PE20091669A1 - Benzofuropirimidinonas - Google Patents

Benzofuropirimidinonas

Info

Publication number
PE20091669A1
PE20091669A1 PE2008002147A PE2008002147A PE20091669A1 PE 20091669 A1 PE20091669 A1 PE 20091669A1 PE 2008002147 A PE2008002147 A PE 2008002147A PE 2008002147 A PE2008002147 A PE 2008002147A PE 20091669 A1 PE20091669 A1 PE 20091669A1
Authority
PE
Peru
Prior art keywords
benzofide
ilmethyl
pyrrolidin
pyrimidin
halo
Prior art date
Application number
PE2008002147A
Other languages
English (en)
Inventor
S David Brown
Hongwang Du
Maurizio Franzini
Adam Antoni Galan
Ping Huang
Patrick Kearney
Moon Hwan Kim
Elena S Koltun
Steven James Richards
Amy L Tsuhako
Cristiana A Zaharia
Original Assignee
Exelixis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40383673&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20091669(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Exelixis Inc filed Critical Exelixis Inc
Publication of PE20091669A1 publication Critical patent/PE20091669A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

REFERIDA A UN COMPUESTO DE FORMULA I, DONDE R1 ES H, ALQUILO; R2 ES AMINOCARBONILALQUILAMINOALQUILO, CICLOALQUILAMINOALQUILO, ARILALQUILO, ENTRE OTROS; R3a ES HALO, ALQUILO, -NO2, ALCOXI, ALQUINILO SUSTITUIDO O NO, ALCOXICARBONILALQUILO, ENTRE OTROS; R3b, R3c Y R3d SON CADA UNO H, -OH, ALCOXILO, HALO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 8-BROMO-2-(PIRROLIDIN-1-ILMETIL)[1]BENZOFURO[3,2-d]PIRIMIDIN-4(3H)-ONA; 8-CLORO-2-(PIRROLIDIN-1-ILMETIL)[1]BENZOFURO[3,2-d]PIRIMIDIN-4(3H)-ONA; ENTRE OTROS. DICHOS COMPUESTOS SON INHIBIDORES DE PROTEINA QUINASA UTILES EN EL TRATAMIENTO DE CANCER
PE2008002147A 2007-12-21 2008-12-19 Benzofuropirimidinonas PE20091669A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US890707P 2007-12-21 2007-12-21
US7097108P 2008-03-25 2008-03-25

Publications (1)

Publication Number Publication Date
PE20091669A1 true PE20091669A1 (es) 2009-12-06

Family

ID=40383673

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008002147A PE20091669A1 (es) 2007-12-21 2008-12-19 Benzofuropirimidinonas

Country Status (20)

Country Link
US (1) US20090247559A1 (es)
EP (1) EP2097419B1 (es)
JP (1) JP2011507908A (es)
KR (1) KR20100098714A (es)
CN (1) CN101965351A (es)
AR (1) AR069869A1 (es)
AT (1) ATE510839T1 (es)
AU (1) AU2008345560A1 (es)
BR (1) BRPI0821573A2 (es)
CA (1) CA2712358A1 (es)
CL (1) CL2008003873A1 (es)
CO (1) CO6321258A2 (es)
EA (1) EA019785B1 (es)
IL (1) IL206416A0 (es)
MX (1) MX2010006799A (es)
NZ (1) NZ586936A (es)
PE (1) PE20091669A1 (es)
TW (1) TW200930375A (es)
WO (1) WO2009086264A1 (es)
ZA (1) ZA201004243B (es)

