MA29816B1 - Composes de benzimidazole thiophene - Google Patents
Composes de benzimidazole thiopheneInfo
- Publication number
- MA29816B1 MA29816B1 MA30794A MA30794A MA29816B1 MA 29816 B1 MA29816 B1 MA 29816B1 MA 30794 A MA30794 A MA 30794A MA 30794 A MA30794 A MA 30794A MA 29816 B1 MA29816 B1 MA 29816B1
- Authority
- MA
- Morocco
- Prior art keywords
- thiophene compounds
- compounds
- benzimidazole thiophene
- benzimidazole
- preparing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurosurgery (AREA)
- Transplantation (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
L'INVENTION CONCERNE DES COMPOSÉS DE BENZIMIDAZOLE THIOPHÈNE, DES COMPOSITIONS PHARMACEUTIQUES CONTENANT LESDITS COMPOSÉS, DES PROCÉDÉS PERMETTANT DE PRÉPARER LESDITS COMPOSÉS ET L'UTILISATION LESDITS COMPOSÉS EN TANT QU'AGENTS PHARMACEUTIQUES.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71433705P | 2005-09-06 | 2005-09-06 | |
US78624406P | 2006-03-27 | 2006-03-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA29816B1 true MA29816B1 (fr) | 2008-09-01 |
Family
ID=37631488
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA30794A MA29816B1 (fr) | 2005-09-06 | 2008-03-31 | Composes de benzimidazole thiophene |
Country Status (29)
Country | Link |
---|---|
US (2) | US7786127B2 (fr) |
EP (1) | EP1937671B1 (fr) |
JP (1) | JP5002597B2 (fr) |
KR (1) | KR20080047585A (fr) |
AR (1) | AR055616A1 (fr) |
AT (1) | ATE452132T1 (fr) |
AU (1) | AU2006287766B2 (fr) |
BR (1) | BRPI0615668A2 (fr) |
CA (1) | CA2621879A1 (fr) |
CR (1) | CR9786A (fr) |
CY (1) | CY1109916T1 (fr) |
DE (1) | DE602006011192D1 (fr) |
DK (1) | DK1937671T3 (fr) |
EA (1) | EA014111B1 (fr) |
ES (1) | ES2337929T3 (fr) |
HK (1) | HK1117504A1 (fr) |
HR (1) | HRP20100122T1 (fr) |
IL (1) | IL189897A0 (fr) |
JO (1) | JO2578B1 (fr) |
MA (1) | MA29816B1 (fr) |
MX (1) | MX2008003173A (fr) |
NO (1) | NO20081160L (fr) |
NZ (1) | NZ566345A (fr) |
PE (1) | PE20070518A1 (fr) |
PL (1) | PL1937671T3 (fr) |
PT (1) | PT1937671E (fr) |
SI (1) | SI1937671T1 (fr) |
TW (1) | TW200800967A (fr) |
WO (1) | WO2007030361A2 (fr) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009538305A (ja) * | 2006-05-23 | 2009-11-05 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼのインヒビターとして有用なチオフェンカルボキサミド |
EP2032564A2 (fr) * | 2006-06-02 | 2009-03-11 | SmithKline Beecham Corporation | Composés d'éther benzylique de benzimidazole thiophène substitué non cyclique |
DE602007006950D1 (de) * | 2006-06-02 | 2010-07-15 | Glaxosmithkline Llc | Benzimidazol-substituierte thiophenderivate mit wirkung auf plk |
US7615643B2 (en) | 2006-06-02 | 2009-11-10 | Smithkline Beecham Corporation | Benzimidazole thiophene compounds |
JPWO2008087736A1 (ja) * | 2007-01-19 | 2010-05-06 | 宇部興産株式会社 | アラルキルオキシ又はヘテロアラルキルオキシ基を有する芳香族アミンの製法 |
JP2010531887A (ja) * | 2007-06-26 | 2010-09-30 | グラクソスミスクライン エルエルシー | ベンズイミダゾールチオフェンの調製方法 |
WO2009003911A1 (fr) * | 2007-06-29 | 2009-01-08 | 4Sc Ag | Thiophène-imidazopyridines |
EP2100894A1 (fr) | 2008-03-12 | 2009-09-16 | 4Sc Ag | Pyridopyrimidinones utilisés comme inhibiteurs de la kinase de type Plk1 (polo-like kinase) |
WO2009151914A1 (fr) * | 2008-05-27 | 2009-12-17 | Smithkline Beecham Corporation | Procédés de traitement de néoplasmes au moyen d'une combinaison d'un inhibiteur de plk et d'un rétinoïde |
WO2009154645A1 (fr) * | 2008-06-20 | 2009-12-23 | Smithkline Beecham Corporation | Méthodes permettant de traiter des tumeurs du système nerveux central |
SG172229A1 (en) * | 2008-12-18 | 2011-07-28 | Hoffmann La Roche | Thiazolyl-benzimidazoles |
WO2011049625A1 (fr) | 2009-10-20 | 2011-04-28 | Mansour Samadpour | Procédé de criblage d'aflatoxine dans des produits |
DK2496567T3 (en) | 2009-11-05 | 2017-10-30 | Rhizen Pharmaceuticals S A | PRESENT UNKNOWN BENZOPYRANKINA MODULATORS |
RS58326B1 (sr) | 2011-05-04 | 2019-03-29 | Rhizen Pharmaceuticals S A | Nova jedinjenja kao modulatori proteinskih kinaza |
KR101988079B1 (ko) | 2012-07-04 | 2019-06-11 | 리젠 파마슈티컬스 소시에떼 아노님 | 선택적 pi3k 델타 억제제 |
KR102574152B1 (ko) * | 2020-03-27 | 2023-09-05 | (주) 업테라 | Plk1의 선택적 분해를 유도하는 벤즈이미다졸 티오펜 유도체 화합물 |
KR20210122164A (ko) * | 2020-03-27 | 2021-10-08 | (주) 업테라 | Plk1의 선택적 분해를 유도하는 벤즈이미다졸 티오펜 유도체 화합물 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5990146A (en) | 1997-08-20 | 1999-11-23 | Warner-Lambert Company | Benzimidazoles for inhibiting protein tyrosine kinase mediated cellular proliferation |
US6162804A (en) | 1997-09-26 | 2000-12-19 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
CA2341409A1 (fr) | 1998-08-31 | 2000-03-09 | Merck And Co., Inc. | Nouveaux inhibiteurs d'angiogenese |
BR0313160A (pt) * | 2002-08-08 | 2005-07-12 | Smithkline Beecham Corp | Composto, composição farmacêutica, métodos para tratar uma condição e um neoplasmo suscetìvel em um animal em um animal, processo para preparar um composto e uso de um composto |
AU2003903440A0 (en) * | 2003-07-04 | 2003-07-17 | James Hardie International Finance B.V. | Rainscreen apparatus and method |
US7465807B2 (en) | 2003-10-16 | 2008-12-16 | Smithkline Beecham Corporation | Process for preparing benzimidazole thiophenes |
WO2005037627A1 (fr) | 2003-10-20 | 2005-04-28 | Nsk Ltd. | Dispositif de commande |
GB0402809D0 (en) * | 2004-02-09 | 2004-03-10 | Glaxo Group Ltd | Chemical compounds |
US20080249301A1 (en) * | 2005-09-06 | 2008-10-09 | Smithkline Beecham Corporation | Regioselective Process for Preparing Benzimidazole Thiophenes |
CN101331126A (zh) * | 2005-09-06 | 2008-12-24 | 史密丝克莱恩比彻姆公司 | 作为plk调节剂的苯并咪唑噻吩化合物 |
US7915305B2 (en) | 2006-01-23 | 2011-03-29 | Vertex Pharmaceuticals Incorporated | Thiophene-carboxamides useful as inhibitors of protein kinases |
EP2032564A2 (fr) * | 2006-06-02 | 2009-03-11 | SmithKline Beecham Corporation | Composés d'éther benzylique de benzimidazole thiophène substitué non cyclique |
DE602007006950D1 (de) * | 2006-06-02 | 2010-07-15 | Glaxosmithkline Llc | Benzimidazol-substituierte thiophenderivate mit wirkung auf plk |
-
2006
- 2006-08-28 MX MX2008003173A patent/MX2008003173A/es active IP Right Grant
- 2006-08-28 SI SI200630582T patent/SI1937671T1/sl unknown
- 2006-08-28 PT PT06813896T patent/PT1937671E/pt unknown
- 2006-08-28 PE PE2006001041A patent/PE20070518A1/es not_active Application Discontinuation
- 2006-08-28 DE DE602006011192T patent/DE602006011192D1/de active Active
- 2006-08-28 NZ NZ566345A patent/NZ566345A/en not_active IP Right Cessation
- 2006-08-28 BR BRPI0615668-1A patent/BRPI0615668A2/pt not_active IP Right Cessation
- 2006-08-28 PL PL06813896T patent/PL1937671T3/pl unknown
- 2006-08-28 WO PCT/US2006/033683 patent/WO2007030361A2/fr active Application Filing
- 2006-08-28 JO JO2006286A patent/JO2578B1/en active
- 2006-08-28 AU AU2006287766A patent/AU2006287766B2/en not_active Ceased
- 2006-08-28 US US12/065,668 patent/US7786127B2/en not_active Expired - Fee Related
- 2006-08-28 TW TW095131590A patent/TW200800967A/zh unknown
- 2006-08-28 JP JP2008529190A patent/JP5002597B2/ja not_active Expired - Fee Related
- 2006-08-28 AT AT06813896T patent/ATE452132T1/de active
- 2006-08-28 EA EA200800546A patent/EA014111B1/ru not_active IP Right Cessation
- 2006-08-28 US US11/467,577 patent/US7595330B2/en not_active Expired - Fee Related
- 2006-08-28 ES ES06813896T patent/ES2337929T3/es active Active
- 2006-08-28 KR KR1020087007794A patent/KR20080047585A/ko not_active Application Discontinuation
- 2006-08-28 CA CA002621879A patent/CA2621879A1/fr not_active Abandoned
- 2006-08-28 EP EP06813896A patent/EP1937671B1/fr active Active
- 2006-08-28 DK DK06813896.5T patent/DK1937671T3/da active
- 2006-08-28 AR ARP060103742A patent/AR055616A1/es not_active Application Discontinuation
-
2008
- 2008-02-29 CR CR9786A patent/CR9786A/es not_active Application Discontinuation
- 2008-03-03 IL IL189897A patent/IL189897A0/en unknown
- 2008-03-05 NO NO20081160A patent/NO20081160L/no not_active Application Discontinuation
- 2008-03-31 MA MA30794A patent/MA29816B1/fr unknown
- 2008-07-15 HK HK08107811.4A patent/HK1117504A1/xx not_active IP Right Cessation
-
2010
- 2010-03-04 HR HR20100122T patent/HRP20100122T1/hr unknown
- 2010-03-09 CY CY20101100224T patent/CY1109916T1/el unknown
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