BR112022020924A2 - Métodos de tratamento de um transtorno do sono, a sonolência diurna em um indivíduo, a insônia, e, daridorexante na forma de sal livre ou farmaceuticamente aceitável - Google Patents
Métodos de tratamento de um transtorno do sono, a sonolência diurna em um indivíduo, a insônia, e, daridorexante na forma de sal livre ou farmaceuticamente aceitávelInfo
- Publication number
- BR112022020924A2 BR112022020924A2 BR112022020924A BR112022020924A BR112022020924A2 BR 112022020924 A2 BR112022020924 A2 BR 112022020924A2 BR 112022020924 A BR112022020924 A BR 112022020924A BR 112022020924 A BR112022020924 A BR 112022020924A BR 112022020924 A2 BR112022020924 A2 BR 112022020924A2
- Authority
- BR
- Brazil
- Prior art keywords
- daytime
- insomnia
- pharmaceutically acceptable
- acceptable salt
- sleep disorder
- Prior art date
Links
- 208000019116 sleep disease Diseases 0.000 title abstract 4
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 title abstract 3
- 206010022437 insomnia Diseases 0.000 title abstract 3
- 150000003839 salts Chemical group 0.000 title abstract 3
- 208000020685 sleep-wake disease Diseases 0.000 title abstract 3
- NBGABHGMJVIVBW-QHCPKHFHSA-N [(2s)-2-(5-chloro-4-methyl-1h-benzimidazol-2-yl)-2-methylpyrrolidin-1-yl]-[5-methoxy-2-(triazol-2-yl)phenyl]methanone Chemical compound N1([C@](CCC1)(C)C=1NC2=CC=C(Cl)C(C)=C2N=1)C(=O)C1=CC(OC)=CC=C1N1N=CC=N1 NBGABHGMJVIVBW-QHCPKHFHSA-N 0.000 abstract 2
- 229940125861 daridorexant Drugs 0.000 abstract 2
- 208000007590 Disorders of Excessive Somnolence Diseases 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical class Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 206010041349 Somnolence Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
MÉTODOS DE TRATAMENTO DE UM TRANSTORNO DO SONO, A SONOLÊNCIA DIURNA EM UM INDIVÍDUO, A INSÔNIA, E, DARIDOREXANTE NA FORMA DE SAL LIVRE OU FARMACEUTICAMENTE ACEITÁVEL. A invenção refere-se ao daridorexante ou um sal farmaceuticamente aceitável do mesmo, tal como especialmente o sal do ácido clorídrico; para uso em um método de tratamento de transtornos do sono, tais como especialmente as insônias, em que o daridorexante melhora o desempenho diurno, especialmente reduz a sonolência diurna associada a este transtorno do sono.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2020060940 | 2020-04-19 | ||
| PCT/EP2021/059943 WO2021213923A1 (en) | 2020-04-19 | 2021-04-16 | Medical use of daridorexant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112022020924A2 true BR112022020924A2 (pt) | 2023-02-14 |
Family
ID=75478068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112022020924A BR112022020924A2 (pt) | 2020-04-19 | 2021-04-16 | Métodos de tratamento de um transtorno do sono, a sonolência diurna em um indivíduo, a insônia, e, daridorexante na forma de sal livre ou farmaceuticamente aceitável |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20230134935A1 (pt) |
| EP (1) | EP4138822A1 (pt) |
| JP (1) | JP2023521492A (pt) |
| KR (1) | KR20230004670A (pt) |
| CN (1) | CN115427037A (pt) |
| AU (1) | AU2021260018A1 (pt) |
| BR (1) | BR112022020924A2 (pt) |
| CA (1) | CA3175369A1 (pt) |
| CL (1) | CL2022002855A1 (pt) |
| IL (1) | IL297234A (pt) |
| MX (1) | MX2022011179A (pt) |
| TW (1) | TW202200133A (pt) |
| WO (1) | WO2021213923A1 (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115925699B (zh) * | 2022-02-25 | 2023-10-03 | 南京知和医药科技有限公司 | 具有镇痛活性的稠环化合物及其制备方法与用途 |
| WO2024019978A2 (en) * | 2022-07-19 | 2024-01-25 | Rutgers, The State University Of New Jersey | Therapeutic combinations and methods |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104334544B (zh) | 2012-06-04 | 2016-10-19 | 埃科特莱茵药品有限公司 | 苯并咪唑脯氨酸衍生物 |
| TWI664177B (zh) | 2013-12-03 | 2019-07-01 | 瑞士商愛杜西亞製藥有限公司 | 晶形 |
| UA119151C2 (uk) | 2013-12-03 | 2019-05-10 | Ідорсія Фармасьютікалз Лтд | КРИСТАЛІЧНА СОЛЬОВА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ЯК АНТАГОНІСТ ОРЕКСИНОВОГО РЕЦЕПТОРА |
| UA116053C2 (uk) | 2013-12-04 | 2018-01-25 | Ідорсія Фармасьютікалз Лтд | Застосування похідних бензоімідазолу-проліну |
| RU2703297C2 (ru) | 2014-10-23 | 2019-10-16 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Композиции и способы для лечения бессонницы |
| TWI756418B (zh) | 2017-05-03 | 2022-03-01 | 瑞士商愛杜西亞製藥有限公司 | 2-([1,2,3]三唑-2-基)-苯甲酸衍生物之製備 |
-
2021
- 2021-04-16 BR BR112022020924A patent/BR112022020924A2/pt not_active Application Discontinuation
- 2021-04-16 AU AU2021260018A patent/AU2021260018A1/en active Pending
- 2021-04-16 IL IL297234A patent/IL297234A/en unknown
- 2021-04-16 CN CN202180028992.7A patent/CN115427037A/zh active Pending
- 2021-04-16 WO PCT/EP2021/059943 patent/WO2021213923A1/en unknown
- 2021-04-16 JP JP2022563036A patent/JP2023521492A/ja active Pending
- 2021-04-16 US US17/996,499 patent/US20230134935A1/en active Pending
- 2021-04-16 KR KR1020227040124A patent/KR20230004670A/ko active Search and Examination
- 2021-04-16 MX MX2022011179A patent/MX2022011179A/es unknown
- 2021-04-16 CA CA3175369A patent/CA3175369A1/en active Pending
- 2021-04-16 EP EP21718142.9A patent/EP4138822A1/en active Pending
- 2021-04-19 TW TW110113975A patent/TW202200133A/zh unknown
-
2022
- 2022-10-17 CL CL2022002855A patent/CL2022002855A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CL2022002855A1 (es) | 2023-06-02 |
| US20230134935A1 (en) | 2023-05-04 |
| AU2021260018A1 (en) | 2022-12-22 |
| CN115427037A (zh) | 2022-12-02 |
| IL297234A (en) | 2022-12-01 |
| EP4138822A1 (en) | 2023-03-01 |
| JP2023521492A (ja) | 2023-05-24 |
| WO2021213923A1 (en) | 2021-10-28 |
| MX2022011179A (es) | 2022-10-07 |
| KR20230004670A (ko) | 2023-01-06 |
| TW202200133A (zh) | 2022-01-01 |
| CA3175369A1 (en) | 2021-10-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing |