GB0130393D0 - Compounds - Google Patents

Compounds

Info

Publication number
GB0130393D0
GB0130393D0 GBGB0130393.2A GB0130393A GB0130393D0 GB 0130393 D0 GB0130393 D0 GB 0130393D0 GB 0130393 A GB0130393 A GB 0130393A GB 0130393 D0 GB0130393 D0 GB 0130393D0
Authority
GB
United Kingdom
Prior art keywords
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB0130393.2A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Priority to GBGB0130393.2A priority Critical patent/GB0130393D0/en
Publication of GB0130393D0 publication Critical patent/GB0130393D0/en
Priority to PCT/GB2002/005676 priority patent/WO2003051873A1/en
Priority to AU2002352389A priority patent/AU2002352389A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GBGB0130393.2A 2001-12-19 2001-12-19 Compounds Ceased GB0130393D0 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
GBGB0130393.2A GB0130393D0 (en) 2001-12-19 2001-12-19 Compounds
PCT/GB2002/005676 WO2003051873A1 (en) 2001-12-19 2002-12-13 Piperazine compounds and their phamaceutical use
AU2002352389A AU2002352389A1 (en) 2001-12-19 2002-12-13 Piperazine compounds and their phamaceutical use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0130393.2A GB0130393D0 (en) 2001-12-19 2001-12-19 Compounds

Publications (1)

Publication Number Publication Date
GB0130393D0 true GB0130393D0 (en) 2002-02-06

Family

ID=9927958

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB0130393.2A Ceased GB0130393D0 (en) 2001-12-19 2001-12-19 Compounds

Country Status (3)

Country Link
AU (1) AU2002352389A1 (en)
GB (1) GB0130393D0 (en)
WO (1) WO2003051873A1 (en)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
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WO2004026866A1 (en) * 2002-09-18 2004-04-01 Glaxo Group Limited N-aroyl cyclic amines as orexin receptor antagonists
NZ538749A (en) 2002-10-11 2006-11-30 Actelion Pharmaceuticals Ltd Sulfonylamino-acetic acid derivatives and their use as orexin receptor antagonists
RU2332412C2 (en) 2003-02-07 2008-08-27 Дайити Фармасьютикал Ко., Лтд. Pyrazole derivatives
ATE383345T1 (en) 2003-04-28 2008-01-15 Actelion Pharmaceuticals Ltd QUINOXALIN-3-ONE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS.
RU2378257C2 (en) 2004-03-01 2010-01-10 Актелион Фармасьютиклз Лтд Substituted derivatives of 1, 2, 3, 4-tetrahydroisoquinoline
US7501395B2 (en) 2005-04-25 2009-03-10 Eisai R & D Management Co., Ltd. Method of screening for antianxiety drugs
JP2009531447A (en) 2006-03-29 2009-09-03 メルク エンド カムパニー インコーポレーテッド Diazepan orexin receptor antagonist
EP2049110B1 (en) 2006-07-14 2014-08-20 Merck Sharp & Dohme Corp. Bridged diazepan orexin receptor antagonists
CL2007002809A1 (en) * 2006-09-29 2008-04-18 Actelion Pharmaceuticals Ltd COMPOUNDS DERIVED FROM 3-AZA BICICLO [3.1.0] HEXANO; AND ITS USE IN THE TREATMENT OF SUCH DISEASES AS PSYCHOTIC AND ANXIETY DISORDERS, DISORDERS OF THE SOUND, USE AND ABUSE OF PSYCHOACTIVE SUBSTANCES, DEMENTIA AND DETERIORATION OF COGNITIVE FUNCTIONS
CN101568533A (en) 2006-12-01 2009-10-28 埃科特莱茵药品有限公司 3-heteroaryl (amino or amido)-1- (biphenyl or phenylthiazolyl) carbonylpiperdine derivatives as orexin receptor inhibitors
PE20081229A1 (en) 2006-12-01 2008-08-28 Merck & Co Inc DIAZEPAM OREXIN RECEPTOR ANTAGONISTS REPLACED
AR064561A1 (en) * 2006-12-28 2009-04-08 Actelion Pharmaceuticals Ltd DERIVATIVES OF 2-AZA-BICYCLE [3.1.0] HEXANE AND ITS USE IN THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF DISEASES RELATED TO GENERAL DYSFUNCTIONS OF THE OREXINE SYSTEM.
CL2008000836A1 (en) 2007-03-26 2008-11-07 Actelion Pharmaceuticals Ltd Thiazolidine derivative compounds, orexin receptor antagonists; pharmaceutical composition that includes them; and its use in the treatment of emotional neurosis, severe depression, psychotic disorders, Alzheimer's, parkinson's, pain, among others.
WO2008143856A1 (en) 2007-05-18 2008-11-27 Merck & Co., Inc. Oxo bridged diazepan orexin receptor antagonists
US8030495B2 (en) 2007-05-23 2011-10-04 Coleman Paul J Cyclopropyl pyrrolidine orexin receptor antagonists
HRP20120240T1 (en) 2007-05-23 2012-04-30 Merck Sharp & Dohme Corp. PIRIDIL PIPERIDIN ORREXIN ANTAGONIST RECEPTORA
KR20100046047A (en) 2007-07-27 2010-05-04 액테리온 파마슈티칼 리미티드 2-aza-bicyclo[3.3.0]octane derivatives
US8288411B2 (en) 2007-09-24 2012-10-16 Actelion Pharmaceuticals Ltd. Pyrrolidines and piperidines as orexin receptor antagonists
AU2009215243A1 (en) 2008-02-21 2009-08-27 Actelion Pharmaceuticals Ltd. 2-aza-bicyclo[2.2.1]heptane derivatives
EP2275421A1 (en) 2009-07-15 2011-01-19 Rottapharm S.p.A. Spiro amino compounds suitable for the treatment of inter alia sleep disorders and drug addiction
AR088352A1 (en) 2011-10-19 2014-05-28 Merck Sharp & Dohme ANTAGONISTS OF THE RECEIVER OF 2-PIRIDILOXI-4-NITRILE OREXINE
JP6346862B2 (en) 2012-02-07 2018-06-20 エオラス セラピューティクス， インコーポレイテッド Substituted proline / piperidine as an orexin receptor antagonist
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
DK2855453T3 (en) 2012-06-04 2017-02-06 Actelion Pharmaceuticals Ltd Benzimidazol-proline derivatives
BR112015007516A2 (en) 2012-10-10 2017-07-04 Actelion Pharmaceuticals Ltd orexin receptor antagonists that are derived from [ortho-bi- (hetero-) aryl] - [2- (meta-bi- (hetero-) aryl) -pyrrolidin-1-yl] -methanone
CN105051040A (en) 2013-03-12 2015-11-11 埃科特莱茵药品有限公司 Azetidine amide derivatives as orexin receptor antagonists
UA119151C2 (en) 2013-12-03 2019-05-10 Ідорсія Фармасьютікалз Лтд Crystalline salt form of (s)-(2-(6-chloro-7-methyl-1 h-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1 -yl)(5-methoxy-2-(2h-1,2,3-triazol-2-yl)phenyl)methanone as orexin receptor antagonist
CN105793257B (en) 2013-12-03 2018-11-13 爱杜西亚药品有限公司 The crystalline form and application thereof of benzimidazole cycle compound
SI3077391T1 (en) 2013-12-04 2018-11-30 Idorsia Pharmaceuticals Ltd Use of benzimidazole-proline derivatives
TW201613902A (en) 2014-08-13 2016-04-16 Eolas Therapeutics Inc Difluoropyrrolidines as orexin receptor modulators
US10894789B2 (en) 2016-02-12 2021-01-19 Astrazeneca Ab Halo-substituted piperidines as orexin receptor modulators
EP3454857A1 (en) 2016-05-10 2019-03-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory diseases
WO2020007964A1 (en) 2018-07-05 2020-01-09 Idorsia Pharmaceuticals Ltd 2-(2-azabicyclo[3.1.0]hexan-1-yl)-1h-benzimidazole derivatives
WO2020099511A1 (en) 2018-11-14 2020-05-22 Idorsia Pharmaceuticals Ltd Benzimidazole-2-methyl-morpholine derivatives
JP2022534704A (en) 2019-06-04 2022-08-03 ヘイガー バイオサイエンシズ，エルエルシー Imidazolo derivatives, compositions and methods as orexin antagonists
WO2023218023A1 (en) 2022-05-13 2023-11-16 Idorsia Pharmaceuticals Ltd Thiazoloaryl-methyl substituted cyclic hydrazine-n-carboxamide derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR900018073A (en) * 1988-05-23 1990-12-20 추후보충 Piperazine Compounds

Also Published As

Publication number Publication date
WO2003051873A1 (en) 2003-06-26
AU2002352389A1 (en) 2003-06-30

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Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)