ATE452132T1 - Benzimidazolthiophenverbindungen als plk- inhibitoren - Google Patents
Benzimidazolthiophenverbindungen als plk- inhibitorenInfo
- Publication number
- ATE452132T1 ATE452132T1 AT06813896T AT06813896T ATE452132T1 AT E452132 T1 ATE452132 T1 AT E452132T1 AT 06813896 T AT06813896 T AT 06813896T AT 06813896 T AT06813896 T AT 06813896T AT E452132 T1 ATE452132 T1 AT E452132T1
- Authority
- AT
- Austria
- Prior art keywords
- benzimidazolethiophene
- compounds
- plk inhibitors
- plk
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71433705P | 2005-09-06 | 2005-09-06 | |
US78624406P | 2006-03-27 | 2006-03-27 | |
PCT/US2006/033683 WO2007030361A2 (en) | 2005-09-06 | 2006-08-28 | Benzimidazole thiophene compounds as plk inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE452132T1 true ATE452132T1 (de) | 2010-01-15 |
Family
ID=37631488
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT06813896T ATE452132T1 (de) | 2005-09-06 | 2006-08-28 | Benzimidazolthiophenverbindungen als plk- inhibitoren |
Country Status (29)
Country | Link |
---|---|
US (2) | US7595330B2 (de) |
EP (1) | EP1937671B1 (de) |
JP (1) | JP5002597B2 (de) |
KR (1) | KR20080047585A (de) |
AR (1) | AR055616A1 (de) |
AT (1) | ATE452132T1 (de) |
AU (1) | AU2006287766B2 (de) |
BR (1) | BRPI0615668A2 (de) |
CA (1) | CA2621879A1 (de) |
CR (1) | CR9786A (de) |
CY (1) | CY1109916T1 (de) |
DE (1) | DE602006011192D1 (de) |
DK (1) | DK1937671T3 (de) |
EA (1) | EA014111B1 (de) |
ES (1) | ES2337929T3 (de) |
HK (1) | HK1117504A1 (de) |
HR (1) | HRP20100122T1 (de) |
IL (1) | IL189897A0 (de) |
JO (1) | JO2578B1 (de) |
MA (1) | MA29816B1 (de) |
MX (1) | MX2008003173A (de) |
NO (1) | NO20081160L (de) |
NZ (1) | NZ566345A (de) |
PE (1) | PE20070518A1 (de) |
PL (1) | PL1937671T3 (de) |
PT (1) | PT1937671E (de) |
SI (1) | SI1937671T1 (de) |
TW (1) | TW200800967A (de) |
WO (1) | WO2007030361A2 (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009538305A (ja) * | 2006-05-23 | 2009-11-05 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼのインヒビターとして有用なチオフェンカルボキサミド |
PE20080710A1 (es) * | 2006-06-02 | 2008-08-07 | Smithkline Beecham Corp | Compuestos de tiofeno de bencimidazol |
US7615643B2 (en) | 2006-06-02 | 2009-11-10 | Smithkline Beecham Corporation | Benzimidazole thiophene compounds |
US20090326029A1 (en) * | 2006-06-02 | 2009-12-31 | Kevin Wayne Kuntz | Non-cyclic substituted benzimidazole thiophene benzyl ether compounds |
EP2123627B1 (de) * | 2007-01-19 | 2013-11-20 | Ube Industries, Ltd. | Verfahren zur herstellung eines aromatischen amins mit einer aralkyloxy- oder heteroaralkyloxygruppe |
EP2170871A2 (de) * | 2007-06-26 | 2010-04-07 | GlaxoSmithKline LLC | Verfahren zur herstellung von benzimidazolthiophenen |
US8273890B2 (en) * | 2007-06-29 | 2012-09-25 | 4Sc Ag | Thiophene-imidazopyridines |
EP2100894A1 (de) | 2008-03-12 | 2009-09-16 | 4Sc Ag | Pyridopyrimidinone verwendbar als Plk1 (polo-like kinase) Hemmen |
WO2009151914A1 (en) * | 2008-05-27 | 2009-12-17 | Smithkline Beecham Corporation | Methods for treating neoplasms with a combination of a plk inhibitor and retinoid |
WO2009154645A1 (en) * | 2008-06-20 | 2009-12-23 | Smithkline Beecham Corporation | Methods for the treatment of central nervous system tumors |
SG172229A1 (en) * | 2008-12-18 | 2011-07-28 | Hoffmann La Roche | Thiazolyl-benzimidazoles |
WO2011049625A1 (en) | 2009-10-20 | 2011-04-28 | Mansour Samadpour | Method for aflatoxin screening of products |
AU2010316780B2 (en) | 2009-11-05 | 2015-07-16 | Rhizen Pharmaceuticals Sa | Novel benzopyran kinase modulators |
MY168757A (en) | 2011-05-04 | 2018-12-04 | Rhizen Pharmaceuticals S A | Novel compounds as modulators of protein kinases |
PL2870157T3 (pl) | 2012-07-04 | 2018-01-31 | Rhizen Pharmaceuticals S A | Selektywne inhibitory pi3k delta |
JP7440940B2 (ja) * | 2020-03-27 | 2024-02-29 | オップテラ インコーポレイテッド | Plk1の選択的分解誘導化合物 |
