GB0130393D0 - Compounds - Google Patents

Compounds

Info

Publication number
GB0130393D0
GB0130393D0 GBGB0130393.2A GB0130393A GB0130393D0 GB 0130393 D0 GB0130393 D0 GB 0130393D0 GB 0130393 A GB0130393 A GB 0130393A GB 0130393 D0 GB0130393 D0 GB 0130393D0
Authority
GB
United Kingdom
Prior art keywords
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB0130393.2A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Priority to GBGB0130393.2A priority Critical patent/GB0130393D0/en
Publication of GB0130393D0 publication Critical patent/GB0130393D0/en
Priority to AU2002352389A priority patent/AU2002352389A1/en
Priority to PCT/GB2002/005676 priority patent/WO2003051873A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GBGB0130393.2A 2001-12-19 2001-12-19 Compounds Ceased GB0130393D0 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
GBGB0130393.2A GB0130393D0 (en) 2001-12-19 2001-12-19 Compounds
AU2002352389A AU2002352389A1 (en) 2001-12-19 2002-12-13 Piperazine compounds and their phamaceutical use
PCT/GB2002/005676 WO2003051873A1 (en) 2001-12-19 2002-12-13 Piperazine compounds and their phamaceutical use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0130393.2A GB0130393D0 (en) 2001-12-19 2001-12-19 Compounds

Publications (1)

Publication Number Publication Date
GB0130393D0 true GB0130393D0 (en) 2002-02-06

Family

ID=9927958

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB0130393.2A Ceased GB0130393D0 (en) 2001-12-19 2001-12-19 Compounds

Country Status (3)

Country Link
AU (1) AU2002352389A1 (en)
GB (1) GB0130393D0 (en)
WO (1) WO2003051873A1 (en)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
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JP2006504695A (en) * 2002-09-18 2006-02-09 グラクソ　グループ　リミテッド N-aroyl cyclic amines as orexin receptor antagonists
RU2334735C2 (en) 2002-10-11 2008-09-27 Актелион Фармасьютиклз Лтд. Sulphonyl aminoacetic acid derivatives and their application as orexin receptor antagonists
JPWO2004069824A1 (en) 2003-02-07 2006-05-25 第一製薬株式会社 Pyrazole derivative
WO2004096780A1 (en) 2003-04-28 2004-11-11 Actelion Pharmaceuticals Ltd Quinoxalinone-3- one derivatives as orexin receptor antagonists
HRP20150371T1 (en) 2004-03-01 2015-05-08 Actelion Pharmaceuticals Ltd. Substituted 1,2,3,4-tetrahydroisoquinoline derivatives
US7501395B2 (en) 2005-04-25 2009-03-10 Eisai R & D Management Co., Ltd. Method of screening for antianxiety drugs
JP2009531447A (en) 2006-03-29 2009-09-03 メルク エンド カムパニー インコーポレーテッド Diazepan orexin receptor antagonist
CA2657623A1 (en) 2006-07-14 2008-01-17 Merck & Co., Inc. Bridged diazepan orexin receptor antagonists
WO2008038251A2 (en) * 2006-09-29 2008-04-03 Actelion Pharmaceuticals Ltd 3-aza-bicyclo[3.1.0]hexane derivatives
US8133901B2 (en) 2006-12-01 2012-03-13 Actelion Pharmaceuticals Ltd. 3-heteroaryl (amino or amido)-1-(biphenyl or phenylthiazolyl) carbonylpiperidine derivatives as orexin receptor inhibitors
PE20081229A1 (en) 2006-12-01 2008-08-28 Merck & Co Inc DIAZEPAM OREXIN RECEPTOR ANTAGONISTS REPLACED
AR064561A1 (en) 2006-12-28 2009-04-08 Actelion Pharmaceuticals Ltd DERIVATIVES OF 2-AZA-BICYCLE [3.1.0] HEXANE AND ITS USE IN THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF DISEASES RELATED TO GENERAL DYSFUNCTIONS OF THE OREXINE SYSTEM.
CL2008000836A1 (en) 2007-03-26 2008-11-07 Actelion Pharmaceuticals Ltd Thiazolidine derivative compounds, orexin receptor antagonists; pharmaceutical composition that includes them; and its use in the treatment of emotional neurosis, severe depression, psychotic disorders, Alzheimer's, parkinson's, pain, among others.
JP2010527924A (en) 2007-05-18 2010-08-19 メルク・シャープ・エンド・ドーム・コーポレイション Oxo-bridged diazepan orexin receptor antagonist
CN101679366B (en) 2007-05-23 2013-08-07 默沙东公司 Pyridyl piperidine orexin receptor antagonists
WO2008150364A1 (en) 2007-05-23 2008-12-11 Merck & Co., Inc. Cyclopropyl pyrrolidine orexin receptor antagonists
NZ583487A (en) 2007-07-27 2011-09-30 Actelion Pharmaceuticals Ltd 2-aza-bicyclo[3.3.0]octane derivatives
JP2010540429A (en) 2007-09-24 2010-12-24 アクテリオン ファーマシューティカルズ リミテッド Pyrrolidines and piperidines as orexin receptor antagonists
WO2009104155A1 (en) 2008-02-21 2009-08-27 Actelion Pharmaceuticals Ltd 2-aza-bicyclo[2.2.1]heptane derivatives
EP2275421A1 (en) 2009-07-15 2011-01-19 Rottapharm S.p.A. Spiro amino compounds suitable for the treatment of inter alia sleep disorders and drug addiction
AR088352A1 (en) 2011-10-19 2014-05-28 Merck Sharp & Dohme ANTAGONISTS OF THE RECEIVER OF 2-PIRIDILOXI-4-NITRILE OREXINE
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
BR112014019426A8 (en) 2012-02-07 2017-07-11 Eolas Therapeutics Inc PROLINES/PIPERIDINES SUBSTITUTED AS OREXIN RECEPTOR ANTAGONISTS
TWI510481B (en) 2012-06-04 2015-12-01 Actelion Pharmaceuticals Ltd Benzimidazole proline derivative
MX2015004638A (en) 2012-10-10 2015-07-14 Actelion Pharmaceuticals Ltd Orexin receptor antagonists which are [ortho bi (hetero )aryl]-[2-(meta bi (hetero )aryl)-pyrrolidin-1-yl]-methanone derivatives.
JP2016510810A (en) 2013-03-12 2016-04-11 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ Azetidine amide derivatives as orexin receptor antagonists
HUE035731T2 (en) 2013-12-03 2018-05-28 Idorsia Pharmaceuticals Ltd Crystalline form of (s)-(2-(6-chloro-7-methyl-1h-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1-yl)(5-methoxy-2-(2h-1,2,3-triazol-2-yl)phenyl)methanone and its use as orexin receptor antagonists
UA119151C2 (en) 2013-12-03 2019-05-10 Ідорсія Фармасьютікалз Лтд Crystalline salt form of (s)-(2-(6-chloro-7-methyl-1 h-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1 -yl)(5-methoxy-2-(2h-1,2,3-triazol-2-yl)phenyl)methanone as orexin receptor antagonist
LT3077391T (en) 2013-12-04 2018-10-25 Idorsia Pharmaceuticals Ltd Use of benzimidazole-proline derivatives
AR101558A1 (en) 2014-08-13 2016-12-28 Eolas Therapeutics Inc DIFLUOROPIRROLIDINS AS MODULATORS OF THE OREXINE RECEIVER
AU2017217931B2 (en) 2016-02-12 2020-10-22 Astrazeneca Ab Halo-substituted piperidines as orexin receptor modulators
EP3454857A1 (en) 2016-05-10 2019-03-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory diseases
WO2020007964A1 (en) 2018-07-05 2020-01-09 Idorsia Pharmaceuticals Ltd 2-(2-azabicyclo[3.1.0]hexan-1-yl)-1h-benzimidazole derivatives
WO2020099511A1 (en) 2018-11-14 2020-05-22 Idorsia Pharmaceuticals Ltd Benzimidazole-2-methyl-morpholine derivatives
WO2020247445A1 (en) 2019-06-04 2020-12-10 Hager Biosciences, Llc Imidazolo derivatives, compositions and methods as orexin antagonists
WO2023218023A1 (en) 2022-05-13 2023-11-16 Idorsia Pharmaceuticals Ltd Thiazoloaryl-methyl substituted cyclic hydrazine-n-carboxamide derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK247789A (en) * 1988-05-23 1989-11-24 Glaxo Group Ltd piperazine

Also Published As

Publication number Publication date
AU2002352389A1 (en) 2003-06-30
WO2003051873A1 (en) 2003-06-26

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Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)