MX2016007215A - Forma cristalina de (s)-(2-(6-cloro)-7-metil-1h-benzo[d]imidazol-2 -il)-2-metilpirrolidin-1-il) (5-metoxi-2-(2h-1,2,3-triazol-2-il)fe nil) metanona y su uso como antagonistas de receptor de orexina. - Google Patents

Forma cristalina de (s)-(2-(6-cloro)-7-metil-1h-benzo[d]imidazol-2 -il)-2-metilpirrolidin-1-il) (5-metoxi-2-(2h-1,2,3-triazol-2-il)fe nil) metanona y su uso como antagonistas de receptor de orexina.

Info

Publication number
MX2016007215A
MX2016007215A MX2016007215A MX2016007215A MX2016007215A MX 2016007215 A MX2016007215 A MX 2016007215A MX 2016007215 A MX2016007215 A MX 2016007215A MX 2016007215 A MX2016007215 A MX 2016007215A MX 2016007215 A MX2016007215 A MX 2016007215A
Authority
MX
Mexico
Prior art keywords
methylpyrrolidin
methanone
triazol
imidazol
benzo
Prior art date
Application number
MX2016007215A
Other languages
English (en)
Other versions
MX364208B (es
Inventor
Von Raumer Markus
Gude Markus
Boss Christoph
Brotschi Christine
Heidmann Bibia
Sifferlen Thierry
T Williams Jodi
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of MX2016007215A publication Critical patent/MX2016007215A/es
Publication of MX364208B publication Critical patent/MX364208B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invención se relaciona con formas cristalinas de (S)-(2-(6-cloro-7-metil-1H-benzo[d]imidazol-2-il)-2-metilpirrolid in-1-il)(5-metoxi-2-(2H-1,2,3-triazol-2-il)fenil)metanona, procesos para la preparación de los mismos, composiciones farmacéuticas conteniendo tales formas cristalinas, composiciones farmacéuticas preparadas a partir de tales formas cristalinas, y su uso como un medicamento, especialmente como antagonistas del receptor de orexina.
MX2016007215A 2013-12-03 2014-12-02 Forma cristalina de (s)-(2-(6-cloro)-7-metil-1h-benzo[d]imidazol-2 -il)-2-metilpirrolidin-1-il) (5-metoxi-2-(2h-1,2,3-triazol-2-il)fe nil) metanona y su uso como antagonistas de receptor de orexina. MX364208B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2013060596 2013-12-03
PCT/IB2014/066508 WO2015083070A1 (en) 2013-12-03 2014-12-02 Crystalline form of (s)-(2-(6-chloro-7-methyl-1h-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1 -yl)(5-methoxy-2-(2h-1,2,3-triazol-2-yl)phenyl)methanone and its use as orexin receptor antagonists

Publications (2)

Publication Number Publication Date
MX2016007215A true MX2016007215A (es) 2016-09-07
MX364208B MX364208B (es) 2019-04-16

Family

ID=52282786

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016007215A MX364208B (es) 2013-12-03 2014-12-02 Forma cristalina de (s)-(2-(6-cloro)-7-metil-1h-benzo[d]imidazol-2 -il)-2-metilpirrolidin-1-il) (5-metoxi-2-(2h-1,2,3-triazol-2-il)fe nil) metanona y su uso como antagonistas de receptor de orexina.

Country Status (31)

Country Link
US (1) US9914720B2 (es)
EP (1) EP3077389B1 (es)
JP (1) JP6496733B2 (es)
KR (1) KR102361418B1 (es)
CN (1) CN105793257B (es)
AU (1) AU2014358742B2 (es)
CA (1) CA2929423C (es)
CL (1) CL2016001342A1 (es)
CY (1) CY1119695T1 (es)
DK (1) DK3077389T3 (es)
EA (1) EA030137B1 (es)
ES (1) ES2651475T3 (es)
HK (1) HK1225731B (es)
HR (1) HRP20171773T1 (es)
HU (1) HUE035731T2 (es)
IL (1) IL245923B (es)
LT (1) LT3077389T (es)
MA (1) MA39163B1 (es)
MX (1) MX364208B (es)
MY (1) MY179862A (es)
NO (1) NO3077389T3 (es)
NZ (1) NZ721438A (es)
PH (1) PH12016500988B1 (es)
PL (1) PL3077389T3 (es)
PT (1) PT3077389T (es)
SA (1) SA516371231B1 (es)
SI (1) SI3077389T1 (es)
TW (1) TWI664177B (es)
UA (1) UA119549C2 (es)
WO (1) WO2015083070A1 (es)
ZA (1) ZA201604499B (es)

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TWI570120B (zh) 2012-06-04 2017-02-11 艾克泰聯製藥有限公司 苯并咪唑脯胺酸衍生物
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CN105873921B (zh) 2013-12-04 2019-03-15 爱杜西亚药品有限公司 苯并咪唑-脯氨酸衍生物的用途
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Also Published As

Publication number Publication date
IL245923A0 (en) 2016-08-02
NZ721438A (en) 2021-12-24
CY1119695T1 (el) 2018-04-04
CA2929423C (en) 2021-12-07
AU2014358742B2 (en) 2019-02-07
HRP20171773T1 (hr) 2017-12-29
CL2016001342A1 (es) 2016-11-18
US9914720B2 (en) 2018-03-13
KR102361418B1 (ko) 2022-02-09
EP3077389B1 (en) 2017-09-13
CN105793257B (zh) 2018-11-13
NO3077389T3 (es) 2018-02-10
EP3077389A1 (en) 2016-10-12
MA39163A1 (fr) 2017-11-30
JP2016539136A (ja) 2016-12-15
PT3077389T (pt) 2017-12-15
HK1225731B (zh) 2017-09-15
PH12016500988A1 (en) 2016-06-20
WO2015083070A1 (en) 2015-06-11
MY179862A (en) 2020-11-18
PH12016500988B1 (en) 2016-06-20
HUE035731T2 (hu) 2018-05-28
DK3077389T3 (da) 2017-11-13
EA201600435A1 (ru) 2016-11-30
EA030137B1 (ru) 2018-06-29
ZA201604499B (en) 2019-04-24
TW201605838A (zh) 2016-02-16
JP6496733B2 (ja) 2019-04-03
IL245923B (en) 2019-09-26
SI3077389T1 (en) 2018-01-31
MA39163B1 (fr) 2018-09-28
BR112016012628A2 (es) 2017-08-22
MX364208B (es) 2019-04-16
ES2651475T3 (es) 2018-01-26
KR20160092015A (ko) 2016-08-03
SA516371231B1 (ar) 2018-02-20
LT3077389T (lt) 2017-12-11
CA2929423A1 (en) 2015-06-11
BR112016012628A8 (pt) 2017-12-26
UA119549C2 (uk) 2019-07-10
US20160368901A1 (en) 2016-12-22
AU2014358742A1 (en) 2016-07-07
PL3077389T3 (pl) 2018-03-30
CN105793257A (zh) 2016-07-20
TWI664177B (zh) 2019-07-01

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