KR102574152B1 (ko) * | 2020-03-27 | 2023-09-05 | (주) 업테라 | Plk1의 선택적 분해를 유도하는 벤즈이미다졸 티오펜 유도체 화합물 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5990146A (en) | 1997-08-20 | 1999-11-23 | Warner-Lambert Company | Benzimidazoles for inhibiting protein tyrosine kinase mediated cellular proliferation |
US6162804A (en) * | 1997-09-26 | 2000-12-19 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
CA2341409A1 (en) | 1998-08-31 | 2000-03-09 | Merck And Co., Inc. | Novel angiogenesis inhibitors |
RU2296758C2 (ru) * | 2002-08-08 | 2007-04-10 | Смитклайн Бичем Корпорейшн | Производные тиофена |
AU2003903440A0 (en) * | 2003-07-04 | 2003-07-17 | James Hardie International Finance B.V. | Rainscreen apparatus and method |
WO2005037827A1 (en) | 2003-10-16 | 2005-04-28 | Smithkline Beecham Corporation | Process for preparing benzimidazole thiophenes |
WO2005037627A1 (ja) | 2003-10-20 | 2005-04-28 | Nsk Ltd. | ステアリング装置 |
GB0402809D0 (en) | 2004-02-09 | 2004-03-10 | Glaxo Group Ltd | Chemical compounds |
CN101304986A (zh) * | 2005-09-06 | 2008-11-12 | 史密丝克莱恩比彻姆公司 | 制备苯并咪唑噻吩类的区域选择性方法 |
ES2339481T3 (es) * | 2005-09-06 | 2010-05-20 | Glaxosmithkline Llc | Compuestos de bencimidazol tiofeno como moduladores de plk. |
WO2007087283A2 (en) | 2006-01-23 | 2007-08-02 | Vertex Pharmaceuticals Incorporated | Thiophene-carboxamides useful as inhibitors of protein kinases |
US20090326029A1 (en) * | 2006-06-02 | 2009-12-31 | Kevin Wayne Kuntz | Non-cyclic substituted benzimidazole thiophene benzyl ether compounds |
PE20080710A1 (es) * | 2006-06-02 | 2008-08-07 | Smithkline Beecham Corp | Compuestos de tiofeno de bencimidazol |
-
2006
- 2006-08-28 US US11/467,577 patent/US7595330B2/en not_active Expired - Fee Related
- 2006-08-28 CA CA002621879A patent/CA2621879A1/en not_active Abandoned
- 2006-08-28 SI SI200630582T patent/SI1937671T1/sl unknown
- 2006-08-28 JP JP2008529190A patent/JP5002597B2/ja not_active Expired - Fee Related
- 2006-08-28 PE PE2006001041A patent/PE20070518A1/es not_active Application Discontinuation
- 2006-08-28 PT PT06813896T patent/PT1937671E/pt unknown
- 2006-08-28 ES ES06813896T patent/ES2337929T3/es active Active
- 2006-08-28 PL PL06813896T patent/PL1937671T3/pl unknown
- 2006-08-28 AR ARP060103742A patent/AR055616A1/es not_active Application Discontinuation
- 2006-08-28 KR KR1020087007794A patent/KR20080047585A/ko not_active Application Discontinuation
- 2006-08-28 EP EP06813896A patent/EP1937671B1/de active Active
- 2006-08-28 DK DK06813896.5T patent/DK1937671T3/da active
- 2006-08-28 US US12/065,668 patent/US7786127B2/en not_active Expired - Fee Related
- 2006-08-28 DE DE602006011192T patent/DE602006011192D1/de active Active
- 2006-08-28 BR BRPI0615668-1A patent/BRPI0615668A2/pt not_active IP Right Cessation
- 2006-08-28 NZ NZ566345A patent/NZ566345A/en not_active IP Right Cessation
- 2006-08-28 AU AU2006287766A patent/AU2006287766B2/en not_active Ceased
- 2006-08-28 TW TW095131590A patent/TW200800967A/zh unknown
- 2006-08-28 EA EA200800546A patent/EA014111B1/ru not_active IP Right Cessation
- 2006-08-28 MX MX2008003173A patent/MX2008003173A/es active IP Right Grant
- 2006-08-28 AT AT06813896T patent/ATE452132T1/de active
- 2006-08-28 WO PCT/US2006/033683 patent/WO2007030361A2/en active Application Filing
- 2006-08-28 JO JO2006286A patent/JO2578B1/en active
-
2008
- 2008-02-29 CR CR9786A patent/CR9786A/es not_active Application Discontinuation
- 2008-03-03 IL IL189897A patent/IL189897A0/en unknown
- 2008-03-05 NO NO20081160A patent/NO20081160L/no not_active Application Discontinuation
- 2008-03-31 MA MA30794A patent/MA29816B1/fr unknown
- 2008-07-15 HK HK08107811.4A patent/HK1117504A1/xx not_active IP Right Cessation
-
2010
- 2010-03-04 HR HR20100122T patent/HRP20100122T1/hr unknown
- 2010-03-09 CY CY20101100224T patent/CY1109916T1/el unknown
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Legal Events
Date | Code | Title | Description |
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EEIH | Change in the person of patent owner | ||
UEP | Publication of translation of european patent specification |
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