MA33132B1 - Derives pyrazole utilises comme antagonistes du recepteur ccr4 - Google Patents
Derives pyrazole utilises comme antagonistes du recepteur ccr4Info
- Publication number
- MA33132B1 MA33132B1 MA34179A MA34179A MA33132B1 MA 33132 B1 MA33132 B1 MA 33132B1 MA 34179 A MA34179 A MA 34179A MA 34179 A MA34179 A MA 34179A MA 33132 B1 MA33132 B1 MA 33132B1
- Authority
- MA
- Morocco
- Prior art keywords
- receptor antagonists
- pyrazole derivatives
- ccr4 receptor
- ccr4
- compounds
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La présente invention concerne des composés indazole (I), des procédés pour leur préparation, des intermédiaires pouvant être utilisés dans ces procédés, des compositions pharmaceutiques contenant de tels composés et leur utilisation en thérapie liée aux antagonistes du récepteur CCR4.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15570209P | 2009-02-26 | 2009-02-26 | |
PCT/EP2010/052307 WO2010097395A1 (fr) | 2009-02-26 | 2010-02-24 | Dérivés pyrazole utilisés comme antagonistes du récepteur ccr4 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA33132B1 true MA33132B1 (fr) | 2012-03-01 |
Family
ID=42110309
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA34179A MA33132B1 (fr) | 2009-02-26 | 2010-02-24 | Derives pyrazole utilises comme antagonistes du recepteur ccr4 |
Country Status (31)
Country | Link |
---|---|
US (3) | US8304446B2 (fr) |
EP (1) | EP2401270B1 (fr) |
JP (1) | JP5520969B2 (fr) |
KR (1) | KR20110128896A (fr) |
CN (1) | CN102388039B (fr) |
AR (1) | AR075594A1 (fr) |
AU (2) | AU2010217629A1 (fr) |
BR (1) | BRPI1013396A2 (fr) |
CA (1) | CA2753337A1 (fr) |
CL (1) | CL2011002103A1 (fr) |
CO (1) | CO6420342A2 (fr) |
DK (1) | DK2401270T3 (fr) |
DO (1) | DOP2011000272A (fr) |
EA (1) | EA021740B1 (fr) |
ES (1) | ES2439773T3 (fr) |
HK (1) | HK1159621A1 (fr) |
HR (1) | HRP20131174T1 (fr) |
IL (1) | IL214655A0 (fr) |
MA (1) | MA33132B1 (fr) |
MX (1) | MX2011008972A (fr) |
NZ (1) | NZ594641A (fr) |
PE (1) | PE20120307A1 (fr) |
PL (1) | PL2401270T3 (fr) |
PT (1) | PT2401270E (fr) |
RS (1) | RS53133B (fr) |
SG (1) | SG173768A1 (fr) |
SI (1) | SI2401270T1 (fr) |
SM (1) | SMT201400001B (fr) |
TW (1) | TW201041879A (fr) |
UY (1) | UY32464A (fr) |
WO (1) | WO2010097395A1 (fr) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR068121A1 (es) | 2007-08-31 | 2009-11-04 | Eisai R&D Man Co Ltd | Compuestos multiciclicos para tratar enfermedades neurodegenerativas |
KR20110122746A (ko) | 2009-02-26 | 2011-11-10 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 질소를 함유하는 융합된 헤테로사이클릭 화합물 및 β 아밀로이드 생산 저해제로서의 용도 |
BRPI1007883A2 (pt) | 2009-02-26 | 2016-02-23 | Eisai R&D Man Co Ltd | sal, e, cristal. |
US8729260B2 (en) * | 2010-05-19 | 2014-05-20 | Savior Lifetec Corporation | Process for the preparation of carbapenem using cabapenem intermediates and recovery of cabapenem |
WO2012025473A1 (fr) * | 2010-08-24 | 2012-03-01 | Glaxo Group Limited | Antagonistes du récepteur 4 des chimiokines cc |
JP6691869B2 (ja) * | 2014-02-20 | 2020-05-13 | コーネル ユニヴァーシティー | ファシンを阻害するための化合物及び方法 |
TWI817929B (zh) * | 2016-07-29 | 2023-10-11 | 美商瑞佩特治療公司 | 趨化介素受體調節劑及其用途 |
US10246462B2 (en) | 2016-09-09 | 2019-04-02 | Flx Bio, Inc. | Chemokine receptor modulators and uses thereof |
JOP20190192A1 (ar) * | 2017-03-01 | 2019-08-08 | Glaxosmithkline Ip No 2 Ltd | مشتقات بيرازول بوصفها مثبطات برومودومين |
WO2018187509A1 (fr) | 2017-04-04 | 2018-10-11 | Flx Bio, Inc. | Composés hétérocycliques utilisés en tant que modulateurs du récepteur de chimiokine |
CA3056501A1 (fr) * | 2017-04-11 | 2018-10-18 | Sunshine Lake Pharma Co., Ltd. | Composes indazole substitues par fluor et leurs utilisations |
RU2020118594A (ru) | 2017-11-06 | 2021-12-09 | Рапт Терапьютикс, Инк. | Противораковые агенты |
CN110028501B (zh) | 2018-01-12 | 2022-02-22 | 迈德欣国际有限公司 | 化合物及其制备方法和用途 |
MX2020007812A (es) | 2018-01-26 | 2020-11-24 | Rapt Therapeutics Inc | Moduladores del receptor de quimiocina y usos de los mismos. |
CN113893220A (zh) * | 2020-07-07 | 2022-01-07 | 迈德欣国际有限公司 | 鼻粘膜给药剂型和其应用 |
WO2023196432A1 (fr) | 2022-04-06 | 2023-10-12 | Rapt Therapeutics, Inc. | Modulateurs du récepteur de la chimiokine et leurs utilisations |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2848554A1 (fr) * | 2002-12-12 | 2004-06-18 | Aventis Pharma Sa | Nouveaux derives d'aminoindazoles a titre de medicaments et compositions pharmaceutiques les renfermant |
PL376789A1 (pl) * | 2002-12-12 | 2006-01-09 | Aventis Pharma S.A. | Pochodne aminoindazoli i ich zastosowanie jako inhibitorów kinazy |
SE0301650D0 (sv) | 2003-06-04 | 2003-06-04 | Astrazeneca Ab | Novel compounds |
WO2008089307A2 (fr) | 2007-01-18 | 2008-07-24 | Lexicon Pharmaceuticals, Inc. | Méthodes et compositions utilisés dans le traitement de la douleur, de l'inflammation et du cancer |
-
2010
- 2010-02-24 PL PL10705594T patent/PL2401270T3/pl unknown
- 2010-02-24 WO PCT/EP2010/052307 patent/WO2010097395A1/fr active Application Filing
- 2010-02-24 CN CN201080016319.3A patent/CN102388039B/zh not_active Expired - Fee Related
- 2010-02-24 SG SG2011059813A patent/SG173768A1/en unknown
- 2010-02-24 US US12/711,283 patent/US8304446B2/en not_active Expired - Fee Related
- 2010-02-24 EP EP10705594.9A patent/EP2401270B1/fr active Active
- 2010-02-24 MX MX2011008972A patent/MX2011008972A/es active IP Right Grant
- 2010-02-24 UY UY0001032464A patent/UY32464A/es not_active Application Discontinuation
- 2010-02-24 JP JP2011551485A patent/JP5520969B2/ja not_active Expired - Fee Related
- 2010-02-24 SI SI201030466T patent/SI2401270T1/sl unknown
- 2010-02-24 US US13/202,139 patent/US8357716B2/en not_active Expired - Fee Related
- 2010-02-24 BR BRPI1013396A patent/BRPI1013396A2/pt not_active IP Right Cessation
- 2010-02-24 NZ NZ594641A patent/NZ594641A/xx not_active IP Right Cessation
- 2010-02-24 ES ES10705594.9T patent/ES2439773T3/es active Active
- 2010-02-24 DK DK10705594.9T patent/DK2401270T3/da active
- 2010-02-24 AU AU2010217629A patent/AU2010217629A1/en not_active Abandoned
- 2010-02-24 MA MA34179A patent/MA33132B1/fr unknown
- 2010-02-24 CA CA2753337A patent/CA2753337A1/fr not_active Abandoned
- 2010-02-24 KR KR1020117022518A patent/KR20110128896A/ko not_active Application Discontinuation
- 2010-02-24 PT PT107055949T patent/PT2401270E/pt unknown
- 2010-02-24 PE PE2011001557A patent/PE20120307A1/es not_active Application Discontinuation
- 2010-02-24 AR ARP100100532A patent/AR075594A1/es not_active Application Discontinuation
- 2010-02-24 TW TW099105340A patent/TW201041879A/zh unknown
- 2010-02-24 RS RS20130585A patent/RS53133B/en unknown
- 2010-02-24 EA EA201190142A patent/EA021740B1/ru not_active IP Right Cessation
-
2011
- 2011-08-15 IL IL214655A patent/IL214655A0/en unknown
- 2011-08-25 DO DO2011000272A patent/DOP2011000272A/es unknown
- 2011-08-26 CO CO11109505A patent/CO6420342A2/es active IP Right Grant
- 2011-08-26 CL CL2011002103A patent/CL2011002103A1/es unknown
-
2012
- 2012-01-04 HK HK12100042.4A patent/HK1159621A1/xx not_active IP Right Cessation
- 2012-10-02 US US13/633,382 patent/US8507543B2/en not_active Expired - Fee Related
-
2013
- 2013-12-10 HR HRP20131174AT patent/HRP20131174T1/hr unknown
-
2014
- 2014-01-03 SM SM201400001T patent/SMT201400001B/xx unknown
-
2016
- 2016-06-02 AU AU2016203684A patent/AU2016203684A1/en not_active Abandoned
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