 2011-09-15 |
Family
ID=34929638
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05794656T ATE520680T1 (de) | 2004-09-30 | 2005-09-29 | Hiv-hemmende 5-heterocyclylpyrimidine |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8575342B2 (de) |
| EP (1) | EP1797069B1 (de) |
| JP (1) | JP5008567B2 (de) |
| KR (1) | KR20070057899A (de) |
| CN (1) | CN101031558B (de) |
| AR (1) | AR050969A1 (de) |
| AT (1) | ATE520680T1 (de) |
| AU (1) | AU2005288864B2 (de) |
| BR (1) | BRPI0516746A (de) |
| CA (1) | CA2577467C (de) |
| ES (1) | ES2371923T3 (de) |
| IL (1) | IL180959A (de) |
| MX (1) | MX2007003797A (de) |
| RU (1) | RU2405778C2 (de) |
| TW (1) | TW200626574A (de) |
| WO (1) | WO2006035067A2 (de) |
| ZA (1) | ZA200702653B (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0516746A (pt) | 2004-09-30 | 2008-09-23 | Tibotec Pharm Ltd | 5-heterociclil pirimidinas para inibição de hiv |
| ES2380631T3 (es) | 2004-09-30 | 2012-05-17 | Tibotec Pharmaceuticals | Pirimidinas sustituidas en posición 5 inhibidoras de VIH |
| US7935711B2 (en) * | 2005-02-18 | 2011-05-03 | Tibotec Pharmaceuticals Ltd. | HIV inhibiting 2-(4-cyanophenylamino) pyrimidine oxide derivatives |
| ES2465666T3 (es) | 2006-03-30 | 2014-06-06 | Janssen R&D Ireland | Pirimidinas 5-amido-sustituidas inhibidoras del HIV |
| AU2007332654B2 (en) | 2006-12-13 | 2013-06-20 | F. Hoffmann-La Roche Ag | 2-(piperidin-4-yl)-4-phenoxy- or phenylamino-pyrimidine derivatives as non-nucleoside reverse transcriptase inhibitors |
| BRPI0720858B8 (pt) | 2006-12-29 | 2021-05-25 | Janssen R & D Ireland | pirimidinas 6-substituídas inibidoras de hiv e composição farmacêutica que as compreende |
| ES2523863T3 (es) | 2006-12-29 | 2014-12-02 | Janssen R&D Ireland | Pirimidinas 5,6-sustituidas inhibidoras del VIH |
| UY32158A (es) * | 2008-10-03 | 2010-04-30 | Astrazeneca Ab | Derivados heterociclicos y metodos de uso de los mismos |
| US9290499B2 (en) | 2010-05-19 | 2016-03-22 | The University Of North Carolina At Chapel Hill | Pyrazolopyrimidine compounds for the treatment of cancer |
| DK3392252T3 (da) | 2011-08-23 | 2024-01-08 | Libertas Bio Inc | Pyrimido-pyridazinonforbindelser og deres anvendelse |
| WO2013052417A1 (en) | 2011-10-03 | 2013-04-11 | The University Of North Carolina At Chapel Hill | Pyrrolopyrimidine compounds for the treatment of cancer |
| RU2014145121A (ru) * | 2012-05-22 | 2016-07-10 | Зэ Юниверсити Оф Норд Каролина Эт Чапел Хилл | Пиримидиновые соединения для лечения злокачественной опухоли |
| EP2909211A4 (de) | 2012-10-17 | 2016-06-22 | Univ North Carolina | Pyrazolopyrimidinverbindungen zur krebsbehandlung |
| EP2925752A4 (de) | 2012-11-27 | 2016-06-01 | Univ North Carolina | Pyrimidinverbindungen zur krebsbehandlung |
| RU2547844C1 (ru) * | 2013-10-29 | 2015-04-10 | Федеральное государственное бюджетное учреждение науки Институт органического синтеза им. И.Я. Постовского Уральского отделения Российской академии наук | Способ получения 5-(гет)арил-4-(2-тиенил)-2-(тио)морфолилпиримидина |
| WO2015157122A1 (en) | 2014-04-11 | 2015-10-15 | The University Of North Carolina At Chapel Hill | Mertk-specific pyrazolopyrimidine compounds |
