SG11202104378SA - Methods of treating rett syndrome using fenfluramine - Google Patents

Methods of treating rett syndrome using fenfluramine

Info

Publication number
SG11202104378SA
SG11202104378SA SG11202104378SA SG11202104378SA SG11202104378SA SG 11202104378S A SG11202104378S A SG 11202104378SA SG 11202104378S A SG11202104378S A SG 11202104378SA SG 11202104378S A SG11202104378S A SG 11202104378SA SG 11202104378S A SG11202104378S A SG 11202104378SA
Authority
SG
Singapore
Prior art keywords
fenfluramine
methods
rett syndrome
treating rett
treating
Prior art date
Application number
SG11202104378SA
Inventor
Bradley S Galer
Bret Megargel
Original Assignee
Zogenix International Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zogenix International Ltd filed Critical Zogenix International Ltd
Publication of SG11202104378SA publication Critical patent/SG11202104378SA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/04Nitro compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05Phenols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
SG11202104378SA 2018-11-19 2019-11-22 Methods of treating rett syndrome using fenfluramine SG11202104378SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862769441P 2018-11-19 2018-11-19
PCT/IB2019/060067 WO2020105005A1 (en) 2018-11-19 2019-11-22 Methods of treating rett syndrome using fenfluramine

Publications (1)

Publication Number Publication Date
SG11202104378SA true SG11202104378SA (en) 2021-05-28

Family

ID=68808446

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202104378SA SG11202104378SA (en) 2018-11-19 2019-11-22 Methods of treating rett syndrome using fenfluramine

Country Status (7)

Country Link
US (1) US20220008389A1 (en)
EP (1) EP3883555A1 (en)
AU (2) AU2019384963B2 (en)
CA (1) CA3117868A1 (en)
EA (1) EA202191079A1 (en)
SG (1) SG11202104378SA (en)
WO (1) WO2020105005A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3007673A1 (en) 2015-12-22 2017-06-29 Zogenix International Limited Metabolism resistant fenfluramine analogs and methods of using the same
BR112018011777A2 (en) 2015-12-22 2018-12-04 Zogenix International Ltd fenfluramine compositions and methods for preparing them
JP2019526544A (en) 2016-08-24 2019-09-19 ゾゲニクス インターナショナル リミテッド Formulations for inhibiting the formation of 5-HT2B agonists and methods of use thereof
US10682317B2 (en) 2017-09-26 2020-06-16 Zogenix International Limited Ketogenic diet compatible fenfluramine formulation
EP3790537A1 (en) 2018-05-11 2021-03-17 Zogenix International Limited Compositions and methods for treating seizure-induced sudden death
US11612574B2 (en) 2020-07-17 2023-03-28 Zogenix International Limited Method of treating patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
GB2597314A (en) * 2020-07-20 2022-01-26 Gw Res Ltd Use of cannabidiol in the treatment of seizures associated with rare epilepsy syndromes related to genetic abnormalities
GB2597321A (en) * 2020-07-20 2022-01-26 Gw Res Ltd Use of cannabidiol in the treatment of seizures associated with rare epilepsy syndromes related to genetic abnormalities

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1413070A (en) 1973-07-27 1975-11-05 Beecham Group Ltd Process for the production of - norfenfluramine and - fenfluramine and salts thereof
GB1413078A (en) 1973-07-27 1975-11-05 Beecham Group Ltd Process for the production of plus-norfenfluramine and plus-fenfluramine and salts thereof
IT1238686B (en) 1990-02-09 1993-09-01 Lab Mag Spa PROCEDURE FOR THE PREPARATION OF LEVO AND RIGHT FENFLURAMINA
WO2010020585A1 (en) * 2008-08-18 2010-02-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Serotonin reuptake inhibitors for the treatment of rett syndrome
CN107868071B (en) 2012-11-05 2021-07-20 爱默蕾大学 7, 8-dihydroxyflavone and 7, 8-substituted flavone derivatives, compositions, and methods related thereto
WO2017035267A1 (en) * 2015-08-24 2017-03-02 Zogenix International Limited Methods of treating lennox-gastaut syndrome using fenfluramine
BR112018011777A2 (en) 2015-12-22 2018-12-04 Zogenix International Ltd fenfluramine compositions and methods for preparing them
US20180092864A1 (en) 2016-09-30 2018-04-05 Zogenix International Limited Compositions and methods for treating seizure disorders
EP3790537A1 (en) * 2018-05-11 2021-03-17 Zogenix International Limited Compositions and methods for treating seizure-induced sudden death

Also Published As

Publication number Publication date
AU2022221450A1 (en) 2022-09-22
AU2019384963B2 (en) 2022-05-26
AU2022221450B2 (en) 2024-04-11
EP3883555A1 (en) 2021-09-29
AU2019384963A1 (en) 2021-06-10
CA3117868A1 (en) 2020-05-28
US20220008389A1 (en) 2022-01-13
WO2020105005A1 (en) 2020-05-28
EA202191079A1 (en) 2021-09-20

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