CO6321258A2 - Benzofuropirimidinonas como inhibidores de proteina de quinasa - Google Patents
Benzofuropirimidinonas como inhibidores de proteina de quinasaInfo
- Publication number
- CO6321258A2 CO6321258A2 CO10088575A CO10088575A CO6321258A2 CO 6321258 A2 CO6321258 A2 CO 6321258A2 CO 10088575 A CO10088575 A CO 10088575A CO 10088575 A CO10088575 A CO 10088575A CO 6321258 A2 CO6321258 A2 CO 6321258A2
- Authority
- CO
- Colombia
- Prior art keywords
- optionally substituted
- alkyl
- aryl
- halo
- aminoalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
1.- Un compuesto de acuerdo con la fórmula I:una sal aceptable para uso farmacéutico del mismo,donde:R1 es hidrógeno o alquilo; R2 se selecciona de aminocarbonilalquilaminoalquilo, arninoalquilaminoalquilo, dialquilaminoalquilaminoalquilo, carboxialquilarninoalquilo, cicloalquilaminoalquilo, dialquilaminoarilalquilantinoalquilo, heteroarilalquilaminoalquilo, arilalquilo opcionalmente sustituido en cualquier posición aril o alquilo con 1-3 grupos seleccionados de halo y -NH2, heterocicloalquilarilalquilaminoalquilo opcionalmente sustituido en la porción heterocicloalquilo con alquilo, aminoalquilo opcionalmente sustituido con 1, 2 o 3 -OH, alquilamino opcionalmente sustituido con 1, 2 o 3 -OH, alquilaminoalquilo opcionalmente sustituido con 1, 2 o 3 -OH, alcoxialquilaminoalquilo, heterocicloalquilaminoalquilo opcionalmente sustituido con alquilo en la porción heterocicloalquilo, hidroxialquilo, cicloalquilaminoalquilo, arilamino(alquil)alquilo opcionalmente sustituido en cualquier posición del anillo con 1, 2 o 3 halo, heterocicloalquilalquilaminoalquilo opcionalmente sustituido en cualquier posición del anillo con 1-2 alquilo, arilalquilaminoalquilo opcionalmente sustituido en la posición arilo con dialquilamino, halo, alcoxi, heteroarilo, o alquilheterocicloalquilo, dialquilaminoalquilo opcionalmente sustituido con 1, 2 o 3 -OH, arilaminoalquilo opcionalmente sustituido en la porción arilo con 1, 2 o 3 grupos seleccionados de halo, heterocicloalquilo, alquilheterocicloalquilo y dialquilamino, heteroarilaminoalquilo, arilamino, ariloxialquilo, heteroarilalquilo no sustituido, heteroarilalquilo sustituido en cualquier posición alquilo con alquilo, arilo, arilalquilo o amino, -(C4-C7)cicloalquilo opcionalmente sustituido con -NH2, -NHC(O)-O-(CH3)3, o aminoalquilo, -N(H)C(O)-O-alquilo, alquilpiperazinilcarbonilo, alquilheterocicloalquilalcoxialquilo, alquilheteroarilalcoxialquilo, heteroarilo opcionalmente sustituido en cualquier posición del anillo con 1, 2 o 3 sustituyentes seleccionados de amino, alquilo, ...
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US890707P | 2007-12-21 | 2007-12-21 | |
| US7097108P | 2008-03-25 | 2008-03-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6321258A2 true CO6321258A2 (es) | 2011-09-20 |
Family
ID=40383673
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO10088575A CO6321258A2 (es) | 2007-12-21 | 2010-07-21 | Benzofuropirimidinonas como inhibidores de proteina de quinasa |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20090247559A1 (es) |
| EP (1) | EP2097419B1 (es) |
| JP (1) | JP2011507908A (es) |
| KR (1) | KR20100098714A (es) |
| CN (1) | CN101965351A (es) |
| AR (1) | AR069869A1 (es) |
| AT (1) | ATE510839T1 (es) |
| AU (1) | AU2008345560A1 (es) |
| BR (1) | BRPI0821573A2 (es) |
| CA (1) | CA2712358A1 (es) |
| CL (1) | CL2008003873A1 (es) |
| CO (1) | CO6321258A2 (es) |
| EA (1) | EA019785B1 (es) |
| IL (1) | IL206416A0 (es) |
| MX (1) | MX2010006799A (es) |
| NZ (1) | NZ586936A (es) |
| PE (1) | PE20091669A1 (es) |
| TW (1) | TW200930375A (es) |
| WO (1) | WO2009086264A1 (es) |
| ZA (1) | ZA201004243B (es) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102007026341A1 (de) | 2007-06-06 | 2008-12-11 | Merck Patent Gmbh | Benzoxazolonderivate |
| DE102007032507A1 (de) | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102007061963A1 (de) | 2007-12-21 | 2009-06-25 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102008019907A1 (de) | 2008-04-21 | 2009-10-22 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102008028905A1 (de) | 2008-06-18 | 2009-12-24 | Merck Patent Gmbh | 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate |
| JP5645840B2 (ja) | 2008-12-02 | 2014-12-24 | 株式会社Ｗａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｊａｐａｎ | リン原子修飾核酸の合成方法 |
| EP2361250B1 (en) | 2008-12-22 | 2013-08-07 | Merck Patent GmbH | Novel polymorphic forms of 6-(1-methyl-1h-pyrazol-4-yl)-2-{3-[5-(2-morpholin-4-yl-ethoxy)-pyrimidin-2-yl]-benzyl}-2h-pyridazin-3-one dihydrogenphosphate and processes of manufacturing thereof |
| JP5998326B2 (ja) | 2009-07-06 | 2016-09-28 | ウェイブ ライフ サイエンス リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． | 新規核酸プロドラッグおよびその使用方法 |
| DK2620428T3 (da) * | 2010-09-24 | 2019-07-01 | Wave Life Sciences Ltd | Asymmetrisk hjælpegruppe |
| MX347361B (es) | 2011-07-19 | 2017-04-12 | Wave Life Sciences Ltd | Metodos para la sintesis de acidos nucleicos funcionalizados. |
| WO2014010718A1 (ja) | 2012-07-13 | 2014-01-16 | 株式会社新日本科学 | キラル核酸アジュバント |
| DK2872485T3 (da) | 2012-07-13 | 2021-03-08 | Wave Life Sciences Ltd | Asymmetrisk hjælpegruppe |
| KR102213609B1 (ko) | 2012-07-13 | 2021-02-08 | 웨이브 라이프 사이언시스 리미티드 | 키랄 제어 |
| CN102875558A (zh) * | 2012-11-05 | 2013-01-16 | 贵州大学 | 2-氯-4-取代-8-硝基苯并呋喃[3,2-d]嘧啶类化合物及其制备方法和用途 |
| CN103044370A (zh) * | 2012-12-28 | 2013-04-17 | 山东邹平大展新材料有限公司 | 一种5-（哌嗪-1-基）苯并呋喃-2-甲酰胺的制备方法 |
| CN104045642B (zh) * | 2013-03-14 | 2016-08-24 | 上海医药工业研究院 | 含嘧啶或吡啶的稠环化合物及其作为抗肿瘤药物的应用 |
| EP3095460A4 (en) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent |
| WO2015108048A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| EP3095461A4 (en) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator |
| SG10201912897UA (en) | 2014-01-16 | 2020-02-27 | Wave Life Sciences Ltd | Chiral design |
| EP3100742B1 (en) | 2014-01-31 | 2020-05-20 | Carna Biosciences Inc. | Anticancer agent composition comprising a cdc7 inhibitor and a wee1 inhibitor |
| CN106255679B (zh) * | 2014-02-27 | 2019-09-06 | 默克专利有限公司 | 用作nav通道抑制剂的杂环化合物及其用途 |
| WO2015152319A1 (ja) * | 2014-04-02 | 2015-10-08 | 株式会社 三和化学研究所 | ５，７－無置換－ピラゾロ［１，５－ａ］ピリミジン－６－カルボン酸の製造方法 |
| KR101837565B1 (ko) | 2014-08-06 | 2018-03-12 | 삼성에스디아이 주식회사 | 유기 화합물, 유기 광전자 소자 및 표시 장치 |
| JP6840931B2 (ja) * | 2015-03-09 | 2021-03-10 | 東ソー株式会社 | 縮環芳香族化合物の製造方法 |
| ES2877140T3 (es) | 2016-11-08 | 2021-11-16 | Cancer Research Tech Ltd | Derivados de pirimidinona como inhibidores de Cdc7 |
| NL2021185B1 (en) | 2018-06-26 | 2020-01-06 | Stichting Het Nederlands Kanker Inst Antoni Van Leeuwenhoek Ziekenhuis | Combination Therapy and Use Thereof for Treating Cancer |
| EP3856348B1 (en) | 2018-09-25 | 2024-01-03 | Incyte Corporation | Pyrazolo[4,3-d]pyrimidine compounds as alk2 and/or fgfr modulators |
| CN111689947B (zh) * | 2019-03-13 | 2023-07-14 | 鲁南制药集团股份有限公司 | 替加氟-l-脯氨酸共晶体及其制备方法 |
| WO2021156774A1 (en) * | 2020-02-03 | 2021-08-12 | Gain Therapeutics Sa | Combination therapy for treating mps1 |
| WO2021198191A1 (en) | 2020-03-30 | 2021-10-07 | Enyo Pharma | Quinazolinone derivatives and uses thereof for treating a cancer |
| BR112023005024A2 (pt) * | 2020-10-05 | 2023-04-18 | Japan Tobacco Inc | Compostos de tetra-hidrobenzofurodiazepinona e aplicações farmacêuticas dos mesmos |
| KR20230158657A (ko) | 2021-03-18 | 2023-11-21 | 메르크 파텐트 게엠베하 | 유기 전계 발광 디바이스용 헤테로방향족 화합물 |
| WO2023156386A2 (en) * | 2022-02-16 | 2023-08-24 | Duke Street Bio Limited | Pharmaceutical compound |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL112248A0 (en) * | 1994-01-25 | 1995-03-30 | Warner Lambert Co | Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them |
| JPWO2002051849A1 (ja) | 2000-12-26 | 2004-04-22 | 第一製薬株式会社 | Ｃｄｋ４活性阻害剤 |
| MXPA03009650A (es) * | 2001-04-20 | 2005-03-07 | Vertex Pharma | Derivados de 9-deazoguanidina como inhibidores de gsk-3. |
| US7345046B2 (en) * | 2003-05-30 | 2008-03-18 | Chiron Corporation | Heteroaryl-fused pyrimidinyl compounds as anticancer agents |
| WO2006023381A1 (en) * | 2004-08-16 | 2006-03-02 | Taigen Biotechnology | Pyrimidinone compounds |
| AU2005303893A1 (en) | 2004-11-11 | 2006-05-18 | Argenta Discovery Ltd | Pyrimidine compounds as histamine modulators |
| EP1776982A1 (en) * | 2005-10-18 | 2007-04-25 | Argenta Discovery Limited | Pyrimidine compounds as histamine modulators |
-
2008
- 2008-12-19 PE PE2008002147A patent/PE20091669A1/es not_active Application Discontinuation
- 2008-12-19 AR ARP080105615A patent/AR069869A1/es unknown
- 2008-12-19 TW TW097149655A patent/TW200930375A/zh unknown
- 2008-12-22 BR BRPI0821573A patent/BRPI0821573A2/pt not_active IP Right Cessation
- 2008-12-22 EA EA201070786A patent/EA019785B1/ru not_active IP Right Cessation
- 2008-12-22 CN CN2008801272275A patent/CN101965351A/zh active Pending
- 2008-12-22 WO PCT/US2008/087939 patent/WO2009086264A1/en active Application Filing
- 2008-12-22 MX MX2010006799A patent/MX2010006799A/es active IP Right Grant
- 2008-12-22 KR KR1020107016179A patent/KR20100098714A/ko not_active Application Discontinuation
- 2008-12-22 CL CL2008003873A patent/CL2008003873A1/es unknown
- 2008-12-22 EP EP08832770A patent/EP2097419B1/en active Active
- 2008-12-22 JP JP2010539930A patent/JP2011507908A/ja not_active Ceased
- 2008-12-22 AU AU2008345560A patent/AU2008345560A1/en not_active Abandoned
- 2008-12-22 NZ NZ586936A patent/NZ586936A/en not_active IP Right Cessation
- 2008-12-22 CA CA2712358A patent/CA2712358A1/en not_active Abandoned
- 2008-12-22 AT AT08832770T patent/ATE510839T1/de not_active IP Right Cessation
- 2008-12-22 US US12/341,210 patent/US20090247559A1/en not_active Abandoned
-
2010
- 2010-06-15 ZA ZA2010/04243A patent/ZA201004243B/en unknown
- 2010-06-16 IL IL206416A patent/IL206416A0/en unknown
- 2010-07-21 CO CO10088575A patent/CO6321258A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN101965351A (zh) | 2011-02-02 |
| BRPI0821573A2 (pt) | 2016-08-09 |
| WO2009086264A1 (en) | 2009-07-09 |
| EA019785B1 (ru) | 2014-06-30 |
| KR20100098714A (ko) | 2010-09-08 |
| EP2097419A1 (en) | 2009-09-09 |
| EA201070786A1 (ru) | 2011-02-28 |
| TW200930375A (en) | 2009-07-16 |
| NZ586936A (en) | 2012-07-27 |
| MX2010006799A (es) | 2010-10-05 |
| ZA201004243B (en) | 2011-03-30 |
| PE20091669A1 (es) | 2009-12-06 |
| AR069869A1 (es) | 2010-02-24 |
| EP2097419B1 (en) | 2011-05-25 |
| IL206416A0 (en) | 2010-12-30 |
| CA2712358A1 (en) | 2009-07-09 |
| ATE510839T1 (de) | 2011-06-15 |
| CL2008003873A1 (es) | 2009-06-26 |
| AU2008345560A1 (en) | 2009-07-09 |
| US20090247559A1 (en) | 2009-10-01 |
| JP2011507908A (ja) | 2011-03-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Application withdrawn |