MX2009005462A - Analogos de 7,8-saturados-4,5-epoxi-morfinano. - Google Patents
Analogos de 7,8-saturados-4,5-epoxi-morfinano.Info
- Publication number
- MX2009005462A MX2009005462A MX2009005462A MX2009005462A MX2009005462A MX 2009005462 A MX2009005462 A MX 2009005462A MX 2009005462 A MX2009005462 A MX 2009005462A MX 2009005462 A MX2009005462 A MX 2009005462A MX 2009005462 A MX2009005462 A MX 2009005462A
- Authority
- MX
- Mexico
- Prior art keywords
- epoxy
- saturated
- morphinanium analogs
- morphinanium
- analogs
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
Se describen análogos 7,8-saturados de 4,5-epoximorfinano novedosos. También se describen composiciones farmacéuticas que contienen los análogos 7,8- saturados de 4,5-epoxi-mofinano y métodos de sus usos farmacéuticos. Los compuestos descritos son útiles, inter alia, como moduladores de los receptores opioides.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86709906P | 2006-11-22 | 2006-11-22 | |
US86739006P | 2006-11-27 | 2006-11-27 | |
PCT/US2007/085461 WO2008064353A2 (en) | 2006-11-22 | 2007-11-21 | 7,8-saturated-4,5-epoxy-morphinanium analogs |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009005462A true MX2009005462A (es) | 2009-08-28 |
Family
ID=39430613
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009005455A MX2009005455A (es) | 2006-11-22 | 2007-11-21 | (r)-n-estereoisomeros de analogos de 7,8-saturados-4,5 epoxi-morfinano. |
MX2009005462A MX2009005462A (es) | 2006-11-22 | 2007-11-21 | Analogos de 7,8-saturados-4,5-epoxi-morfinano. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009005455A MX2009005455A (es) | 2006-11-22 | 2007-11-21 | (r)-n-estereoisomeros de analogos de 7,8-saturados-4,5 epoxi-morfinano. |
Country Status (8)
Country | Link |
---|---|
US (2) | US20090047279A1 (es) |
EP (2) | EP2101773A2 (es) |
JP (2) | JP2010510328A (es) |
AU (2) | AU2007323571A1 (es) |
BR (1) | BRPI0719305A2 (es) |
CA (2) | CA2670382A1 (es) |
MX (2) | MX2009005455A (es) |
WO (2) | WO2008064353A2 (es) |
Families Citing this family (37)
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DK2368553T3 (en) | 2003-04-08 | 2015-02-09 | Progenics Pharm Inc | Pharmaceutical preparation comprising methylnaltrexone |
AR057035A1 (es) | 2005-05-25 | 2007-11-14 | Progenics Pharm Inc | SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS |
AR057325A1 (es) | 2005-05-25 | 2007-11-28 | Progenics Pharm Inc | Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos |
TW200815451A (en) | 2006-08-04 | 2008-04-01 | Wyeth Corp | 6-carboxy-normorphinan derivatives, synthesis and uses thereof |
AU2008223328B2 (en) * | 2007-03-06 | 2012-10-11 | SpecGx LLC | Process for the preparation of quaternary N-alkyl morphinan alkaloid salts |
MX351611B (es) | 2007-03-29 | 2017-10-20 | Wyeth Llc | Formas de cristal de bromuro de (r)-n-metilnaltrexona y uso de las mismas. |
CA2682125C (en) | 2007-03-29 | 2015-06-16 | Progenics Pharmaceuticals, Inc. | Peripheral opioid receptor antagonists and uses thereof |
DK2139890T3 (da) | 2007-03-29 | 2014-08-25 | Wyeth Llc | Perifere opioidreceptor-antagonister og anvendelser deraf |
CN101959892B (zh) | 2008-02-06 | 2014-01-08 | 普罗热尼奇制药公司 | (r),(r)-2,2’-二-甲基纳曲酮的制备和用途 |
US8685995B2 (en) | 2008-03-21 | 2014-04-01 | The University Of Chicago | Treatment with opioid antagonists and mTOR inhibitors |
US8877524B2 (en) * | 2008-03-31 | 2014-11-04 | Cree, Inc. | Emission tuning methods and devices fabricated utilizing methods |
CN101607963B (zh) * | 2008-06-20 | 2013-04-03 | 重庆医药工业研究院有限责任公司 | 吗啡喃衍生物及其制备方法 |
GB0814043D0 (en) * | 2008-07-31 | 2008-09-10 | Serentis Ltd | The treatment of skin disorders |
CA2676881C (en) | 2008-09-30 | 2017-04-25 | Wyeth | Peripheral opioid receptor antagonists and uses thereof |
WO2010096791A1 (en) * | 2009-02-23 | 2010-08-26 | Mallinckrodt Inc. | (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
CN102325777B (zh) * | 2009-02-23 | 2015-08-12 | 马林克罗特公司 | (+)-吗啡喃*n-氧化物及其制备方法 |
US8946419B2 (en) | 2009-02-23 | 2015-02-03 | Mallinckrodt Llc | (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
JP5784507B2 (ja) * | 2009-02-23 | 2015-09-24 | マリンクロッド エルエルシー | (+)−モルフィナニウム第四級塩およびその生成方法 |
US8829020B2 (en) | 2009-07-16 | 2014-09-09 | Mallinckrodt Llc | Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers |
AU2011263416B2 (en) | 2010-06-11 | 2014-04-10 | Rhodes Technologies | Process for N-dealkylation of tertiary amines |
TWI478928B (zh) | 2010-06-11 | 2015-04-01 | Rhodes Technologies | 用於製備n-烯丙基化合物之過渡金屬催化的製程及其用途 |
AU2012217903A1 (en) * | 2011-02-14 | 2013-08-15 | Alkermes, Inc. | Peripherially acting mu opioid antagonists |
BR112013027976A2 (pt) * | 2011-05-02 | 2016-08-09 | Univ Brock | processos e intermediários na preparação de análogos de morfina através da n-desmetilação dos n-óxidos utilizando os reagentes de ciclodesidratação |
WO2012166891A2 (en) * | 2011-05-31 | 2012-12-06 | Algynomics Inc. | Mu-opioid receptor binding compounds |
RU2014112493A (ru) | 2011-09-08 | 2015-10-20 | МАЛЛИНКРОДТ Эл-Эл-Си | Получения алкалоидов без выделения промежуточных продуктов |
US8987289B2 (en) | 2012-12-14 | 2015-03-24 | Trevi Therapeutics, Inc. | Methods for treating pruritus |
US20140179727A1 (en) | 2012-12-14 | 2014-06-26 | Trevi Therapeutics, Inc. | Methods for treating pruritus |
US8637538B1 (en) | 2012-12-14 | 2014-01-28 | Trevi Therapeutics, Inc. | Methods for treatment of pruritis |
EP2941430B1 (en) * | 2012-12-28 | 2017-04-26 | Purdue Pharma LP | 7,8-cyclicmorphinan analogs |
ES2784690T3 (es) | 2013-12-05 | 2020-09-29 | Univ Bath | Nuevos compuestos opioides y sus usos |
WO2015095644A1 (en) | 2013-12-20 | 2015-06-25 | AntiOP, Inc. | Intranasal naloxone compositions and methods of making and using same |
US9701687B2 (en) * | 2014-05-05 | 2017-07-11 | Noramco, Inc. | Process for the preparation of opioid compounds |
US9701688B2 (en) | 2014-05-05 | 2017-07-11 | Noramco, Inc. | Process for the preparation of opioid compounds |
CN105985348B (zh) * | 2015-02-12 | 2019-02-01 | 正大天晴药业集团股份有限公司 | 一种溴甲基纳曲酮的制备方法 |
WO2020023486A1 (en) | 2018-07-23 | 2020-01-30 | Trevi Therapeutics, Inc. | Treatment of chronic cough, breathlessness and dyspnea |
KR20210057132A (ko) * | 2018-09-14 | 2021-05-20 | 케러 테라퓨틱스, 인코포레이티드 | 카파 오피오이드 수용체 효능제의 경구 제형 |
WO2021152113A1 (en) | 2020-01-31 | 2021-08-05 | Bayer Aktiengesellschaft | Substituted 2,3-benzodiazepines derivatives |
Family Cites Families (28)
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US3217006A (en) * | 1965-11-09 | Purification of d-j-methoxy-n-methyl-ar morphinan | ||
US2813097A (en) * | 1955-08-16 | 1957-11-12 | Upjohn Co | 3-hydroxy-n-methylmorphinan-n-oxide |
US2813098A (en) * | 1955-08-16 | 1957-11-12 | Upjohn Co | 3-methoxy-n-methylmorphinan n-oxide |
US3131185A (en) * | 1959-03-18 | 1964-04-28 | Orsymonde | Nicotinic esters of hydroxyl derivatives of the phenanthrenic alkaloids of opium, and process for the preparation of these esters |
DE1420015B1 (de) * | 1959-10-16 | 1971-08-26 | Boehringer Sohn Ingelheim | 2'-Hydroxy-5,9-dimethyl-6,7-benzomorphane |
US3144459A (en) * | 1962-08-06 | 1964-08-11 | Shionogi & Co | D-3-methoxy-4-phenoxy-nu-methyl-delta6-morphinan, derivatives thereof, and method for the purification thereof |
BE638369A (es) * | 1962-10-10 | |||
US4176186A (en) * | 1978-07-28 | 1979-11-27 | Boehringer Ingelheim Gmbh | Quaternary derivatives of noroxymorphone which relieve intestinal immobility |
US4990617A (en) * | 1985-12-02 | 1991-02-05 | E. I. Du Pont De Nemours And Company | N-oxide prodrug derivatives of 3-hydroxy morphinans and partial morphinans and derivatives |
US4730048A (en) * | 1985-12-12 | 1988-03-08 | Regents Of The University Of Minnesota | Gut-selective opiates |
US4806556A (en) * | 1985-12-12 | 1989-02-21 | Regents Of The University Of Minnesota | Gut-selective opiates |
US5159081A (en) * | 1991-03-29 | 1992-10-27 | Eli Lilly And Company | Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists |
US5270328A (en) * | 1991-03-29 | 1993-12-14 | Eli Lilly And Company | Peripherally selective piperidine opioid antagonists |
US5250542A (en) * | 1991-03-29 | 1993-10-05 | Eli Lilly And Company | Peripherally selective piperidine carboxylate opioid antagonists |
US5434171A (en) * | 1993-12-08 | 1995-07-18 | Eli Lilly And Company | Preparation of 3,4,4-trisubstituted-piperidinyl-N-alkylcarboxylates and intermediates |
US5866154A (en) * | 1994-10-07 | 1999-02-02 | The Dupont Merck Pharmaceutical Company | Stabilized naloxone formulations |
US5804595A (en) * | 1995-12-05 | 1998-09-08 | Regents Of The University Of Minnesota | Kappa opioid receptor agonists |
US6559158B1 (en) * | 1997-11-03 | 2003-05-06 | Ur Labs, Inc. | Use of methylnaltrexone and related compounds to treat chronic opioid use side affects |
EP1206264A2 (en) * | 1999-08-25 | 2002-05-22 | Barrett R. Cooper | Compositions and methods for treating opiate intolerance |
US6469030B2 (en) * | 1999-11-29 | 2002-10-22 | Adolor Corporation | Methods for the treatment and prevention of ileus |
CA2449175A1 (en) * | 2001-06-05 | 2002-12-12 | University Of Chicago | Use of methylnaltrexone to treat immune suppression |
US7056500B2 (en) * | 2001-10-18 | 2006-06-06 | Nektar Therapeutics Al, Corporation | Polymer conjugates of opioid antagonists |
US20030191147A1 (en) * | 2002-04-09 | 2003-10-09 | Barry Sherman | Opioid antagonist compositions and dosage forms |
DE10229842A1 (de) * | 2002-07-03 | 2004-02-05 | Helmut Prof. Dr. Schmidhammer | Morphinanderivate und deren quartäre Ammoniumsalze substituiert in Position 14, Herstellungsverfahren und Verwendung |
JP4806190B2 (ja) * | 2002-09-25 | 2011-11-02 | ユーロ−セルティーク エス.エイ. | N−置換ヒドロモルホン及びそれらの使用 |
PT1562953E (pt) * | 2002-11-08 | 2009-11-19 | Mallinckrodt Inc | Processo para a preparação de sais quaternários de n -alquilmorfinano |
AR057035A1 (es) * | 2005-05-25 | 2007-11-14 | Progenics Pharm Inc | SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS |
AR057325A1 (es) * | 2005-05-25 | 2007-11-28 | Progenics Pharm Inc | Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos |
-
2007
- 2007-11-21 EP EP07871565A patent/EP2101773A2/en not_active Withdrawn
- 2007-11-21 BR BRPI0719305-0A patent/BRPI0719305A2/pt not_active Application Discontinuation
- 2007-11-21 CA CA002670382A patent/CA2670382A1/en not_active Abandoned
- 2007-11-21 US US11/944,389 patent/US20090047279A1/en not_active Abandoned
- 2007-11-21 EP EP07871566A patent/EP2101774A2/en not_active Withdrawn
- 2007-11-21 AU AU2007323571A patent/AU2007323571A1/en not_active Abandoned
- 2007-11-21 WO PCT/US2007/085461 patent/WO2008064353A2/en active Application Filing
- 2007-11-21 MX MX2009005455A patent/MX2009005455A/es unknown
- 2007-11-21 MX MX2009005462A patent/MX2009005462A/es unknown
- 2007-11-21 WO PCT/US2007/085458 patent/WO2008064351A2/en active Application Filing
- 2007-11-21 JP JP2009538522A patent/JP2010510328A/ja active Pending
- 2007-11-21 JP JP2009538524A patent/JP2010510329A/ja active Pending
- 2007-11-21 AU AU2007323573A patent/AU2007323573A1/en not_active Abandoned
- 2007-11-21 CA CA002670136A patent/CA2670136A1/en not_active Abandoned
- 2007-11-21 US US11/944,400 patent/US20080176884A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2007323573A1 (en) | 2008-05-29 |
JP2010510329A (ja) | 2010-04-02 |
WO2008064353A2 (en) | 2008-05-29 |
BRPI0719305A2 (pt) | 2014-02-04 |
US20080176884A1 (en) | 2008-07-24 |
US20090047279A1 (en) | 2009-02-19 |
MX2009005455A (es) | 2009-08-28 |
EP2101773A2 (en) | 2009-09-23 |
EP2101774A2 (en) | 2009-09-23 |
CA2670136A1 (en) | 2008-05-29 |
AU2007323571A1 (en) | 2008-05-29 |
WO2008064351A3 (en) | 2008-11-20 |
CA2670382A1 (en) | 2008-05-29 |
WO2008064353A3 (en) | 2008-11-27 |
JP2010510328A (ja) | 2010-04-02 |
WO2008064351A2 (en) | 2008-05-29 |
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