ATE510839T1 - Benzofuropyrimidinone als proteinkinase-hemmer - Google Patents

Benzofuropyrimidinone als proteinkinase-hemmer

Info

Publication number
ATE510839T1
ATE510839T1 AT08832770T AT08832770T ATE510839T1 AT E510839 T1 ATE510839 T1 AT E510839T1 AT 08832770 T AT08832770 T AT 08832770T AT 08832770 T AT08832770 T AT 08832770T AT E510839 T1 ATE510839 T1 AT E510839T1
Authority
AT
Austria
Prior art keywords
benzofuropyrimidinone
protein kinase
kinase inhibitor
inhibitor
protein
Prior art date
Application number
AT08832770T
Other languages
English (en)
Inventor
S Brown
Hongwang Du
Maurizio Franzini
Adam Galan
Ping Huang
Patrick Kearney
Moon Kim
Elena Koltun
Steven Richards
Amy Tsuhako
Cristiana Zaharia
Original Assignee
Exelixis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40383673&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE510839(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Exelixis Inc filed Critical Exelixis Inc
Application granted granted Critical
Publication of ATE510839T1 publication Critical patent/ATE510839T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
AT08832770T 2007-12-21 2008-12-22 Benzofuropyrimidinone als proteinkinase-hemmer ATE510839T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US890707P 2007-12-21 2007-12-21
US7097108P 2008-03-25 2008-03-25
PCT/US2008/087939 WO2009086264A1 (en) 2007-12-21 2008-12-22 Benzofuropyrimidinones as protein kinase inhibitors

Publications (1)

Publication Number Publication Date
ATE510839T1 true ATE510839T1 (de) 2011-06-15

Family

ID=40383673

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08832770T ATE510839T1 (de) 2007-12-21 2008-12-22 Benzofuropyrimidinone als proteinkinase-hemmer

Country Status (20)