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DE102007026341A1 (de) 2007-06-06 2008-12-11 Merck Patent Gmbh Benzoxazolonderivate
DE102007032507A1 (de) 2007-07-12 2009-04-02 Merck Patent Gmbh Pyridazinonderivate
DE102007061963A1 (de) 2007-12-21 2009-06-25 Merck Patent Gmbh Pyridazinonderivate
DE102008019907A1 (de) 2008-04-21 2009-10-22 Merck Patent Gmbh Pyridazinonderivate
DE102008028905A1 (de) 2008-06-18 2009-12-24 Merck Patent Gmbh 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate
JP5645840B2 (ja) 2008-12-02 2014-12-24 株式会社Ｗａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｊａｐａｎ リン原子修飾核酸の合成方法
PT2361250E (pt) 2008-12-22 2013-11-11 Merck Patent Gmbh Novas formas polimórficas de di-hidrogenofosfato de 6-(1-metil-1h-pirazol-4-il)-2-{3-[5-(2-morfolin-4-il-etoxi)-pirimidin-2-il]-benzil}-2h-piridazin-3-ona e processos de fabrico das mesmas
MX342945B (es) 2009-07-06 2016-10-18 Ontorii Inc * Profármacos de ácido nucleico novedosos y métodos de uso de los mismos.
WO2012039448A1 (ja) 2010-09-24 2012-03-29 株式会社キラルジェン 不斉補助基
DK2734208T3 (en) 2011-07-19 2017-06-19 Wave Life Sciences Ltd PROCEDURES FOR SYNTHESIS OF FUNCTIONALIZED NUCLEIC ACIDS
CN104684923B (zh) 2012-07-13 2018-09-28 株式会社新日本科学 手性核酸佐剂
DK2872147T3 (da) 2012-07-13 2023-02-20 Wave Life Sciences Ltd Fremgangsmåde til fremstilling af kirale oligonukleotider
ES2862073T3 (es) 2012-07-13 2021-10-06 Wave Life Sciences Ltd Grupo auxiliar asimétrico
CN102875558A (zh) * 2012-11-05 2013-01-16 贵州大学 2-氯-4-取代-8-硝基苯并呋喃[3,2-d]嘧啶类化合物及其制备方法和用途
CN103044370A (zh) * 2012-12-28 2013-04-17 山东邹平大展新材料有限公司 一种5-（哌嗪-1-基）苯并呋喃-2-甲酰胺的制备方法
CN104045642B (zh) * 2013-03-14 2016-08-24 上海医药工业研究院 含嘧啶或吡啶的稠环化合物及其作为抗肿瘤药物的应用
US10322173B2 (en) 2014-01-15 2019-06-18 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
US10144933B2 (en) 2014-01-15 2018-12-04 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
WO2015108048A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
AU2015207773B2 (en) 2014-01-16 2021-06-17 Wave Life Sciences Ltd. Chiral design
US9974795B2 (en) 2014-01-31 2018-05-22 Carna Biosciences, Inc. Anticancer agent composition
CN106255679B (zh) 2014-02-27 2019-09-06 默克专利有限公司 用作nav通道抑制剂的杂环化合物及其用途
WO2015152319A1 (ja) * 2014-04-02 2015-10-08 株式会社 三和化学研究所 ５，７－無置換－ピラゾロ［１，５－ａ］ピリミジン－６－カルボン酸の製造方法
KR101837565B1 (ko) 2014-08-06 2018-03-12 삼성에스디아이 주식회사 유기 화합물, 유기 광전자 소자 및 표시 장치
JP6840931B2 (ja) * 2015-03-09 2021-03-10 東ソー株式会社 縮環芳香族化合物の製造方法
WO2018087527A1 (en) 2016-11-08 2018-05-17 Cancer Research Technology Limited Pyrimidinone derivatives as cdc7 inhibitors
NL2021185B1 (en) 2018-06-26 2020-01-06 Stichting Het Nederlands Kanker Inst Antoni Van Leeuwenhoek Ziekenhuis Combination Therapy and Use Thereof for Treating Cancer
JP7399968B2 (ja) 2018-09-25 2023-12-18 インサイト・コーポレイション Ａｌｋ２及び／またはｆｇｆｒ調節剤としてのピラゾロ［４，３－ｄ］ピリミジン化合物
CN111689947B (zh) * 2019-03-13 2023-07-14 鲁南制药集团股份有限公司 替加氟-l-脯氨酸共晶体及其制备方法
AU2021217816A1 (en) * 2020-02-03 2022-08-11 Gt Gain Therapeutics Sa Combination therapy for treating MPS1
WO2021198191A1 (en) 2020-03-30 2021-10-07 Enyo Pharma Quinazolinone derivatives and uses thereof for treating a cancer
AU2021357608A1 (en) * 2020-10-05 2023-06-08 Japan Tobacco Inc. Tetrahydrobenzofurodiazepinone compounds and pharmaceutical applications thereof
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WO2023156386A2 (en) * 2022-02-16 2023-08-24 Duke Street Bio Limited Pharmaceutical compound

Family Cites Families (7)

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IL112248A0 (en) * 1994-01-25 1995-03-30 Warner Lambert Co Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
JPWO2002051849A1 (ja) 2000-12-26 2004-04-22 第一製薬株式会社 Ｃｄｋ４活性阻害剤
JP2005504730A (ja) * 2001-04-20 2005-02-17 バーテックス　ファーマシューティカルズ　インコーポレイテッド Ｇｓｋ−３インヒビターとして有用な組成物
US7345046B2 (en) 2003-05-30 2008-03-18 Chiron Corporation Heteroaryl-fused pyrimidinyl compounds as anticancer agents
WO2006023381A1 (en) * 2004-08-16 2006-03-02 Taigen Biotechnology Pyrimidinone compounds
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CA2586316A1 (en) 2004-11-11 2006-05-18 Argenta Discovery Ltd. Pyrimidine compounds as histamine modulators

Also Published As

Publication number Publication date
CL2008003873A1 (es) 2009-06-26
AU2008345560A1 (en) 2009-07-09
EP2097419A1 (en) 2009-09-09
EP2097419B1 (en) 2011-05-25
NZ586936A (en) 2012-07-27
MX2010006799A (es) 2010-10-05
ZA201004243B (en) 2011-03-30
IL206416A0 (en) 2010-12-30
WO2009086264A1 (en) 2009-07-09
KR20100098714A (ko) 2010-09-08
EA019785B1 (ru) 2014-06-30
BRPI0821573A2 (pt) 2016-08-09
CA2712358A1 (en) 2009-07-09
TW200930375A (en) 2009-07-16
EA201070786A1 (ru) 2011-02-28
CN101965351A (zh) 2011-02-02
ATE510839T1 (de) 2011-06-15
JP2011507908A (ja) 2011-03-10
US20090247559A1 (en) 2009-10-01
AR069869A1 (es) 2010-02-24
CO6321258A2 (es) 2011-09-20

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