AU2002352389A1 - Piperazine compounds and their phamaceutical use - Google Patents

Piperazine compounds and their phamaceutical use

Info

Publication number
AU2002352389A1
AU2002352389A1 AU2002352389A AU2002352389A AU2002352389A1 AU 2002352389 A1 AU2002352389 A1 AU 2002352389A1 AU 2002352389 A AU2002352389 A AU 2002352389A AU 2002352389 A AU2002352389 A AU 2002352389A AU 2002352389 A1 AU2002352389 A1 AU 2002352389A1
Authority
AU
Australia
Prior art keywords
phamaceutical
piperazine compounds
piperazine
compounds
phamaceutical use
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002352389A
Inventor
Clive Leslie Branch
Steven Coulton
David John Nash
Roderick Alan Porter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of AU2002352389A1 publication Critical patent/AU2002352389A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
AU2002352389A 2001-12-19 2002-12-13 Piperazine compounds and their phamaceutical use Abandoned AU2002352389A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0130393.2 2001-12-19
GBGB0130393.2A GB0130393D0 (en) 2001-12-19 2001-12-19 Compounds
PCT/GB2002/005676 WO2003051873A1 (en) 2001-12-19 2002-12-13 Piperazine compounds and their phamaceutical use

Publications (1)

Publication Number Publication Date
AU2002352389A1 true AU2002352389A1 (en) 2003-06-30

Family

ID=9927958

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002352389A Abandoned AU2002352389A1 (en) 2001-12-19 2002-12-13 Piperazine compounds and their phamaceutical use

Country Status (3)

Country Link
AU (1) AU2002352389A1 (en)
GB (1) GB0130393D0 (en)
WO (1) WO2003051873A1 (en)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60309481T2 (en) * 2002-09-18 2007-06-21 Glaxo Group Ltd., Greenford CYCLIC N-AROYLAMINES AS OREXINE RECEPTOR ANTAGONISTS
WO2004033418A2 (en) 2002-10-11 2004-04-22 Actelion Pharmaceuticals Ltd. Sulfonylamino-acetic derivatives and their use as orexin receptor antagonists
PL377848A1 (en) 2003-02-07 2006-02-20 Daiichi Pharmaceutical Co., Ltd. Pyrazole derivative
US7538109B2 (en) 2003-04-28 2009-05-26 Actelion Pharmaceuticals Ltd Quinoxalin-3-one derivatives as orexin receptor antagonists
SI1751111T1 (en) 2004-03-01 2015-04-30 Actelion Pharmaceuticals Ltd. Substituted 1,2,3,4-tetrahydroisoquinoline derivatives
US7501395B2 (en) 2005-04-25 2009-03-10 Eisai R & D Management Co., Ltd. Method of screening for antianxiety drugs
CA2647678A1 (en) 2006-03-29 2007-11-08 Merck & Co., Inc. Diazepan orexin receptor antagonists
WO2008008517A2 (en) 2006-07-14 2008-01-17 Merck & Co., Inc. Bridged diazepan orexin receptor antagonists
JP2010504957A (en) * 2006-09-29 2010-02-18 アクテリオン ファーマシューティカルズ リミテッド 3-Aza-bicyclo [3.1.0] hexane derivatives
US8133901B2 (en) 2006-12-01 2012-03-13 Actelion Pharmaceuticals Ltd. 3-heteroaryl (amino or amido)-1-(biphenyl or phenylthiazolyl) carbonylpiperidine derivatives as orexin receptor inhibitors
PE20081229A1 (en) 2006-12-01 2008-08-28 Merck & Co Inc DIAZEPAM OREXIN RECEPTOR ANTAGONISTS REPLACED
CL2007003827A1 (en) * 2006-12-28 2008-09-26 Actelion Pharmaceuticals Ltd COMPOUNDS DERIVED FROM N- (2-AZA-BICYCLE (3.1.0) HEX-3-ILMETIL) AMIDA; AND ITS USE TO PREVENT OR TREAT DEPRESSION, NEUROSIS, SCHIZOPHRENIA, ANXIETY, ADDICTIONS, EPILEPSY, PAIN, HEART DISEASES, AMONG OTHERS.
CL2008000836A1 (en) 2007-03-26 2008-11-07 Actelion Pharmaceuticals Ltd Thiazolidine derivative compounds, orexin receptor antagonists; pharmaceutical composition that includes them; and its use in the treatment of emotional neurosis, severe depression, psychotic disorders, Alzheimer's, parkinson's, pain, among others.
EP2150114A4 (en) 2007-05-18 2012-01-18 Merck Sharp & Dohme Oxo bridged diazepan orexin receptor antagonists
RU2470021C2 (en) 2007-05-23 2012-12-20 Мерк Шарп Энд Домэ Корп. Pyridyl-piperidine antagonists of orexin receptors
WO2008150364A1 (en) 2007-05-23 2008-12-11 Merck & Co., Inc. Cyclopropyl pyrrolidine orexin receptor antagonists
RU2478099C2 (en) 2007-07-27 2013-03-27 Актелион Фармасьютиклз Лтд 2-aza-bicyclo[3,3,0]octane derivatives
JP2010540429A (en) 2007-09-24 2010-12-24 アクテリオン ファーマシューティカルズ リミテッド Pyrrolidines and piperidines as orexin receptor antagonists
CN101965343A (en) 2008-02-21 2011-02-02 埃科特莱茵药品有限公司 2-aza-bicyclo[2.2.1]heptane derivatives
EP2275421A1 (en) 2009-07-15 2011-01-19 Rottapharm S.p.A. Spiro amino compounds suitable for the treatment of inter alia sleep disorders and drug addiction
AR088352A1 (en) 2011-10-19 2014-05-28 Merck Sharp & Dohme ANTAGONISTS OF THE RECEIVER OF 2-PIRIDILOXI-4-NITRILE OREXINE
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
WO2013119639A1 (en) 2012-02-07 2013-08-15 Eolas Therapeutics, Inc. Substituted prolines / piperidines as orexin receptor antagonists
ES2617863T3 (en) 2012-06-04 2017-06-20 Actelion Pharmaceuticals Ltd. Benzimidazole-proline derivatives
AU2013328301A1 (en) 2012-10-10 2015-05-28 Actelion Pharmaceuticals Ltd Orexin receptor antagonists which are [ortho bi (hetero-)aryl]-[2-(meta bi (hetero-)aryl)-pyrrolidin-1-yl]-methanone derivatives
CN105051040A (en) 2013-03-12 2015-11-11 埃科特莱茵药品有限公司 Azetidine amide derivatives as orexin receptor antagonists
UA119151C2 (en) 2013-12-03 2019-05-10 Ідорсія Фармасьютікалз Лтд Crystalline salt form of (s)-(2-(6-chloro-7-methyl-1 h-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1 -yl)(5-methoxy-2-(2h-1,2,3-triazol-2-yl)phenyl)methanone as orexin receptor antagonist
DK3077389T3 (en) 2013-12-03 2017-11-13 Idorsia Pharmaceuticals Ltd CRYSTALLIC FORM OF (S) - (2- (6-CHLOR-7-METHYL-1H-BENZO [D] IMIDAZOL-2-YL) -2-METHYLPYRROLIDIN-1-YL) (5-METHOXY-2- (2H- 1,2,3-TRIAZOL-2-YL) PHENYL) METHANON AND ITS USE AS OREXIN RECEPTOR ANTAGONISTS
US9914721B2 (en) 2013-12-04 2018-03-13 Idorsia Pharmaceuticals Ltd Use of benzimidazole-proline derivatives
WO2016025669A1 (en) 2014-08-13 2016-02-18 Eolas Therapeutics, Inc. Difluoropyrrolidines as orexin receptor modulators
CN109219606B (en) 2016-02-12 2021-10-01 阿斯利康(瑞典)有限公司 Halogen substituted piperidines as orexin receptor modulators
US20190151304A1 (en) 2016-05-10 2019-05-23 Inserm (Institut National De La Santé Et De La Rechercjae Médicale Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory
WO2020007964A1 (en) 2018-07-05 2020-01-09 Idorsia Pharmaceuticals Ltd 2-(2-azabicyclo[3.1.0]hexan-1-yl)-1h-benzimidazole derivatives
WO2020099511A1 (en) 2018-11-14 2020-05-22 Idorsia Pharmaceuticals Ltd Benzimidazole-2-methyl-morpholine derivatives
TW202400149A (en) 2022-05-13 2024-01-01 瑞士商愛杜西亞製藥有限公司 Thiazoloaryl-methyl substituted cyclic hydrazine-n-carboxamide derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK247789A (en) * 1988-05-23 1989-11-24 Glaxo Group Ltd piperazine

Also Published As

Publication number Publication date
WO2003051873A1 (en) 2003-06-26
GB0130393D0 (en) 2002-02-06

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase