BR112016012628A8 - Forma cristalina de (s)-(2-(6-cloro-7-metil-1h-benzo[d]imidazol-2-il)-2-metilpirrolidin-1-il)(5-metóxi-2-(2h-1,2,3-triazol-2-il)fenil)metanona e seu uso como antagonistas dos receptores da orexina - Google Patents

Forma cristalina de (s)-(2-(6-cloro-7-metil-1h-benzo[d]imidazol-2-il)-2-metilpirrolidin-1-il)(5-metóxi-2-(2h-1,2,3-triazol-2-il)fenil)metanona e seu uso como antagonistas dos receptores da orexina

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Publication number
BR112016012628A8
BR112016012628A8 BR112016012628A BR112016012628A BR112016012628A8 BR 112016012628 A8 BR112016012628 A8 BR 112016012628A8 BR 112016012628 A BR112016012628 A BR 112016012628A BR 112016012628 A BR112016012628 A BR 112016012628A BR 112016012628 A8 BR112016012628 A8 BR 112016012628A8
Authority
BR
Brazil
Prior art keywords
methylpyrrolidin
methanone
triazol
imidazol
benzo
Prior art date
Application number
BR112016012628A
Other languages
English (en)
Other versions
BR112016012628B1 (pt
BR112016012628A2 (pt
Inventor
Boss Christoph
Brotschi Christine
Gude Markus
Heidmann Bibia
Sifferlen Thierry
Von Raumer Markus
T Williams Jodi
Original Assignee
Actelion Pharmaceuticals Ltd
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd, Idorsia Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of BR112016012628A2 publication Critical patent/BR112016012628A2/pt
Publication of BR112016012628A8 publication Critical patent/BR112016012628A8/pt
Publication of BR112016012628B1 publication Critical patent/BR112016012628B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

FORMA CRISTALINA DE (S)-(2-(6-CLORO-7-METIL-1H- BENZO[D]IMIDAZOL-2-IL)-2-METILPIRROLIDIN-1-IL)(5-METÓXI-2- (2H-1,2,3-TRIAZOL-2-IL)FENIL)METANONA E SEU USO COM O ANTAGONISTAS DOS RECEPTORES DA OREXINA A invenção se refere às formas cristalinas de (S)-(2-(6-cloro-7-metil-1H-benzo[d]imidazol-2-il)-2-metilpirrolidin-1-il) (5-metóxi-2-(2H-1,2,3-triazol-2-il)fenil)metanona, processos para a sua preparação, composições farmacêuticas contendo tais formas cristalinas, composições farmacêuticas preparadas de tais formas cristalinas e seu uso como medicamento, especialmente como antagonistas de receptor de orexina.
BR112016012628-9A 2013-12-03 2014-12-02 Forma cristalina de hemi-hidrato do composto (s)-(2-(6-cloro-7-metil- 1h-benzo[d]imidazol-2-il)-2- metilpirrolidin-1-il)(5-metóxi-2-(2h-1,2,3-triazol-2-il) fenil)metanona, seu uso como antagonistas dos receptores da orexina, e, composição farmacêutica BR112016012628B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IB2013060596 2013-12-03
IBPCT/IB2013/060596 2013-12-03
PCT/IB2014/066508 WO2015083070A1 (en) 2013-12-03 2014-12-02 Crystalline form of (s)-(2-(6-chloro-7-methyl-1h-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1 -yl)(5-methoxy-2-(2h-1,2,3-triazol-2-yl)phenyl)methanone and its use as orexin receptor antagonists

Publications (3)

Publication Number Publication Date
BR112016012628A2 BR112016012628A2 (pt) 2017-08-22
BR112016012628A8 true BR112016012628A8 (pt) 2017-12-26
BR112016012628B1 BR112016012628B1 (pt) 2023-08-08

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Also Published As

Publication number Publication date
IL245923A0 (en) 2016-08-02
NZ721438A (en) 2021-12-24
CY1119695T1 (el) 2018-04-04
CA2929423C (en) 2021-12-07
AU2014358742B2 (en) 2019-02-07
HRP20171773T1 (hr) 2017-12-29
CL2016001342A1 (es) 2016-11-18
US9914720B2 (en) 2018-03-13
KR102361418B1 (ko) 2022-02-09
EP3077389B1 (en) 2017-09-13
CN105793257B (zh) 2018-11-13
NO3077389T3 (pt) 2018-02-10
EP3077389A1 (en) 2016-10-12
MX2016007215A (es) 2016-09-07
MA39163A1 (fr) 2017-11-30
JP2016539136A (ja) 2016-12-15
PT3077389T (pt) 2017-12-15
HK1225731B (zh) 2017-09-15
PH12016500988A1 (en) 2016-06-20
WO2015083070A1 (en) 2015-06-11
MY179862A (en) 2020-11-18
PH12016500988B1 (en) 2016-06-20
HUE035731T2 (hu) 2018-05-28
DK3077389T3 (da) 2017-11-13
EA201600435A1 (ru) 2016-11-30
EA030137B1 (ru) 2018-06-29
ZA201604499B (en) 2019-04-24
TW201605838A (zh) 2016-02-16
JP6496733B2 (ja) 2019-04-03
IL245923B (en) 2019-09-26
SI3077389T1 (en) 2018-01-31
MA39163B1 (fr) 2018-09-28
BR112016012628A2 (pt) 2017-08-22
MX364208B (es) 2019-04-16
ES2651475T3 (es) 2018-01-26
KR20160092015A (ko) 2016-08-03
SA516371231B1 (ar) 2018-02-20
LT3077389T (lt) 2017-12-11
CA2929423A1 (en) 2015-06-11
UA119549C2 (uk) 2019-07-10
US20160368901A1 (en) 2016-12-22
AU2014358742A1 (en) 2016-07-07
PL3077389T3 (pl) 2018-03-30
CN105793257A (zh) 2016-07-20
TWI664177B (zh) 2019-07-01

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: IDORSIA PHARMACEUTICALS LTD (CH)

B25L Entry of change of name and/or headquarter and transfer of application, patent and certificate of addition of invention: publication cancelled

Owner name: ACTELION PHARMACEUTICALS LTD (CH)

B25C Requirement related to requested transfer of rights

Owner name: ACTELION PHARMACEUTICALS LTD (CH)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B25A Requested transfer of rights approved

Owner name: IDORSIA PHARMACEUTICALS LTD (CH)

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

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