BR112015027282A2 - fenfluramina para uso no tratamento de síndrome de dravet - Google Patents
fenfluramina para uso no tratamento de síndrome de dravetInfo
- Publication number
- BR112015027282A2 BR112015027282A2 BR112015027282A BR112015027282A BR112015027282A2 BR 112015027282 A2 BR112015027282 A2 BR 112015027282A2 BR 112015027282 A BR112015027282 A BR 112015027282A BR 112015027282 A BR112015027282 A BR 112015027282A BR 112015027282 A2 BR112015027282 A2 BR 112015027282A2
- Authority
- BR
- Brazil
- Prior art keywords
- fenfluramine
- dravet syndrome
- treatment
- patient
- syndrome
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Abstract
resumo patente de invenção: "fenfluramina para uso no tratamento de síndrome de dravet". a presente invenção refere-se a uma dose eficaz de fenfluramina ou sal farmaceuticamente aceitável da mesma para uso em um método para tratamento e/ou prevenção da síndrome de dravet em um paciente como um paciente diagnosticado anteriormente com síndrome de dravet.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/887,014 US9549909B2 (en) | 2013-05-03 | 2013-05-03 | Method for the treatment of dravet syndrome |
PCT/EP2014/058954 WO2014177676A1 (en) | 2013-05-03 | 2014-05-01 | Fenfluramine for use in the treatment of dravet syndrome |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112015027282A2 true BR112015027282A2 (pt) | 2017-07-25 |
BR112015027282A8 BR112015027282A8 (pt) | 2019-12-24 |
Family
ID=50729472
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015027282A BR112015027282A8 (pt) | 2013-05-03 | 2014-05-01 | formulação líquida e kit compreendendo fenfluramina, e usos da mesma no tratamento de síndrome de dravet |
Country Status (17)
Country | Link |
---|---|
US (13) | US9549909B2 (pt) |
EP (2) | EP2991637B1 (pt) |
JP (3) | JP6441313B2 (pt) |
AU (4) | AU2014261329B2 (pt) |
BR (1) | BR112015027282A8 (pt) |
CA (1) | CA2909335C (pt) |
CY (1) | CY1124298T1 (pt) |
DK (2) | DK2991637T3 (pt) |
ES (2) | ES2863929T3 (pt) |
HR (1) | HRP20210819T1 (pt) |
HU (1) | HUE054577T2 (pt) |
LT (1) | LT3329909T (pt) |
NO (1) | NO3092234T3 (pt) |
PL (2) | PL2991637T3 (pt) |
PT (2) | PT2991637T (pt) |
SI (1) | SI3329909T1 (pt) |
WO (1) | WO2014177676A1 (pt) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2514054A (en) | 2011-09-29 | 2014-11-12 | Gw Pharma Ltd | A pharmaceutical composition comprising the phytocannabinoids cannabidivarin (CBDV) and cannabidiol (CBD) |
US9549909B2 (en) | 2013-05-03 | 2017-01-24 | The Katholieke Universiteit Leuven | Method for the treatment of dravet syndrome |
GB2530001B (en) | 2014-06-17 | 2019-01-16 | Gw Pharma Ltd | Use of cannabidiol in the reduction of convulsive seizure frequency in treatment-resistant epilepsy |
KR102245345B1 (ko) | 2014-09-29 | 2021-04-28 | 조게닉스 인터내셔널 리미티드 | 의약품 배포 제어를 위한 제어 시스템 |
GB2531282A (en) | 2014-10-14 | 2016-04-20 | Gw Pharma Ltd | Use of cannabinoids in the treatment of epilepsy |
GB2531278A (en) | 2014-10-14 | 2016-04-20 | Gw Pharma Ltd | Use of cannabidiol in the treatment of intractable epilepsy |
GB2531281A (en) | 2014-10-14 | 2016-04-20 | Gw Pharma Ltd | Use of cannabidiol in the treatment of intractable epilepsy |
EA201791882A1 (ru) * | 2015-02-25 | 2018-02-28 | Дзе Риджентс Оф Дзе Юниверсити Оф Калифорниа | Агонисты 5ht для лечения нарушений |
JP6668045B2 (ja) * | 2015-05-15 | 2020-03-18 | ゾゲニクス インターナショナル リミテッド | ドラベ症候群を処置するための選択的5−ht受容体アゴニストおよびアンタゴニスト |
GB2539472A (en) | 2015-06-17 | 2016-12-21 | Gw Res Ltd | Use of cannabinoids in the treatment of epilepsy |
GB2541191A (en) | 2015-08-10 | 2017-02-15 | Gw Pharma Ltd | Use of cannabinoids in the treatment of epilepsy |
CA2993665C (en) * | 2015-08-24 | 2023-03-07 | Zogenix International Limited | Methods of treating lennox-gastaut syndrome using fenfluramine |
WO2017060731A1 (en) | 2015-10-09 | 2017-04-13 | University Of Southampton | Modulation of gene expression and screening for deregulated protein expression |
EP3390636B1 (en) | 2015-12-14 | 2021-05-19 | Cold Spring Harbor Laboratory | Antisense oligomers for treatment of dravet syndrome |
EP3800177A1 (en) | 2015-12-22 | 2021-04-07 | Zogenix International Limited | Fenfluramine compositions and methods of preparing the same |
EP3393470B1 (en) | 2015-12-22 | 2021-01-20 | Zogenix International Limited | Metabolism resistant fenfluramine analogs and methods of using the same |
GB2548873B (en) | 2016-03-31 | 2020-12-02 | Gw Res Ltd | Use of Cannabidiol in the Treatment of SturgeWeber Syndrome |
GB2551986A (en) | 2016-07-01 | 2018-01-10 | Gw Res Ltd | Parenteral formulations |
GB2551987A (en) | 2016-07-01 | 2018-01-10 | Gw Res Ltd | Oral cannabinoid formulations |
KR20230021172A (ko) * | 2016-08-24 | 2023-02-13 | 조게닉스 인터내셔널 리미티드 | 5-ht2b 작용물질의 형성을 억제하기 위한 제제 및 그것의 사용 방법 |
GB2553139A (en) | 2016-08-25 | 2018-02-28 | Gw Res Ltd | Use of cannabinoids in the treatment of multiple myeloma |
US20180092864A1 (en) * | 2016-09-30 | 2018-04-05 | Zogenix International Limited | Compositions and methods for treating seizure disorders |
AU2017363598A1 (en) * | 2016-11-22 | 2019-05-23 | Ovid Therapeutics Inc. | Methods of treating developmental disorders and/or seizure disorders with flupirtine |
GB2557921A (en) | 2016-12-16 | 2018-07-04 | Gw Res Ltd | Use of cannabinoids in the treatment of angelman syndrome |
GB2559774B (en) | 2017-02-17 | 2021-09-29 | Gw Res Ltd | Oral cannabinoid formulations |
CA3059775A1 (en) | 2017-04-13 | 2018-10-18 | Ovid Therapeutics Inc. | Methods of treating developmental encephalopathies |
AU2018265353A1 (en) * | 2017-05-09 | 2019-11-21 | Zogenix International Limited | Methods of treating Doose syndrome using fenfluramine |
CA3073515A1 (en) | 2017-08-25 | 2019-02-28 | Stoke Therapeutics, Inc. | Antisense oligomers for treatment of conditions and diseases |
US20190091177A1 (en) * | 2017-09-26 | 2019-03-28 | Zogenix International Limited | Method of treating selected patient population experiencing dravet syndrome |
US10682317B2 (en) | 2017-09-26 | 2020-06-16 | Zogenix International Limited | Ketogenic diet compatible fenfluramine formulation |
WO2019067413A1 (en) * | 2017-09-26 | 2019-04-04 | Zogenix International Limited | USE OF A FENFLURAMINE FORMULATION TO REDUCE THE NUMBER AND FREQUENCIES OF CONVULSIVE CRISES IN PATIENT POPULATIONS |
US20190091179A1 (en) * | 2017-09-26 | 2019-03-28 | Zogenix International Limited | Congnitive function with fenfluramine |
GB201715919D0 (en) | 2017-09-29 | 2017-11-15 | Gw Res Ltd | use of cannabinoids in the treatment of epilepsy |
GB2569961B (en) | 2018-01-03 | 2021-12-22 | Gw Res Ltd | Pharmaceutical |
GB201806953D0 (en) | 2018-04-27 | 2018-06-13 | Gw Res Ltd | Cannabidiol Preparations |
CA3097335A1 (en) * | 2018-05-11 | 2019-11-14 | Zogenix International Limited | Compositions and methods for treating seizure-induced sudden death |
EP3806835A1 (en) * | 2018-06-14 | 2021-04-21 | Zogenix International Limited | Compositions and methods for treating respiratory depression with fenfluramine |
US20210113495A1 (en) * | 2018-07-10 | 2021-04-22 | Zogenix International Limited | Method of treating epilepsy or epileptic encephalopathy with fenfluramine in patients without pulmonary hypertension |
WO2020023923A1 (en) * | 2018-07-27 | 2020-01-30 | Xenon Pharmaceuticals Inc. | Method for treating epilepsy |
EP3930841A4 (en) * | 2019-02-25 | 2022-11-30 | Zogenix International Limited | FORMULATION TO IMPROVE SEIZURE CONTROL |
CN111944835B (zh) * | 2019-05-14 | 2022-03-29 | 南通大学 | 一种突变型gabrg2转基因斑马鱼癫痫模型的构建方法及应用 |
EP4021454A1 (en) * | 2019-08-30 | 2022-07-06 | Research Institute at Nationwide Children's Hospital | Copper-atsm for treating neurodegenerative disorders associated with mitochondrial dysfunction |
KR20220101610A (ko) * | 2019-09-17 | 2022-07-19 | 조게닉스 인터내셔널 리미티드 | 펜플루라민을 사용하여 간질 환자를 치료하는 방법 |
US20210299064A1 (en) | 2020-02-05 | 2021-09-30 | Zogenix International Limited | Method of treating patients with lennox-gastaut syndrome |
GB202002754D0 (en) | 2020-02-27 | 2020-04-15 | Gw Res Ltd | Methods of treating tuberous sclerosis complex with cannabidiol and everolimus |
US20230287410A1 (en) | 2020-05-11 | 2023-09-14 | Stoke Therapeutics, Inc. | Opa1 antisense oligomers for treatment of conditions and diseases |
US11612574B2 (en) | 2020-07-17 | 2023-03-28 | Zogenix International Limited | Method of treating patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) |
US11160757B1 (en) | 2020-10-12 | 2021-11-02 | GW Research Limited | pH dependent release coated microparticle cannabinoid formulations |
Family Cites Families (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1413070A (en) | 1973-07-27 | 1975-11-05 | Beecham Group Ltd | Process for the production of - norfenfluramine and - fenfluramine and salts thereof |
GB1413078A (en) | 1973-07-27 | 1975-11-05 | Beecham Group Ltd | Process for the production of plus-norfenfluramine and plus-fenfluramine and salts thereof |
US4452815A (en) | 1980-06-16 | 1984-06-05 | Massachusetts Institute Of Technology | Method of utilizing d,l-fenfluramine for modifying feeding behavior |
IT1238686B (it) | 1990-02-09 | 1993-09-01 | Lab Mag Spa | Procedimento per la preparazione di levo e destro fenfluramina |
FR2684552B1 (fr) | 1991-12-06 | 1995-04-28 | Adir | Utilisation de la d-fenfluramine et de derives de la fenfluramine dans le traitement de l'hypertension chez des sujets insulino-resistants. |
US5985880A (en) | 1996-06-05 | 1999-11-16 | Delta Pharmaceuticals | Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds |
US5834477A (en) | 1993-12-08 | 1998-11-10 | The United States Of America As Represented By The Secretary Of The Army | Opiate analgesic formulation with improved safety |
CA2455939C (en) | 2001-07-31 | 2011-03-22 | Wyeth Llc | Sucralose formulations to mask unpleasant tastes |
US6599901B1 (en) | 2001-11-19 | 2003-07-29 | Hoffman-La Roche Inc. | Pyridone substituted benzothiazole derivatives |
US7101572B2 (en) | 2001-12-07 | 2006-09-05 | Unilab Pharmatech, Ltd. | Taste masked aqueous liquid pharmaceutical composition |
JP2008542237A (ja) | 2005-05-25 | 2008-11-27 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | トピラメートの小児科用製剤 |
GB0515090D0 (en) | 2005-07-22 | 2005-08-31 | Birmingham Res & Dev Ltd | Novel epilepsy treatment |
US9125900B2 (en) | 2005-09-14 | 2015-09-08 | University Of The Witwatersrand, Johannesburg | Pharmaceutical composition |
CN101600436A (zh) | 2006-08-31 | 2009-12-09 | 艾伯塔大学校董 | 使用正变构ampa受体调节剂抑制呼吸抑制的方法 |
JP2011507800A (ja) | 2007-12-26 | 2011-03-10 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 癲癇、精神障害、または感覚器官の障害のためのampa受容体アンタゴニスト |
EP2240022B1 (en) | 2008-01-09 | 2016-12-28 | Charleston Laboratories, Inc. | Bilayered tablets comprising oxycodone and promethazine |
EA018401B1 (ru) | 2008-10-09 | 2013-07-30 | Ацьенде Кимике Рьюните Анджелини Франческо А.К.Р.А.Ф. С.П.А. | Жидкий фармацевтический состав, содержащий парацетамол |
AU2010236404B2 (en) | 2009-04-15 | 2016-11-03 | Research Triangle Institute | Monoamine reuptake inhibitors |
US9453027B2 (en) | 2009-07-27 | 2016-09-27 | Daljit Singh Dhanoa | Deuterium-enriched pyridinonecarboxamides and derivatives |
US20110212171A1 (en) | 2010-01-08 | 2011-09-01 | Eurand, Inc. | Taste masked topiramate composition and an orally disintegrating tablet comprising the same |
CA2805760A1 (en) | 2010-07-30 | 2012-02-02 | Merck Sharp & Dohme Corp. | Inhibition of cyp3a drug metabolism |
US20120270848A1 (en) | 2010-10-22 | 2012-10-25 | Galleon Pharmaceuticals, Inc. | Novel Compositions and Therapeutic Methods Using Same |
BR112013009267A2 (pt) | 2010-10-26 | 2016-07-26 | Alpharma Pharmaceuticals Llc | formulações e métodos para atenuar a depressão respiratória induzida por overdose de opioides |
GB2487712B (en) | 2011-01-04 | 2015-10-28 | Otsuka Pharma Co Ltd | Use of the phytocannabinoid cannabidiol (CBD) in combination with a standard anti-epileptic drug (SAED) in the treatment of epilepsy |
KR20150082633A (ko) | 2012-11-15 | 2015-07-15 | 갈레온 파마슈티칼스, 인코포레이티드 | 경구적으로 생체이용가능한 신규 호흡 조절 제어 화합물 및 그의 사용 방법 |
US9549909B2 (en) | 2013-05-03 | 2017-01-24 | The Katholieke Universiteit Leuven | Method for the treatment of dravet syndrome |
LT3035926T (lt) | 2013-08-19 | 2020-11-25 | The Regents Of The University Of California | Junginiai ir būdai, skirti epileptinio sutrikimo gydymui |
WO2015066344A1 (en) | 2013-11-01 | 2015-05-07 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists and compositions and methods of use |
GB2530001B (en) | 2014-06-17 | 2019-01-16 | Gw Pharma Ltd | Use of cannabidiol in the reduction of convulsive seizure frequency in treatment-resistant epilepsy |
EA201791882A1 (ru) | 2015-02-25 | 2018-02-28 | Дзе Риджентс Оф Дзе Юниверсити Оф Калифорниа | Агонисты 5ht для лечения нарушений |
KR102207539B1 (ko) | 2015-06-30 | 2021-01-26 | 네우라드 리미티드 | 신규한 호흡 제어 조절 화합물, 및 그의 제조 및 사용 방법 |
US10004749B2 (en) | 2015-07-22 | 2018-06-26 | John Hsu | Composition comprising a therapeutic agent and a respiratory stimulant and methods for the use thereof |
CA2993665C (en) | 2015-08-24 | 2023-03-07 | Zogenix International Limited | Methods of treating lennox-gastaut syndrome using fenfluramine |
US20170071949A1 (en) | 2015-09-14 | 2017-03-16 | Zogenix International Limited | Combination treatment of specific forms of epilepsy |
EP3800177A1 (en) | 2015-12-22 | 2021-04-07 | Zogenix International Limited | Fenfluramine compositions and methods of preparing the same |
KR20230021172A (ko) | 2016-08-24 | 2023-02-13 | 조게닉스 인터내셔널 리미티드 | 5-ht2b 작용물질의 형성을 억제하기 위한 제제 및 그것의 사용 방법 |
US20180092864A1 (en) | 2016-09-30 | 2018-04-05 | Zogenix International Limited | Compositions and methods for treating seizure disorders |
AU2018265353A1 (en) | 2017-05-09 | 2019-11-21 | Zogenix International Limited | Methods of treating Doose syndrome using fenfluramine |
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2013
- 2013-05-03 US US13/887,014 patent/US9549909B2/en active Active
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2014
- 2014-05-01 DK DK14724037.8T patent/DK2991637T3/en active
- 2014-05-01 JP JP2016511083A patent/JP6441313B2/ja active Active
- 2014-05-01 EP EP14724037.8A patent/EP2991637B1/en not_active Revoked
- 2014-05-01 PL PL14724037T patent/PL2991637T3/pl unknown
- 2014-05-01 WO PCT/EP2014/058954 patent/WO2014177676A1/en active Application Filing
- 2014-05-01 ES ES18152406T patent/ES2863929T3/es active Active
- 2014-05-01 PL PL18152406T patent/PL3329909T3/pl unknown
- 2014-05-01 EP EP18152406.7A patent/EP3329909B1/en active Active
- 2014-05-01 PT PT147240378T patent/PT2991637T/pt unknown
- 2014-05-01 PT PT181524067T patent/PT3329909T/pt unknown
- 2014-05-01 DK DK18152406.7T patent/DK3329909T3/da active
- 2014-05-01 LT LTEP18152406.7T patent/LT3329909T/lt unknown
- 2014-05-01 AU AU2014261329A patent/AU2014261329B2/en active Active
- 2014-05-01 CA CA2909335A patent/CA2909335C/en active Active
- 2014-05-01 BR BR112015027282A patent/BR112015027282A8/pt not_active Application Discontinuation
- 2014-05-01 ES ES14724037.8T patent/ES2666657T3/es active Active
- 2014-05-01 SI SI201431811T patent/SI3329909T1/sl unknown
- 2014-05-01 HU HUE18152406A patent/HUE054577T2/hu unknown
- 2014-07-30 US US14/447,253 patent/US9610260B2/en active Active
- 2014-07-30 US US14/447,303 patent/US9603814B2/en active Active
- 2014-07-30 US US14/447,369 patent/US20140343044A1/en not_active Abandoned
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2016
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2017
- 2017-02-10 US US15/429,516 patent/US10478441B2/en active Active
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- 2017-02-10 US US15/429,650 patent/US20170151194A1/en not_active Abandoned
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2018
- 2018-11-21 JP JP2018218149A patent/JP6655156B2/ja active Active
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2019
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- 2019-05-31 AU AU2019203832A patent/AU2019203832B2/en active Active
- 2019-10-08 US US16/596,166 patent/US20200030341A1/en not_active Abandoned
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2020
- 2020-01-31 JP JP2020014754A patent/JP6966584B2/ja active Active
- 2020-06-12 US US16/900,055 patent/US20210121479A1/en not_active Abandoned
- 2020-11-12 AU AU2020267264A patent/AU2020267264A1/en not_active Abandoned
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2021
- 2021-05-21 HR HRP20210819TT patent/HRP20210819T1/hr unknown
- 2021-06-14 CY CY20211100530T patent/CY1124298T1/el unknown
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2022
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