Country Link
US (1) US20090247559A1 (de)
EP (1) EP2097419B1 (de)
JP (1) JP2011507908A (de)
KR (1) KR20100098714A (de)
CN (1) CN101965351A (de)
AR (1) AR069869A1 (de)
AT (1) ATE510839T1 (de)
AU (1) AU2008345560A1 (de)
BR (1) BRPI0821573A2 (de)
CA (1) CA2712358A1 (de)
CL (1) CL2008003873A1 (de)
CO (1) CO6321258A2 (de)
EA (1) EA019785B1 (de)
IL (1) IL206416A0 (de)
MX (1) MX2010006799A (de)
NZ (1) NZ586936A (de)
PE (1) PE20091669A1 (de)
TW (1) TW200930375A (de)
WO (1) WO2009086264A1 (de)
ZA (1) ZA201004243B (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007026341A1 (de) 2007-06-06 2008-12-11 Merck Patent Gmbh Benzoxazolonderivate
DE102007032507A1 (de) 2007-07-12 2009-04-02 Merck Patent Gmbh Pyridazinonderivate
DE102007061963A1 (de) 2007-12-21 2009-06-25 Merck Patent Gmbh Pyridazinonderivate
DE102008019907A1 (de) 2008-04-21 2009-10-22 Merck Patent Gmbh Pyridazinonderivate
DE102008028905A1 (de) 2008-06-18 2009-12-24 Merck Patent Gmbh 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate
CA2744987C (en) 2008-12-02 2018-01-16 Chiralgen, Ltd. Method for the synthesis of phosphorus atom modified nucleic acids
KR101663335B1 (ko) 2008-12-22 2016-10-06 메르크 파텐트 게엠베하 6-（1-메틸-1ｈ-피라졸-4-일）-2-｛3-［5-（2-모르폴린-4-일-에톡시）-피리미딘-2-일］-벤질｝-2ｈ-피리다진-3-온디히드로겐포스페이트의 신규한 다형체 및 이의 제조 방법
BR112012000828A8 (pt) 2009-07-06 2017-10-10 Ontorii Inc Novas pró-drogas de ácido nucleico e métodos de uso das mesmas
US10428019B2 (en) 2010-09-24 2019-10-01 Wave Life Sciences Ltd. Chiral auxiliaries
RU2014105311A (ru) 2011-07-19 2015-08-27 Уэйв Лайф Сайенсес Пте. Лтд. Способы синтеза функционализованных нуклеиновых кислот
JP6268157B2 (ja) 2012-07-13 2018-01-24 株式会社Ｗａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｊａｐａｎ 不斉補助基
MX356830B (es) 2012-07-13 2018-06-15 Shin Nippon Biomedical Laboratories Ltd Adyuvante de acido nucleico quiral.
SG10201912895PA (en) 2012-07-13 2020-02-27 Wave Life Sciences Ltd Chiral control
CN102875558A (zh) * 2012-11-05 2013-01-16 贵州大学 2-氯-4-取代-8-硝基苯并呋喃[3,2-d]嘧啶类化合物及其制备方法和用途
CN103044370A (zh) * 2012-12-28 2013-04-17 山东邹平大展新材料有限公司 一种5-（哌嗪-1-基）苯并呋喃-2-甲酰胺的制备方法
CN104045642B (zh) * 2013-03-14 2016-08-24 上海医药工业研究院 含嘧啶或吡啶的稠环化合物及其作为抗肿瘤药物的应用
JPWO2015108047A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
JPWO2015108046A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤
WO2015108048A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
KR102423317B1 (ko) 2014-01-16 2022-07-22 웨이브 라이프 사이언시스 리미티드 키랄 디자인
JP6569908B2 (ja) 2014-01-31 2019-09-04 カルナバイオサイエンス株式会社 抗がん剤組成物
US9676757B2 (en) 2014-02-27 2017-06-13 Merck Patent Gmbh Heterocyclic compounds as NaV channel inhibitors and uses thereof
WO2015152319A1 (ja) * 2014-04-02 2015-10-08 株式会社 三和化学研究所 ５，７－無置換－ピラゾロ［１，５－ａ］ピリミジン－６－カルボン酸の製造方法
KR101837565B1 (ko) 2014-08-06 2018-03-12 삼성에스디아이 주식회사 유기 화합물, 유기 광전자 소자 및 표시 장치
JP6840931B2 (ja) * 2015-03-09 2021-03-10 東ソー株式会社 縮環芳香族化合物の製造方法
US11020396B2 (en) 2016-11-08 2021-06-01 Cancer Research Technology Limited Pyrimidinone derivatives as Cdc7 inhibitors
NL2021185B1 (en) 2018-06-26 2020-01-06 Stichting Het Nederlands Kanker Inst Antoni Van Leeuwenhoek Ziekenhuis Combination Therapy and Use Thereof for Treating Cancer
JP7399968B2 (ja) 2018-09-25 2023-12-18 インサイト・コーポレイション Ａｌｋ２及び／またはｆｇｆｒ調節剤としてのピラゾロ［４，３－ｄ］ピリミジン化合物
CN111689947B (zh) * 2019-03-13 2023-07-14 鲁南制药集团股份有限公司 替加氟-l-脯氨酸共晶体及其制备方法
CA3164707A1 (en) * 2020-02-03 2021-08-12 Ana Maria Garcia Collazo Combination therapy for treating mps1
WO2021198191A1 (en) 2020-03-30 2021-10-07 Enyo Pharma Quinazolinone derivatives and uses thereof for treating a cancer
AR123684A1 (es) * 2020-10-05 2023-01-04 Japan Tobacco Inc Compuesto de tetrahidrobenzofurodiazepinona y uso farmacéutico del mismo
US20240092783A1 (en) 2021-03-18 2024-03-21 Merck Patent Gmbh Heteroaromatic compounds for organic electroluminescent devices
WO2023156386A2 (en) * 2022-02-16 2023-08-24 Duke Street Bio Limited Pharmaceutical compound