| PT3137455T (pt) * | 2014-04-28 | 2018-11-21 | Medicines For Malaria Venture Mmv | Compostos de triaminopirimidina úteis para prevenir ou tratar malária |
| TWI718102B (zh) * | 2014-08-08 | 2021-02-11 | 日商中外製藥股份有限公司 | ４環性化合物的非晶質體 |
| US10709708B2 (en) | 2016-03-17 | 2020-07-14 | The University Of North Carolina At Chapel Hill | Method of treating cancer with a combination of MER tyrosine kinase inhibitor and an epidermal growth factor receptor (EGFR) inhibitor |
| CN110809471A (zh) | 2017-04-28 | 2020-02-18 | 阿沙纳生物科学公司 | 治疗特应性皮炎以及提高活性药物成分稳定性的制剂、方法、试剂盒和剂型 |
| WO2019222538A1 (en) * | 2018-05-16 | 2019-11-21 | The University Of North Carolina At Chapel Hill | Aminopyrimidines and aminopyridines as mertk inhibitors and their application in cancer treatment |
| AU2021224460A1 (en) | 2020-02-19 | 2022-12-15 | Pharmasyntez, Joint Stock Company | Pyrimidine-based bicycles as antiviral agents for the treatment and prevention of HIV infection |
| US12577240B2 (en) | 2020-07-11 | 2026-03-17 | Pfizer Inc. | Antiviral heteroaryl ketone derivatives |
| CN111875548A (zh) * | 2020-07-16 | 2020-11-03 | 山东大学 | 一种5位芳环取代的二芳基嘧啶类衍生物及其制备方法与应用 |
| US11351149B2 (en) | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
| WO2022059996A1 (ko) * | 2020-09-15 | 2022-03-24 | 서울대학교 기술지주 주식회사 | 혈액 순환 미세체외소체 매개 암 치료용 조성물 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3459731A (en) | 1966-12-16 | 1969-08-05 | Corn Products Co | Cyclodextrin polyethers and their production |
| EP0862463A1 (de) | 1995-11-23 | 1998-09-09 | Janssen Pharmaceutica N.V. | Feste mischungen von cyclodextrinen, hergestellt durch schmelzextrusionsverfahren |
| NO311614B1 (no) | 1996-10-01 | 2001-12-17 | Janssen Pharmaceutica Nv | Substituerte diamino-1,3,5-triazinderivater |
| EP0945447A1 (de) | 1998-03-27 | 1999-09-29 | Janssen Pharmaceutica N.V. | Trisubstituierte 1,3,5-Triazinderivate zur Behandlung von HIV Infektionen |
| NZ506679A (en) | 1998-03-27 | 2002-11-26 | Janssen Pharmaceutica Nv | HIV inhibiting pyrimidine derivatives |
| SK287269B6 (sk) * | 1998-11-10 | 2010-05-07 | Janssen Pharmaceutica N. V. | Derivát pyrimidínu, jeho použitie, spôsob jeho prípravy a farmaceutická kompozícia, kombinácia a produkt s jeho obsahom |
| GB9828511D0 (en) | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
| WO2001058700A1 (de) | 2000-02-14 | 2001-08-16 | Claus Rayhle | Klammer |
| JP5230050B2 (ja) * | 2000-05-08 | 2013-07-10 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Ｈｉｖ複製阻害剤 |
| GB0016877D0 (en) * | 2000-07-11 | 2000-08-30 | Astrazeneca Ab | Chemical compounds |
| HUP0400639A3 (en) * | 2000-12-21 | 2010-03-29 | Vertex Pharma | Pyrazole compounds useful as protein kinase inhibitors and pharmaceutical compositions containing them |
| JO3429B1 (ar) | 2001-08-13 | 2019-10-20 | Janssen Pharmaceutica Nv | مشتقات برميدينات مثبطة فيروس الايدز |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| AU2003296760B2 (en) | 2002-11-15 | 2009-11-19 | Tibotec Pharmaceuticals Ltd. | Substituted indolepyridinium as anti-infective compounds |
| US7504396B2 (en) | 2003-06-24 | 2009-03-17 | Amgen Inc. | Substituted heterocyclic compounds and methods of use |
| BRPI0516746A (pt) | 2004-09-30 | 2008-09-23 | Tibotec Pharm Ltd | 5-heterociclil pirimidinas para inibição de hiv |
| KR20070057798A (ko) | 2004-09-30 | 2007-06-07 | 티보텍 파마슈티칼즈 리미티드 | Ｈｉｖ를 저해하는 5-탄소환 또는 복소환으로 치환된피리미딘 |
| ES2380631T3 (es) | 2004-09-30 | 2012-05-17 | Tibotec Pharmaceuticals | Pirimidinas sustituidas en posición 5 inhibidoras de VIH |
| ES2465666T3 (es) | 2006-03-30 | 2014-06-06 | Janssen R&D Ireland | Pirimidinas 5-amido-sustituidas inhibidoras del HIV |
| BRPI0720858B8 (pt) | 2006-12-29 | 2021-05-25 | Janssen R & D Ireland | pirimidinas 6-substituídas inibidoras de hiv e composição farmacêutica que as compreende |
| ES2523863T3 (es) | 2006-12-29 | 2014-12-02 | Janssen R&D Ireland | Pirimidinas 5,6-sustituidas inhibidoras del VIH |
-
2005
- 2005-09-29 BR BRPI0516746-9A patent/BRPI0516746A/pt active Search and Examination
- 2005-09-29 US US11/575,818 patent/US8575342B2/en not_active Expired - Fee Related
- 2005-09-29 CA CA2577467A patent/CA2577467C/en not_active Expired - Fee Related
- 2005-09-29 JP JP2007534026A patent/JP5008567B2/ja not_active Expired - Fee Related
- 2005-09-29 RU RU2007116152/04A patent/RU2405778C2/ru active
- 2005-09-29 KR KR1020077007388A patent/KR20070057899A/ko not_active Ceased
- 2005-09-29 TW TW094134107A patent/TW200626574A/zh unknown
- 2005-09-29 AU AU2005288864A patent/AU2005288864B2/en not_active Ceased
- 2005-09-29 CN CN2005800331107A patent/CN101031558B/zh not_active Expired - Fee Related
- 2005-09-29 ES ES05794656T patent/ES2371923T3/es active Active
- 2005-09-29 MX MX2007003797A patent/MX2007003797A/es active IP Right Grant
- 2005-09-29 EP EP05794656A patent/EP1797069B1/de not_active Expired - Lifetime
- 2005-09-29 AT AT05794656T patent/ATE520680T1/de not_active IP Right Cessation
- 2005-09-29 WO PCT/EP2005/054930 patent/WO2006035067A2/en not_active Ceased
- 2005-09-30 AR ARP050104153A patent/AR050969A1/es not_active Application Discontinuation
-
2007
- 2007-01-25 IL IL180959A patent/IL180959A/en active IP Right Grant
- 2007-03-29 ZA ZA200702653A patent/ZA200702653B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006035067A2 (en) | 2006-04-06 |
| CA2577467A1 (en) | 2006-04-06 |
| CA2577467C (en) | 2013-05-28 |
| KR20070057899A (ko) | 2007-06-07 |
| CN101031558B (zh) | 2011-10-05 |
| US8575342B2 (en) | 2013-11-05 |
| ES2371923T3 (es) | 2012-01-11 |
| MX2007003797A (es) | 2007-04-23 |
| RU2007116152A (ru) | 2008-11-10 |
| US20090181993A1 (en) | 2009-07-16 |
| AU2005288864B2 (en) | 2012-08-23 |
| RU2405778C2 (ru) | 2010-12-10 |
| WO2006035067A3 (en) | 2006-08-24 |
| JP2008514679A (ja) | 2008-05-08 |
| BRPI0516746A (pt) | 2008-09-23 |
| ZA200702653B (en) | 2008-08-27 |
| EP1797069A2 (de) | 2007-06-20 |
| AU2005288864A1 (en) | 2006-04-06 |
| TW200626574A (en) | 2006-08-01 |
| IL180959A (en) | 2012-08-30 |
| CN101031558A (zh) | 2007-09-05 |
| AR050969A1 (es) | 2006-12-06 |
| EP1797069B1 (de) | 2011-08-17 |
| IL180959A0 (en) | 2007-07-04 |
| JP5008567B2 (ja) | 2012-08-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |