MA39163A1 - Forme cristalline de (s)-(2-(6-chloro-7-methyl-1h-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1 -yl)(5-methoxy-2-(2h-1,2,3-triazol-2-yl)phenyl)methanone et utilisation de celle-ci en tant qu'antagonistes des recepteurs de l'orexine - Google Patents

Forme cristalline de (s)-(2-(6-chloro-7-methyl-1h-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1 -yl)(5-methoxy-2-(2h-1,2,3-triazol-2-yl)phenyl)methanone et utilisation de celle-ci en tant qu'antagonistes des recepteurs de l'orexine

Info

Publication number
MA39163A1
MA39163A1 MA39163A MA39163A MA39163A1 MA 39163 A1 MA39163 A1 MA 39163A1 MA 39163 A MA39163 A MA 39163A MA 39163 A MA39163 A MA 39163A MA 39163 A1 MA39163 A1 MA 39163A1
Authority
MA
Morocco
Prior art keywords
methylpyrrolidin
methanone
triazol
imidazol
benzo
Prior art date
Application number
MA39163A
Other languages
English (en)
Other versions
MA39163B1 (fr
Inventor
Christoph Boss
Christine Brotschi
Bibia Heidmann
Thierry Sifferlen
Markus Gude
Jodi T Williams
Raumer Markus Von
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of MA39163A1 publication Critical patent/MA39163A1/fr
Publication of MA39163B1 publication Critical patent/MA39163B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

L'invention concerne des formes cristallines de (s)-(2-(6-chloro-7-méthyl-1h-benzo[d]imidazol-2- yl)-2-méthylpyrrolidin-1-yl)(5-méthoxy-2-(2h-1,2,3-triazol-2-yl)phényl)méthanone, des procédés de préparation de celles-ci, des compositions pharmaceutiques contenant de telles formes cristallines, des compositions pharmaceutiques préparées à partir de telles formes cristallines ainsi que leur utilisation en tant que médicament, notamment en tant qu'antagonistes des récepteurs de l'orexine.
MA39163A 2013-12-03 2014-12-02 Forme cristalline de (s)-(2-(6-chloro-7-methyl-1h-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1 -yl)(5-methoxy-2-(2h-1,2,3-triazol-2-yl)phenyl)methanone et utilisation de celle-ci en tant qu'antagonistes des recepteurs de l'orexine MA39163B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2013060596 2013-12-03
PCT/IB2014/066508 WO2015083070A1 (fr) 2013-12-03 2014-12-02 Forme cristalline de (s)-(2-(6-chloro-7-methyl-1h-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1 -yl)(5-methoxy-2-(2h-1,2,3-triazol-2-yl)phenyl)methanone et utilisation de celle-ci en tant qu'antagonistes des recepteurs de l'orexine

Publications (2)

Publication Number Publication Date
MA39163A1 true MA39163A1 (fr) 2017-11-30
MA39163B1 MA39163B1 (fr) 2018-09-28

Family

ID=52282786

Family Applications (1)

Application Number Title Priority Date Filing Date
MA39163A MA39163B1 (fr) 2013-12-03 2014-12-02 Forme cristalline de (s)-(2-(6-chloro-7-methyl-1h-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1 -yl)(5-methoxy-2-(2h-1,2,3-triazol-2-yl)phenyl)methanone et utilisation de celle-ci en tant qu'antagonistes des recepteurs de l'orexine

Country Status (31)

Country Link
US (1) US9914720B2 (fr)
EP (1) EP3077389B1 (fr)
JP (1) JP6496733B2 (fr)
KR (1) KR102361418B1 (fr)
CN (1) CN105793257B (fr)
AU (1) AU2014358742B2 (fr)
CA (1) CA2929423C (fr)
CL (1) CL2016001342A1 (fr)
CY (1) CY1119695T1 (fr)
DK (1) DK3077389T3 (fr)
EA (1) EA030137B1 (fr)
ES (1) ES2651475T3 (fr)
HK (1) HK1225731B (fr)
HR (1) HRP20171773T1 (fr)
HU (1) HUE035731T2 (fr)
IL (1) IL245923B (fr)
LT (1) LT3077389T (fr)
MA (1) MA39163B1 (fr)
MX (1) MX364208B (fr)
MY (1) MY179862A (fr)
NO (1) NO3077389T3 (fr)
NZ (1) NZ721438A (fr)
PH (1) PH12016500988B1 (fr)
PL (1) PL3077389T3 (fr)
PT (1) PT3077389T (fr)
SA (1) SA516371231B1 (fr)
SI (1) SI3077389T1 (fr)
TW (1) TWI664177B (fr)
UA (1) UA119549C2 (fr)
WO (1) WO2015083070A1 (fr)
ZA (1) ZA201604499B (fr)

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BR112022020924A2 (pt) 2020-04-19 2023-02-14 Idorsia Pharmaceuticals Ltd Métodos de tratamento de um transtorno do sono, a sonolência diurna em um indivíduo, a insônia, e, daridorexante na forma de sal livre ou farmaceuticamente aceitável
WO2022166768A1 (fr) * 2021-02-02 2022-08-11 南京明德新药研发有限公司 Composé tétrahydropyrrolocyclique et son application
WO2023160004A1 (fr) * 2022-02-25 2023-08-31 南京知和医药科技有限公司 Composé à cycle fusionné ayant une activité analgésique, son procédé de préparation et son utilisation

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Also Published As

Publication number Publication date
IL245923B (en) 2019-09-26
AU2014358742B2 (en) 2019-02-07
EA201600435A1 (ru) 2016-11-30
HRP20171773T1 (hr) 2017-12-29
MX364208B (es) 2019-04-16
NO3077389T3 (fr) 2018-02-10
MX2016007215A (es) 2016-09-07
HUE035731T2 (hu) 2018-05-28
LT3077389T (lt) 2017-12-11
IL245923A0 (en) 2016-08-02
WO2015083070A1 (fr) 2015-06-11
SI3077389T1 (en) 2018-01-31
NZ721438A (en) 2021-12-24
AU2014358742A1 (en) 2016-07-07
KR102361418B1 (ko) 2022-02-09
PT3077389T (pt) 2017-12-15
HK1225731B (zh) 2017-09-15
CA2929423A1 (fr) 2015-06-11
BR112016012628A2 (fr) 2017-08-22
ZA201604499B (en) 2019-04-24
KR20160092015A (ko) 2016-08-03
EA030137B1 (ru) 2018-06-29
US9914720B2 (en) 2018-03-13
MA39163B1 (fr) 2018-09-28
CA2929423C (fr) 2021-12-07
DK3077389T3 (da) 2017-11-13
US20160368901A1 (en) 2016-12-22
UA119549C2 (uk) 2019-07-10
CL2016001342A1 (es) 2016-11-18
MY179862A (en) 2020-11-18
SA516371231B1 (ar) 2018-02-20
ES2651475T3 (es) 2018-01-26
PH12016500988A1 (en) 2016-06-20
JP2016539136A (ja) 2016-12-15
JP6496733B2 (ja) 2019-04-03
CN105793257B (zh) 2018-11-13
EP3077389B1 (fr) 2017-09-13
CY1119695T1 (el) 2018-04-04
TW201605838A (zh) 2016-02-16
BR112016012628A8 (pt) 2017-12-26
CN105793257A (zh) 2016-07-20
PH12016500988B1 (en) 2016-06-20
TWI664177B (zh) 2019-07-01
EP3077389A1 (fr) 2016-10-12
PL3077389T3 (pl) 2018-03-30

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