MA34094B1 - Dérivés de 3-(hétéroarylamino)-1,2,3,4-tétrahydro-9h-carbazole et leur utilisation comme modulateurs du récepteur de la prostaglandine d2 - Google Patents
Dérivés de 3-(hétéroarylamino)-1,2,3,4-tétrahydro-9h-carbazole et leur utilisation comme modulateurs du récepteur de la prostaglandine d2Info
- Publication number
- MA34094B1 MA34094B1 MA35260A MA35260A MA34094B1 MA 34094 B1 MA34094 B1 MA 34094B1 MA 35260 A MA35260 A MA 35260A MA 35260 A MA35260 A MA 35260A MA 34094 B1 MA34094 B1 MA 34094B1
- Authority
- MA
- Morocco
- Prior art keywords
- prostaglandin
- tetrahydro
- receptor
- modulators
- heteroarylamino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Toxicology (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
La présente invention concerne des dérivés de 3-(hétéroarylamino)-1,2,3,4-tétrahydro-9h-carbazole représentés par la formule (i), dans laquelle r1, r2 et r3 sont tels que décrits dans la description, ainsi que leur utilisation comme modulateurs de récepteurs de prostaglandine, plus particulièrement comme modulateurs du récepteur de la prostaglandine d2, dans le traitement de diverses maladies et divers troubles à médiation par la prostaglandine. L'invention concerne également des compositions pharmaceutiques contenant ces composés et des procédés pour leur préparation.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IB2010051228 | 2010-03-22 | ||
PCT/IB2011/051165 WO2011117798A1 (fr) | 2010-03-22 | 2011-03-21 | Dérivés de 3-(hétéroarylamino)-1,2,3,4-tétrahydro-9h-carbazole et leur utilisation comme modulateurs du récepteur de la prostaglandine d2 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA34094B1 true MA34094B1 (fr) | 2013-03-05 |
Family
ID=43929122
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA35260A MA34094B1 (fr) | 2010-03-22 | 2011-03-21 | Dérivés de 3-(hétéroarylamino)-1,2,3,4-tétrahydro-9h-carbazole et leur utilisation comme modulateurs du récepteur de la prostaglandine d2 |
Country Status (28)
Country | Link |
---|---|
US (1) | US8697869B2 (fr) |
EP (1) | EP2558447B1 (fr) |
JP (1) | JP5291265B2 (fr) |
KR (1) | KR101444572B1 (fr) |
CN (1) | CN102791689B (fr) |
AR (1) | AR080703A1 (fr) |
AU (1) | AU2011231208B2 (fr) |
BR (1) | BR112012024114B1 (fr) |
CA (1) | CA2790139C (fr) |
CL (1) | CL2012002570A1 (fr) |
CY (1) | CY1115800T1 (fr) |
DK (1) | DK2558447T3 (fr) |
ES (1) | ES2524079T3 (fr) |
HK (1) | HK1181048A1 (fr) |
HR (1) | HRP20141208T1 (fr) |
IL (1) | IL221977A (fr) |
MA (1) | MA34094B1 (fr) |
MX (1) | MX2012010820A (fr) |
MY (1) | MY183111A (fr) |
NZ (1) | NZ603108A (fr) |
PL (1) | PL2558447T3 (fr) |
PT (1) | PT2558447E (fr) |
RU (1) | RU2562255C2 (fr) |
SG (1) | SG183835A1 (fr) |
SI (1) | SI2558447T1 (fr) |
TW (1) | TWI562987B (fr) |
WO (1) | WO2011117798A1 (fr) |
ZA (1) | ZA201207894B (fr) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LT2697223T (lt) | 2011-04-14 | 2016-10-10 | Actelion Pharmaceuticals Ltd. | 7-(heteroaril-amino)-6,7,8,9-tetrahidropirido[1,2-a]indolacto rūgšties dariniai ir jų, kaip prostaglandino d2 receptoriaus moduliatorių, panaudojimas |
CN103450218B (zh) * | 2012-05-29 | 2015-12-23 | 山东亨利医药科技有限责任公司 | 作为crth2受体拮抗剂的吲哚类三并环衍生物 |
WO2014066568A1 (fr) | 2012-10-24 | 2014-05-01 | Winthrop-University Hospital | Biomarqueur non invasif permettant d'identifier des sujets risquant un accouchement avant terme |
WO2014181001A1 (fr) * | 2013-05-10 | 2014-11-13 | Cnic Fundación Centro Nacional De Investigaciones Cardiovasculares Carlos Iii | Composés appropriés au traitement de néoplasmes myéloprolifératifs |
PL3119779T3 (pl) * | 2014-03-17 | 2019-01-31 | Idorsia Pharmaceuticals Ltd | Pochodne kwasu azaindolooctowego i ich zastosowanie jako modulatorów receptora prostaglandyny d2 |
AU2015233046A1 (en) * | 2014-03-18 | 2016-11-03 | Idorsia Pharmaceuticals Ltd | Azaindole acetic acid derivatives and their use as prostaglandin D2 receptor modulators |
AU2016323262B2 (en) * | 2015-09-15 | 2020-11-19 | Idorsia Pharmaceuticals Ltd | Crystalline forms |
KR20200109293A (ko) | 2017-09-13 | 2020-09-22 | 프로제너티, 인크. | 자간전증 바이오마커 및 관련된 시스템 및 방법 |
EP4070113A4 (fr) | 2019-12-04 | 2023-12-20 | Biora Therapeutics, Inc. | Évaluation de la prééclampsie à l'aide de dosages du facteur de croissance placentaire libre et dissocié |
CN113995758B (zh) * | 2021-11-04 | 2023-06-02 | 中山大学 | 咔唑-嘧啶衍生物在制备治疗抗肿瘤药物中的应用 |
Family Cites Families (94)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4808608A (en) | 1986-01-23 | 1989-02-28 | Merck & Co., Inc. | Tetrahydrocarbazole 1-alkanoic acids, pharmaceutical compositions and use |
DE3631824A1 (de) | 1986-02-21 | 1988-03-31 | Bayer Ag | Cycloalkano(1.2-b)indol-sulfonamide |
ID23053A (id) * | 1997-06-04 | 2000-01-20 | Lilly Co Eli | Karboksamida yang digunakan sebagai agonis 5-ht <if> |
WO2001078697A2 (fr) | 2000-04-12 | 2001-10-25 | Merck Frosst Canada & Co. | Procede et compositions destines au traitement d'etats allergiques faisant appel a des antagonistes du recepteur pgd2 |
US20010047027A1 (en) | 2000-04-12 | 2001-11-29 | Marc Labelle | Prostaglandin D2 receptor antagonists |
ES2272712T3 (es) | 2001-05-23 | 2007-05-01 | Merck Frosst Canada Ltd. | Derivados de dihidropirrolo-1,2-aiindol y tetrahidropirido -1,2-aiindol como antagonistas de receptores de prostaglandina d2. |
DE10164564B4 (de) * | 2001-12-14 | 2007-05-16 | Zentaris Gmbh | Tetrahydrocarbazolderivate als Liganden für G-Protein gekoppelte Rezeptoren (GPCR) |
NZ533430A (en) | 2001-12-14 | 2005-12-23 | Zentaris Gmbh | Tetrahydrocarbozole derivatives as ligands for G-protein coupled receptors (GPCR) |
AR038136A1 (es) | 2002-01-24 | 2004-12-29 | Merck Frosst Canada Inc | Cicloalcanindoles con sustitucion con fluor composiciones que contienen estos compuestos y metodos de tratamiento |
SE0200356D0 (sv) | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
SE0200411D0 (sv) | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
WO2003097042A1 (fr) | 2002-05-16 | 2003-11-27 | Shionogi & Co., Ltd. | Antagoniste de recepteur de pdg2 |
US7534897B2 (en) | 2002-05-16 | 2009-05-19 | Shionogi & Co., Ltd. | Indole arylsulfonaimide compounds exhibiting PGD 2 receptor antagonism |
GB2388540A (en) | 2002-05-17 | 2003-11-19 | Bayer Ag | New use of Ramatroban |
SE0201635D0 (sv) | 2002-05-30 | 2002-05-30 | Astrazeneca Ab | Novel compounds |
TW200307542A (en) | 2002-05-30 | 2003-12-16 | Astrazeneca Ab | Novel compounds |
SE0202241D0 (sv) | 2002-07-17 | 2002-07-17 | Astrazeneca Ab | Novel Compounds |
DE60334015D1 (de) | 2002-10-30 | 2010-10-14 | Merck Frosst Canada Ltd | Pyridopyrrolizin- und pyridoindolizinderivate |
WO2004078719A1 (fr) | 2003-03-06 | 2004-09-16 | Ono Pharmaceutical Co., Ltd. | Composes a base de derives d'indole et medicaments contenant lesdits composes en tant que principe actif |
WO2004103970A1 (fr) | 2003-05-20 | 2004-12-02 | Merck Frosst Canada Ltd. | Fluoro-methanesulfonyl- cycloalkanoindoles substitues et leur utilisation en tant qu'antagonistes de prostaglandine d2 |
SE0301569D0 (sv) | 2003-05-27 | 2003-05-27 | Astrazeneca Ab | Novel compounds |
CN1805959A (zh) | 2003-06-12 | 2006-07-19 | 麦克弗罗斯特加拿大有限公司 | 作为dp拮抗剂的环烷吡咯并吡啶 |
SE0302232D0 (sv) | 2003-08-18 | 2003-08-18 | Astrazeneca Ab | Novel Compounds |
WO2005033099A2 (fr) | 2003-10-03 | 2005-04-14 | Glenmark Pharmaceuticals Ltd. | Nouveaux inhibiteurs de dipeptidylpeptidase iv, leurs procedes de preparation et compositions les contenant |
RU2006109108A (ru) | 2003-10-14 | 2007-11-20 | Оксаген Лимитед (GB) | Соединения, обладающие активностью антагонистов crth2 рецепторов |
WO2005040112A1 (fr) | 2003-10-14 | 2005-05-06 | Oxagen Limited | Composes a activite antagoniste de pgd2 |
GB2407318A (en) | 2003-10-23 | 2005-04-27 | Oxagen Ltd | Substituted Indol-3-yl acetic acid derivatives |
GB0324763D0 (en) | 2003-10-23 | 2003-11-26 | Oxagen Ltd | Use of compounds in therapy |
SE0303180D0 (sv) | 2003-11-26 | 2003-11-26 | Astrazeneca Ab | Novel compounds |
US7019022B2 (en) * | 2003-12-15 | 2006-03-28 | Merck Frosst Canada & Co. | Substituted tetrahydrocarbazole and cyclopentanoindole derivatives |
ATE433452T1 (de) | 2004-01-31 | 2009-06-15 | Actimis Pharmaceuticals Inc | Imidazoä1,2-cüpyrimidinylessigsäurederivate |
US7897788B2 (en) | 2004-03-11 | 2011-03-01 | Actelion Pharmaceutical Ltd. | Indol-1-yl-acetic acid derivatives |
JP4051398B2 (ja) | 2004-03-11 | 2008-02-20 | アクテリオン ファマシューティカルズ リミテッド | テトラヒドロピリドインドール誘導体 |
US20050234030A1 (en) | 2004-04-20 | 2005-10-20 | Wilmin Bartolini | Modulators of CRTH2, COX-2 and FAAH |
FR2869878B1 (fr) | 2004-05-04 | 2006-08-04 | Mecan Outil Sa Sa | Procede et dispositif d'emballage d'objets allonges fragiles |
GB0412914D0 (en) | 2004-06-10 | 2004-07-14 | Oxagen Ltd | Compounds |
MY144903A (en) | 2004-06-17 | 2011-11-30 | Novartis Ag | Pyrrolopyridine derivatives and their use as crth2 antagonists |
JP2008513512A (ja) | 2004-09-21 | 2008-05-01 | アサーシス, インク. | Crth2受容体拮抗作用を示すインドール酢酸およびこれらの使用 |
JP2008513511A (ja) | 2004-09-21 | 2008-05-01 | アサーシス, インク. | Crth2受容体拮抗作用を示すベンズイミダゾール酢酸およびこれらの使用 |
GB0427381D0 (en) | 2004-12-14 | 2005-01-19 | Novartis Ag | Organic compounds |
RU2404163C2 (ru) * | 2004-12-27 | 2010-11-20 | Актелион Фармасьютиклз Лтд | Производные 2,3,4,9-тетрагидро-1h-карбазола в качестве антагонистов рецептора crth2 |
DOP2006000016A (es) | 2005-01-26 | 2006-07-31 | Aventis Pharma Inc | 2-fenil-indoles como antagonistas del receptor de la prostaglandina d2. |
GB2422830A (en) | 2005-02-04 | 2006-08-09 | Oxagen Ltd | Pyrrolopyridines and their use in the treatment of diseases mediated by PGD2 at the CRTH2 receptor |
GB2422831A (en) | 2005-02-04 | 2006-08-09 | Oxagen Ltd | Pyrrolopyridines and their use in the treatment of diseases mediated by PGD2 at the CRTH2 receptor |
GB2422829A (en) | 2005-02-04 | 2006-08-09 | Oxagen Ltd | Pyrrolopyridines and their use in the treatment of diseases mediated by PGD2 at the CRTH2 receptor |
NZ560513A (en) | 2005-02-25 | 2010-07-30 | Ono Pharmaceutical Co | Indole compound and use thereof |
GB0504150D0 (en) | 2005-03-01 | 2005-04-06 | Oxagen Ltd | Microcrystalline material |
GB0505048D0 (en) | 2005-03-11 | 2005-04-20 | Oxagen Ltd | Compounds with PGD antagonist activity |
KR101333861B1 (ko) | 2005-05-24 | 2013-11-28 | 메르크 세로노 에스. 에이. | Crth2 조정자로서 삼환계 스피로 유도체 |
GB0512944D0 (en) | 2005-06-24 | 2005-08-03 | Argenta Discovery Ltd | Indolizine compounds |
ES2372701T3 (es) | 2005-07-22 | 2012-01-25 | Shionogi & Co., Ltd. | Derivado de indol que tiene actividad antagonista del receptor de pgd2. |
US7842692B2 (en) | 2005-07-22 | 2010-11-30 | Shionogi & Co., Ltd. | Azaindole derivative having PGD2 receptor antagonistic activity |
ES2443022T3 (es) | 2005-08-12 | 2014-02-17 | Merck Frosst Canada Inc. | Derivados de indol como antagonistas del receptor CRTH2 |
WO2007022501A2 (fr) | 2005-08-18 | 2007-02-22 | Microbia, Inc. | Composes indoles utiles |
WO2007029629A1 (fr) | 2005-09-06 | 2007-03-15 | Shionogi & Co., Ltd. | Dérivé d’acide indolécarboxylate ayant une activité à effet antagoniste du récepteur pgd2 |
GB0518783D0 (en) | 2005-09-14 | 2005-10-26 | Argenta Discovery Ltd | Indolizine compounds |
GB0521275D0 (en) | 2005-10-19 | 2005-11-30 | Argenta Discovery Ltd | 3-Aminoindole compounds |
GB0525143D0 (en) | 2005-12-09 | 2006-01-18 | Novartis Ag | Organic compounds |
GB0525144D0 (en) | 2005-12-09 | 2006-01-18 | Novartis Ag | Organic compounds |
GB0525141D0 (en) | 2005-12-09 | 2006-01-18 | Novartis Ag | Organic compounds |
GB0525337D0 (en) | 2005-12-13 | 2006-01-18 | Novartis Ag | Organic compounds |
GB0605743D0 (en) | 2006-03-22 | 2006-05-03 | Oxagen Ltd | Salts with CRTH2 antagonist activity |
US7741360B2 (en) | 2006-05-26 | 2010-06-22 | Astrazeneca Ab | Bi-aryl or aryl-heteroaryl substituted indoles |
GB0611695D0 (en) | 2006-06-13 | 2006-07-26 | Novartis Ag | Organic compounds |
JP5270542B2 (ja) | 2006-07-22 | 2013-08-21 | オキサジェン リミテッド | Crth2アンタゴニスト活性を有する化合物 |
BRPI0714554A2 (pt) | 2006-07-25 | 2013-05-07 | Sanofi Aventis | 2-fenil-indàis como antagonistas do receptor de prostaglandina d2 |
PL2051962T3 (pl) * | 2006-08-07 | 2012-03-30 | Actelion Pharmaceuticals Ltd | Pochodne kwasu (3-amino-1,2,3,4-tetrahydro-9h-karbazol-9-ilo)-octowego |
EA200970590A1 (ru) | 2006-12-21 | 2009-12-30 | Арджента Дискавери Лимитед | Антагонисты crth2 |
GB0625842D0 (en) | 2006-12-22 | 2007-02-07 | Argenta Discovery Ltd | Indolizine derivatives |
EP2136804A1 (fr) | 2007-03-21 | 2009-12-30 | Argenta Oral Therapeutics Limited | Dérivés indolizine d'acide acétique utilisés comme antagonistes de crth2 |
GB0719521D0 (en) | 2007-10-05 | 2007-11-14 | Argenta Discovery Ltd | Compounds |
GB0719485D0 (en) | 2007-10-05 | 2007-11-14 | Argenta Discovery Ltd | Compounds |
CN101896178B (zh) | 2007-10-10 | 2013-11-20 | 北京赛林泰医药技术有限公司 | 作为crth2受体拮抗剂的杂环化合物 |
US20100280049A1 (en) | 2007-11-06 | 2010-11-04 | Amira Pharmaceuticals, Inc. | Antagonists of pgd2 receptors |
GB0722203D0 (en) | 2007-11-13 | 2007-12-19 | Oxagen Ltd | Use of CRTH2 antagonist compounds |
GB0722216D0 (en) | 2007-11-13 | 2007-12-27 | Oxagen Ltd | Use of crth2 antagonist compounds |
DK2229358T3 (da) | 2007-12-14 | 2011-07-04 | Pulmagen Therapeutics Asthma Ltd | Indoler og deres terapeutiske anvendelse |
CN101932571B (zh) | 2008-01-18 | 2014-04-23 | 奥克萨根有限公司 | 具有crth2拮抗活性的化合物 |
US7750027B2 (en) | 2008-01-18 | 2010-07-06 | Oxagen Limited | Compounds having CRTH2 antagonist activity |
WO2009090399A1 (fr) | 2008-01-18 | 2009-07-23 | Argenta Discovery Limited | Indoles actifs sur le récepteur crth2 |
WO2009093026A1 (fr) | 2008-01-22 | 2009-07-30 | Oxagen Limited | Composés présentant une activité antagoniste du récepteur crth2 |
WO2009093029A1 (fr) | 2008-01-22 | 2009-07-30 | Oxagen Limited | Composés présentant une activité antagoniste de crth2 |
JP2011088826A (ja) | 2008-01-31 | 2011-05-06 | Astellas Pharma Inc | 芳香族カルボン酸化合物 |
US20110112134A1 (en) | 2008-05-16 | 2011-05-12 | Amira Pharmaceuticals, Inc. | Tricyclic Antagonists of Prostaglandin D2 Receptors |
WO2010008864A2 (fr) | 2008-06-24 | 2010-01-21 | Amira Pharmaceuticals, Inc. | Antagonistes de cycloalcane[b]indole de récepteurs de prostaglandine d2 |
