IT1238686B - Procedimento per la preparazione di levo e destro fenfluramina - Google Patents

Procedimento per la preparazione di levo e destro fenfluramina

Info

Publication number
IT1238686B
IT1238686B IT19331A IT1933190A IT1238686B IT 1238686 B IT1238686 B IT 1238686B IT 19331 A IT19331 A IT 19331A IT 1933190 A IT1933190 A IT 1933190A IT 1238686 B IT1238686 B IT 1238686B
Authority
IT
Italy
Prior art keywords
levo
fenfluramina
procedure
preparation
enantiomer forms
Prior art date
Application number
IT19331A
Other languages
English (en)
Other versions
IT9019331A0 (it
IT9019331A1 (it
Inventor
Grato Magnone
Original Assignee
Lab Mag Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lab Mag Spa filed Critical Lab Mag Spa
Priority to IT19331A priority Critical patent/IT1238686B/it
Publication of IT9019331A0 publication Critical patent/IT9019331A0/it
Priority to EP91100712A priority patent/EP0441160B1/en
Priority to DE69110917T priority patent/DE69110917T2/de
Priority to AT91100712T priority patent/ATE124680T1/de
Publication of IT9019331A1 publication Critical patent/IT9019331A1/it
Application granted granted Critical
Publication of IT1238686B publication Critical patent/IT1238686B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
IT19331A 1990-02-09 1990-02-09 Procedimento per la preparazione di levo e destro fenfluramina IT1238686B (it)

Priority Applications (4)

Application Number Priority Date Filing Date Title
IT19331A IT1238686B (it) 1990-02-09 1990-02-09 Procedimento per la preparazione di levo e destro fenfluramina
EP91100712A EP0441160B1 (en) 1990-02-09 1991-01-21 Process for preparing levo and dextro fenfluramine
DE69110917T DE69110917T2 (de) 1990-02-09 1991-01-21 Verfahren zur Herstellung von links- und rechtsdrehendem Fenfluramin.
AT91100712T ATE124680T1 (de) 1990-02-09 1991-01-21 Verfahren zur herstellung von links- und rechtsdrehendem fenfluramin.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT19331A IT1238686B (it) 1990-02-09 1990-02-09 Procedimento per la preparazione di levo e destro fenfluramina

Publications (3)

Publication Number Publication Date
IT9019331A0 IT9019331A0 (it) 1990-02-09
IT9019331A1 IT9019331A1 (it) 1991-08-09
IT1238686B true IT1238686B (it) 1993-09-01

Family

ID=11156806

Family Applications (1)

Application Number Title Priority Date Filing Date
IT19331A IT1238686B (it) 1990-02-09 1990-02-09 Procedimento per la preparazione di levo e destro fenfluramina

Country Status (4)

Country Link
EP (1) EP0441160B1 (it)
AT (1) ATE124680T1 (it)
DE (1) DE69110917T2 (it)
IT (1) IT1238686B (it)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1292595B1 (it) * 1997-06-03 1999-02-08 Alfa Chem Ital Processo per la produzione della dexfenfluramina cloridrato.
ITMI20010047A1 (it) * 2001-01-12 2002-07-12 Consiglio Nazionale Ricerche Procedimento di preparazione degli enantiomeri di 1-(3-trifluo-rometilfenil)-propan-2-olo
US9549909B2 (en) 2013-05-03 2017-01-24 The Katholieke Universiteit Leuven Method for the treatment of dravet syndrome
RU2740919C2 (ru) 2015-08-24 2021-01-21 Зодженикс Интернэшнл Лимитед Способы лечения синдрома леннокса-гасто с использованием фенфлурамина
EP3170807B1 (en) 2015-11-23 2019-12-11 Frau Pharma S.r.l. New method for synthesis of fenfluramine
IL286391B (en) * 2015-12-22 2022-08-01 Zogenix International Ltd Penfluramine preparations and methods for their preparation
JP2019507111A (ja) 2015-12-22 2019-03-14 ゾゲニクス インターナショナル リミテッド 代謝抵抗性フェンフルラミン類縁体およびその使用法
RU2021106383A (ru) 2016-08-24 2021-04-05 Зодженикс Интернэшнл Лимитед Состав для ингибирования образования агонистов 5-ht2b и способы его применения
MX2019013279A (es) 2017-05-09 2020-01-15 Zogenix International Ltd Metodos de tratamiento del sindrome de doose utilizando fenfluramina.
WO2019067413A1 (en) 2017-09-26 2019-04-04 Zogenix International Limited USE OF A FENFLURAMINE FORMULATION TO REDUCE THE NUMBER AND FREQUENCIES OF CONVULSIVE CRISES IN PATIENT POPULATIONS
US20190091179A1 (en) 2017-09-26 2019-03-28 Zogenix International Limited Congnitive function with fenfluramine
US10682317B2 (en) 2017-09-26 2020-06-16 Zogenix International Limited Ketogenic diet compatible fenfluramine formulation
US11571397B2 (en) 2018-05-11 2023-02-07 Zogenix International Limited Compositions and methods for treating seizure-induced sudden death
JP2021530481A (ja) 2018-07-10 2021-11-11 ゾゲニクス インターナショナル リミテッド 肺高血圧症を有さない患者においててんかんまたはてんかん性脳症を処置するために使用するためのフェンフルラミン
US20220008389A1 (en) 2018-11-19 2022-01-13 Zogenix International Limited Methods of treating rett syndrome using fenfluramine
AU2020351305A1 (en) 2019-09-17 2022-03-24 Zogenix International Limited Methods of treating epileptic patients with fenfluramine
US20210299064A1 (en) 2020-02-05 2021-09-30 Zogenix International Limited Method of treating patients with lennox-gastaut syndrome
US11612574B2 (en) 2020-07-17 2023-03-28 Zogenix International Limited Method of treating patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE788850A (fr) * 1972-09-15 1973-03-15 Hoffmann La Roche Derives d'acide benzoique
KR890003368A (ko) * 1987-08-06 1989-04-14 원본미기재 특정의 치환된 페닐알킬아미노(및 아미노산) 유도체 및 기타 세로토닌농도 저하제로 오심 및 구토를 치료하는 방법

Also Published As

Publication number Publication date
IT9019331A0 (it) 1990-02-09
IT9019331A1 (it) 1991-08-09
ATE124680T1 (de) 1995-07-15
DE69110917D1 (de) 1995-08-10
DE69110917T2 (de) 1995-12-14
EP0441160A1 (en) 1991-08-14
EP0441160B1 (en) 1995-07-05

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Legal Events

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0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19950227