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL112248A0 (en) * 1994-01-25 1995-03-30 Warner Lambert Co Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
JPWO2002051849A1 (ja) 2000-12-26 2004-04-22 第一製薬株式会社 Ｃｄｋ４活性阻害剤
CA2444598A1 (en) * 2001-04-20 2003-10-31 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of gsk-3
US7345046B2 (en) 2003-05-30 2008-03-18 Chiron Corporation Heteroaryl-fused pyrimidinyl compounds as anticancer agents
WO2006023381A1 (en) * 2004-08-16 2006-03-02 Taigen Biotechnology Pyrimidinone compounds
EP1776982A1 (de) 2005-10-18 2007-04-25 Argenta Discovery Limited Pyrimidine Derivate als Modulator der Histamine Rezeptor
US20080269239A1 (en) 2004-11-11 2008-10-30 Argenta Discovery Ltd. Pyrimidine Compounds as Histamine Modulators

Also Published As

Publication number Publication date
MX2010006799A (es) 2010-10-05
EP2097419B1 (de) 2011-05-25
BRPI0821573A2 (pt) 2016-08-09
TW200930375A (en) 2009-07-16
EA019785B1 (ru) 2014-06-30
WO2009086264A1 (en) 2009-07-09
EP2097419A1 (de) 2009-09-09
EA201070786A1 (ru) 2011-02-28
KR20100098714A (ko) 2010-09-08
CO6321258A2 (es) 2011-09-20
JP2011507908A (ja) 2011-03-10
AU2008345560A1 (en) 2009-07-09
US20090247559A1 (en) 2009-10-01
CN101965351A (zh) 2011-02-02
PE20091669A1 (es) 2009-12-06
AR069869A1 (es) 2010-02-24
CL2008003873A1 (es) 2009-06-26
NZ586936A (en) 2012-07-27
ZA201004243B (en) 2011-03-30
CA2712358A1 (en) 2009-07-09
IL206416A0 (en) 2010-12-30

Similar Documents

Publication Publication Date Title
ATE510839T1 (de) Benzofuropyrimidinone als proteinkinase-hemmer
CY2019009I2 (el) Αναστολεις πρωτεϊνικων κινασων
CY2017016I1 (el) Αναστολεις πρωτεασωματος
ATE479434T1 (de) Als protein-kinase-inhibitoren nutzbare dyhydrodiazepine
DK2041138T3 (da) Pyrroltriazinkinase-inhibitorer
DK2024375T3 (da) Cyclopropyl-kondenserede indolobenzazepin-HCV-NS5B-hæmmere
DK2215092T3 (da) Substitueret piperidino-dihydrothienopyrimidin
BRPI0910668A2 (pt) inibidores de proteína quinases
DE602006004717D1 (de) Kapselperforationsmodul
DE602007012130D1 (de) Modifizierte flavin-adenin-dinucleotid-abhängige glucose-dehydrogenase
ATE506358T1 (de) 2-benzylpyridazinonderivate als met-kinasehemmer
ATE524477T1 (de) Aziridinylepothilonverbindungen
AT504580A3 (de) Scan-einrichtung
DE602006019150D1 (de) Riemenscheibenanorndung
ATE546437T1 (de) Aminomethyl-4-imidazole
DE502007000218D1 (de) nsetzungen
DE502007002453D1 (de) Kunstoffverdichtergehäuse
DE602006016174D1 (de) Blisterverpackungsverfahren
ATE534010T1 (de) Zielfernrohr
ITMI20060943A1 (it) Nessuno
BRPI0921509A2 (pt) inibidor triazolotiadiazol de proteína quinase c-met
DE502007001629D1 (de) Rfahren
DK2066662T3 (da) Serinhydrolaseinhibitorer
DE102006045567A8 (de) Crimpstabilisierung
DE112007003147A5 (de) Rohr-Biegevorrichtung

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties