IT9019331A0 - Procedimento per la preparazione di levo e destro fenfluramina - Google Patents
Procedimento per la preparazione di levo e destro fenfluraminaInfo
- Publication number
- IT9019331A0 IT9019331A0 IT19331A IT1933190A IT9019331A0 IT 9019331 A0 IT9019331 A0 IT 9019331A0 IT 19331 A IT19331 A IT 19331A IT 1933190 A IT1933190 A IT 1933190A IT 9019331 A0 IT9019331 A0 IT 9019331A0
- Authority
- IT
- Italy
- Prior art keywords
- phenfluramine
- destro
- levo
- procedure
- preparation
- Prior art date
Links
- DBGIVFWFUFKIQN-UHFFFAOYSA-N (+-)-Fenfluramine Chemical compound CCNC(C)CC1=CC=CC(C(F)(F)F)=C1 DBGIVFWFUFKIQN-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT19331A IT1238686B (it) | 1990-02-09 | 1990-02-09 | Procedimento per la preparazione di levo e destro fenfluramina |
| EP91100712A EP0441160B1 (en) | 1990-02-09 | 1991-01-21 | Process for preparing levo and dextro fenfluramine |
| AT91100712T ATE124680T1 (de) | 1990-02-09 | 1991-01-21 | Verfahren zur herstellung von links- und rechtsdrehendem fenfluramin. |
| DE69110917T DE69110917T2 (de) | 1990-02-09 | 1991-01-21 | Verfahren zur Herstellung von links- und rechtsdrehendem Fenfluramin. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT19331A IT1238686B (it) | 1990-02-09 | 1990-02-09 | Procedimento per la preparazione di levo e destro fenfluramina |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IT9019331A0 true IT9019331A0 (it) | 1990-02-09 |
| IT9019331A1 IT9019331A1 (it) | 1991-08-09 |
| IT1238686B IT1238686B (it) | 1993-09-01 |
Family
ID=11156806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT19331A IT1238686B (it) | 1990-02-09 | 1990-02-09 | Procedimento per la preparazione di levo e destro fenfluramina |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0441160B1 (it) |
| AT (1) | ATE124680T1 (it) |
| DE (1) | DE69110917T2 (it) |
| IT (1) | IT1238686B (it) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1292595B1 (it) * | 1997-06-03 | 1999-02-08 | Alfa Chem Ital | Processo per la produzione della dexfenfluramina cloridrato. |
| ITMI20010047A1 (it) | 2001-01-12 | 2002-07-12 | Consiglio Nazionale Ricerche | Procedimento di preparazione degli enantiomeri di 1-(3-trifluo-rometilfenil)-propan-2-olo |
| US9549909B2 (en) | 2013-05-03 | 2017-01-24 | The Katholieke Universiteit Leuven | Method for the treatment of dravet syndrome |
| EP3340971B1 (en) | 2015-08-24 | 2024-03-13 | Zogenix International Limited | Methods of treating lennox-gastaut syndrome using fenfluramine |
| EP3170807B1 (en) | 2015-11-23 | 2019-12-11 | Frau Pharma S.r.l. | New method for synthesis of fenfluramine |
| WO2017112701A1 (en) | 2015-12-22 | 2017-06-29 | Zogenix International Limited | Metabolism resistant fenfluramine analogs and methods of using the same |
| HUE053114T2 (hu) * | 2015-12-22 | 2021-06-28 | Zogenix International Ltd | Fenfluramin kompozíciók és eljárások azok elõállítására |
| WO2018037306A1 (en) | 2016-08-24 | 2018-03-01 | Zogenix International Limited | Formulation for inhibiting formation of 5-ht 2b agonists and methods of using same |
| EP3634392A1 (en) | 2017-05-09 | 2020-04-15 | Zogenix International Limited | Methods of treating doose syndrome using fenfluramine |
| WO2019067413A1 (en) | 2017-09-26 | 2019-04-04 | Zogenix International Limited | USE OF A FENFLURAMINE FORMULATION TO REDUCE THE NUMBER AND FREQUENCIES OF CONVULSIVE CRISES IN PATIENT POPULATIONS |
| US20190091179A1 (en) | 2017-09-26 | 2019-03-28 | Zogenix International Limited | Congnitive function with fenfluramine |
| US10682317B2 (en) | 2017-09-26 | 2020-06-16 | Zogenix International Limited | Ketogenic diet compatible fenfluramine formulation |
| CA3097335A1 (en) | 2018-05-11 | 2019-11-14 | Zogenix International Limited | Compositions and methods for treating seizure-induced sudden death |
| JP2021530481A (ja) | 2018-07-10 | 2021-11-11 | ゾゲニクス インターナショナル リミテッド | 肺高血圧症を有さない患者においててんかんまたはてんかん性脳症を処置するために使用するためのフェンフルラミン |
| SG11202104378SA (en) | 2018-11-19 | 2021-05-28 | Zogenix International Ltd | Methods of treating rett syndrome using fenfluramine |
| CA3153099A1 (en) | 2019-09-17 | 2021-03-25 | Zogenix International Limited | Methods of treating epileptic patients with fenfluramine |
| US20210299064A1 (en) | 2020-02-05 | 2021-09-30 | Zogenix International Limited | Method of treating patients with lennox-gastaut syndrome |
| US11612574B2 (en) | 2020-07-17 | 2023-03-28 | Zogenix International Limited | Method of treating patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE788850A (fr) * | 1972-09-15 | 1973-03-15 | Hoffmann La Roche | Derives d'acide benzoique |
| KR890003368A (ko) * | 1987-08-06 | 1989-04-14 | 원본미기재 | 특정의 치환된 페닐알킬아미노(및 아미노산) 유도체 및 기타 세로토닌농도 저하제로 오심 및 구토를 치료하는 방법 |
-
1990
- 1990-02-09 IT IT19331A patent/IT1238686B/it active IP Right Grant
-
1991
- 1991-01-21 DE DE69110917T patent/DE69110917T2/de not_active Expired - Fee Related
- 1991-01-21 EP EP91100712A patent/EP0441160B1/en not_active Expired - Lifetime
- 1991-01-21 AT AT91100712T patent/ATE124680T1/de active
Also Published As
| Publication number | Publication date |
|---|---|
| DE69110917D1 (de) | 1995-08-10 |
| EP0441160B1 (en) | 1995-07-05 |
| ATE124680T1 (de) | 1995-07-15 |
| EP0441160A1 (en) | 1991-08-14 |
| DE69110917T2 (de) | 1995-12-14 |
| IT9019331A1 (it) | 1991-08-09 |
| IT1238686B (it) | 1993-09-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19950227 |