CU24366B1 - Compuestos que poseen un anillo que contiene nitrógeno salicílico unido a un grupo heteroarilo bicíclico útiles como inhibidores rorc2 - Google Patents

Compuestos que poseen un anillo que contiene nitrógeno salicílico unido a un grupo heteroarilo bicíclico útiles como inhibidores rorc2

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Publication number
CU24366B1
CU24366B1 CU2016000015A CU20160015A CU24366B1 CU 24366 B1 CU24366 B1 CU 24366B1 CU 2016000015 A CU2016000015 A CU 2016000015A CU 20160015 A CU20160015 A CU 20160015A CU 24366 B1 CU24366 B1 CU 24366B1
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CU
Cuba
Prior art keywords
compounds
rorc2
inhibitors
ring containing
nitrogen
Prior art date
Application number
CU2016000015A
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English (en)
Other versions
CU20160015A7 (es
Inventor
James Robert Blinn
Andrew Christopher Flick
Peter Jones
Neelu Kaila
James Richard Kiefer Jr
Ravi G Kurumbail
Scot Richard Mente
Marvin Jay Meyers
Mark Edward Schnute
Atli Thorarensen
Göran Mattias Wennerstal
Li Xing
Edouard Zamaratski
Christoph Wolfgang Zapf
Original Assignee
Pfizer
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Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CU20160015A7 publication Critical patent/CU20160015A7/es
Publication of CU24366B1 publication Critical patent/CU24366B1/es

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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención proporciona un compuesto de Fórmula I:</p> <p>ESPACIO PARA FÓRMULA</p> <p>que posee un anillo que contiene nitrógeno salicílico unido a un grupo heteroarilo bicíclico útiles como inhibidores RORC2, y una composición farmacéutica que comprende dichos compuestos.</p>
CU2016000015A 2013-08-02 2014-07-24 Compuestos que poseen un anillo que contiene nitrógeno salicílico unido a un grupo heteroarilo bicíclico útiles como inhibidores rorc2 CU24366B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361861709P 2013-08-02 2013-08-02
PCT/IB2014/063383 WO2015015378A2 (en) 2013-08-02 2014-07-24 Rorc2 inhibitors and methods of use thereof

Publications (2)

Publication Number Publication Date
CU20160015A7 CU20160015A7 (es) 2016-09-30
CU24366B1 true CU24366B1 (es) 2018-10-04

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ID=51570793

Family Applications (2)

Application Number Title Priority Date Filing Date
CU2016000145A CU24398B1 (es) 2013-08-02 2014-07-24 3-(piperidin,pirrol o azetidin)-indoles sustituidos útiles como inhibidores rorc2
CU2016000015A CU24366B1 (es) 2013-08-02 2014-07-24 Compuestos que poseen un anillo que contiene nitrógeno salicílico unido a un grupo heteroarilo bicíclico útiles como inhibidores rorc2

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CU2016000145A CU24398B1 (es) 2013-08-02 2014-07-24 3-(piperidin,pirrol o azetidin)-indoles sustituidos útiles como inhibidores rorc2

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US (6) US20160046597A1 (es)
EP (2) EP3027603B1 (es)
JP (1) JP6224832B2 (es)
KR (1) KR101821903B1 (es)
CN (1) CN105492434B (es)
AP (1) AP2016009017A0 (es)
AR (1) AR097199A1 (es)
AU (1) AU2014298017B2 (es)
BR (1) BR112016001781A2 (es)
CA (1) CA2919783C (es)
CL (1) CL2016000235A1 (es)
CR (1) CR20160047A (es)
CU (2) CU24398B1 (es)
CY (1) CY1120751T1 (es)
DK (1) DK3027603T3 (es)
DO (1) DOP2016000039A (es)
EA (1) EA029499B9 (es)
EC (1) ECSP16008797A (es)
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PH (1) PH12016500140A1 (es)
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MA40759A (fr) * 2014-09-26 2017-08-01 Pfizer Modulateurs de rorc2 de type pyrrolopyridine substitué par un méthyle et trifluorométhyle et leurs procédés d'utilisation
CA2975157C (en) * 2015-01-30 2019-09-17 Pfizer Inc. Sulfonamide-substituted indole modulators of rorc2 and methods of use thereof
WO2016120849A1 (en) * 2015-01-30 2016-08-04 Pfizer Inc. Methoxy-substituted pyrrolopyridine modulators of rorc2 and methods of use thereof
CN104672121B (zh) * 2015-02-16 2017-10-24 上海华默西医药科技有限公司 2r‑(2,5‑二氟苯基)吡咯烷盐酸盐的制备方法
HRP20200064T1 (hr) * 2015-06-09 2020-04-03 Abbvie Inc. Modulatori nuklearnih receptora (ror) namijenjeni liječenju upalnih i autoimunih bolesti
EP3558363A1 (en) 2016-12-21 2019-10-30 Amgen Inc. Anti-tnf alpha antibody formulations
GB201709456D0 (en) * 2017-06-14 2017-07-26 Ucb Biopharma Sprl Therapeutic agents
CN109206401B (zh) * 2017-06-29 2021-03-05 南京柯菲平盛辉制药有限公司 一类甲基-1H-吲唑类RORγ调节剂及其用途
AR117398A1 (es) * 2018-03-12 2021-08-04 Abbvie Inc Inhibidores de la señalización mediada por tirosina cinasa 2
US11427558B1 (en) 2019-07-11 2022-08-30 ESCAPE Bio, Inc. Indazoles and azaindazoles as LRRK2 inhibitors
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