PT1562953E - Processo para a preparação de sais quaternários de n -alquilmorfinano - Google Patents

Processo para a preparação de sais quaternários de n -alquilmorfinano Download PDF

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Publication number
PT1562953E
PT1562953E PT03783211T PT03783211T PT1562953E PT 1562953 E PT1562953 E PT 1562953E PT 03783211 T PT03783211 T PT 03783211T PT 03783211 T PT03783211 T PT 03783211T PT 1562953 E PT1562953 E PT 1562953E
Authority
PT
Portugal
Prior art keywords
preparation
morphinan alkaloid
quaternary
alkaloid salts
alkyl morphinan
Prior art date
Application number
PT03783211T
Other languages
English (en)
Inventor
Gary L Cantrell
Robert E Halvachs
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of PT1562953E publication Critical patent/PT1562953E/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
PT03783211T 2002-11-08 2003-11-05 Processo para a preparação de sais quaternários de n -alquilmorfinano PT1562953E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42474802P 2002-11-08 2002-11-08
US42558002P 2002-11-12 2002-11-12

Publications (1)

Publication Number Publication Date
PT1562953E true PT1562953E (pt) 2009-11-19

Family

ID=32314554

Family Applications (1)

Application Number Title Priority Date Filing Date
PT03783211T PT1562953E (pt) 2002-11-08 2003-11-05 Processo para a preparação de sais quaternários de n -alquilmorfinano

Country Status (11)

Country Link
US (1) US7285665B2 (pt)
EP (1) EP1562953B1 (pt)
JP (1) JP2006509745A (pt)
AT (1) ATE444295T1 (pt)
AU (1) AU2003290630B2 (pt)
CA (1) CA2504262C (pt)
DE (1) DE60329520D1 (pt)
ES (1) ES2332453T3 (pt)
MX (1) MXPA05004759A (pt)
PT (1) PT1562953E (pt)
WO (1) WO2004043964A2 (pt)

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US8524731B2 (en) 2005-03-07 2013-09-03 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US8518962B2 (en) 2005-03-07 2013-08-27 The University Of Chicago Use of opioid antagonists
US9662325B2 (en) 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
AU2006220682B2 (en) 2005-03-07 2012-05-31 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
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AU2013200437B2 (en) * 2005-05-25 2015-01-15 Progenics Pharmaceuticals, Inc. (S)-N-methylnaltrexone, process for its synthesis and its pharmaceutical use
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
TW200815451A (en) * 2006-08-04 2008-04-01 Wyeth Corp 6-carboxy-normorphinan derivatives, synthesis and uses thereof
AU2007297827B2 (en) 2006-09-20 2012-09-20 Mallinckrodt Llc Preparation of substituted morphinan-6-ones and salts and intermediates thereof
FR2906252B1 (fr) * 2006-09-21 2008-11-28 Sanofi Aventis Sa Procede de preparation d'halogenures de n-aklyl naltrexone
JP2010510329A (ja) * 2006-11-22 2010-04-02 プロジェニックス ファーマスーティカルス インコーポレーテッド ７，８−飽和−４，５−エポキシ−モルフィナニウム類似体
CA2670386A1 (en) * 2006-11-22 2008-05-29 Progenics Pharmaceuticals, Inc. Processes for synthesizing quaternary 4,5-epoxy-morphinan analogs and isolating their n-stereoisomers
US9040726B2 (en) 2007-03-06 2015-05-26 Mallinckrodt Llc Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
EP2137189B1 (en) 2007-03-06 2015-05-06 Mallinckrodt LLC Process for the preparation of quaternary n-alkyl morphinan alkaloid salts
US20100305323A1 (en) * 2007-03-29 2010-12-02 Smolenskaya Valeriya N Crystal forms of (r)-n-methylnaltrexone bromide and uses thereof
CA2682550C (en) 2007-03-29 2016-05-17 Wyeth Peripheral opioid receptor antagonists and uses thereof
PE20090700A1 (es) 2007-03-29 2009-07-13 Progenics Pharm Inc Compuestos heterociclicos como antagonistas del receptor opioide periferico
WO2008138383A1 (de) 2007-05-16 2008-11-20 Cilag Ag Verfahren zur herstellung von n-methylnaltrexonbromid
WO2009009292A2 (en) * 2007-07-11 2009-01-15 Mallinckrodt Inc. Crystalline forms of naltrexone methobromide
EP2019105A1 (en) * 2007-07-19 2009-01-28 Siegfried Ltd. Process for the preparation of quaternary n-alkyl morphine or morphinane alkaloid derivatives
MX2010001371A (es) * 2007-08-09 2010-03-10 Rensselaer Polytech Inst Carboxamidas opioides cuaternarias.
US20110112129A2 (en) * 2007-11-26 2011-05-12 Pharmacofore, Inc. Peripheral Phenolic Opioid Antagonist
WO2009099411A1 (en) 2008-02-06 2009-08-13 Progenics Pharmaceuticals, Inc. Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone
AU2009214500B2 (en) * 2008-02-14 2014-10-23 Alkermes, Inc. Selective opioid compounds
CA2719134C (en) 2008-03-21 2015-06-30 The University Of Chicago Treatment with opioid antagonists and mtor inhibitors
EP2285780B1 (en) 2008-05-27 2015-08-26 Mallinckrodt LLC Processes and compounds for the preparation of normorphinans
CN101607963B (zh) 2008-06-20 2013-04-03 重庆医药工业研究院有限责任公司 吗啡喃衍生物及其制备方法
WO2010028004A2 (en) 2008-09-03 2010-03-11 Mallinckrodt Inc. Substituted berbines and processes for their synthesis
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof
JP2012518652A (ja) 2009-02-23 2012-08-16 マリンクロッド インコーポレイテッド （＋）−６−ヒドロキシ−モルフィナンまたは（＋）−６−アミノ−モルフィナン誘導体
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
EP2398806A1 (en) 2009-02-23 2011-12-28 Mallinckrodt LLC (+)-morphinanium n-oxides and processes for their production
NZ595591A (en) 2009-04-24 2013-11-29 Univ Brock Processes for the preparation of morphinane and morphinone compounds
US8829020B2 (en) 2009-07-16 2014-09-09 Mallinckrodt Llc Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
EP2995614B8 (en) 2010-06-11 2018-03-28 Rhodes Technologies Inc. Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
JP2013529595A (ja) 2010-06-11 2013-07-22 ローズ テクノロジーズ 第３級アミンのｎ−脱アルキル化方法
KR20140063763A (ko) 2011-09-08 2014-05-27 말린크로트 엘엘씨 중간체를 단리하지 않는 알칼로이드의 제조 방법
US9969746B2 (en) 2013-12-05 2018-05-15 The University Of Bath Opioid compounds and their uses

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Also Published As

Publication number Publication date
US20060014771A1 (en) 2006-01-19
CA2504262A1 (en) 2004-05-27
EP1562953B1 (en) 2009-09-30
WO2004043964A2 (en) 2004-05-27
EP1562953A2 (en) 2005-08-17
AU2003290630A1 (en) 2004-06-03
ATE444295T1 (de) 2009-10-15
DE60329520D1 (de) 2009-11-12
AU2003290630B2 (en) 2009-01-29
US7285665B2 (en) 2007-10-23
MXPA05004759A (es) 2005-08-02
JP2006509745A (ja) 2006-03-23
WO2004043964A3 (en) 2004-08-26
ES2332453T3 (es) 2010-02-05
CA2504262C (en) 2012-01-10

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