ECSP16008797A - Derivados de heterobicicloaril como inhibidores rorc2 y métodos de uso de los mismos - Google Patents

Derivados de heterobicicloaril como inhibidores rorc2 y métodos de uso de los mismos

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Publication number
ECSP16008797A
ECSP16008797A ECIEPI20168797A ECPI201608797A ECSP16008797A EC SP16008797 A ECSP16008797 A EC SP16008797A EC IEPI20168797 A ECIEPI20168797 A EC IEPI20168797A EC PI201608797 A ECPI201608797 A EC PI201608797A EC SP16008797 A ECSP16008797 A EC SP16008797A
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EC
Ecuador
Prior art keywords
methods
heterobicicloaril
derivatives
same
rorc2
Prior art date
Application number
ECIEPI20168797A
Other languages
English (en)
Inventor
Edouard Zamaratski
Atli Thorarensen
Mark Edward Schnute
Marvin Jay Meyers
James Richard Kiefer
Andrew Christopher Flick
James Robert Blinn
Göran Mattias Wennerstål
Scot R Mente
Li Xing
Christoph Wolfgang Zapf
Neelu Kaila
Peter Jones
Ravi G Kurumbail
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ECSP16008797A publication Critical patent/ECSP16008797A/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • C07D487/04—Ortho-condensed systems
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Abstract

La presente invención proporciona compuestos, composiciones farmacéuticas, métodos para inhibir la actividad de RORγ y/o reducir la cantidad de IL-17 en un sujeto, y métodos para tratar los diversos trastornos médicos usando estos compuestos y composiciones farmacéuticas.
ECIEPI20168797A 2013-08-02 2016-03-01 Derivados de heterobicicloaril como inhibidores rorc2 y métodos de uso de los mismos ECSP16008797A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361861709P 2013-08-02 2013-08-02

Publications (1)

Publication Number Publication Date
ECSP16008797A true ECSP16008797A (es) 2017-08-31

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US (6) US20160046597A1 (es)
EP (2) EP3428160A1 (es)
JP (1) JP6224832B2 (es)
KR (1) KR101821903B1 (es)
CN (1) CN105492434B (es)
AP (1) AP2016009017A0 (es)
AR (1) AR097199A1 (es)
AU (1) AU2014298017B2 (es)
BR (1) BR112016001781A2 (es)
CA (1) CA2919783C (es)
CL (1) CL2016000235A1 (es)
CR (1) CR20160047A (es)
CU (2) CU24366B1 (es)
CY (1) CY1120751T1 (es)
DK (1) DK3027603T3 (es)
DO (1) DOP2016000039A (es)
EA (1) EA029499B9 (es)
EC (1) ECSP16008797A (es)
ES (1) ES2685839T3 (es)
GE (1) GEP20186876B (es)
GT (1) GT201600027A (es)
HK (1) HK1219093A1 (es)
HR (1) HRP20181291T1 (es)
HU (1) HUE039972T2 (es)
IL (1) IL243728B (es)
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MA (1) MA38810B1 (es)
MD (1) MD20160007A2 (es)
MX (1) MX2016001446A (es)
NI (1) NI201600021A (es)
PE (1) PE20160801A1 (es)
PH (1) PH12016500140A1 (es)
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TW (2) TWI652263B (es)
UA (1) UA115908C2 (es)
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