CN102099342B (zh) | 2008-07-15 | 2013-07-10 | 霍夫曼-拉罗奇有限公司 | 氨基四氢吲唑基乙酸类 |
WO2010006944A1 (fr) | 2008-07-15 | 2010-01-21 | F. Hoffmann-La Roche Ag | Acides aminotétrahydroindazoloacétiques |
AU2009295230A1 (en) | 2008-09-22 | 2010-03-25 | Merck Canada Inc. | Indole derivatives as CRTH2 receptor antagonists |
EP2342201A4 (fr) | 2008-09-22 | 2012-05-02 | Merck Canada Inc | Dérivés d'indole utilisables en tant qu'antagonistes du récepteur crth2 |
JP2012502928A (ja) | 2008-09-22 | 2012-02-02 | メルク カナダ インコーポレイテッド | Crth2受容体アンタゴニストとしてのアザインドール誘導体 |
WO2010039982A1 (fr) | 2008-10-01 | 2010-04-08 | Ironwood Pharmaceuticals, Inc. | Modulateurs de crth2 |
GB2465062B (en) | 2008-11-06 | 2011-04-13 | Amira Pharmaceuticals Inc | Cycloalkane(B)azaindole antagonists of prostaglandin D2 receptors |
US20110311483A1 (en) | 2010-03-30 | 2011-12-22 | Ironwood Pharmaceuticals, Inc. | Crth2 modulators |
LT2697223T (lt) | 2011-04-14 | 2016-10-10 | Actelion Pharmaceuticals Ltd. | 7-(heteroaril-amino)-6,7,8,9-tetrahidropirido[1,2-a]indolacto rūgšties dariniai ir jų, kaip prostaglandino d2 receptoriaus moduliatorių, panaudojimas |
-
2011
- 2011-03-21 US US13/637,005 patent/US8697869B2/en not_active Expired - Fee Related
- 2011-03-21 DK DK11715042.5T patent/DK2558447T3/da active
- 2011-03-21 AR ARP110100914A patent/AR080703A1/es unknown
- 2011-03-21 BR BR112012024114-1A patent/BR112012024114B1/pt not_active IP Right Cessation
- 2011-03-21 RU RU2012144543/04A patent/RU2562255C2/ru not_active IP Right Cessation
- 2011-03-21 MA MA35260A patent/MA34094B1/fr unknown
- 2011-03-21 PT PT117150425T patent/PT2558447E/pt unknown
- 2011-03-21 CA CA2790139A patent/CA2790139C/fr not_active Expired - Fee Related
- 2011-03-21 SG SG2012064358A patent/SG183835A1/en unknown
- 2011-03-21 MY MYPI2012004149A patent/MY183111A/en unknown
- 2011-03-21 SI SI201130326T patent/SI2558447T1/sl unknown
- 2011-03-21 AU AU2011231208A patent/AU2011231208B2/en not_active Ceased
- 2011-03-21 MX MX2012010820A patent/MX2012010820A/es active IP Right Grant
- 2011-03-21 PL PL11715042T patent/PL2558447T3/pl unknown
- 2011-03-21 WO PCT/IB2011/051165 patent/WO2011117798A1/fr active Application Filing
- 2011-03-21 EP EP11715042.5A patent/EP2558447B1/fr active Active
- 2011-03-21 NZ NZ603108A patent/NZ603108A/en not_active IP Right Cessation
- 2011-03-21 ES ES11715042.5T patent/ES2524079T3/es active Active
- 2011-03-21 KR KR1020127027402A patent/KR101444572B1/ko active IP Right Grant
- 2011-03-21 TW TW100109588A patent/TWI562987B/zh not_active IP Right Cessation
- 2011-03-21 CN CN201180013742.2A patent/CN102791689B/zh not_active Expired - Fee Related
- 2011-03-21 JP JP2013500636A patent/JP5291265B2/ja not_active Expired - Fee Related
-
2012
- 2012-09-19 IL IL221977A patent/IL221977A/en not_active IP Right Cessation
- 2012-09-20 CL CL2012002570A patent/CL2012002570A1/es unknown
- 2012-10-19 ZA ZA2012/07894A patent/ZA201207894B/en unknown
-
2013
- 2013-07-17 HK HK13108389.7A patent/HK1181048A1/xx not_active IP Right Cessation
-
2014
- 2014-12-02 CY CY20141101005T patent/CY1115800T1/el unknown
- 2014-12-15 HR HRP20141208AT patent/HRP20141208T1/hr unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA34094B1 (fr) | Dérivés de 3-(hétéroarylamino)-1,2,3,4-tétrahydro-9h-carbazole et leur utilisation comme modulateurs du récepteur de la prostaglandine d2 | |
WO2008152099A3 (fr) | Aryl/hétarylamides en tant que modulateurs du récepteur ep2 | |
WO2012009009A3 (fr) | Nouveaux dérivés de 2-amino-4-pyrazolyl-thiazole et leur utilisation en tant que modulateurs allostériques des récepteurs métabotropiques du glutamate | |
MX2010009752A (es) | Compuestos de oxadiazoantraceno para el tratamiento de diabetes. | |
EA200970612A1 (ru) | Производные индола в качестве агонистов рецептора s1p1 | |
MX2010005861A (es) | Agonistas novedosos de los receptores de glucocorticoides. | |
MX2015003653A (es) | Derivados de amida del acido benzoimidazol-carboxilico como moduladores del receptor apj. | |
EA201190139A1 (ru) | Производные тиенопиримидиндиона в качестве модуляторов trpa1 | |
EA201390947A1 (ru) | Соединения 2-амино-4-арилтиазола в качестве антагонистов trpa1 | |
MY149855A (en) | Benzimidazole derivatives and their use for modulating the gaba? receptor complex | |
EA200970065A1 (ru) | Производные пиперазинила, предназначенные для лечения заболеваний, опосредованных рецептором gpr38 | |
MA32943B1 (fr) | Piperidine spiro pyrrolidione et piperidinone substituees, leur preparation et leur utilisation therapeutique | |
GEP20135806B (en) | Lactams as beta secretase inhibitors | |
WO2009025785A3 (fr) | Ligands de récepteur cb2 pour le traitement de la douleur | |
WO2011006935A3 (fr) | Dérivés de tétrazole | |
MX2010009462A (es) | Derivados de indazol. | |
EA201190004A1 (ru) | Конденсированные имидазол карбоксамиды в качестве модуляторов trpv3 | |
MX2011012669A (es) | Nuevos agonistas del receptor de glucocorticoides. | |
MX2009010374A (es) | Derivados de tetrahidro-naftalenamina sustituidos con heterociclilo, su preparacion y su uso como medicamentos. | |
WO2007042544A3 (fr) | Derives d'imidazole utilises pour moduler le complexe du recepteur gabaa | |
MA32945B1 (fr) | Tétrahydropyrane spiro pyrrolidinone et pipéridinone substituées, leur préparation et leur utilisation thérapeutique | |
EA200870606A1 (ru) | Серосодержащие производные пиразола в качестве избирательных антагонистов рецептора каннабиноидов св | |
UY32744A (es) | Derivados de 2-carboxamida-7-piperazinil-benzofurano 774 | |
EA201001566A1 (ru) | Новый класс спиропиперидинов для лечения нейродегенеративных заболеваний | |
MA32479B1 (fr) | Compoés nouveaux actifs comme antagonistes des recepteurs muscariniques |